scholarly journals Steroid Dermatitis Resembling Rosacea: A Clinical Evaluation of 75 Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ammar F. Hameed
Keyword(s):  
Prospective Observational Study ◽  
Clinical Manifestations ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Clinical Presentations ◽  
Common Causes ◽  
The Face ◽  
History Of ◽  
Rebound Phenomenon ◽  
Papulopustular Eruption

Background. The use of topical steroids on the skin of the face should be carefully evaluated by the dermatologist; however, its misuse still occurs producing dermatological problem resembling rosacea. Objectives. To report the different clinical manifestations of steroid dermatitis resembling rosacea and to discover causes behind abusing topical steroids on the face. Methods. In this prospective observational study, 75 patients with steroid dermatitis resembling rosacea who had history of topical steroid use on their faces for at least 1–3 months were evaluated at the Department of Dermatology, Baghdad Teaching Hospital, between August 2010 and December 2012. Results. The majority of patients were young women who used a combinations of potent and very potent topical steroid for average period of 0.25–10 years. Facial redness and hotness, telangiectasia, and rebound phenomenon with papulopustular eruption were the main clinical presentations. The most common causes of using topical steroid on the face were pigmentary problems and acne through recommendations from nonmedical personnel. Conclusion. Topical steroid should not be used on the face unless it is under strict dermatological supervision.

scholarly journals Topical steroid application can induce branched/reticular vessels in Bowen disease on the upper trunk

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Hiroyo Hashimoto ◽  
Yaei Togawa ◽  
Naoki Aoyagi ◽  
Ryoji Kurita ◽  
Rena Oguma ◽  
...  
Keyword(s):  
Medical Records ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Steroid Use ◽  
Keratinocyte Proliferation ◽  
History Of ◽  
Superficial Dermis ◽  
Bowen Disease ◽  
Epidermal Atrophy ◽  
Chronic Eczema

We aimed to elucidate the dermoscopic vasculature of patients with Bowen Disease (BD) that was misdiagnosed as chronic eczema and had branched and/or reticular vessels after topical steroid application. The medical records of 19 patients with BD on the upper trunk were retrospectively reviewed for steroid use history, vascular structure observed in dermoscopy, and corresponding histological findings. Four patients treated with strong topical steroids showed remarkable branched and/or reticular vessels on dermoscopy. Histopathology showed partial epidermal atrophy with irregular thin elongation of the rete ridges, atypical keratinocyte proliferation in the epidermis, and vasodilation in the superficial dermis. We considered that vasodilation and partial epidermal atrophy may be induced by topical steroid application in BD-affected areas. In cases of suspected BD with reddish-brown plaque showing branched and/or reticulated vessels in dermoscopy, confirming a history of topical steroid use is helpful.

scholarly journals CLAPO syndrome: Identification of somatic activating PIK3CA mutations and delineation of the natural history and phenotype

2017 ◽  
Author(s):  
Lara Rodriguez-Laguna ◽  
Kristina Ibañez ◽  
Gema Gordo ◽  
Sixto Garcia-Minaur ◽  
Fernando Santos-Simarro ◽  
...  
Keyword(s):  
Natural History ◽  
Developmental Disorders ◽  
Somatic Mosaicism ◽  
Clinical Manifestations ◽  
Tissue Samples ◽  
Lower Lip ◽  
Pik3ca Mutations ◽  
Activating Mutations ◽  
The Face ◽  
History Of

AbstractBackgroundCLAPO syndrome is a rare vascular disorder characterized by Capillary malformation of the lower lip, Lymphatic malformation predominant on the face and neck, Asymmetry, and Partial/generalized Overgrowth. Although the genetic cause is not known, the tissue distribution of the clinical manifestations in CLAPO seems to follow a pattern of somatic mosaicism.Subjects and methodsWe clinically evaluated a cohort of 13 patients with CLAPO and screened 20 DNA blood/tissue samples from nine patients using high-throughput, deep sequencing.ResultsWe identified five activating mutations in the PIK3CA gene in affected tissues from six of the nine patients studied; one of the variants (NM_006218.2:c.248T>C; p.Phe83Ser) has not been previously described in developmental disorders.ConclusionsWe describe for the first time the presence of somatic activating PIK3CA mutations in patients with CLAPO. We also report an update of the phenotype and natural history of the syndrome.

scholarly journals Successful treatment of granuloma faciale

2020 ◽  
Vol 7 (1) ◽  
pp. 129
Author(s):  
Sahar H. Alsharif ◽  
Reda H. Saifaldeen ◽  
Logain G. Alghanemi
Keyword(s):  
Successful Treatment ◽  
Topical Steroids ◽  
Erythematous Plaque ◽  
Gradual Improvement ◽  
Topical Tacrolimus ◽  
Therapeutic Modalities ◽  
Granuloma Faciale ◽  
The Face ◽  
History Of

<p class="abstract">Granuloma faciale (GF) is a chronic condition characterized by asymptomatic erythematous plaque with prominent telangiectasia presenting usually over the face. Although the condition is benign, its treatment is often unsatisfactory. Therapeutic modalities that have been tried include topical steroids and topical tacrolimus sometimes enhanced with topical dapsone. Others include intralesional corticosteroids, antimalarials, isoniazid and pulsed-dye laser. We report a case of a 58 years old female with a 1 year history of a solitary slowly progressive plaque over the nose. Diagnosis of GF was made based on the histopathological findings. The patient was started on the combination of topical tacrolimus, intralesional corticosteroids injection and oral doxycycline for 3 months. The patient showed gradual improvement in 3 months without any side effects. This case supports previous papers of successful treatment of GF with topical tacrolimus. There was no recurrence at follow-up 18 months later. It also supports the use of combination therapy especially in resistant cases.</p>

scholarly journals Erosive Pustular Dermatosis of the Scalp Induced by Imiquimod

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Maria Teresa Corradin ◽  
Marina Forcione ◽  
Erika Giulioni ◽  
Renzo Fiorentino ◽  
Anna Ferrazzi ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Clinical Manifestations ◽  
Rare Condition ◽  
Unknown Origin ◽  
Systemic Steroid ◽  
Topical Steroids ◽  
Inflammatory Disorder ◽  
Imiquimod Cream ◽  
Topical Antibiotics ◽  
History Of

Erosive pustular dermatosis of the scalp (EPDS) is a rare condition characterized by sterile pustules, erosions, and crusted lesions on the scalp of elderly patients. This inflammatory disorder has an unknown origin and it could develop into areas of alopecia that tend to be atrophic. An 84-year-old Caucasian man presented with a several months history of painful erythematous erosions and crusts on his scalp. The lesions appeared after treatment with imiquimod cream for actinic keratoses. Previous therapies included topical antibiotics and topical steroids. Physical examination revealed the presence of extensive erosions and crusts on the scalp, with minute pustules on the sides. The clinical features and the medical history led us to the diagnosis of EPDS. Treatment with systemic steroid was administered with improvement observed after ten days. The clinical manifestations of EPDS completely resolved after 2 months, without clinical relapses.

scholarly journals Erosive pustular dermatosis of the scalp - is it really a rare condition?

2014 ◽  
Vol 71 (3) ◽  
pp. 307-310 ◽  
Author(s):  
Olivera Levakov ◽  
Branislava Gajic
Keyword(s):  
Infectious Agent ◽  
Rare Condition ◽  
The Elderly ◽  
Unknown Etiology ◽  
Topical Steroids ◽  
Physical Trauma ◽  
Scarring Alopecia ◽  
Clinical Presentations ◽  
Local Trauma ◽  
History Of

Introduction. Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of unknown etiology that usually occurs in the elderly and is characterized by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is the reason that EPDS is a frequently misdiagnosed condition. Case report. We presented two patients with EPDS. The first patient had the known history of local trauma, both patients had chronic recidivant process, classic clinical presentations, and nonspecific histological findings. Each patient had prompt therapeutical response to potent topical steroids. Conclusion. The diagnosis of EPDS can be made if a condition fulfills the following criteria: atrophic or actinic damaged skin, clinical association of erosions, pustules, scales and crusts, no specific histopathology, no infectious agent found responsible for the condition, and chronic course leading to scarring alopecia, and prompt response to the treatment with topical steroids. The history of chemical or physical trauma is often present.

scholarly journals A Clinical Study of Steroid Induced Dermatoses

2018 ◽  
Vol 16 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Sudip Parajuli ◽  
Upama Paudel ◽  
Amod Kumar Poudyal ◽  
Dinesh Binod Pokhrel
Keyword(s):  
Topical Steroid ◽  
Cross Sectional Study ◽  
Small Scale ◽  
Cross Sectional ◽  
Over The Counter ◽  
Steroid Abuse ◽  
Clinical Presentations ◽  
Rebound Phenomenon ◽  
Structured Questionnaire

Introduction: Steroid induced dermatoses on face are one of the common presentations in Dermatological practice.Objectives: 1) Understand the clinical patterns of adverse effects of long term abuse of topical steroid on face and 2) Assess the factor which promotes its abuse.Materials and Methods: This was a descriptive exploratory cross-sectional study carried out from December, 2013 through November, 2014. A total of 39 patients fulfilling the inclusion criteria were enrolled into the study. All the study variables were recorded using preformed structured questionnaire and analyzed.Results: The following effects of steroid abuse on face were seen: pruritus (38.5%), burning (15.4%), eythema (74.4%), telangiectasias (66.7%), acneiform eruptions (59%), comedones (35.9%), xerosis (55.1%), photosensitivity (51.3%), rebound phenomenon (38.5%) and others (38.5%). Most of them used steroids on recommendation of their friends (38.5%) and pharmacists (20.5%). All of them used steroid for different dermatoses on their face.Limitations: This is a hospital-based small-scale study and might not be true picture of problem in the community.Conclusion: Long term use of steroid on face results in different clinical presentations. Most of the patients used steroidon recommendation of their friends facilitated by easy availability of the drug over- the -counter.

scholarly journals Prophylaxis AgainstMycobacterium aviumComplex Infection in AIDS

1994 ◽  
Vol 5 (suppl b) ◽  
pp. 10B-13B
Author(s):  
DW Cameron
Keyword(s):  
Human Immunodeficiency Virus ◽  
Natural History ◽  
Mycobacterium Avium Complex ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Diagnostic Methods ◽  
Wasting Syndrome ◽  
Immunodeficiency Virus ◽  
The Face ◽  
History Of

Disseminated Mycobacterium avium complex (MAC) infection in AIDS is increasing in frequency, although it remains under-recognized due to unlocalized clinical manifestations and subtle initial presentation, if not the need for specialized laboratory diagnostic methods. Ultimately, MAC accounts for much of the “wasting syndrome” in the natural history of human immunodeficiency virus disease. Multidrug treatment of MAC in AIDS is problematic. That MAC is preventable has been demonstrated, and how much clinical benefit can be had from successful prophylaxis remains to be evaluated in the face of improved efficacy of both treatment and prophylaxis regimens under investigation.

scholarly journals Status epilepticus and diabetes ketoacidosis: uncommon clinical presentations of acromegaly

2021 ◽  
Vol 2021 ◽  
Author(s):  
Nyasatu G Chamba ◽  
Ahlam A Amour ◽  
Abid M Sadiq ◽  
Tecla R Lyamuya ◽  
Emmanuel V Assey ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Mass Effect ◽  
Prolactin Secretion ◽  
List Type ◽  
Resource Setting ◽  
Clinical Presentations ◽  
History Of ◽  
New Onset

Summary Acromegaly is a rare disease caused by hypersecretion of the growth hormone (GH). Most cases are caused by either pituitary microadenoma or macroadenoma. The GH producing tumors present with clinical manifestations of acromegaly due to excessive GH secretion or symptoms resulting from mass effects of the enlarging tumor. The physical changes are usually slow and, therefore, recognition of the disease is delayed. These adenomas are never malignant but can have significant morbidity and mortality. A subgroup of patients with acromegaly present with severe hyperglycemia resulting in diabetic ketoacidosis (DKA) which requires insulin. Rarely are pituitary tumors responsible for generalized convulsions except when they are too large. We hereby present two cases, the first is that of a 26-year-old female who presented with new onset status epilepticus, DKA with a 1-year history of diabetes mellitus (DM). On examination, she had clinical features of acromegaly. The second case is that of a 34-year-old female who presented with new onset status epilepticus, hyperglycemia with a history of recently diagnosed DM, and features of gigantism. In both cases, their diagnosis was confirmed by elevated serum GH and later by elevated insulin-like growth factor type 1 levels, and CT of the head demonstrating large pituitary macroadenoma. The importance of clinical history and examination, as well as investigations is vital in the recognition of acromegaly. The prognosis of acromegalic patients depends on early clinical recognition and tumor size reduction by either medical or surgical therapy. Learning points Conditions such as status epilepticus and DKA may be clinical presentations in patients presenting with acromegaly. Seizures are rare in people with pituitary adenoma and typically occur when the tumor invades the suprasellar area due to mass effect on the brain. This article shows how best we were able to manage the acromegaly complications in a low resource setting. Hyperprolactinemia in acromegaly may be due to disruption of the normal dopaminergic inhibition of prolactin secretion due to mass effect of the macroadenoma, and around 25% of GH-secreting adenomas co-secrete prolactin.

scholarly journals Misuse of topical corticosteroids and attitude towards self-medication: a rising alarm

2017 ◽  
Vol 3 (4) ◽  
pp. 485
Author(s):  
Savita Chaudhary
Keyword(s):  
Indian Population ◽  
Topical Steroid ◽  
Medical Practitioner ◽  
Topical Steroids ◽  
Self Medication ◽  
Topical Medication ◽  
Inappropriate Use ◽  
Topical Corticosteroids ◽  
Number Of Patients ◽  
History Of

<p class="abstract" style="margin-bottom: .0001pt;"><strong><span lang="EN-US">Background:</span></strong>Topical corticosteroids (TC) are among the most commonly used medications for treatment of skin disorders. They give immediate relief from symptoms in many inflammatory dermatoses. Even inappropriate use in infectious dermatoses relieves the symptoms. This study was done to analyze the misuse of topical corticosteroids in Indian population and to analyze the attitude of patients towards self-medication.</p><p class="abstract" style="margin-bottom: .0001pt;"><strong><span lang="EN-US">Methods:</span></strong>All patients presenting with various dermatoses to the investigator were asked about history of usage of any topical medication on the lesion. In case of a positive answer, the investigator ascertained whether the topical medication in question contained a corticosteroid. The total number of patients seen during the recruitment period (January 2012 – December 2012) was noted on a separate list. Full questionnaires were only filled for patients with history of using topical corticosteroids<span lang="EN-US">.<strong></strong></span></p><p class="abstract" style="margin-bottom: .0001pt;"><strong><span lang="EN-US">Results:</span></strong>5256 patients were screened out of which 4100 (78%) were already using topical medications. 3154 (60%) patients were using topical steroid in various forms. About 80% of the patients using topical steroids confessed that they have not consulted qualified medical practitioner. They were advised these medications by chemists, friends or quacks, neighbours, barbers, beauticians etc.</p><p class="abstract" style="margin-bottom: .0001pt;"><strong><span lang="EN-US">Conclusions:</span></strong>Misuse of topical corticosteroids is common in Indian population and results in various complications. Educating public, chemists, general practitioners along with strict vigil by law enforcing agencies is needed for optimal and safe use of corticosteroids.</p>

scholarly journals IATROSACEA FOLLOWING ABUSE OF TOPICAL STEROIDS AS A FACE-WHITENING CREAM IN MOSUL CITY

2021 ◽  
Vol 12 (2) ◽  
pp. 5-10
Author(s):  
Deena Al-Samman ◽  
Mohammed Attar Bashi
Keyword(s):  
Side Effects ◽  
Public Awareness ◽  
Educational Status ◽  
Clinical Aspects ◽  
Topical Steroids ◽  
Inappropriate Use ◽  
Facial Erythema ◽  
The Face ◽  
History Of ◽  
And Control

Objectives: To highlight the knowledge, frequency, types, and the clinical aspects of overusing TCs on the face as well as the motivation for such practice, with the aim of rising the public awareness in Mosul City. Methods: This prospective observational study included 180 patients aged 13-53 years, with steroid dermatitis resembling rosacea "Iatrosacea" with history of using TCs on face > 1 month, were evaluated at Al-Qudis Health Center for Family Medicine. Patients contradicted using TCs, or with classical rosacea were excluded. Results: The majority were females (90%). Duration was 2 months to 7 years. The motives were fairness (55%) and melasma (19%). The commonly abused drug was Betamethasone Valerate (35%). The reported side effects were facial erythema (84%), telangiectasia (79%), rebound phenomenon (66%), rosacea (56%), and acne (42%). The exacerbation on stopping TCs (63%) and skin lightening (37%) were the main reasons behind continued use; 59% were unaware about side effects of TCs; 42% obtained the products from cosmetic shop/Beautician and 27% from nurse clinic. In spite of observable side effects, 74% of abusers didn't feel guilty for applying them for protracted periods. Conclusion: Inappropriate use of TCs for cosmetic purposes is still commonly encountered in our environment, with believe TCs will correct any facial imperfection. As fair skin is correlated with beauty and social privilege, both genders of different ages, social, and educational status are indulged in this practice that exposed them to medical and social problems. It is a multiphase issue necessitates collaboration of different sectors to raise public awareness and control their easy availability to overcome this dilemma.

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