scholarly journals Recent Advances in Understanding Magnetic Nanoparticles in AC Magnetic Fields and Optimal Design for Targeted Hyperthermia

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Hiroaki Mamiya

Targeted hyperthermia treatment using magnetic nanoparticles is a promising cancer therapy that enables selective heating of hidden microcancer tissues. In this review, I outline the present status of chemical synthesis of such magnetic nanoparticles. Then, the latest progress in understanding their heat dissipation mechanisms under large magnetic fields is overviewed. This review covers the recently predicted novel phenomena: magnetic hysteresis loops of superparamagnetic states and steady orientations of easy axes at the directions parallel, perpendicular, or oblique to the AC magnetic field. Finally, this review ends with future prospects from the viewpoint of optimal design for efficacy with a low side-effect profile.

2011 ◽  
Vol 4 (1) ◽  
pp. 99 ◽  
Author(s):  
M. S. Islam ◽  
J. Kurawaki ◽  
Y. Kusumoto ◽  
M. Abdulla-Al-Mamun ◽  
M. Z. Bin Mukhlish

Novel neck-structured Fe3O4, γ-Fe2O3 and α-Fe2O3 magnetic nanoparticles were successfully prepared by a modified hydrothermal method. Ferrous chloride tetrahydrate was solely used as a precursor for the novel nanomaterials. The X-ray diffractometric study revealed the purity of the nanomaterials thus synthesized. All of the products were characterized using a field-emission scanning electron microscope (FE-SEM) and a transmission electron microscope (TEM) for the particle size and morphology. Neck-structured particle morphology was observed for the first time in all of iron oxides with magnetic properties. The particle size observed was 50–60 nm. The synthesized nanomaterials showed excellent magnetization values when magnetic hysteresis loops were measured using a superconducting quantum interference device (SQUID). Moreover, the as-prepared magnetic nanoparticles suspensions showed significant temperature increments under an AC (alternating current) magnetic-field induction condition at room temperature which indicates the hyperthermia feasibility. Keywords: Magnetic materials; Neck-structured; Hyperthermia; Heat dissipation. © 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v4i1.8727J. Sci. Res. 4 (1), 99-107 (2012)


2014 ◽  
Vol 116 (12) ◽  
pp. 123910 ◽  
Author(s):  
M. L. Plumer ◽  
J. van Ek ◽  
J. P. Whitehead ◽  
T. J. Fal ◽  
J. I. Mercer

Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Suho Choi ◽  
Seul-Ki Bac ◽  
Xinyu Liu ◽  
Sanghoon Lee ◽  
Sining Dong ◽  
...  

Abstract We report the observation of exchange bias in a ferromagnetic Ga0.94Mn0.06As0.77P0.23/ Ga0.94Mn0.06As bilayer, in which the easy axis in one layer is oriented out-of-plane, and in the other in-plane. Magnetization reversal in this system is explored using planar Hall effect (PHE) measurements under various initial conditions and with various field-cooling orientations. Our results show that the two magnetic layers are ferromagnetically exchange-coupled, and that such coupling results in pronounced exchange-bias-like shifts of magnetic hysteresis loops during reversal of in-plane magnetization. The presence of exchange bias in this system can be understood on the basis of magnetic closure domains formed in the layer with the out-of-plane easy axis.


1989 ◽  
Vol 03 (01) ◽  
pp. 77-85 ◽  
Author(s):  
Y. D. DAI ◽  
C. LIN ◽  
W. B. ZHANG ◽  
S. Q. FENG ◽  
X. ZHU ◽  
...  

Magnetic properties of the high T c superconductors BiSrCaCuO and TlBaCaCuO were investigated systematically. Magnetic current densities were calculated from magnetic hysteresis loops of bulk and powdered samples by Bean model. The results showed that flux pinning in these materials is much weaker than that in YBaCuO.


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