scholarly journals Microscopic Colitis with Macroscopic Endoscopic Findings

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Atif Saleem ◽  
Parag A. Brahmbhatt ◽  
Sarah Khan ◽  
Mark Young ◽  
Gene D. LeSage
Keyword(s):  
White Light ◽  
Colonic Mucosa ◽  
Collagenous Colitis ◽  
Microscopic Colitis ◽  
Watery Diarrhea ◽  
White Light Endoscopy ◽  
Endoscopic Findings ◽  
Microscopic Inflammation

Microscopic Colitis (MC) is characterized by chronic watery diarrhea, grossly normal appearing colonic mucosa during conventional white light endoscopy, and biopsy showing microscopic inflammation. We report a case of collagenous colitis with gross endoscopic findings.

scholarly journals Microscopic Colitis: Epidemiology, Pathophysiology, Diagnosis and Current Management—An Update 2013

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Martin Alexander Storr
Keyword(s):  
Colonic Mucosa ◽  
Chronic Diarrhea ◽  
Treatment Options ◽  
Correct Diagnosis ◽  
Collagenous Colitis ◽  
Microscopic Colitis ◽  
Normal Colonic Mucosa ◽  
Clinical Value ◽  
Current Management ◽  
And Gender

Microscopic colitis is a common cause of chronic diarrhea. Over the last years the incidence and the prevalence of microscopic colitis are rising and this rise is largely attributed to a rising awareness, and concomitantly an increasing number of diagnoses are made. Patients with microscopic colitis report watery, nonbloody diarrhea of chronic, intermittent, or chronic recurrent course. Following an unremarkable physical examination the diagnosis of microscopic colitis is made by colonoscopy, which shows essentially a normal colonic mucosa. Biopsies taken during the colonoscopy procedure will then finally establish the correct diagnosis. Histological workup can then confirm a diagnosis of microscopic colitis and can distinguish the two distinct histological forms, namely, collagenous colitis and lymphocytic colitis. Presently both forms are diagnosed and treated in the same way; thus the description of the two forms is not of clinical value, though this may change in future. Depending on the patients age and gender 10–30% of patients investigated for chronic diarrhea will be diagnosed with microscopic colitis if biopsies are taken. Microscopic colitis is most common in older patients, especially in female patients and is frequently associated with autoimmune disorders and the consumption of several drugs. This review summarizes the present knowledge of the epidemiology, the pathophysiology, and the diagnosis of microscopic colitis and discusses the former and the present treatment options.

scholarly journals Microscopic Colitis: An Approach to Treatment

2008 ◽  
Vol 22 (8) ◽  
pp. 686-688 ◽  
Author(s):  
Nilesh Chande
Keyword(s):  
Celiac Disease ◽  
Adverse Events ◽  
Elderly Patients ◽  
Medical Treatment ◽  
Treatment Response ◽  
Collagenous Colitis ◽  
Microscopic Colitis ◽  
Watery Diarrhea ◽  
Evidence Based ◽  
Refractory Disease

Microscopic colitis – including collagenous colitis and lymphocytic colitis – causes chronic watery diarrhea, usually in middle-aged or elderly patients. There is an association with celiac disease and certain medications. Medical treatment includes various antidiarrheal agents, mesalamine, corticosteroids and immunosuppressant drugs. Rarely, patients require surgery for refractory disease. An evidence-based and practical approach to treatment should optimize the treatment response while minimizing potential adverse events.

scholarly journals Reduced T Cell Receptor Excision Circle Levels in the Colonic Mucosa of Microscopic Colitis Patients Indicate Local Proliferation rather than Homing of Peripheral Lymphocytes to the Inflamed Mucosa

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ashok Kumar Kumawat ◽  
Kristina Elgbratt ◽  
Curt Tysk ◽  
Johan Bohr ◽  
Elisabeth Hultgren Hörnquist
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Colonic Mucosa ◽  
Statistical Significance ◽  
Collagenous Colitis ◽  
T Cell Responses ◽  
Cell Receptor ◽  
Microscopic Colitis ◽  
Cell Responses ◽  
Enhanced Expression

Dysregulated T cell responses in the intestine may lead to chronic bowel inflammation such as collagenous colitis (CC) and lymphocytic colitis (LC), together known as microscopic colitis (MC). Having demonstrated increased local T cell responses in the intestinal mucosa of MC patients, we investigated the recent thymic emigrants by measuring T cell receptor excision circle (TREC) levels in the colonic biopsies from CC (n=8), LC (n=5), and CC or LC patients in histopathological remission (CC-HR,n=3) (LC-HR,n=6), non-inflamed diarrhoea patients (n=17), and controls (n=10) by real-time PCR. We observed lower median TREC levels in both CC and LC patients as well as in LC-HR patients compared to controls. In contrast to MC patients, non-inflamed diarrhoea patients presented with enhanced TREC levels compared to controls. None of the recorded differences did, however, reach statistical significance. A trend towards increased relative expression of CD3 was noted in all MC subgroups examined and reached statistical significance in LC patients compared to controls. In conclusion, reduced TRECs level in the colonic mucosa, together with our previously demonstrated enhanced expression of Ki67+T cells, suggests local expansion of resident T lymphocytes in the inflamed mucosa of MC patients.

Microscopic Colitis

2015 ◽  
Author(s):  
Anthony O’Connor ◽  
Alan C. Moss
Keyword(s):  
Differential Diagnosis ◽  
Colonic Mucosa ◽  
Collagenous Colitis ◽  
Evidence Base ◽  
Intraepithelial Lymphocytes ◽  
Microscopic Colitis ◽  
Lymphocytic Colitis ◽  
Colonic Epithelium ◽  
Treatment Complications

Microscopic colitis (MC) is defined by the presence of specific histologic abnormalities in patients with diarrhea and a normal-appearing colon at endoscopy. MC can be categorized into two types: collagenous colitis (CC) and lymphocytic colitis (LC). CC is characterized by a thickened subepithelial collagen band in the colonic mucosa of at least 10 mm in thickness, whereas LC describes infiltration of the colonic epithelium with lymphocytes (intraepithelial lymphocytes), without excess collagen in the mucosa. This review of MC addresses the epidemiology, pathogenesis, etiology/genetics, diagnosis, differential diagnosis, treatment, complications, and prognosis between the two types. Tables list potential etiologic factors in MC, medications associated with MC, and treatments used for MC and evidence base. This review contains 3 tables and 55 references.

scholarly journals Acute Onset Collagenous Colitis with Unique Endoscopic Findings

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Rintaro Moroi ◽  
Katsuya Endo ◽  
Masatake Kuhroha ◽  
Hisashi Shiga ◽  
Yoichi Kakuta ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Ischemic Colitis ◽  
Rare Case ◽  
Acute Abdominal Pain ◽  
Collagenous Colitis ◽  
Acute Onset ◽  
Watery Diarrhea ◽  
Endoscopic Findings ◽  
Points Of View

We experienced a rare case of 72-year-old woman with acute onset collagenous colitis (CC) induced by lansoprazole. The patient developed acute abdominal pain, watery diarrhea, and melena that are quite rare in usual CC. We could find the characteristic colonoscopic findings such as active long liner ulcers in the patient. We also observed the healing courses of these unique findings. Our case indicates two important points of view. (1) CC sometimes develops with acute onset symptoms which resemble those of ischemic colitis. (2) Colonoscopy would be useful and necessary to distinguish acute onset CC and ischemic colitis.

The Efficacy of Virtual Chromoendoscopy in the Diagnosis of Portal Hypertensive Gastropathy

2016 ◽  
Vol 25 (3) ◽  
pp. 289-293
Author(s):  
Anda Carmen Achim ◽  
Stefan Cristian Vesa ◽  
Eugen Dumitru
Keyword(s):  
Diagnostic Criteria ◽  
White Light ◽  
Narrow Band Imaging ◽  
Endoscopic Examination ◽  
Kappa Statistics ◽  
Portal Hypertensive Gastropathy ◽  
Mosaic Pattern ◽  
White Light Endoscopy ◽  
A New Technique ◽  
Virtual Chromoendoscopy

Background: Diagnosis of portal hypertensive gastropathy (PHG) is based on endoscopic criteria. I-scan technology, a new technique of virtual chromoendoscopy, increases the diagnostic accuracy for lesions in the gastrointestinal tract. Aim: To establish the role of i-scan endoscopy in the diagnosis of PHG. Method: In this prospective study, endoscopic examination was conducted first by using white light and after that i-scan 1 and i-scan 2 technology in a group of 50 consecutive cirrhotic patients. The endoscopic diagnostic criteria for PHG followed the Baveno criteria. The interobserver agreement between white light endoscopy and i-scan endoscopy was determined using Cohen’s kappa statistics. Results: Forty-five of the 50 patients met the diagnostic criteria for PHG when examined by i-scan endoscopy and 39 patients were diagnosed with PHG by white light endoscopy. The strength of agreement between the two methods for the diagnosis of PHG was moderate (k=0.565; 95%CI 0.271-0.859; p<0.001). I-scan 1 classified the mosaic pattern better than classic endoscopy; i-scan 2 described better the red spots. Conclusion: I-scan examination increased the diagnostic sensitivity of PHG. The diagnostic criteria (mosaic pattern and red spots) were easier to observe endoscopically using i-scan than in white light.Abbreviations: FICE: Fuji Intelligent chromoendoscopy; GAVE: gastric antral vascular ectasia; NBI: narrow band imaging; PHG: portal hypertensive gastropathy; PHT: portal hypertension; UGIB: upper gastrointestinal bleeding.

scholarly journals The Impact of Narrow-band Imaging on the Pre- and Intra- operative Assessments of Neoplastic and Preneoplastic Laryngeal Lesions. A Systematic Review

2020 ◽  
Author(s):  
Carmelo Saraniti ◽  
Enzo Chianetta ◽  
Giuseppe Greco ◽  
Norhafiza Mat Lazim ◽  
Barbara Verro
Keyword(s):  
White Light ◽  
Diagnostic Tool ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Resection Margins ◽  
Predictive Values ◽  
White Light Endoscopy ◽  
Laryngeal Lesions ◽  
Sensitivity Specificity ◽  
The Impact

Introduction Narrow-band imaging is an endoscopic diagnostic tool that, focusing on superficial vascular changes, is useful to detect suspicious laryngeal lesions, enabling their complete excision with safe and tailored resection margins. Objectives To analyze the applications and benefits of narrow-band imaging in detecting premalignant and malignant laryngeal lesions through a comparison with white-light endoscopy. Data Synthesis A literature search was performed in the PubMed, Scopus and Web of Science databases using strict keywords. Then, two authors independently analyzed the articles, read the titles and abstracts, and read completely only the relevant studies according to certain eligibility criteria. In total, 14 articles have been included in the present review; the sensitivity, specificity, positive and negative predictive values, and accuracy of pre- and/or intraoperative narrow-band imaging were analyzed. The analysis showed that narrow-band imaging is better than white-light endoscopy in terms of sensitivity, specificity, positive and negative predictive values, and accuracy regarding the ability to identify cancer and/or precancerous laryngeal lesions. Moreover, the intraoperative performance of narrow-band imaging resulted more effective than the in-office performance. Conclusion Narrow-band imaging is an effective diagnostic tool to detect premalignant and malignant laryngeal lesions and to define proper resection margins. Moreover, narrow-band imaging is useful in cases of leukoplakia that may cover a possible malignant lesion and that cannot be easily assessed with white-light endoscopy. Finally, a shared, simple and practical classification of laryngeal lesions, such as that of the European Laryngological Society, is required to identify a shared lesion management strategy. Key Points

Sa1727 - Chromoendoscopy Versus High Definition White Light Endoscopy for Dysplasia Detection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-371
Author(s):  
Ramprasad Jegadeesan ◽  
Madhav Desai ◽  
Tharani Sundararajan ◽  
Venkata Subhash Gorrepati ◽  
Viveksandeep Thogulva Chandrasekar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
White Light ◽  
Bowel Disease ◽  
Meta Analysis ◽  
High Definition ◽  
White Light Endoscopy ◽  
Inflammatory Bowel
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