scholarly journals Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Siddaraju M. Nanjundaiah ◽  
David Y.-W. Lee ◽  
Brian M. Berman ◽  
Kamal D. Moudgil
Keyword(s):  
Bone Remodeling ◽  
Adjuvant Arthritis ◽  
Cartilage Damage ◽  
Effective Management ◽  
Promising Alternative ◽  
Adjunct Treatment ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Bone Damage ◽  
Receptor Activator

Huo-luo-xiao-ling dan (HLXL) is an herbal mixture that has long been used in traditional Chinese medicine for the treatment of rheumatoid arthritis (RA) and other inflammatory disorders. Despite the availability of potent conventionally used drugs for RA, their limited efficacy in a proportion of patients coupled with their high cost and severe adverse effects has necessitated the search for novel therapeutics for this debilitating disease. Further, the control of both inflammation and bone damage is essential for effective management of arthritis. The aim of our study was to evaluate the efficacy of HLXL against arthritic bone damage in adjuvant arthritis (AA) model of RA. Our results show that HLXL treatment suppressed inflammatory arthritis and reduced bone and cartilage damage in the joints of arthritic Lewis rats. HLXL-induced protection against bone damage was mediated primarily via inhibition of mediators of osteoclastic bone remodeling (e.g., receptor activator of nuclear factor kappa-B ligand; RANKL), skewing of RANKL/osteoprotegerin (OPG) ratio in favor of antiosteoclastic activity, reduction in the number of osteoclasts in the arthrodial joint's bone, and inhibition of cytokine production and MMP activity. Our results suggest that HLXL might offer a promising alternative/adjunct treatment for both inflammation and bone damage in RA.

scholarly journals Kinetics and Interplay of Mediators of Inflammation-Induced Bone Damage in the Course of Adjuvant Arthritis

2013 ◽  
Vol 26 (1) ◽  
pp. 37-48 ◽  
Author(s):  
S.M. Nanjundaiah ◽  
J.P. Stains ◽  
K.D. Moudgil
Keyword(s):  
Bone Remodeling ◽  
Inflammatory Cytokines ◽  
Adjuvant Arthritis ◽  
Bone Erosion ◽  
Experimental Conditions ◽  
Mediators Of Inflammation ◽  
Bone Damage ◽  
Tnf Α ◽  
Kinetics Of ◽  
Pro Inflammatory Cytokines

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, bone erosion, and cartilage destruction in the joints. It is increasingly being realized that inflammation might play an important role in inducing bone damage in arthritis. However, there is limited validation of this concept in vivo in well-controlled experimental conditions. We addressed this issue using the adjuvant arthritis (AA) model of RA. In AA, the draining lymph nodes are the main sites of activation of pathogenic leukocytes, which then migrate into the joints leading to the induction of arthritis. We tested the temporal kinetics of mediators of bone damage [e.g., receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) and osteopontin (OPN)] and inflammation (pro-inflammatory cytokines and chemokines) in the draining lymph node cells (LNC) at different phases of AA, and then examined their inter-relationships. Our study revealed that, together with cytokines/chemokines, some of the mediators of bone remodeling are also produced in LNC. Various cytokines/chemokines showed distinct kinetics of expression as well as patterns of correlation with mediators of bone remodeling at different phases of the disease. Pro-inflammatory cytokines such as TNF-α are known to play an important role in bone damage. Interestingly, there was a positive correlation between TNF-α and RANKL, between RANKL and each of the 3 chemokines tested (RANTES, MIP-1α, and GRO/KC), and between TNF-α and RANTES. Our results in the AA model lend support to the concept of osteo-immune crosstalk during the course of autoimmune arthritis.

scholarly journals Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats

2009 ◽  
Vol 121 (3) ◽  
pp. 366-371 ◽  
Author(s):  
Rui-Xin Zhang ◽  
Arthur Yin Fan ◽  
An-Nan Zhou ◽  
Kamal D. Moudgil ◽  
Zhong-Ze Ma ◽  
...  
Keyword(s):  
Adjuvant Arthritis ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal

Inhibition of RANKL-mediated bone remodeling decreases bone damage and improves strength in response to fatigue loading

2014 ◽  
Author(s):  
Nicolas Bonnet ◽  
Maude Gerbaix ◽  
Paul Kostenuik ◽  
Mike Ominsky ◽  
Serge Ferrari
Keyword(s):  
Bone Remodeling ◽  
Fatigue Loading ◽  
Bone Damage

Inhibitory effects of Chinese herbal formula Bingdeling on four common bacteria in vitro

2010 ◽  
Vol 30 (2) ◽  
pp. 212-214
Author(s):  
Hong QIAN ◽  
Nong XIAO ◽  
Zhi-feng QIN ◽  
Yan-jun LIU ◽  
Yi-jun SHEN ◽  
...  
Keyword(s):  
Herbal Formula ◽  
Inhibitory Effects ◽  
Chinese Herbal Formula ◽  
Chinese Herbal

scholarly journals Metabolomics study of the therapeutic mechanism of a Chinese herbal formula on collagen-induced arthritis mice

RSC Advances ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 3716-3725 ◽  
Author(s):  
Zhen Jin ◽  
Ji-da Zhang ◽  
Xin Wu ◽  
Gang Cao
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Formula ◽  
Collagen Induced Arthritis ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Therapeutic Mechanism ◽  
Metabolomics Study

Wenjinghuoluo (WJHL) prescription, the typical rheumatoid arthritis (RA) treatment compound in traditional Chinese medicine, shows favorable efficacy.

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