scholarly journals Suppression of Osteopontin Functions by Levocetirizine, a Histamine Receptor Antagonist, In Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-12
Author(s):  
Toshimitsu Komatsuzaki ◽  
Isao Suzaki ◽  
Kojiro Hirano ◽  
Ken-Ichi Kanai ◽  
Kazuhito Asano ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Histamine Receptor ◽  
Histamine Receptor Antagonist

scholarly journals H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice

2016 ◽  
Vol 31 (5) ◽  
pp. 1023-1029 ◽  
Author(s):  
Magdalena Dudek ◽  
Kamil Kuder ◽  
Marcin Kołaczkowski ◽  
Adrian Olczyk ◽  
Elżbieta Żmudzka ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Histamine Receptor ◽  
Histamine Receptor Antagonist

scholarly journals Minimal role for H1 and H2 histamine receptors in cutaneous thermal hyperemia to local heating in humans

2006 ◽  
Vol 100 (2) ◽  
pp. 535-540 ◽  
Author(s):  
Brett J. Wong ◽  
Sarah J. Williams ◽  
Christopher T. Minson
Keyword(s):  
Blood Flow ◽  
Receptor Antagonist ◽  
Skin Blood Flow ◽  
Local Heating ◽  
Histamine Receptor ◽  
Receptor Activation ◽  
Control Site ◽  
Doppler Flowmetry ◽  
Histamine Receptor Antagonist ◽  
And Control

The precise mechanism(s) underlying the thermal hyperemic response to local heating of human skin are not fully understood. The purpose of this study was to investigate a potential role for H1 and H2 histamine-receptor activation in this response. Two groups of six subjects participated in two separate protocols and were instrumented with three microdialysis fibers on the ventral forearm. In both protocols, sites were randomly assigned to receive one of three treatments. In protocol 1, sites received 1) 500 μM pyrilamine maleate (H1-receptor antagonist), 2) 10 mM l-NAME to inhibit nitric oxide synthase, and 3) 500 μM pyrilamine with 10 mM NG-nitro-l-arginine methyl ester (l-NAME). In protocol 2, sites received 1) 2 mM cimetidine (H2 antagonist), 2) 10 mM l-NAME, and 3) 2 mM cimetidine with 10 mM l-NAME. A fourth site served as a control site (no microdialysis fiber). Skin sites were locally heated from a baseline of 33 to 42°C at a rate of 0.5°C/5 s, and skin blood flow was monitored using laser-Doppler flowmetry (LDF). Cutaneous vascular conductance was calculated as LDF/mean arterial pressure. To normalize skin blood flow to maximal vasodilation, microdialysis sites were perfused with 28 mM sodium nitroprusside, and control sites were heated to 43°C. In both H1 and H2 antagonist studies, no differences in initial peak or secondary plateau phase were observed between control and histamine-receptor antagonist only sites or between l-NAME and l-NAME with histamine receptor antagonist. There were no differences in nadir response between l-NAME and l-NAME with histamine-receptor antagonist. However, the nadir response in H1 antagonist sites was significantly reduced compared with control sites, but there was no effect of H2 antagonist on the nadir response. These data suggest only a modest role for H1-receptor activation in the cutaneous response to local heating as evidenced by a diminished nadir response and no role for H2-receptor activation.

scholarly journals Effects of Olopatadine Hydrochloride, a Histamine Receptor Antagonist, on Histamine-Induced Skin Responses

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Takashi Hashimoto ◽  
Norito Ishii ◽  
Takahiro Hamada ◽  
Teruki Dainichi ◽  
Tadashi Karashima ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Histamine Receptor ◽  
Histamine Receptor Antagonist ◽  
Skin Responses ◽  
Olopatadine Hydrochloride
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