scholarly journals Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Badlishah Sham Nurul-Iman ◽  
Yusof Kamisah ◽  
Kamsiah Jaarin ◽  
Hj Mohd Saad Qodriyah
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Palm Oil ◽  
Coconut Oil ◽  
Male Rats ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Blood Pressure Elevation ◽  
Pressure Elevation ◽  
Endothelial Functions

This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated palm oil (15%) (5HPO), and (iv) five-times-heated palm oil (15%) and VCO (1.42 mL/kg, oral) (5HPO + VCO). Blood pressure was significantly increased in the group that was given the 5HPO diet compared to the control group. Blood pressure in the 5HPO + VCO group was significantly lower than the 5HPO group. Plasma nitric oxide (NO) level in the 5HPO group was significantly lower compared to the control group, whereas in the 5HPO + VCO group, the plasma NO level was significantly higher compared to the 5HPO group. Aortic rings from the 5HPO group exhibited attenuated relaxation in response to acetylcholine and sodium nitroprusside as well as increased vasoconstriction to phenylephrine compared to the control group. Aortic rings from the 5HPO + VCO group showed only attenuated vasoconstriction to phenylephrine compared to the 5HPO group. In conclusion, VCO prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil.

scholarly journals Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

2016 ◽  
Vol 41 (10) ◽  
pp. 1033-1038 ◽  
Author(s):  
Yusof Kamisah ◽  
Shu-Min Ang ◽  
Faizah Othman ◽  
Badlishah Sham Nurul-Iman ◽  
Hj Mohd Saad Qodriyah
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Heme Oxygenase ◽  
Palm Oil ◽  
Coconut Oil ◽  
Thiobarbituric Acid Reactive Substance ◽  
Virgin Coconut Oil ◽  
Heated Oil ◽  
Heme Oxygenase Activity ◽  
Oxygenase Activity

Virgin coconut oil, rich in antioxidants, was shown to attenuate hypertension. This study aimed to investigate the effects of virgin coconut oil on blood pressure and related parameters in kidneys in rats fed with 5-times-heated palm oil (5HPO). Thirty-two male Sprague–Dawley rats were divided into 4 groups. Two groups were fed 5HPO (15%) diet and the second group was also given virgin coconut oil (1.42 mL/kg, oral) daily for 16 weeks. The other 2 groups were given basal diet without (control) and with virgin coconut oil. Systolic blood pressure was measured pre- and post-treatment. After 16 weeks, the rats were sacrificed and kidneys were harvested. Dietary 5HPO increased blood pressure, renal thiobarbituric acid reactive substance (TBARS), and nitric oxide contents, but decreased heme oxygenase activity. Virgin coconut oil prevented increase in 5HPO-induced blood pressure and renal nitric oxide content as well as the decrease in renal heme oxygenase activity. The virgin coconut oil also reduced the elevation of renal TBARS induced by the heated oil. However, neither dietary 5HPO nor virgin coconut oil affected renal histomorphometry. In conclusion, virgin coconut oil has a potential to reduce the development of hypertension and renal injury induced by dietary heated oil, possibly via its antioxidant protective effects on the kidneys.

Evidence for Peripheral Vascular Involvement in Mild Elevation of Blood Pressure in Man

1976 ◽  
Vol 51 (s3) ◽  
pp. 65s-68s
Author(s):  
R. Sivertsson ◽  
R. Sannerstedt ◽  
Y. Lundgren
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cardiac Index ◽  
Structural Changes ◽  
Vascular Involvement ◽  
Control Group ◽  
Study Group ◽  
Blood Pressure Elevation ◽  
Pressure Elevation ◽  
Arterial Blood

1. Cardiac output at rest, intra-arterial blood pressure and hand blood flow at maximal vasodilatation were studied in two groups of 18–25-year-old men: forty-four with mild blood pressure elevation were referred from a military enlistment centre, and twenty-nine normotensive volunteers were mainly recruited from the same enlistment centre. 2. The study group was characterized by a significantly higher cardiac index at rest, and a significantly higher blood flow resistance in the hand at maximal vasodilatation than the control group, indicating the presence of structural modifications in the resistance vessels of patients with mild blood pressure elevation. 3. The tendency to increased vascular resistance in the blood vessels of the hand at maximal vasodilatation was more pronounced in patients with a normal cardiac index than in those with a high index. This suggests inclusion in the study group of tense, anxious individuals with an elevated cardiac index but otherwise normal circulation, but does not exclude the possibility that these patients may develop structural changes later on.

scholarly journals ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF VIRGIN COCONUT OIL AT MAXIMUM PHYSICAL ACTIVITY

2019 ◽  
pp. 272-276 ◽  
Author(s):  
FAJAR APOLLO SINAGA ◽  
URIP HARAHAP ◽  
JANSEN SILALAHI ◽  
HERBERT SIPAHUTAR
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Transaminase Level ◽  
Coconut Oil ◽  
Male Rats ◽  
Antioxidant Defenses ◽  
Control Group ◽  
Time To Exhaustion ◽  
Protective Effects ◽  
Virgin Coconut Oil

Objective: The purpose of this study was to determine the protective effects of virgin coconut oil (VCO) treatment on hepatic oxidative stress and antioxidant defenses after maximum physical activity. Methods: This study used 24 healthy male rats. The rats were divided into four groups randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 ml/200 g BW, 2 ml/200 g BW, and 4 ml/200 g BW, respectively, per day using gavage spuit. The rats were trained to swim for a month, 30 min/day in the 1st week, 35 min/day in the 2nd week, 40 min/ day in the 3rd week, and 45 min/day in the 4th week. After 28 days, the rats were forced to perform the maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity, and then, all rats were killed and liver tissues were collected. The malondialdehyde (MDA), glutathione peroxidase (GPx), and serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvate transaminase level were then measured. Results: VCO increased swimming time to exhaustion, levels of GPx in the liver, which were accompanied by corresponding decreases in the MDA, alanine transaminase, and aspartate transaminase content. Conclusion: The results from this study indicate that VCO is effective in the prevention of oxidative stress following maximum physical activity.

scholarly journals THE EFFECT OF DIETARY OILS AND HYDROLYZED COCONUT OIL ON MINERALS ABSORPTION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 185
Author(s):  
Linda Margata ◽  
Jansen Silalahi ◽  
Urip Harahap ◽  
Denny Satria
Keyword(s):  
Palm Oil ◽  
Oil Palm ◽  
Corn Oil ◽  
Tap Water ◽  
Coconut Oil ◽  
Male Rats ◽  
Control Group ◽  
Balance Study ◽  
Dietary Oils ◽  
Calcium And Magnesium

Objective: The objective of this study was to investigate the effect of coconut oil (virgin coconut oil; VCO), corn oil, palm oil, and hydrolyzed VCO (HVCO) on minerals (calcium and magnesium) absorption in rats.Methods: The oils used were corn oil, palm oil, VCO, and HVCO. VCO hydrolysis was done using lipase from Rhizomucor miehei (active on sn-1,3 position). The effect of oils and HVCO on minerals absorption was carried out on 25 male rats, weighing approximately 150–200 g. Rats were housed in air-conditioned room at 22–25°C, under 12-light/dark cycle, fed on basal diet and tap water ad libitum. After 1-week acclimatization, rats were given oils and HVCO for 21 days. The effect of oils on the minerals absorption were determined over the 4-day metabolic balance study. Mineral concentrations in diet, feces, urine, and serum were measured using atomic absorption spectrometry. Minerals absorption are expressed as apparent minerals absorption, apparent minerals absorption rate, and apparent minerals balance.Results: Calcium absorption in rats given with VCO, corn oil, palm oil, and HVCO is 47.09%, 45.46%, 44.48%, and 49.33%, respectively, whereas, magnesium absorption in rats given with VCO, corn oil, palm oil, and HVCO is 34.87%, 32.08%, 29.39%, and 37.11%, respectively. The results of this study show that minerals absorption in rats given with dietary oils is significantly lower than the control group (51.79% for calcium and 42.34% for magnesium). Mineral absorption in rats given with HVCO results in the highest rate of all rats given with the other oils tested.Conclusion: Corn oil and palm oil, which belong to the long chain triglycerides oil, lower calcium, and magnesium absorption more significantly than VCO as a medium chain triglyceride oil does. HVCO results in significantly higher calcium and magnesium absorption compared to non-HVCO.

scholarly journals Antioxidant Effect of Virgin Coconut Oil on Urea and Creatinine Levels on Maximum Physical Activity

2019 ◽  
Vol 7 (22) ◽  
pp. 3781-3785
Author(s):  
Fajar Apollo Sinaga ◽  
Urip Harahap ◽  
Jansen Silalahi
Keyword(s):  
Physical Activity ◽  
Tissue Injury ◽  
Coconut Oil ◽  
Maximal Activity ◽  
Male Rats ◽  
Control Group ◽  
Healthy Male ◽  
Virgin Coconut Oil ◽  
Blood Samples ◽  
Treatment Groups

BACKGROUND: Maximal physical activity can produce an imbalance between reactive oxygen species (ROS) and antioxidants which are possibly related to fatigue and tissue injury. One of the natural sources that contain antioxidants is virgin coconut oil (VCO). AIM: This study aimed to determine the protective effects antioxidant of virgin coconut oil (VCO) treatment on urea and creatine level on maximum physical activity METHODS: This study used 24 healthy male rats. The rats were divided into four groups, randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 mL/200 gBW, 2 mL/200 gBW and 4 ml/200 gBW, respectively, per day using gavage spuit. After 28 days, the rats were forced to perform maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity. The urea, creatinine, malondialdehyde and glutation peroxidase level was then measured. RESULTS: This study used 24 healthy male rats. The rats were divided into four groups randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 mL/200 gBW, 2 mL/200 gBW and 4 ml/200 gBW, respectively, per day using gavage spuit. After 28 days, the rats were forced to perform the maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity. The urea, creatinine, malondialdehyde and glutathione peroxidase level was then measured. CONCLUSION: The results of this study indicate that virgin coconut oil is effective in the prevention of oxidative stress following maximum physical activity.

scholarly journals THE EFFECT OF DIETARY OILS AND HYDROLYZED COCONUT OIL ON MINERALS ABSORPTION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 185
Author(s):  
Linda Margata ◽  
Jansen Silalahi ◽  
Urip Harahap ◽  
Denny Satria
Keyword(s):  
Palm Oil ◽  
Oil Palm ◽  
Corn Oil ◽  
Tap Water ◽  
Coconut Oil ◽  
Male Rats ◽  
Control Group ◽  
Balance Study ◽  
Dietary Oils ◽  
Calcium And Magnesium

Objective: The objective of this study was to investigate the effect of coconut oil (virgin coconut oil; VCO), corn oil, palm oil, and hydrolyzed VCO (HVCO) on minerals (calcium and magnesium) absorption in rats.Methods: The oils used were corn oil, palm oil, VCO, and HVCO. VCO hydrolysis was done using lipase from Rhizomucor miehei (active on sn-1,3 position). The effect of oils and HVCO on minerals absorption was carried out on 25 male rats, weighing approximately 150–200 g. Rats were housed in air-conditioned room at 22–25°C, under 12-light/dark cycle, fed on basal diet and tap water ad libitum. After 1-week acclimatization, rats were given oils and HVCO for 21 days. The effect of oils on the minerals absorption were determined over the 4-day metabolic balance study. Mineral concentrations in diet, feces, urine, and serum were measured using atomic absorption spectrometry. Minerals absorption are expressed as apparent minerals absorption, apparent minerals absorption rate, and apparent minerals balance.Results: Calcium absorption in rats given with VCO, corn oil, palm oil, and HVCO is 47.09%, 45.46%, 44.48%, and 49.33%, respectively, whereas, magnesium absorption in rats given with VCO, corn oil, palm oil, and HVCO is 34.87%, 32.08%, 29.39%, and 37.11%, respectively. The results of this study show that minerals absorption in rats given with dietary oils is significantly lower than the control group (51.79% for calcium and 42.34% for magnesium). Mineral absorption in rats given with HVCO results in the highest rate of all rats given with the other oils tested.Conclusion: Corn oil and palm oil, which belong to the long chain triglycerides oil, lower calcium, and magnesium absorption more significantly than VCO as a medium chain triglyceride oil does. HVCO results in significantly higher calcium and magnesium absorption compared to non-HVCO.

Abstract P175: Chronic Exercise Attenuates Blood Pressure Elevation and Albuminuria With Improvement of Renal Lipid Metabolism in High Fructose-fed Rats

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Gaizun Hu ◽  
Osamu Ito ◽  
Lusi Xu
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Synthase ◽  
Control Group ◽  
Chronic Exercise ◽  
Blood Pressure Elevation ◽  
Pressure Elevation ◽  
High Fructose ◽  
Renal Expression

High fructose diet (HFr) can lead to metabolic disorder, hypertension, and renal disease. Although chronic exercise (Ex) provides various beneficial effects on hypertension and kidney disease, the precise mechanism is not fully clarified. Thus, present study examined the effects of Ex on the blood pressure, renal function and renal lipid metabolism in rats fed with HFr. Sprague-Dawley rats were allocated to 3 groups. The HFr and Ex groups were fed with HFr (60%, w/w), the control group was fed with the diet in which fructose was replaced by starch. The Ex group underwent treadmill exercise at aerobic intensity. After 12 weeks, renal triglyceride (TG) content were measured, and expression of enzymes and regulators of fatty acid metabolism were analyzed by Western blot. HFr increased systolic blood pressure (SBP) and albuminuria and Ex decreased the HFr-increased SBP and albuminuria (85±4 vs. 122±9 vs. 91±4 mmHg, P<0.01, 326±67 vs. 534±79 vs. 176±54 mg/day, P<0.01). HFr increased plasma TG and uric acid (UA) and Ex decreased the HFr-increased TG and UA (124±20 vs. 474±35 vs. 238±23 mg/dL, P<0.01, 1.15±0.10 vs. 2.14±0.10 vs. 1.50±0.13 mg/dL, P<0.01), whereas HFr or Ex did not affect plasma creatinine. HFr increased renal TG content and Ex decreased the HFr-increased TG content (12.2±0.5 vs. 14.1±0.5 vs. 10.3±1.1 mg/100mg tissue, P<0.01). Among enzymes of fatty acid synthesis, HFr increased the renal expression of fatty acid synthase (FAS), and Ex decrease the expression of FAS (P<0.01). Among enzymes and regulators of fatty acid oxidation, HFr decreased the renal expression of PPARα, carnitine palmitoyltransferase I (CPTI), medium-chain acyl-CoA dehydrogenase (MCAD) (P<0.05), and Ex increased the expression of PPARα, CPTI, MCAD, and acyl-coenzyme A oxidase (ACOX). These results indicated that Ex attenuates blood pressure elevation, albuminuria with an improvement of renal lipid metabolism in the HFr-fed rats. These effects of Ex may relate to an improvement of the renal lipid metabolism.

Sign in / Sign up

Export Citation Format

Share Document