scholarly journals The Use of Carbon Nanotubes to Reinforce 45S5 Bioglass-Based Scaffolds for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
R. Touri ◽  
F. Moztarzadeh ◽  
Z. Sadeghian ◽  
D. Bizari ◽  
M. Tahriri ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Elastic Modulus ◽  
Sol Gel ◽  
Casting Process ◽  
Multiwall Carbon Nanotube ◽  
Filling Material ◽  
45S5 Bioglass ◽  
Gel Processing

Bioglass has been used for bone-filling material in bone tissue engineering, but its lean mechanical strength limits its applications in load-bearing positions. Carbon nanotubes (CNTs), with their high aspect ratio and excellent mechanical properties, have the potential to strengthen and toughen bioactive glass material without offsetting its bioactivity. Therefore, in this research, multiwall carbon nanotube (MWCNT)/45S5 Bioglass composite scaffolds have been successfully prepared by means of freeze casting process. 45S5 Bioglass was synthesized by the sol-gel processing method. The obtained material was characterized with X-ray powder diffraction (XRD). The mechanical properties of the scaffolds, such as compression strength and elastic modulus, were measured. Finally, compared with the scaffolds prepared by 100% 45S5 Bioglass powders, the addition of 0.25 wt.% MWCNTs increases the compressive strength and elastic modulus of 45S5 Bioglass scaffolds from 2.08 to 4.56 MPa (a 119% increase) and 111.50 to 266.59 MPa (a 139% increase), respectively.

Apatite-forming ability and mechanical properties of PTMO-modified CaO–SiO2 hybrids prepared by sol–gel processing: effect of CaO and PTMO contents

Biomaterials ◽  
2002 ◽  
Vol 23 (14) ◽  
pp. 3033-3040 ◽  
Author(s):  
Noboru Miyata ◽  
Ken-ichi Fuke ◽  
Qi Chen ◽  
Masakazu Kawashita ◽  
Tadashi Kokubo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Sol Gel ◽  
Processing Effect ◽  
Gel Processing

Apatite-forming ability and mechanical properties of PTMO-modified CaO–SiO2–TiO2 hybrids derived from sol–gel processing

Biomaterials ◽  
2004 ◽  
Vol 25 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Noboru Miyata ◽  
Ken-ichi Fuke ◽  
Qi Chen ◽  
Masakazu Kawashita ◽  
Tadashi Kokubo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Sol Gel ◽  
Gel Processing

The influence of functionalization time of carbon nanotube on the mechanical properties of the epoxy composites

2017 ◽  
Vol 51 (12) ◽  
pp. 1693-1701 ◽  
Author(s):  
EA Zakharychev ◽  
EN Razov ◽  
Yu D Semchikov ◽  
NS Zakharycheva ◽  
MA Kabina
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Tensile Strength ◽  
Elastic Modulus ◽  
Carbon Nanotube ◽  
Composite Materials ◽  
Polymer Composites ◽  
Epoxy Composites ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

This paper investigates the structure, length, and percentage of functional groups of multi-walled carbon nanotubes (CNT) depending on the time taken for functionalization in HNO3 and H2SO4 mixture. The carbon nanotube content and influence of functionalization time on mechanical properties of polymer composite materials based on epoxy matrix are studied. The extreme dependencies of mechanical properties of carbon nanotube functionalization time of polymer composites were established. The rise in tensile strength of obtained composites reaches 102% and elastic modulus reaches 227% as compared to that of unfilled polymer. The composites exhibited best mechanical properties by including carbon nanotube with 0.5 h functionalization time.

PEG Cross-Linked Alginate Hydrogels with Controlled Mechanical Properties

1998 ◽  
Vol 530 ◽  
Author(s):  
Petra Eiselt ◽  
Jon A. Rowley ◽  
David J. Mooney
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Molecular Weight ◽  
Elastic Modulus ◽  
Cell Transplantation ◽  
Cross Linking ◽  
Cross Link ◽  
Link Density ◽  
A Cell ◽  
Cross Link Density

AbstractReconstruction of tissues and organs utilizing cell transplantation offers an attractive approach for the treatment of patients suffering from organ failure or loss. Highly porous synthetic materials are often used to mimic the function of the extracellular matrix (ECM) in tissue engineering, and serve as a cell delivery vehicle for the formation of tissues in vivo. Alginate, a linear copolysaccharide composed of D-mannuronic acid (M) and L-guluronic acid (G) units is widely used as a cell transplantation matrix. Alginate is considered to be biocompatible, and hydrogels are formed in the presence of divalent cations such as Ca2+, Ba2+ and Sr2+. However, ionically cross-linked alginate gels continuously lose their mechanical properties over time with uncontrollable degradation behavior. We have modified alginate via covalent coupling of cross-linking molecules to expand and stabilize the mechanical property ranges of these gels. Several diamino PEG molecules of varying molecular weight (200, 400, 1000, 3400) were synthesized utilizing carbodiimide chemistry. Sodium alginate was covalently cross-linked with these cross-linking molecules, and mechanical properties of the resulting hydrogels were determined. The elastic modulus of the cross-linked alginates depended on the molecular weight of the cross-linking molecules, and ranged from 10-110 kPa. The theoretical cross-link density in the hydrogels was also varied from 3 to 47% (relative to the carboxylic groups in the alginate) and the mechanical properties were measured. The elastic modulus increased gradually and reached a maximum at a cross-link density of 15%. In summary, covalently coupled hydrogels can be synthesized which exhibit a wide range of mechanical properties, and these materials may be useful in a number of tissue engineering applications.

Fracture Toughness and Adhesion Energy of Sol-gel Coatings on Glass

2002 ◽  
Vol 17 (1) ◽  
pp. 224-233 ◽  
Author(s):  
Jaap Den Toonder ◽  
Jürgen Malzbender ◽  
Gijsbertus De With ◽  
Ruud Balkenende
Keyword(s):  
Mechanical Properties ◽  
Fracture Toughness ◽  
Elastic Modulus ◽  
Sol Gel ◽  
Industrial Applications ◽  
Adhesion Energy ◽  
Scratch Testing ◽  
New Methods ◽  
Quantitative Results ◽  
Coating Fracture

The reliability of coatings that are used in industrial applications critically depends on their mechanical properties. Nanoindentation and scratch testing are well-established techniques to measure some of these properties, namely the elastic modulus and hardness of coatings. In this paper, we investigate the possibility of also assessing the coating fracture toughness and the energy of adhesion between the coating and the substrate using indentation and scratch testing. Various existing and new methods are discussed, and they are illustrated by measurements on particle-filled sol-gel coatings on glass. All methods are based on the occurrence of cracking, and they are therefore only applicable to coating systems that act like brittle materials and exhibit cracking during indentation and scratching. The methods for determining the fracture toughness give comparable results, but the values still differ to within about 50%. The values of the adhesion energy obtained from different measurements are consistent, but it remains uncertain to which extent the obtained values are quantitatively correct. The results show that the methods used are promising, but more research is needed to obtain reliable quantitative results.

scholarly journals Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1930 ◽  
Author(s):  
Ming-You Shie ◽  
Jian-Jr Lee ◽  
Chia-Che Ho ◽  
Ssu-Yin Yen ◽  
Hooi Yee Ng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physical Properties ◽  
Dermal Fibroblast ◽  
Sol Gel ◽  
Biological Properties ◽  
Human Dermal Fibroblast ◽  
Natural Material ◽  
Matrix Remodeling ◽  
Proliferation Markers

Gelatin-methacryloyl (GelMa) is a very versatile biomaterial widely used in various biomedical applications. The addition of methacryloyl makes it possible to have hydrogels with varying mechanical properties due to its photocuring characteristics. In addition, gelatin is obtained and derived from natural material; thus, it retains various cell-friendly motifs, such as arginine-glycine-aspartic acid, which then provides implanted cells with a friendly environment for proliferation and differentiation. In this study, we fabricated human dermal fibroblast cell (hDF)-laden photocurable GelMa hydrogels with varying physical properties (5%, 10%, and 15%) and assessed them for cellular responses and behavior, including cell spreading, proliferation, and the degree of extracellular matrix remodeling. Under similar photocuring conditions, lower concentrations of GelMa hydrogels had lower mechanical properties than higher concentrations. Furthermore, other properties, such as swelling and degradation, were compared in this study. In addition, our findings revealed that there were increased remodeling and proliferation markers in the 5% GelMa group, which had lower mechanical properties. However, it was important to note that cellular viabilities were not affected by the stiffness of the hydrogels. With this result in mind, we attempted to fabricate 5–15% GelMa scaffolds (20 × 20 × 3 mm3) to assess their feasibility for use in skin regeneration applications. The results showed that both 10% and 15% GelMa scaffolds could be fabricated easily at room temperature by adjusting several parameters, such as printing speed and extrusion pressure. However, since the sol-gel temperature of 5% GelMa was noted to be lower than its counterparts, 5% GelMa scaffolds had to be printed at low temperatures. In conclusion, GelMa once again was shown to be an ideal biomaterial for various tissue engineering applications due to its versatile mechanical and biological properties. This study showed the feasibility of GelMa in skin tissue engineering and its potential as an alternative for skin transplants.

scholarly journals A Comparison of Bioactive Glass Scaffolds Fabricated ‎by Robocasting from Powders Made by Sol–Gel and Melt-Quenching Methods

Processes ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 615
Author(s):  
Basam A. E. Ben-Arfa ◽  
Robert C. Pullar
Keyword(s):  
Mechanical Properties ◽  
Bioactive Glass ◽  
Bone Growth ◽  
Sol Gel ◽  
Glass Network ◽  
Silica Content ◽  
Bioactive Glasses ◽  
Phosphorous Content ◽  
High Silica ◽  
45S5 Bioglass

Bioactive glass scaffolds are used in bone and tissue biomedical implants, and there is great interest in their fabrication by additive manufacturing/3D printing techniques, such as robocasting. Scaffolds need to be macroporous with voids ≥100 m to allow cell growth and vascularization, biocompatible and bioactive, with mechanical properties matching the host tissue (cancellous bone for bone implants), and able to dissolve/resorb over time. Most bioactive glasses are based on silica to form the glass network, with calcium and phosphorous content for new bone growth, and a glass modifier such as sodium, the best known being 45S5 Bioglass®. 45S5 scaffolds were first robocast in 2013 from melt-quenched glass powder. Sol–gel-synthesized bioactive glasses have potential advantages over melt-produced glasses (e.g., greater porosity and bioactivity), but until recently were never robocast as scaffolds, due to inherent problems, until 2019 when high-silica-content sol–gel bioactive glasses (HSSGG) were robocast for the first time. In this review, we look at the sintering, porosity, bioactivity, biocompatibility, and mechanical properties of robocast sol–gel bioactive glass scaffolds and compare them to the reported results for robocast melt-quench-synthesized 45S5 Bioglass® scaffolds. The discussion includes formulation of the printing paste/ink and the effects of variations in scaffold morphology and inorganic additives/dopants.

On the mechanical properties of functionally graded materials reinforced by carbon nanotubes

2017 ◽  
Vol 232 (9) ◽  
pp. 1632-1646 ◽  
Author(s):  
Saeed Rouhi ◽  
Seyed H Alavi
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Elastic Modulus ◽  
Functionally Graded Materials ◽  
Volume Fraction ◽  
Single Walled Carbon Nanotubes ◽  
Functionally Graded ◽  
Graded Materials ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

In this paper, the elastic properties of functionally graded materials reinforced by single-walled carbon nanotubes are studied. Three different matrices, including steel-silicon, iron-alumina and alumina-zirconia are considered. Besides, the effects of nanotube length, radius and volume fraction on the Young’s modulus of functionally graded matrices reinforced by single-walled carbon nanotubes are investigated. It is observed that short nanotubes not only cannot increase the longitudinal elastic modulus of the matrices, but sometimes decrease their elastic modulus. Of the three selected matrices, steel-silicon matrix would have the most enhancement. Investigation of the effect of nanotube volume fraction on the mechanical properties of nanocomposites shows that increasing the volume fraction of long single-walled carbon nanotube results in increasing the elastic modulus of the nanocomposites.

scholarly journals Dispersion of aminoalkylsilyl ester or amine alkyl-phosphonic acid side wall functionalized carbon nanotubes in silica using sol–gel processing

2008 ◽  
Vol 62 (6-7) ◽  
pp. 918-922 ◽  
Author(s):  
Aderemi Oki ◽  
Luqman Adams ◽  
Valery Khabashesku ◽  
Yamen Edigin ◽  
Paul Biney ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Phosphonic Acid ◽  
Sol Gel ◽  
Side Wall ◽  
Functionalized Carbon Nanotubes ◽  
Gel Processing
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