scholarly journals Is ICSI Risky?

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
May Y. W. Wong ◽  
William L. Ledger
Keyword(s):  
England Journal ◽  
New England ◽  
Assisted Reproductive Technology ◽  
Intracytoplasmic Sperm Injection ◽  
Infertility Treatment ◽  
Reproductive Technology ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Art Methods

As assisted reproductive technology (ART) methods become the mainstream of infertility treatment, it has become even more critical to reassess its safety. Following the results of a study published by the Robinson Institute in the New England Journal of Medicine, the risk of ART, especially intracytoplasmic sperm injection (ICSI), has never been so closely scrutinized. This paper traces the origins and development of ICSI, assesses the risks documented in the literature, and finally interprets the implications of the study for couples contemplating therapy. We support the need for continued vigilance towards ICSI and the importance in investigating male-factor infertility as a prequel to its use.

scholarly journals Intracytoplasmic sperm injection: state of the art in humans

Reproduction ◽  
2017 ◽  
Vol 154 (6) ◽  
pp. F93-F110 ◽  
Author(s):  
G D Palermo ◽  
C L O’Neill ◽  
S Chow ◽  
S Cheung ◽  
A Parrella ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Poor Prognosis ◽  
State Of The Art ◽  
Semen Analysis ◽  
Reproductive Technology ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Current Application ◽  
Infertile Couples ◽  
The Impact

Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART. The development of ICSI in 1992 has drastically decreased the impact of male factor, resulting in millions of pregnancies worldwide for couples who, without ICSI, would have had little chance of having their own biological child. This review focuses on the state of the art of ICSI regarding utility of bioassays that evaluate male factor infertility beyond the standard semen analysis and describes the current application and advances in regard to ICSI, particularly the genetic and epigenetic characteristics of spermatozoa and their impact on reproductive outcome.

Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications

2018 ◽  
Vol 36 (03/04) ◽  
pp. 195-203
Author(s):  
Emre Seli ◽  
Scott Morin
Keyword(s):  
Assisted Reproductive Technology ◽  
Premature Birth ◽  
Absolute Risk ◽  
Reproductive Technology ◽  
Multiple Gestation ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Monogenic Disorder ◽  
Increased Risk ◽  
Confounding Variables

AbstractThe majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies fail to account for the increased risk of many of these pathologies in the offspring of subfertile women in general. Lastly, the absolute risk of most of the ailments studied is extremely low. In nearly all examples, the number of women who would need to be treated to observe one additional diagnosis is substantially high. When compared with the number of couples who would have remained childless due to severe male factor infertility or would have been exposed to the risk of passing on a severe monogenic disorder, the general increased risks to ART-exposed children is very small.

scholarly journals The use of assisted reproductive technology before male factor infertility evaluation

2018 ◽  
Vol 7 (4) ◽  
pp. 678-685 ◽  
Author(s):  
Madhur Nayan ◽  
Nahid Punjani ◽  
Ethan Grober ◽  
Kirk Lo ◽  
Keith Jarvi
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Male Factor Infertility ◽  
Male Factor

Impact of preimplantation genetic testing on assisted reproductive technology outcomes in couples with male factor infertility

2021 ◽  
Vol 11_2021 ◽  
pp. 154-164
Author(s):  
Makarova N.P. Makarova ◽  
Lobanova N.N. Lobanova ◽  
Kulakova E.V. Kulakova ◽  
Nepsha O.S. Nepsha ◽  
Ekimov A.N. Ekimov ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Preimplantation Genetic Testing
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