scholarly journals P.R.L. Platelet Rich Lipotransfert: Our Experience and Current State of Art in the Combined Use of Fat and PRP

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
V. Cervelli ◽  
I. Bocchini ◽  
C. Di Pasquali ◽  
B. De Angelis ◽  
G. Cervelli ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Platelet Rich Plasma ◽  
Soft Tissue Defect ◽  
Fat Grafting ◽  
Promising Alternative ◽  
Hemifacial Atrophy ◽  
Innovative Methods ◽  
Current State ◽  
Combined Use ◽  
Natural Healing

The authors report their experience about the use of P.R.L. PLATELET RICH LIPOTRANSFERT method (platelet rich plasma mixed fat grafting) in 223 patients affected by soft tissue defects (ulcers, Romberg syndrome, Hemifacial atrophy, loss of substance, and signs of aging). This paper introduces the reader to PRP therapy and reviews the current literature on this emerging treatment modality, showing at the current clinical use of PRP in plastic and reconstructive surgery, with description of innovative methods and future prospects. This technique provides a promising alternative to surgery by promoting safe and natural healing. Here recent studies concerning the use of PRP in the treatment of chronic ulcers and soft tissue defect are reviewed.

Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction

2019 ◽  
Vol 11 (490) ◽  
pp. eaau6210 ◽  
Author(s):  
Xiaowei Li ◽  
Brian Cho ◽  
Russell Martin ◽  
Michelle Seu ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Donor Site ◽  
Rabbit Model ◽  
Soft Tissue Defect ◽  
Fat Grafting ◽  
Foreign Body Response ◽  
Soft Tissue Reconstruction ◽  
Hydrogel Composite ◽  
Tissue Flaps ◽  
Tissue Restoration

Soft tissue losses from tumor removal, trauma, aging, and congenital malformation affect millions of people each year. Existing options for soft tissue restoration have several drawbacks: Surgical options such as the use of autologous tissue flaps lead to donor site defects, prosthetic implants are prone to foreign body response leading to fibrosis, and fat grafting and dermal fillers are limited to small-volume defects and only provide transient volume restoration. In addition, large-volume fat grafting and other tissue-engineering attempts are hampered by poor vascular ingrowth. Currently, there are no off-the-shelf materials that can fill the volume lost in soft tissue defects while promoting early angiogenesis. Here, we report a nanofiber-hydrogel composite that addresses these issues. By incorporating interfacial bonding between electrospun poly(ε-caprolactone) fibers and a hyaluronic acid hydrogel network, we generated a composite that mimics the microarchitecture and mechanical properties of soft tissue extracellular matrix. Upon subcutaneous injection in a rat model, this composite permitted infiltration of host macrophages and conditioned them into the pro-regenerative phenotype. By secreting pro-angiogenic cytokines and growth factors, these polarized macrophages enabled gradual remodeling and replacement of the composite with vascularized soft tissue. Such host cell infiltration and angiogenesis were also observed in a rabbit model for repairing a soft tissue defect filled with the composite. This injectable nanofiber-hydrogel composite augments native tissue regenerative responses, thus enabling durable soft tissue restoration outcomes.

scholarly journals Autologous Fat Grafting in Management of Patients with Progressive Hemifacial Atrophy

2016 ◽  
Vol 2 (1) ◽  
pp. 66-70
Author(s):  
Jainath Reddappa ◽  
Keyword(s):  
Soft Tissue ◽  
Face Mask ◽  
Fat Grafting ◽  
Fat Absorption ◽  
Autologous Fat Grafting ◽  
Hemifacial Atrophy ◽  
Autologous Fat ◽  
Progressive Hemifacial Atrophy ◽  
Grade 3 ◽  
Approximate Amount

Background: Progressive hemi facial atrophy or Romberg disease is a rare neurocutaneous syndrome characterized by slow progressive atrophy on one side of face involving skin, subcutaneous and connective tissue. Various methods have been described for soft tissue augmentation in patients with progressive hemi facial atrophy. Autologous fat, dermofat, fascial grafts have been used for grade 1,2 and 3 atrophy. Free flaps, cartilage and bone grafts are described for grade 3 and 4 atrophy. Aims and objectives: To study efficacy of autologous fat graft in patients with grade 1, 2 and 3 hemi facial atrophy. Strategies to reduce fat absorption and to calculate approximate amount of fat required required by facial mask template. Observations: It is a prospective study conducted in Department of plastic surgery, Bangalore Medical college and Research Institute, Bangalore in 10 patients with grade 2 and 3 Progressive hemi facial atrophy. All patients with stable non-progressive atrophy were graded for severity of disease and face-mask templates were prepared by pro-sthodontists to know approximate amount of fat required for injection. Fat was aspirated by low-pressure small suction cannulas manually and infiltrated at multiple points and in multiple planes after sedimentation and separation of fat. Five of the patients with grade 2 and 3 of patients with grade 3 atrophy were satisfied with symmetric face and with emotional betterment. Two patients needed repeat fat grafting after 2 years of follow-up. Conclusion: Autologous fat grafting is a simple and safe method for augmentation of soft tissue in patients with grade 1, 2 and 3 Progressive hemi facial atrophy. Aspiration of fat with low-pressure small cannulas and infiltrating in multiple planes improves fat survival. Preparing face-mask templates gives an idea of approximate volume of fat required. Keywords: Progressive hemifacial atrophy, Autologous fat grafting, Face-mask templates, Strategies for decreased fat absorption.

scholarly journals Autologous Fat Grafting Provides Good Outcomes as a Soft-Tissue Replacement in Hemifacial Atrophy

2019 ◽  
Vol 40 (3) ◽  
pp. NP103-NP105
Author(s):  
Faith H K Jeon ◽  
Keerthusan Koneswaran ◽  
Jajini Varghese ◽  
Michelle Griffin ◽  
Carole Frosdick ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Hemifacial Atrophy ◽  
Autologous Fat ◽  
Tissue Replacement

Heterodigital Free Flap of Index Finger Amputee for Coverage of the Long Finger Soft Tissue Defect

2013 ◽  
Vol 22 (2) ◽  
pp. 82-85 ◽  
Author(s):  
So-Min Hwang ◽  
Jang Hyuk Kim ◽  
Hong-Il Kim ◽  
Yong-Hui Jung ◽  
Hyung-Do Kim
Keyword(s):  
Soft Tissue ◽  
Free Flap ◽  
Index Finger ◽  
Soft Tissue Defect ◽  
Tissue Defect

scholarly journals No implant, no solution, lost cases to surgery: orthopedic trauma triage for surgery in an NGO hospital in Sierra Leone

2021 ◽  
Author(s):  
F. Wichlas ◽  
V. Hofmann ◽  
M. Moursy ◽  
G. Strada ◽  
C. Deininger
Keyword(s):  
Surgical Treatment ◽  
Soft Tissue ◽  
Sierra Leone ◽  
Low Income ◽  
Soft Tissue Defect ◽  
Low Income Countries ◽  
Pelvic Surgery ◽  
Closed Fractures ◽  
Trauma Triage ◽  
Tissue Defects

Abstract Introduction In low-income countries (LIC), international surgeons face the fact that there are patients they cannot treat. The goal of this study was to identify and analyze patients lost to treatment. Material and methods We analyzed retrospectively the data of 282 trauma victims from a non-governmental organizational (NGO) hospital in Sierra Leone, Africa. During a 3-month period (10.10.2015–08.01.2016), these patients had 367 injuries and underwent 263 orthopedic surgeries. Despite a clear indication, some patients did not receive surgical treatment. We identified these injuries and the reason why they could not be operated. The anatomic region of the injury was evaluated and if they had a bone or soft tissue defect or were infected. Results We identified 95 (25.89%) injuries in 70 patients (47 males; 23 females) that were not be operated. The reasons were lack of specific implants (no implant group; N = 33), no treatment strategy for the injury (no solution group; N = 29), and patients that were lost (lost patient group; N = 33), almost equally distributed by 1/3. In the no implant group were mainly closed fractures and fractures of the pelvis and the proximal femur. The implants needed were locking plates (N = 19), proximal femoral nails (N = 8), and implants for pelvic surgery (N = 6). In the no solution group were nearly all bone (P < 0.0000), soft tissue defects (P < 0.00001) and infections (P = 0.00003) compared to the rest and more open fractures (P < 0.00001). In the lost patients group, most fractures were closed (24 out of 33, P = 0.033). These fractures were mostly not urgent and were postponed repeatedly. Conclusion One quarter of the patients did not receive the surgical treatment needed. Besides acquisition of implants, surgical skills and expertise could be a solution for this issue. Nevertheless, these skills must be passed to local surgeons.

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