scholarly journals Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
A. Romigi ◽  
M. Albanese ◽  
C. Liguori ◽  
F. Placidi ◽  
M. G. Marciani ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Myotonic Dystrophy ◽  
Rem Sleep ◽  
Sleep Disturbances ◽  
Periodic Limb Movements ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2 ◽  
Rem Sleep Without Atonia ◽  
Central Apnoea

Myotonic dystrophy is the most common type of muscular dystrophy in adults and is characterized by progressive myopathy, myotonia, and multiorgan involvement. Two genetically distinct entities have been identified, myotonic dystrophy type 1 (DM1 or Steinert’s Disease) and myotonic dystrophy type 2 (DM2). Myotonic dystrophies are strongly associated with sleep dysfunction. Sleep disturbances in DM1 are common and include sleep-disordered breathing (SDB), periodic limb movements (PLMS), central hypersomnia, and REM sleep dysregulation (high REM density and narcoleptic-like phenotype). Interestingly, drowsiness in DM1 seems to be due to a central dysfunction of sleep-wake regulation more than SDB. To date, little is known regarding the occurrence of sleep disorders in DM2. SDB (obstructive and central apnoea), REM sleep without atonia, and restless legs syndrome have been described. Further polysomnographic, controlled studies are strongly needed, particularly in DM2, in order to clarify the role of sleep disorders in the myotonic dystrophies.

Sleep disorders in myotonic dystrophy type 2: a controlled polysomnographic study and self-reported questionnaires

2013 ◽  
Vol 21 (6) ◽  
pp. 929-934 ◽  
Author(s):  
A. Romigi ◽  
M. Albanese ◽  
F. Placidi ◽  
F. Izzi ◽  
C. Liguori ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Myotonic Dystrophy ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2

scholarly journals Sleep Disturbances in Myotonic Dystrophy Type 2

2012 ◽  
Vol 68 (6) ◽  
pp. 377-380 ◽  
Author(s):  
Paul Shepard ◽  
Erek M. Lam ◽  
Erik K. St. Louis ◽  
Jacob Dominik
Keyword(s):  
Myotonic Dystrophy ◽  
Sleep Disturbances ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2

G.P.14.06 Sleep disturbances in myotonic dystrophy type 2: A comparison with myotonic dystrophy type 1 and healthy controls

2009 ◽  
Vol 19 (8-9) ◽  
pp. 645
Author(s):  
A.A. Tieleman ◽  
H. Knoop ◽  
A. van de Logt ◽  
G. Bleijenberg ◽  
B.G.M. van Engelen ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Sleep Disturbances ◽  
Myotonic Dystrophy Type 1 ◽  
Healthy Controls ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2

Sleep disorders in myotonic dystrophy type 2: a controlled polysomnographic study and self-reported questionnaires

2013 ◽  
Vol 14 ◽  
pp. e248
Author(s):  
A. Romigi ◽  
M. Albanese ◽  
F. Placidi ◽  
F. Izzi ◽  
M. Marciani ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Myotonic Dystrophy ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2

Decoding the Inter-relationship between Sleep Disorders and Alzheimer’s disease Pathogenesis

2020 ◽  
Vol 19 ◽  
Author(s):  
Zeba Mueed ◽  
Pankaj Kumar Rai ◽  
Mohammad A. Kamal ◽  
Nitesh Kumar Poddar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Mammalian Target Of Rapamycin ◽  
Light Therapy ◽  
Paired Helical Filaments ◽  
Bidirectional Relationship ◽  
Causative Agents

Alzheimer’s disease (AD), characterized by abnormally phosphorylated tau, paired helical filaments (PHFs), neurofibrillary tangles (NFTs), deregulated mammalian target of rapamycin (mTOR), Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its association with AD pathology. We have also discussed the role of melatonin in regulating sleep disorders and AD. The neuroprotective action of melatonin via inhibiting tau hyperphosphorylation and Aβ deposition has also been pondered upon. Moreover, astrocytes involvement in aggravating AD has also been highlighted in this review. Several therapeutic approaches aimed at improving both sleep disorders and AD have been duly discussed such as administration of antidepressants and antihistamines, immunotherapy, metal chelators, melatonin supplementation, light therapy and physical activity. Despite consistent efforts, the complete etiology concerning sleep disorder and AD is still unclear. Therefore, further research is needed to unravel the mechanism involved and also to develop strategies that may help in obstructing AD in its preclinical stage.

523 Characteristics of Patients with REM Sleep without Atonia/Periodic Limb Movements of Sleep without Dream Enactment Behaviors

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A206-A206
Author(s):  
Lina Barker ◽  
Maja Tippmann-Peikert
Keyword(s):  
Rem Sleep ◽  
Psychiatric Diagnosis ◽  
Neurological Disorders ◽  
Rem Sleep Behavior Disorder ◽  
Control Group ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Sleep Behavior ◽  
Rem Sleep Without Atonia ◽  
Antidepressant Use

Abstract Introduction While REM sleep without atonia (RSWA) in REM sleep behavior disorder (RBD) is associated with male sex, age greater than or equal to 50 years, alpha-synucleinopathies, and narcolepsy, the characteristics of patients with RSWA/persistent periodic limb movements of sleep in REM sleep (RSWA/PLMS-REM) without dream enactment behaviors are unexplored. The aim of this study was to compare the demographics, comorbidities, and concomitant medication use between RSWA/PLMS-REM patients and non-RSWA/non-PLMS-REM controls. Based on anecdotal clinical observations, we hypothesized that these patients are more commonly young, women, have psychiatric or neurological diseases, and use antidepressants. Methods We conducted a retrospective review of the Mayo Clinic electronic medical record to identify all patients with RSWA/PLMS-REM between November 2018 and November 2020. After excluding all patients with RBD, restless legs syndrome, narcolepsy, and RSWA/non-PLMS-REM, we identified 27 patients. All in-lab polysomnograms (PSGs) were reviewed to calculate the periodic limb movement index per hour of REM sleep (REM-PLMI). We also identified a control group of 15 individuals without RSWA, reviewed their PSGs, and calculated the REM-PLMI. Results The mean REM-PLMI of patients with RSWA was 64 +/- 8.3 (standard error of mean (SEM)) per hour versus 1 +/- 0.6 (SEM) per hour in non-RSWA controls (p < 0.001). Patients with RSWA/PLMS-REM and non-RSWA controls had similar age and gender, 62 +/- 3 (SEM) versus 58 +/- 3 (SEM) years and 81% versus 87% men, respectively. However, psychiatric diagnosis, neurological disorders, and antidepressants use were more common among RSWA/PLMS-REM patients compared to non-RSWA controls with p = 0.0002, p = 0.0035 and p = 0.0074 respectively (Fisher’s Exact Test). Conclusion Psychiatric diagnosis, neurological disorders, and antidepressant use are more common among RSWA/PLMS-REM patients compared to non-RSWA/non-PLMS-REM controls. Further research to determine the implications of a diagnosis of RSWA/PLMS-REM for the future development of alpha-synucleinopathies are needed and currently ongoing. Support (if any):

Effect of exercise training on functional capacity and body composition in myotonic dystrophy type 2 patients

2020 ◽  
Author(s):  
Eleni Kontou ◽  
Constantinos Papadopoulos ◽  
Giorgos Papadimas ◽  
Argyris Toubekis ◽  
Gregory Bogdanis ◽  
...  
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Myotonic Dystrophy ◽  
Functional Capacity ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2
Sign in / Sign up

Export Citation Format

Share Document