scholarly journals In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fahima M. Hashem ◽  
Mohamed Mostafa ◽  
Mahmoud Shaker ◽  
Mohamed Nasr
Keyword(s):  
Inclusion Complex ◽  
Drug Product ◽  
Water Soluble ◽  
In Vivo Evaluation ◽  
Water Soluble Polymers ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Dissolution Efficiency

The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide with β-cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.

Erlotinib/hydroxypropyl-β-cyclodextrin inclusion complex: characterization and in vitro and in vivo evaluation

2015 ◽  
Vol 83 (3-4) ◽  
pp. 267-279 ◽  
Author(s):  
Sávio M. L. Gontijo ◽  
Pedro P. G. Guimarães ◽  
Celso T. R. Viana ◽  
Ângelo M. L. Denadai ◽  
Alinne D. M. Gomes ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vivo Evaluation ◽  
Cyclodextrin Inclusion ◽  
Complex Characterization ◽  
Cyclodextrin Inclusion Complex

In vitro and in vivo evaluation of a posaconazole-sulfobutyl ether-β -cyclodextrin inclusion complex

2018 ◽  
Vol 32 (12) ◽  
pp. e4364 ◽  
Author(s):  
Miao Wang ◽  
Juan Jiang ◽  
Yi Cai ◽  
Min Zhao ◽  
Qijuan Wu ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vivo Evaluation ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Sulfobutyl Ether

Development of an oral satraplatin pharmaceutical formulation by encapsulation with cyclodextrin

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17074-17082 ◽  
Author(s):  
Jian-Qiang Zhang ◽  
Ke Li ◽  
Kun-Ming Jiang ◽  
Yan-Wei Cong ◽  
Shao-Ping Pu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Inclusion Complex ◽  
In Vitro Cytotoxicity ◽  
Pharmaceutical Formulation ◽  
Water Soluble ◽  
Cytotoxicity Test ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

A novel water-soluble oral satraplatin/β-cyclodextrin inclusion complex was prepared and characterized with a variety of techniques. The inclusion complex showed much higher antitumor activity in vitro cytotoxicity test and in vivo antitumor test.

BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 19-23
Author(s):  
J Shaikh ◽  
◽  
S. V. Deshmane ◽  
R. N Purohit ◽  
K. R. Biyani
Keyword(s):  
Inclusion Complex ◽  
Solid Dispersion ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Solubility Study ◽  
Cyclodextrin Inclusion ◽  
Poorly Water Soluble ◽  
Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

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