scholarly journals Breath Tests in Respiratory and Critical Care Medicine: From Research to Practice in Current Perspectives

2013 ◽  
Vol 2013 ◽  
pp. 1-20 ◽  
Author(s):  
Attapon Cheepsattayakorn ◽  
Ruangrong Cheepsattayakorn

Today, exhaled nitric oxide has been studied the most, and most researches have now focusd on asthma. More than a thousand different volatile organic compounds have been observed in low concentrations in normal human breath. Alkanes and methylalkanes, the majority of breath volatile organic compounds, have been increasingly used by physicians as a novel method to diagnose many diseases without discomforts of invasive procedures. None of the individual exhaled volatile organic compound alone is specific for disease. Exhaled breath analysis techniques may be available to diagnose and monitor the diseases in home setting when their sensitivity and specificity are improved in the future.

2013 ◽  
Vol 3 (2) ◽  
pp. 243-244
Author(s):  
Ranabir Pal ◽  
S Dahal ◽  
A Gurung

Sixty years ago, Nobel Prize winner Linus Pauling proposed the concept that human breath is a complex and dynamic gaseous mixture of more than 200 different endogenous volatile organic compounds (VOCs) that are continually being released in different quantities within the internal environment during health and disease. The researchers estimate that more than a thousand chemicals produced in different organ-systems as metabolic end products come out every minute through the respiratory tract. Volatile organic compounds and other products of oxidative stress are a big chunk among these exhaled breath elements.DOI: http://doi.dx.org/10.3126/nje.v3i2.8509


Author(s):  
Yasir I. Syed ◽  
Chris O. Phillips ◽  
Juan J. Rodriguez ◽  
Neil Mac Parthalain ◽  
Ludmila I. Kuncheva ◽  
...  

2019 ◽  
Vol 23 (04n05) ◽  
pp. 477-488 ◽  
Author(s):  
Funda Kus ◽  
Cihat Tasaltin ◽  
Mohamad Albakour ◽  
Ayşe Gül Gürek ◽  
İlke Gürol

The synthesis and characterization of novel asymmetric zinc(II) phthalocyanines (4–9) and their linking through peripheral and nonperipheral positions on the phthalocyanine ring via click coupling to alkyne-functionalized 2,3,6,7,10,11-hexakis(prop-2-ynyloxy)triphenylene core are described for the first time. These phthalocyanines (Pcs) (4–12) were characterized by elemental analysis and different spectroscopic techniques such as UV-vis, 1H-NMR, FT-IR and mass spectroscopy. Furthermore, the utilization of thin films of novel Pcs as a sensitive layer for detection of lung cancer from exhaled human breath at room temperature under exposure to marker volatile organic compounds (VOCs) are presented. The developed sensors were tested for acetone, ethanol, [Formula: see text]-hexane, toluene, chloroform and isoprene in a range of 300–14560 ppm. The obtained results have confirmed the possibility of utilization of Pc-based Surface Acoustic Wave (SAW) sensors for medical diagnosis based on exhaled breath analysis.


Lung ◽  
2017 ◽  
Vol 195 (2) ◽  
pp. 247-254 ◽  
Author(s):  
Yu-ichi Yamada ◽  
Gen Yamada ◽  
Mitsuo Otsuka ◽  
Hirotaka Nishikiori ◽  
Kimiyuki Ikeda ◽  
...  

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