scholarly journals Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Suman Malik ◽  
Suparna Ghosh ◽  
Bharti Jain ◽  
Archana Singh ◽  
Mamta Bhattacharya
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Elemental Analysis Data ◽  
Central Metal

The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.

scholarly journals Synthesis, Characterisation, and Biological Evaluation of Zn(II) Complex with Tridentate (NNO Donor) Schiff Base Ligand

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Nayaz Ahmed ◽  
Mohd Riaz ◽  
Altaf Ahmed ◽  
Madhulika Bhagat
Keyword(s):  
Schiff Base ◽  
Metal Complex ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Elemental Analysis Data ◽  
Central Metal

The present paper deals with the synthesis and characterization of metal complex of tridentate Schiff base ligand derived from the inserted condensation of 2-aminobenzimidazole (1H-benzimidazol-2-amine) with salicylaldehyde (2-hydroxybenzaldehyde) in a 1 : 1 molar ratio. Using this tridentate ligand, complex of Zn(II) with general formula ML has been synthesized. The synthesized complex was characterized by several techniques using molar conductance, elemental analysis, FT-IR, and mass and 1HNMR spectroscopy. The elemental analysis data suggest the stoichiometry to be 1 : 1 [M : L]. The complex is nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen, imidazole nitrogen of benzimidazole ring, and azomethine nitrogen atom. Spectral studies suggest tetrahedral geometry for the complex. The pure compound, synthesized ligand, and metal complex were screened for their antimicrobial activity.

scholarly journals Some Organotellurium(IV) Complexes of 1-Methyl-3-(p-tolylimino)indolin-2-one Schiff Base

2021 ◽  
Vol 33 (6) ◽  
pp. 1236-1244
Author(s):  
Manish Kumar ◽  
K.K. Verma ◽  
Sapana Garg
Keyword(s):  
Schiff Base ◽  
Xanthomonas Campestris ◽  
Computational Study ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Octahedral Geometry ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
No Donor

Six new hexa-coordinated organotellurium(IV) complexes of type RTeCl3·NMeIPT and R2TeCl2·NMeIPT (R = 4-hydroxyphenyl, 4-methoxyphenyl or 3-methy-4-hydroxyphenyl; NMeIPT(L) = Schiff base (1-methyl-3-(p-tolylimino)indolin-2-one) derived from condensation of 4-methylisatin and p-toluidine) have been synthesized and characterized by different spectral studies like elemental analyses, molar conductance, infrared, mass spectrometry, 1H NMR, 13C NMR and UV-visible spectroscopy. On the basis of spectroscopic data, it is evident that Schiff base behaves as NO donor bidentate ligand via azomethine nitrogen atom and oxygen atom from carbonyl group for all the tellurium(IV) complexes. The results showed that all the organotellurium(IV) complexes possess distorted octahedral geometry. Geometry of the all organotellurium(IV) complexes was optimized and their theoretical quantum mechanical parameters were calculated. This computational study also suggests octahedral geometry for complexes. The antimicrobial activity of NMeIPT and all the organotellurium(IV) complexes were screened against bacteria i.e. Xanthomonas campestris and Bacillus cereus and fungi i.e. Fusarium oxysporum, Candida albicans and Sclerotinia sclerotium.

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
F. K. Ommenya ◽  
E. A. Nyawade ◽  
D. M. Andala ◽  
J. Kinyua
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Elemental Analysis Data ◽  
Ft Ir

A new series of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of the Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C13H9ClFNO), was synthesized in a methanolic medium. The Schiff base was derived from the condensation reaction of 5-chlorosalicylaldehyde and 4-fluoroaniline at room temperature. Elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductance measurements, and melting points were used to characterize the Schiff base and the metal complexes. From the elemental analysis data, the metal complexes formed had the general formulae [M(L)2(H2O)2], where L = Schiff base ligand (C13H9ClFNO) and M = Mn, Co, Ni, Cu, and Zn. On the basis of FT-IR, electronic spectra, and NMR data, “O” and “N” donor atoms of the Schiff base ligand participated in coordination with the metal (II) ions, and thus, a six coordinated octahedral geometry for all these complexes was proposed. Molar conductance studies on the complexes indicated they were nonelectrolytic in nature. The Schiff base ligand and its metal (II) complexes were tested in vitro to evaluate their bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus typhi) using the disc diffusion method. The antibacterial evaluation results revealed that the metal (II) complexes exhibited higher antibacterial activity than the free Schiff base ligand.

scholarly journals Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and Methionine

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Har Lal Singh ◽  
J. B. Singh
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Analytical Data ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Carboxylate Oxygen

New Schiff base (HL) ligand is prepared via condensation of isatins and amino acids in 1:1 molar ratio. Metal complexes are prepared and characterized by elemental analysis, molar conductance, electronic, infrared, and multinuclear magnetic resonance (1H NMR, 13C NMR, and 119Sn NMR). The analytical data showed that the ligand acts as bidentate toward metal ions via azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of metal : ligand (1 : 2) to from metal complexes (Pb(II)(L)2 and Bu2Sn(L)2, where L is the Schiff base ligands of histidine and methionine). The conductivity values between 15 and 25 Ω−1cm2 mol−1 in DMF imply the presence of nonelectrolyte species. On the basis of the above spectral studies, distorted octahedral and tetrahedral geometry have been proposed for the resulting organotin(IV) and lead(II) complexes.

scholarly journals Structural, Spectroscopic and Biological Aspects of O, N- Donor Schiff Base Ligand and its Cr(III), Co(II), Ni(II) and Cu(II) Complexes Synthesized through Green Chemical Approach

2010 ◽  
Vol 7 (s1) ◽  
pp. S566-S572 ◽  
Author(s):  
Kavita Rathore ◽  
Rajiv K. R. Singh ◽  
H. B. Singh
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Central Metal ◽  
Bacterial Strains ◽  
Phenolic Oxygen ◽  
Bidentate Schiff Base Ligand

The monofunctional bidentate Schiff base ligand (o-vanillin)p-chloroaniline and its four new complexes of chromium(III), cobalt(II), nickel(II) and copper(II) have been synthesized by classical thermal and microwave-irradiated techniques. All the new derivatives have been characterized by elemental analysis, molecular weight determinations, molar conductance measurements, UV-Vis, IR and NMR spectral studies. The IR spectral data suggest the involvement of phenolic oxygen after deprotonation and azomethine nitrogen in coordination to the central metal ion. The growth inhibiting potential of the ligands and complexes has been assessed against a variety of fungal and bacterial strains.

scholarly journals Synthesis, DFT and Bio-Potential Activities of Mn(II) and Hg(II) Complexes with Bidentate (E)-N′[(E)-3-Phenylallylidene]benzene-1,2-diamine

2021 ◽  
Vol 33 (6) ◽  
pp. 1222-1228
Author(s):  
R. Selvarani ◽  
S. Balasubramaniyan ◽  
K. Rajasekar ◽  
M. Thairiyaraja ◽  
R. Meenakshi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Radical Scavenging ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Dpph Method

A new bidentate Schiff base (E)-N′[(E)-3-phenylallylidene]benzene-1,2-diamine derived from the condensation of o-phenylenediamine and cinnamaldehyde and its Mn(II) and Hg(II) complexes were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, electronic spectra, IR, far-IR and NMR (1H & 13C) spectral studies. The elemental analysis and these metal proposed the metal:ligand stoichiometry and molecular formulae of the metal complexes. The molar conductance and electrochemical property indicates monomeric, neutral nature and redox properties of the metal complexes. The UV-visible spectral study supports the octahedral geometry for Mn(II) complex and square planar geometry for Hg(II) complex and further confirmed by magnetic moment. IR spectral data examined the coordination mode but far-IR is useful to identify the metal-ligand vibrations. The geometry, magnetic property and unsymmetrical nature of these metal complexes corroborated by NMR (1H & 13C) spectra. The DFT of Mn(II) complex studied and the structure optimized by B3LYP/Lan L2DZ using Gaussian 09W. Quantum chemical calculations were done by Mullikan population analysis, HOMO-LUMO and molecular electrostatic potential. The in vitro biological screening effects of the investigated complexes were tested against some bacteria and fungus by agar-well diffusion method. The results indicated that Mn(II) and Hg(II) complexes exhibit potentially active than the Schiff base which was further confirmed by pharmacokinetics study. The antioxidant activity of Schiff base and its Mn(II) complex was examined by radical scavenging DPPH method.

scholarly journals Synthesis, Spectral Characterization and Biological Evaluation of Metal Complexes of 2-Thioxoquinoline Aminophenol

2021 ◽  
Vol 33 (6) ◽  
pp. 1439-1446
Author(s):  
G. Gokulnath ◽  
P. Anitha ◽  
R. Manikandan ◽  
C. Umarani
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Cervical Cancer Cells ◽  
Ft Ir ◽  
Escherichia Coli Bacteria

A series of novel 2-thioxoquinoline aminophenol Schiff base based Co(II), Ni(II), Cu(II) and Zn(II) metal complexes [M(L)2], (M = Co2+, Ni2+, Cu2+ & Zn2+; L = 2-thioxoquinoline aminophenol) were synthesized and characterized by elemental analysis and spectral studies (FT-IR, UV-Vis, 1H NMR, ESR and ESI-Mass). All experimental results showed that in these metal complexes, the central metal atom was coordinated by oxygen, nitrogen and sulfur donor atoms of deprotonated Schiff base. Further, the ligand and its metal(II) complexes were screened against Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacteria and fungus (Candida albicans) strains. in vitro Anticancer activity of ligand and its metal(II) complexes were also screened against HeLa cells (Human cervical cancer cells).

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Spectral, Magnetic and Biological Studie on Some Bivalent 3d Metal Complexes of Hydrazine Derived Schiff-Base Ligands

1997 ◽  
Vol 4 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Zahid H. Chohan ◽  
Syed K. A. Sherazi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Bacterial Species ◽  
Biological Properties ◽  
Molar Conductance ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
3D Metal Complexes

Metal(II) complexes of hydrazine derived Schiff-base ligands of the type M(L)2Cl2 where M = Co, Cu, Ni and Zn and L = L1 and L2 have been prepared and characterised by molar conductance, magnetic moment, elemental analysis and electronic, IR, H-NMR and C13 spectral data.The different modes of chelation of the ligands and their comparative biological properties against different bacterial species are reported.

Sign in / Sign up

Export Citation Format

Share Document