scholarly journals The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Emma Roberts ◽  
Davina A. F. Cossigny ◽  
Gerald M. Y. Quan
Keyword(s):  
Prostate Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumour Cell ◽  
Molecular Mechanisms ◽  
Cancer Metastasis ◽  
Spinal Metastases ◽  
Bone Destruction ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Despite the clinical implication and high incidence of bone and spinal metastases, the molecular mechanisms behind prostate cancer metastasis to bone and spine are not well understood. In this review the molecular mechanisms that may contribute to the highly metastatic phenotype of prostate cancer are discussed. Proangiogenic factors such as vascular endothelial growth factor (VEGF) have been shown to not only aid in the metastatic capabilities of prostate cancer but also encourage the colonization and growth of prostate tumour cells in the skeleton. The importance of VEGF in the complex process of prostate cancer dissemination to the skeleton is discussed, including its role in the development of the bone premetastatic niche, metastatic tumour cell recognition of bone, and bone remodeling. The expression of VEGF has also been shown to be upregulated in prostate cancer and is associated with clinical stage, Gleason score, tumour stage, progression, metastasis, and survival. Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials.

scholarly journals Regulation of vascular endothelial growth factor in prostate cancer

2015 ◽  
Vol 22 (3) ◽  
pp. R107-R123 ◽  
Author(s):  
Simone de Brot ◽  
Atara Ntekim ◽  
Ryan Cardenas ◽  
Victoria James ◽  
Cinzia Allegrucci ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Molecular Mechanisms ◽  
Western World ◽  
Vascular Endothelial ◽  
Prostate Carcinogenesis ◽  
Duration Of Response ◽  
Preclinical Animal Models ◽  
Endothelial Growth Factor

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen-dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Such androgen deprivation therapies (ADT) are effective initially, but the duration of response is typically ≤24 months. Although ADT and taxane-based chemotherapy have delivered survival benefits, metastatic PCa remains incurable. Therefore, it is essential to establish the cellular and molecular mechanisms that enable localized PCas to invade and disseminate. It has long been accepted that metastases require angiogenesis. In the present review, we examine the essential role for angiogenesis in PCa metastases, and we focus in particular on the current understanding of the regulation of vascular endothelial growth factor (VEGF) in localized and metastatic PCa. We highlight recent advances in understanding the role of VEGF in regulating the interaction of cancer cells with tumor-associated immune cells during the metastatic process of PCa. We summarize the established mechanisms of transcriptional and post-transcriptional regulation of VEGF in PCa cells and outline the molecular insights obtained from preclinical animal models of PCa. Finally, we summarize the current state of anti-angiogenesis therapies for PCa and consider how existing therapies impact VEGF signaling.

Expression and prognostic significance of vascular endothelial growth factor‐A (VEGF‐A) and its receptor in canine prostate cancer

The Prostate ◽  
2021 ◽  
Author(s):  
Antonio Fernando Leis‐Filho ◽  
Patricia deFaria Lainetti ◽  
Priscila Emiko Kobayashi ◽  
Chiara Palmieri ◽  
Renée Laufer Amorim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Prognostic Significance ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Plasma levels and expression of vascular endothelial growth factor-A in human localized prostate cancer

2007 ◽  
Author(s):  
Michaël Peyromaure ◽  
Cécile Badoual ◽  
Philippe Camparo ◽  
Sophie Grabar ◽  
Claire Goulvestre ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Plasma Levels ◽  
Localized Prostate Cancer ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Associations Between Gene Polymorphisms of Vascular Endothelial Growth Factor and Prostate Cancer

2019 ◽  
Vol 39 (6) ◽  
pp. 2903-2909
Author(s):  
HENRIETA DROBKOVÁ ◽  
JANA JUREČEKOVÁ ◽  
MONIKA KMEŤOVÁ SIVOŇOVÁ ◽  
JANA MAZUCHOVÁ ◽  
MICHAELA ŠKORVANOVÁ ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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