scholarly journals Therapeutic Efficacy of Fuzheng-Huayu Tablet Based Traditional Chinese Medicine Syndrome Differentiation on Hepatitis-B-Caused Cirrhosis: A Multicenter Double-Blind Randomized Controlled Trail

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ya-Nan Song ◽  
Ji-Jia Sun ◽  
Yi-Yu Lu ◽  
Lie-Ming Xu ◽  
Yue-Qiu Gao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hepatitis B ◽  
Therapeutic Efficacy ◽  
Life Quality ◽  
Classification Model ◽  
Syndrome Differentiation ◽  
Double Blind ◽  
Forecasting Method ◽  
Tcm Syndrome

Aim. To evaluate and predict the therapeutic efficacy of Fuzheng-Huayu tablet (FZHY) based traditional Chinese Medicine (TCM) syndrome differentiation or TCM symptoms on chronic hepatitis B caused cirrhosis (HBC).Methods.The trial was designed according to CONSORT statement. It was a multi-center, double-blind, randomized, placebo-controlled trail. Several clinical parameters, Child-Pugh classification and TCM symptoms were detected and evaluated. The FZHY efficacy was predicted by an established Bayes forecasting method following the Bayes classification model.Results.The levels of HA and TCM syndrome score in FZHY group were significantly decreased (P<0.05) compared to placebo group, respectively. The efficacy of FZHY on TCM syndrome score in HBC patients with some TCM syndromes was better. In TCM syndrome score evaluation, there were 53 effective and 22 invalid in FZHY group. TCM symptoms predicted FZHY efficacy on HBC were close to Child-Pugh score prediction.Conclusion.FZHY decreases the levels of HA and TCM syndrome scores, improves the life quality of HBC patients. Moreover, there were different therapeutic efficacies among different TCM syndromes, indicating that accurate TCM syndrome differentiation might guide the better TCM treatment. Furthermore, the FZHY efficacy was able to predict by Bayes forecasting method through the alteration of TCM symptoms.

scholarly journals A Series of N-of-1 Trials for Traditional Chinese Medicine Using a Bayesian Method: Study Rationale and Protocol

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Lizhi Lu ◽  
Jiaqi An ◽  
Huijia Chen ◽  
Peilan Yang ◽  
Minhua Xu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Statistical Method ◽  
Evaluation Method ◽  
Reference Value ◽  
Syndrome Differentiation ◽  
Single Subject ◽  
Hierarchical Bayesian ◽  
Double Blind ◽  
Tcm Syndrome

Background. Our previous studies showed that N-of-1 trials could reflect the individualized characteristics of traditional Chinese medicine (TCM) syndrome differentiation with good feasibility, but the sensitivity was low. Therefore, this study will use hierarchical Bayesian statistical method to improve the sensitivity and applicability of N-of-1 trials of TCM. Methods/Design. This is a randomized, double-blind, placebo-controlled, three-pair crossover trial for a single subject, including 4–8 weeks of run-in period and 24 weeks of formal trial. In this study, we will recruit a total of 30 participants who are in the stable stage of bronchiectasis. The trial will be divided into three pairs (cycles), and one cycle contains two observation periods. The medications will be taken for three weeks and stopped for one week in the last week of each observation period. The order of syndrome differentiation decoction and placebo will be randomly determined. Patient self-reported symptom score (on a 7-point Likert scale) is the primary outcome. Discussion. Some confounding variables (such as TCM syndrome type and potential carryover effect of TCM) will be introduced into hierarchical Bayesian statistical method to improve the sensitivity and applicability of N-of-1 trials of TCM, and the use of prior available information (e.g., “borrowing from strength” of previous trial results) within the analysis may improve the sensitivity of the results of a series of N-of-1 trials, from both the individual and population level to study the efficacy of TCM syndrome differentiation. It is the exploration of improving the objective evaluation method of the clinical efficacy of TCM and may provide reference value for clinical trials of TCM in other chronic diseases. This trial is registered with ClinicalTrials.gov (ID: NCT04601792).

scholarly journals Treatment of Oral Ulcer Based on TCM Syndrome Differentiation

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ying Yao ◽  
Li Liu
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Severe Case ◽  
Oral Ulcer ◽  
Syndrome Differentiation ◽  
Tcm Syndrome ◽  
Chinese Medicine Treatment

Oral ulcer is a kind of ulcerative injury that occurs in the oral mucosa and is very common in clinic. In severe case, it can affect the quality of life of the patients. Western medicine treatment of oral ulcer is often prone to relapse, while the effect of traditional Chinese medicine treatment is remarkable.

scholarly journals Syndrome Differentiation and Treatment Regularity in Traditional Chinese Medicine for Type 2 Diabetes: A Text Mining Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhili Dou ◽  
Ye Xia ◽  
Jiawei Zhang ◽  
Yizhen Li ◽  
Yunan Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Current Status ◽  
Syndrome Differentiation ◽  
Acupuncture Points ◽  
Acupoint Therapy ◽  
Clinical Databases ◽  
Tcm Syndrome

ObjectiveThe goal of this study was to systematically summarize and categorize the syndrome differentiation, medication rules, and acupoint therapy in the domestic traditional Chinese medicine (TCM) literature on type 2 diabetes mellitus (T2DM), such that guidelines and new insights can be provided for future practitioners and researchers.MethodsTaking randomized controlled trials (RCTs) on the treatment of T2DM in TCM as the research theme, we searched for full-text literature in three major clinical databases, including CNKI, Wan Fang, and VIP, published between 1990 and 2020. We then conducted frequency statistics, cluster analysis, association rules extraction, and topic modeling based on a corpus of medical academic words extracted from 3,654 research articles.ResultsThe TCM syndrome types, subjective symptoms, objective indicators, Chinese herbal medicine, acupuncture points, and TCM prescriptions for T2DM were compiled based on invigorating the kidney and Qi, nourishing Yin, and strengthening the spleen. Most TCM syndrome differentiation for T2DM was identified as “Zhongxiao” (the lesion in the spleen and stomach) and “Xiaxiao” (the lesion in the kidney) deficiency syndromes, and most medications and acupoint therapies were focused on the “Spleen Channel” and “Kidney Channel.” However, stagnation of liver Qi was mentioned less when compared with other syndromes, which did not have symptomatic medicines.ConclusionThis study provides an in-depth perspective for the TCM syndrome differentiation, medication rules, and acupoint therapy for T2DM and provides practitioners and researchers with valuable information about the current status and frontier trends of TCM research on T2DM in terms of both diagnosis and treatment.

scholarly journals Research Progress of Traditional Chinese Medicine in Prevention and Treatment of AIDS

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Guoqiang Yang ◽  
Lu Jiao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Salvia Miltiorrhiza ◽  
Internal Resistance ◽  
Research Progress ◽  
Syndrome Differentiation ◽  
Therapeutic Effects ◽  
Hiv Replication ◽  
Deficiency Type ◽  
Tcm Syndrome

Objective: To review the research progress of using Chinese medicine ginseng to prevent and treat AIDS in China. Methods: Based on the method of TCM syndrome differentiation, Chinese medical researchers divided AIDS into four types: heat toxin stagnation type, Qi and blood deficiency type, stasis and internal resistance type, and Qi and Yin injury type. Results: The therapeutic effects of the compound preparation of traditional Chinese medicine were significant, such as Aikang capsule, Tangcao tablet, Wuweilingqi capsule, Aining granule, compound Sanhuang powder, etc. Astragalus, licorice, honeysuckle, Scutellaria, bupleurum, Salvia miltiorrhiza, Viola, Hedyotis diffusa and other 8 kinds of traditional Chinese medicine have been proved to have anti HIV effect. Conclusion: Among the 27 kinds of Chinese medicine ginseng, Andrographis paniculata, Viola, Arnebia, Arctium lappa, Sophora flavescens, honeysuckle, Guanzhong, Prunella, Coptis, Wolfberry, Wedelia and epimedium have been proved to have the effect of preventing HIV replication.

scholarly journals On the Modern Clinical Application of Wendan Decoction

2021 ◽  
Vol 5 (5) ◽  
pp. 62-64
Author(s):  
Yina Xiao ◽  
Mingjun Zhao ◽  
Zijuan He ◽  
Gejing Chen ◽  
Mingming Wei
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Application ◽  
Daily Life ◽  
Syndrome Differentiation ◽  
Wide Range ◽  
Tcm Syndrome

Wendan Decoction is one of the commonly used prescriptions in clinical practice.it has a wide range of applications. On the basis of traditional Chinese medicine (TCM) syndrome differentiation, as long as it can be added or subdivided flexibly, it can be used to conquer various difficult and miscellaneous diseases seen in daily life.

scholarly journals Professor Xiaoquan Du’s Seven Methods of Treating Stomachache

2021 ◽  
Vol 5 (4) ◽  
pp. 117-120
Author(s):  
Xuzhao Wang ◽  
Li Liu ◽  
Xiaoquan Du ◽  
Chunxia Ma ◽  
Wei Cui
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Diagnosis ◽  
Diagnosis And Treatment ◽  
Syndrome Differentiation ◽  
Main Symptom ◽  
Stomach Diseases ◽  
Characteristic Methods ◽  
Tcm Syndrome

Stomachache is the main symptom of stomach duct pain near the heart. Professor Xiaoquan Du is experienced in treating spleen and stomach diseases with traditional Chinese medicine (TCM) syndrome differentiation. He has vast practical TCM experience through years of clinical diagnosis and treatment, and incorporated his own characteristic methods in treatments, thereby developing seven methods for the treatment of stomachache. Clinically, methods such as “invigorating the spleen and benefiting the stomach” and “warming the middle and dispersing cold” are mostly adopted to treat stomach duct pain.

A Traditional Chinese Medicine Syndrome Classification Model based on Cross-FGCNN: Model Development and Validation (Preprint)

2021 ◽  
Author(s):  
Zonghai Huang ◽  
Ju Chen ◽  
Yanmei Zhong ◽  
Simin Yang ◽  
Yiyi Ma ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Model Development ◽  
Classification Model ◽  
Syndrome Differentiation ◽  
Traditional Chinese Medicine Syndrome ◽  
Nonlinear Features ◽  
Syndrome Differentiation And Treatment ◽  
Development And Validation ◽  
Multi Classification

UNSTRUCTURED Syndrome differentiation and treatment is the core of traditional Chinese medicine(TCM) in the treatment of diseases. TCM doctors can dialectically classify the syndrome according to the patients' symptoms and conduct treatment. Syndrome differentiation can be regarded as a mathematical model for multi-classification of different high-dimensional sparse symptom vectors. The FGCNN can quickly and effectively extract the nonlinear cross features of sparse vectors in the CTR task. On this basis, we selected the data of 5273 real cases of dysmenorrhea and divided the symptoms into field according to the four diagnosis of TCM, so as to construct an improved Cross-FGCNN model and apply it to the intelligent dialectics of TCM. We used 6 kinds of intelligent dialectical models and 3 kinds of CTR models as comparisons at the same time. Cross-FGCNN can achieve 96.21% accuracy and 0.836 Log-Loss, which is better than other models. We maintain that the model of Cross-FGCNN can automatically extract the linear and nonlinear features of symptoms and classify them, having great potential in the intelligent dialectics of TCM in the future.

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