scholarly journals Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study

2013 ◽  
Vol 35 ◽  
pp. 791-798 ◽  
Author(s):  
Maria do Sameiro-Faria ◽  
Sandra Ribeiro ◽  
Elísio Costa ◽  
Denisa Mendonça ◽  
Laetitia Teixeira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Iron Metabolism ◽  
Venous Catheter ◽  
Large Set ◽  
Dialysis Adequacy ◽  
Risk Of Death ◽  
Follow Up Study ◽  
Stage Renal Disease ◽  
Fourth Quartile

Background.End-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study.Methods and Results.A large set of data was obtained from 189 HD patients (55.0% male; 66.4 ± 13.9 years old), including hematological data, lipid profile, iron metabolism, nutritional, inflammatory, and endothelial (dys)function markers, and dialysis adequacy.Results.35 patients (18.5%) died along the follow-up period. Our data showed that the type of vascular access, C-reactive protein (CRP), and triglycerides (TG) are significant predictors of death. The risk of death was higher in patients using central venous catheter (CVC) (Hazard ratio [HR] =3.03, 95% CI = 1.49–6.13), with higher CRP levels (fourth quartile), compared with those with lower levels (first quartile) (HR = 17.3, 95% CI = 2.40–124.9). Patients with higher TG levels (fourth quartile) presented a lower risk of death, compared with those with the lower TG levels (first quartile) (HR = 0.18, 95% CI = 0.05–0.58).Conclusions.The use of CVC, high CRP, and low TG values seem to be independent risk factors for mortality in HD patients.

scholarly journals Competing Risk of Death and Time-Varying Covariates in Cardiovascular Epidemiologic Research: Modeling the Hazards of Coronary Heart Disease in the First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study

2019 ◽  
Vol 3 (1) ◽  
pp. 20
Author(s):  
Rodrigue Pierre ◽  
C. Perry Brown ◽  
Charlotte Baker ◽  
Matthew Dutton ◽  
Oghenekome Onokpise ◽  
...  
Keyword(s):  
Risk Factors ◽  
Competing Risk ◽  
Time Varying ◽  
Nutrition Examination Survey ◽  
Coefficient Estimates ◽  
Risk Of Death ◽  
Follow Up Study ◽  
Health And Nutrition ◽  
Time Varying Covariates

<p><em>Competing risk of death and time-varying covariates, often overlooked during statistical analyses of longitudinal studies, can alter the magnitude of estimates of the effect of covariates on the hazards of health outcomes. This study aimed to investigate whether estimates obtained when modeling the effect of risk factors on the hazards of coronary heart disease (CHD) varied significantly while accounting for the presence of competing risk of death and time-varying covariates. We used data from the First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study (n=6346) to model estimates of the effect of risk factors on the hazards of CHD using Cox proportional hazards model, Cox extension with time-varying covariates, and the Fine Gray approach. We used a chi-square test to compare coefficient estimates obtained from the three modeling techniques. We obtained a P-value &gt; 0.05 when comparing coefficient estimates for body mass index, age, cholesterol, smoking, and diabetes after fitting the three models. Coefficient estimates obtained when modeling the effect of risk factors on the hazards of CHD did not vary significantly in the presence of competing risk of death and time-varying covariates. Researchers should consider exploring these concepts more systematically in cohort studies with cardiovascular outcomes.</em><em></em></p>

scholarly journals Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

2009 ◽  
Vol 63 (10) ◽  
pp. 1233-1240 ◽  
Author(s):  
L L N Husemoen ◽  
A Linneberg ◽  
M Fenger ◽  
B H Thuesen ◽  
T Jørgensen
Keyword(s):  
Risk Factors ◽  
Mthfr C677t ◽  
Biological Risk ◽  
Follow Up Study ◽  
Total Homocysteine ◽  
Genotype A

scholarly journals THU0254 Risk factors for back pain in a cross sectional and in a one-year follow up study in nurses

2001 ◽  
Author(s):  
M Brzosko ◽  
I Fiedorowicz-Fabrycy ◽  
J Fliciñski ◽  
H Przepiera-Bêdzak ◽  
K Prajs
Keyword(s):  
Risk Factors ◽  
Back Pain ◽  
Cross Sectional ◽  
Follow Up Study ◽  
One Year

scholarly journals Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Runzhen Chen ◽  
Chen Liu ◽  
Peng Zhou ◽  
Yu Tan ◽  
Zhaoxue Sheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Percutaneous Coronary Intervention ◽  
Prognostic Value ◽  
Coronary Intervention ◽  
Risk Scores ◽  
Risk Of Death ◽  
Clinical Risk ◽  
Percutaneous Coronary ◽  
D Dimer

Abstract Background Associations between D-dimer and outcomes of patients with acute coronary syndromes (ACS) remain controversial. This study aimed to investigate the prognostic value of D-dimer in ACS patients treated by percutaneous coronary intervention (PCI). Methods In this observational study, 3972 consecutive patients with ACS treated by PCI were retrospectively recruited. The X-tile program was used to determine the optimal D-dimer thresholds for risk stratifications. Cox regression with multiple adjustments was used for outcome analysis. Restricted cubic spline (RCS) analysis was performed to assess the dose-response association between D-dimer and outcomes. The C-index was calculated to evaluate the additional prognostic value of D-dimer when added to clinical risk factors and commonly used clinical risk scores, with internal validations using bootstrapping methods. The primary outcome was all-cause death. Results During a median follow-up of 720 days, 225 deaths occurred. Based on the thresholds generated by X-tile, ACS-PCI patients with median (420–1150 ng/mL, hazard ratio [HR]: 1.58, 95 % confidence interval [CI]: 1.14–2.20, P = 0.007) and high (≥ 1150 ng/mL, HR: 1.98, 95 % CI: 1.36–2.89, P < 0.001) levels of D-dimer showed substantially higher risk of death compared to those with low D-dimer (< 420 ng/mL). RCS analysis depicted a constant relation between D-dimer and various outcomes. The addition of D-dimer levels significantly improved risk predictions for all-cause death when combined with the fully adjusted models (C-index: 0.853 vs. 0.845, P difference = 0.021), the GRACE score (C-index: 0.826 vs. 0.814, P difference = 0.027), and the TIMI score (C-index: 0.804 vs. 0.776, P difference < 0.001). The predicted mortality at the median follow-up (two years) was 1.7 %, 5.2 %, and 10.9 % for patients with low, median, and high D-dimer, respectively, which was well matched with the observed mortality (low D-dimer group: 1.2 %, median D-dimer group: 5.2 %, and high D-dimer group: 12.6 %). Conclusions For ACS patients treated by PCI, D-dimer level was an independent predictor for adverse outcomes, and provided additional prognostic value when combined with clinical risk factors and risk scores. Risk stratifications based on D-dimer was plausible to differentiate ACS-PCI patients with higher risk of death.

scholarly journals PUTRA-Adol study: protocol for an observational follow-up study to assess the tracking of dietary patterns linked to cardiometabolic risk factors and its prospective relationship with non-alcoholic fatty liver disease, carotid intima-medial thickness and mental well-being during adolescence in Malaysia

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e044747
Author(s):  
Geeta Appannah ◽  
Nor Aishah Emi ◽  
Mugambikai Magendiran ◽  
Zalilah Mohd Shariff ◽  
Azriyanti Anuar Zaini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Well Being ◽  
Cardiometabolic Risk Factors ◽  
Dietary Intakes ◽  
Alcoholic Fatty Liver ◽  
Follow Up Study ◽  
Carotid Intima Medial Thickness ◽  
Mental Well Being

IntroductionGrowing evidence suggesting that dietary intakes of adolescents are generally of poor quality but not adequately assessed in relation to the early manifestation of non-communicable diseases. This study aimed; (1) to examine tracking of an empirical dietary pattern (DP) linked to cardiometabolic risk factors and, (2) to assess prospective relationships between a DP characterised by high intakes of dietary energy density (DED) and added sugar, and cardiometabolic risk factors, non-alcoholic fatty liver disease (NAFLD), carotid intima-medial thickness (CIMT) and mental well-being during adolescence.Methods and analysisThe PUTRA-Adol is a prospective follow-up study that builds up from 933 Malaysian adolescents who were initially recruited from three southern states in Peninsular Malaysia in 2016 (aged 13 years then). Two sessions are planned; the first session will involve the collection of socio-economy, physical activity, dietary intakes, mental well-being, body image, risk taking behaviour, sun exposure, family functioning and menstrual (in women) information. The second session of data collection will be focused on direct assessments such as venesection for blood biochemistry, anthropometry and ultrasonography imaging of liver and bilateral carotid arteries. Z-scores for an empirical DP will be identified at 16 years using reduced rank regression. Multilevel modelling will be conducted to assess the tracking of DP and prospective analysis between the DP, cardiometabolic health, NAFLD, CIMT and mental well-being.Ethics and disseminationEthical approval for the conduct of this follow-up study was obtained from the Universiti Putra Malaysia’s Ethics Committee for Research Involving Human Subjects (JKEUPM) (Reference number: JKEUPM-2019–267). The findings from this study will be disseminated in conferences and peer-reviewed journals.DiscussionThe findings gathered from this study will provide evidence on prospective relationships between DPs, cardiometabolic risk factors, NAFLD, early atherosclerosis and mental well-being and that it may be mediated particularly DED and added sugar during adolescence.

Incidence and risk factors for trocar site hernia following laparoscopic cholecystectomy: A long-term follow-up study

Hernia ◽  
2012 ◽  
Vol 16 (4) ◽  
pp. 431-437 ◽  
Author(s):  
E. Erdas ◽  
C. Dazzi ◽  
F. Secchi ◽  
S. Aresu ◽  
A. Pitzalis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Laparoscopic Cholecystectomy ◽  
Trocar Site ◽  
Follow Up Study ◽  
Trocar Site Hernia ◽  
Long Term Follow Up

Diabetes and Nontraumatic Lower Extremity Amputations: Incidence, risk factors, and prevention--a 12-year follow-up study in Nauru

Diabetes Care ◽  
1996 ◽  
Vol 19 (7) ◽  
pp. 710-714 ◽  
Author(s):  
A. R. G. Humphrey ◽  
G. K. Dowse ◽  
K. Thoma ◽  
P. Z. Zimmet
Keyword(s):  
Risk Factors ◽  
Lower Extremity ◽  
Follow Up Study ◽  
Incidence Risk
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