scholarly journals Innate Immune Responses in House Dust Mite Allergy

ISRN Allergy ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Alain Jacquet
Keyword(s):  
House Dust ◽  
Molecular Model ◽  
Inflammatory Cells ◽  
Specific Ige ◽  
Innate Immune ◽  
Allergic Response ◽  
House Dust Mites ◽  
T Cell Epitopes ◽  
House Dust Mite Allergy ◽  
Mite Allergy

Sensitizations to house dust mites (HDM) trigger strong exacerbated allergen-induced inflammation of the skin and airways mucosa from atopic subjects resulting in atopic dermatitis as well as allergic rhinitis and asthma. Initially, the Th2-biased HDM allergic response was considered to be mediated only by allergen B- and T-cell epitopes to promote allergen-specific IgE production as well as IL-4, IL-5, and IL-13 to recruit inflammatory cells. But this general molecular model of HDM allergenicity must be revisited as a growing literature suggests that stimulations of innate immune activation pathways by HDM allergens offer new answers to the following question: what makes an HDM allergen an allergen? Indeed, HDM is a carrier not only for allergenic proteins but also microbial adjuvant compounds, both of which are able to stimulate innate signaling pathways leading to allergy. This paper will describe the multiple ways used by HDM allergens together with microbial compounds to control the initiation of the allergic response through engagement of innate immunity.

Serum IgE Levels and Specific IgE Antibodies in House Dust Mite Allergy: Predictive Value

1983 ◽  
Vol 20 (2) ◽  
pp. 93-96 ◽  
Author(s):  
LF. Perrin ◽  
J. Sroussi ◽  
F Cea-Gil ◽  
P. Deviller ◽  
Y. Lasne
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Predictive Value ◽  
Specific Ige ◽  
Ige Antibodies ◽  
Serum Ige ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite ◽  
Specific Ige Antibodies

scholarly journals Isolation and characterization of the 68 kD allergen from house dust mite Dermatophagoides pteronyssinus

2009 ◽  
Vol 74 (5) ◽  
pp. 513-522 ◽  
Author(s):  
Katarina Milovanovic ◽  
Lidija Burazer ◽  
Olga Vuckovic ◽  
Marina Atanaskovic-Markovic ◽  
Tanja Cirkovic-Velickovic ◽  
...  
Keyword(s):  
Molecular Mass ◽  
House Dust ◽  
House Dust Mite ◽  
Blot Analysis ◽  
High Molecular Mass ◽  
House Dust Mites ◽  
House Dust Mite Allergy ◽  
Ige Reactivity ◽  
Mite Allergy ◽  
Dust Mite

House dust mites (HDM) represent a major source of allergens, contributing to the increasing incidence of type I hypersensitivity disease worldwide. Over 30 different IgE-binding proteins from the HDM extract were detected. Although group 1 and 2 have been identified as major allergens, due to the safety and efficacy of allergy diagnosis and immunotherapy, there is a need to carefully evaluate the clinical relevance of other allergens present in the HDM extract. In regard to this, a high molecular mass allergen of about 68 kD was purified from the HDM extract using a combination of gel permeation chromatography and reversed-phase chromatography. The IgG and IgE reactivity of the purified protein were preserved during the purification process, as confirmed by Western blot analysis with polyclonal rabbit antibodies and dot blot analysis with a pool of sera from subjects with house dust mite allergy, respectively. In addition, the IgE reactivity was confirmed using ELISA testing with nine patient sera. The biological potency of the 68 kD allergen was confirmed by skin prick testing in five allergic subjects, suggesting that the high molecular mass allergen is a good candidate for component-resolved diagnosis of house dust mite allergy and eventual therapeutic treatment.

scholarly journals CONFIRMATION OF ETIOLOGIC DIAGNOSIS IN CHILDREN WITH HOUSE DUST MITE ALLERGY AS AN ESSENTIAL STAGE BEFORE ALLERGEN SPECIFIC IMMUNOTHERAPY. A REVIEW

2017 ◽  
Vol 14 (6) ◽  
pp. 98-106
Author(s):  
O V Trusova ◽  
A V Kamaev ◽  
N L Lyashenko ◽  
I V Makarova
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
House Dust Mites ◽  
Skin Tests ◽  
Allergen Specific Immunotherapy ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite

House dust mites are important cause for allergic rhinitis, and almost half of allergic rhinitis patients is sensitized to them. In patients with house dust mite allergy evidence of sensitivity can not be strictly achieved with medical history and patients complaints, since the cause-effect relationships are not obvious. At the same time incomplete allergological examination can lead to an incorrect definition of the main relevant allergens, and expensive treatment may not give the desired result in this cases. The estimation of the allergens for allergenspecific immunotherapy should be based on the disease history, detection of offending allergens by means of allergological examination in vivo with skin tests, nasal or conjunctival provocational tests, and component diagnostics if necessary. This approach based on use of provocational tests as a part of allergological examination is considered to be one of the ways to personalized therapy.

House dust mite allergy: Its innate immune response and immunotherapy

Immunobiology ◽  
2018 ◽  
Vol 223 (3) ◽  
pp. 300-302 ◽  
Author(s):  
Fang-Liang Huang ◽  
En-Chih Liao ◽  
Sheng-Jie Yu
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
House Dust ◽  
House Dust Mite ◽  
Innate Immune ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite

What is House Dust Mite Allergy in a Community with no House Dust Mites?

2006 ◽  
Vol 117 (2) ◽  
pp. S115
Author(s):  
S.T. Sigurdardottir ◽  
B. Adalsteinsdottir ◽  
T. Gislason ◽  
B. Kristensen ◽  
D. Gislason
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
House Dust Mites ◽  
Dust Mites ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite

Dust-Free Bedrooms in the Treatment of Asthmatic Children with House Dust or House Dust Mite Allergy: A Controlled Trial

PEDIATRICS ◽  
1983 ◽  
Vol 71 (3) ◽  
pp. 418-422 ◽  
Author(s):  
Andrew B. Murray ◽  
Alexander C. Ferguson
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Controlled Trial ◽  
House Dust Mites ◽  
Dust Mites ◽  
House Dust Mite Allergy ◽  
Asthmatic Children ◽  
Mite Allergy ◽  
Significant Difference ◽  
Dust Mite

Twenty asthmatic children with prick tests positive for house dust or house dust mites were allocated to two groups that were matched for severity. One group was provided with zippered vinyl covers for pillows, mattresses, and box springs, and instructions for making the bedroom as easy to keep clean as a hospital ward; the other group was not. At the end of a 1-month study period, there was a marked and statistically significant difference in symptoms and signs of asthma between the two groups. Those with a dust-free bedroom had fewer days on which wheezing was observed, medication was given, or an abnormally low peak expiratory flow rate was recorded. Bronchial tolerance to aerosolized histamine significantly improved in the group whose bedrooms had been modified. A dust-free bedroom diminishes bronchial irritability and is a practical and effective method for decreasing asthma in children with house dust or house dust mite allergy.

scholarly journals House dust mite allergy: from T-cell epitopes to immuno-therapy

1993 ◽  
Vol 23 (12) ◽  
pp. 763-772 ◽  
Author(s):  
R. E. O'HEHIR ◽  
G. F. HOYNE ◽  
W. R. THOMAS ◽  
J. R. LAMB
Keyword(s):  
T Cell ◽  
House Dust ◽  
House Dust Mite ◽  
T Cell Epitopes ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite

scholarly journals House Dust Mite Allergy and the Der p1 Conundrum: A Literature Review and Case Series

Allergies ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 108-114
Author(s):  
Miriana d’Alessandro ◽  
Laura Bergantini ◽  
Anna Perrone ◽  
Paolo Cameli ◽  
Valerio Beltrami ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Case Series ◽  
Specific Ige ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Der P2 ◽  
Dust Mite ◽  
Der P1

The house dust mite (HDM) is globally ubiquitous in human habitats. Thirty-two allergens for Dermatophagoides farinae and 21 for Dermatophagoides pteronyssinus have been detected so far. The present minireview summarizes information about the role of Der p 1 as a key coordinator of the HDM-induced allergic response and reports on a series of Italian patients who are allergic to HDMs. We studied the specific IgE profiles in a population of patients with allergic asthma and rhinitis screened for specific immunotherapy (SIT) for HDM allergies, with the aim of obtaining insights into the pathogenic role of Der p1. Patients co-sensitized to other airborne allergens showed a higher prevalence of asthma (9/12 (75%) vs. 2/7 (29%); p < 0.05) than did HDM mono-sensitized patients. The latter group showed higher Der p1 concentrations than that of the co-sensitized group (p = 0.0360), and a direct correlation between Der p1 and Der p2 (r = 0.93; p = 0.0003) was observed. In conclusion, our study offers insights into the role of Der p1 in a population of patients with allergic rhinitis and asthma who were candidates for SIT. Interestingly, Der p1 positivity was associated with bronchial asthma and co-sensitization.

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