scholarly journals Arteriovenous Passage Times and Visual Field Progression in Normal Tension Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Eva Charlotte Koch ◽  
Kay Oliver Arend ◽  
Marion Bienert ◽  
Andreas Remky ◽  
Niklas Plange
Keyword(s):  
Visual Field ◽  
Field Tests ◽  
Normal Tension Glaucoma ◽  
Retinal Blood Flow ◽  
Visual Field Progression ◽  
Confocal Scanning Laser Ophthalmoscope ◽  
Confocal Scanning ◽  
Confocal Scanning Laser ◽  
Passage Times

Purpose. Fluorescein angiographic studies revealed prolonged arteriovenous passage (AVP) times and increased fluorescein filling defects in normal tension glaucoma (NTG) compared to healthy controls. The purpose of this study was to correlate baseline AVP and fluorescein filling defects with visual field progression in patients with NTG.Patients and Methods. Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study. Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz). Visual field progression was evaluated using regression analysis of the MD (Humphrey-Zeiss, SITA-24-2, MD progression per year (dB/year)). 72 patients with NTG were included, 44 patients in study 1 (fluorescein filling defects) and 28 patients in study 2 (AVP).Results. In study 1 (mean follow-up years, visual field tests), MD progression per year ( dB/year) was significantly correlated to the age (, ) but not to fluorescein filling defects, IOP, or MD at baseline. In study 2 (mean follow-up years, visual field tests), MD progression per year ( dB/year) was significantly correlated to AVP (, ) but not to age, IOP, or MD at baseline.Conclusion. Longer AVP times at baseline are correlated to visual field progression in NTG. Impaired retinal blood flow seems to be an important factor for glaucoma progression.

Long-term follow-up of visual field progression after trabeculectomy in progressive normal-tension glaucoma

Ophthalmology ◽  
2002 ◽  
Vol 109 (4) ◽  
pp. 766-770 ◽  
Author(s):  
Takashi Shigeeda ◽  
Atsuo Tomidokoro ◽  
Makoto Araie ◽  
Nobuyuki Koseki ◽  
Seiichiro Yamamoto
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Visual Field Progression ◽  
Long Term Follow Up

scholarly journals Retrobulbar Hemodynamics and Visual Field Progression in Normal Tension Glaucoma: A Long-Term Follow-Up Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
D. Kuerten ◽  
M. Fuest ◽  
E. C. Koch ◽  
A. Koutsonas ◽  
N. Plange
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Doppler Imaging ◽  
Progression Rate ◽  
Visual Field Progression ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Retrobulbar Hemodynamics

Purpose. Vascular risk factors are important factors in the pathogenesis of glaucoma. The purpose of this research was to investigate retrobulbar hemodynamics and visual field progression in patients with normal tension glaucoma (NTG).Patients and Methods. 31 eyes of 16 patients with NTG were included in a retrospective long-term follow-up study. Colour Doppler imaging was performed at baseline to determine various CDI parameters in the different retrobulbar vessels. The rate of visual field progression was determined using the Visual Field Index (VFI) progression rate per year (in %). To be included in the analysis, patients had at least 4 visual field examinations with a follow-up of at least 2 years.Results. Mean follow-up was 7.6 ± 4.1 years with an average of 10 ± 5 visual field tests. The mean MD (mean defect) at baseline was −7.61 ± 7.49 dB. The overall VFI progression was −1.14 ± 1.40% per year. A statistical significant correlation between VFI progression and the RI of the NPCA and PSV of the CRA was found.Conclusion. Long-term visual field progression may be linked to impaired retrobulbar hemodynamics in patients with NTG only to a limited degree. Interpretation of the data for an individual patient seems to be limited due to the variability of parameters.

scholarly journals Visual Subfield Progression in Glaucoma Subtypes

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Wei-Wen Su ◽  
Shian-Sen Hsieh ◽  
Shih-Tsung Cheng ◽  
Cheng-Wen Su ◽  
Wei-Chi Wu ◽  
...  
Keyword(s):  
Visual Field ◽  
Open Angle Glaucoma ◽  
Demographic Data ◽  
Normal Tension Glaucoma ◽  
Rate Of Change ◽  
Threshold Sensitivity ◽  
Angle Closure ◽  
Visual Field Progression

Purpose. To investigate visual field progression pattern and factors associated with progression in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and chronic angle-closure glaucoma (CACG). Methods. The raw data of the 30-2 Humphrey Field Analyzer from glaucoma patients with definite visual field progression were processed with pointwise linear regression (PLR) analysis. The rate of change of retinal threshold sensitivity in the ten glaucoma hemifield test (GHT) zones, the upper and the lower hemifields, and the whole field was evaluated and was correlated with patients’ basic demographic data. Results. An average follow-up of 6.94 ± 2.69 years that showed the rate of change of visual field threshold sensitivity was correlated with the peak posttreatment intraocular pressure (IOP) and the long-term IOP fluctuations in all GHT zones except in the inferior arcuate area. The baseline IOP, the trough posttreatment IOP, the refractive status, and the CCT were not correlated with VF progression. Conclusion. The rate of visual field progression was correlated with the peak posttreatment IOP and the long-term IOP fluctuation but with subfield differences.

scholarly journals Population-based associations between progression of normal-tension glaucoma and Yang-deficient constitution among Chinese persons

2021 ◽  
pp. bjophthalmol-2021-319210
Author(s):  
Lewei Tang ◽  
Liang Chen ◽  
Cong Ye ◽  
Jingwei Zheng ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Chinese Medicine ◽  
Visual Field ◽  
Traditional Chinese Medicine ◽  
Normal Tension Glaucoma ◽  
Population Based ◽  
The Body ◽  
Mean Deviation ◽  
Visual Field Progression

PurposeTo explore the association between constitution types as defined by traditional Chinese medicine (TCM) and risk for normal-tension glaucoma (NTG).DesignPopulation-based cohort study.MethodsPersons were identified in a population cohort aged ≥30 years with NTG, defined as having an untreated mean intraocular pressure measurement ≤21 mm Hg over six separate occasions, with no single reading >24 mm Hg (as in the Collaborative Normal Tension Glaucoma Study). The Body Constitution in Traditional Chinese Medicine Questionnaire was used to assess each participant’s TCM constitution types. The association between various constitutions and visual field progression according to Early Manifest Glaucoma Trial criteria was assessed using Cox regression HR models.ResultsAmong 142 participants (245 eyes), 23 persons (17.6%) and 25 eyes (10.2%) progressed, over a mean (SD) follow-up duration of 3.49 (0.99) years. Progression rates were highest in participants with Yang-deficient constitution (n=19, 13.4%), among whom 7 (36.8%) exhibited worsening fields. After adjusting for sex, age, central corneal thickness, retinal nerve fibre layer thickness and mean deviation on visual field testing, Yang-deficient constitution (HR 4.63, 95% CI 1.77 to 12.1, p=0.002) and higher mean intraocular pressure during follow-up (HR 1.25, 95% CI 1.01 to 1.56, p=0.044) were associated with field progression.ConclusionsYang-deficient constitution and higher intraocular pressure are risk factors for visual field progression in NTG patients. Yang deficiency is characterised by abnormal vasoregulation, and these results may be consistent with prior studies linking NTG progression to Raynaud’s phenomenon and migraine.

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