scholarly journals Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mustapha Ahsaini ◽  
Omar Riyach ◽  
Mohammed Fadl Tazi ◽  
Mohammed Jamal El Fassi ◽  
My Hassan Farih ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Neoadjuvant Chemotherapy ◽  
Neuroendocrine Carcinoma ◽  
Rare Case ◽  
Distant Metastases ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Case Presentation ◽  
Aggressive Clinical Course ◽  
Neuroendocrine Carcinomas

Introduction. Small cell neuroendocrine carcinomas of the urinary tract is an extremely rare entity and very few cases have been reported in the literature. Small cell neuroendocrine carcinoma of the urinary tract (SCC-UT) is the association between bladder and urinary upper tract-small cell carcinoma (UUT-SCC). It characterized by an aggressive clinical course. The prognosis is poor due to local or distant metastases, and usually the muscle of the bladder is invaded.Case Presentation. We report a rare case of a 54-year-old Arab male native of moroccan; he is a smoker and was referred to our institution for intermittent hematuria. Following a diagnosis of small cell neuroendocrine carcinomas of the ureter and the bladder, thoracoabdominal-pelvic CT was done, and the staging of the tumor was done in the bladder (T2N0M0) and (T1N0M0) in the ureter. Neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin was realized, and nephroureterectomy associated to a cystoprostatectomy was carried out. After 24 months of followup, no local or distant metastasis was detected.Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors.

Small cell neuroendocrine carcinoma of the ureter: A rare case

2021 ◽  
Vol 47 (2) ◽  
pp. e61
Author(s):  
Aaliya Uddin ◽  
Rebecca Harsten ◽  
Qasif Qavi ◽  
Firas Alkistawi ◽  
Smita Singh ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Rare Case ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma

scholarly journals Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Yingying Zhu ◽  
Liming Gao ◽  
Yunxiao Meng ◽  
Wenwen Diao ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Survival Time ◽  
Neuroendocrine Carcinoma ◽  
Clinical Manifestations ◽  
Small Cell ◽  
Atypical Carcinoid ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Typical Carcinoid ◽  
Mean Survival Time ◽  
The Mean ◽  
Neuroendocrine Carcinomas

Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous which present a wide spectrum of pathological and clinical manifestations. Fourteen patients with histologically demonstrated LNEC were collected and analyzed retrospectively. The 14 cases were classified into 3 subtypes: typical carcinoid in 2, atypical carcinoid in 5, and small cell neuroendocrine carcinoma in 7. The mean survival time of the 14 patients in this study was 112.5 months (95% CI, 81.5–143.6). Surgeries were performed for 2 patients of typical carcinoid, and they were alive with no evidence of recurrence after 24 and 47 months of follow-ups. Patients in the atypical carcinoid group were treated with surgeries and postoperative radiotherapy. After 58.4 months of follow-ups (range: 9–144), 2 patients showed no evidence of disease and 1 was lost to follow-up after 72 months. The other 2 patients died of other unrelated diseases. In the small cell neuroendocrine carcinoma group, a combination of chemotherapy and radiotherapy was applied. The mean survival time was 79.7 months (95% CI, 37.9–121.4), and the 5-year survival rate was 53.6%. In conclusion, the clinical behaviors, treatment protocols, and prognosis are different for each subtype of LNECs.

Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses: a rare case

2012 ◽  
Vol 126 (12) ◽  
pp. 1284-1286 ◽  
Author(s):  
I P Tang ◽  
S Singh ◽  
G Krishnan ◽  
L M Looi
Keyword(s):  
Nasal Cavity ◽  
Neuroendocrine Carcinoma ◽  
Paranasal Sinuses ◽  
Rare Case ◽  
Surgical Excision ◽  
Small Cell ◽  
High Rate ◽  
Intracranial Extension ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Rare Tumour

AbstractObjective:We report a rare case of small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses with intracranial extension, and discuss the management of this rare tumour.Results:Small cell neuroendocrine carcinoma involving the nasal cavity and paranasal sinuses with intracranial extension may be treated successfully with surgery alone, without development of local recurrence.Conclusion:Small cell neuroendocrine carcinoma is a locally aggressive tumour with a high rate of recurrence. Early and aggressive surgical excision with or without radiotherapy or chemotherapy can improve a patient's outcome and prognosis. Regular follow up is needed to detect any local or distant recurrence.

scholarly journals Small-Cell Neuroendocrine Carcinoma of the Cervix Masquerading as a Cervical Fibroid: Report of a rare entity

2018 ◽  
Vol 18 (1) ◽  
pp. 100
Author(s):  
Mukta Pujani ◽  
Kanika Singh ◽  
Varsha Chauhan ◽  
Raina Chawla ◽  
Rashmi Ahuja
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Neuroendocrine Tumours ◽  
Small Cell ◽  
Rare Entity ◽  
Diagnostic Challenge ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Term Survival ◽  
Medical College ◽  
Neuroendocrine Carcinomas

Primary neuroendocrine tumours of the cervix are extremely rare, with an incidence of only 0.5–1%; as such, these entities can present a clinical and diagnostic challenge. Small-cell neuroendocrine carcinomas of the cervix are highly aggressive tumours that have a tendency to metastasise. We report a 44-year-old woman who presented to the Gynaecology Clinic of the Employees State Insurance Corporation Medical College & Hospital, Faridabad, India, in 2016 with menorrhagia. Based on a clinical examination, she was provisionally diagnosed with a cervical fibroid. However, a biopsy revealed features of a small-cell neuroendocrine carcinoma of the cervix which was subsequently confirmed via immunohistochemistry. An accurate diagnosis of a neuroendocrine carcinoma is vital as it forms the basis for treatment decisions as well as informing predictions for long-term survival.

scholarly journals Primary Small Cell Neuroendocrine Carcinoma of Paranasal Sinuses

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Maliha Khan ◽  
Sobia Nizami ◽  
Aibek E. Mirrakhimov ◽  
Benjamin Maughan ◽  
Justin A. Bishop ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Cell Cancer ◽  
Distant Metastases ◽  
Management Plan ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Cervical Lymph Nodes ◽  
Platinum Based Chemotherapy

Small cell neuroendocrine carcinoma of the paranasal sinuses is an extremely rare and aggressive neoplasm. Despite aggressive management, the tumor carries a poor prognosis, with a high risk of local recurrence or distant metastases. The management strategy is based on that for pulmonary small cell cancer and includes platinum-based chemotherapy combined with radiotherapy. We are reporting a case of an 89-year-old female patient diagnosed with small cell carcinoma of right-sided ethmoid and sphenoid sinuses. The tumor was found to have invaded the right orbit and anterior cranial fossa. Metastases to cervical lymph nodes and bone were also found. Due to the extended stage and poor prognosis of the patient, the management plan is palliative chemoradiotherapy.

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