scholarly journals Pacing Lead-Induced Granuloma in the Atrium: A Foreign Body Reaction to Polyurethane

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Shinagawa Yoko ◽  
Yuka Kobayashi ◽  
Takao Iiri ◽  
Hitoshi Kitazawa ◽  
Masaaki Okabe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Foreign Body ◽  
Allergic Reaction ◽  
Superior Mesenteric Artery ◽  
Histological Examination ◽  
Mesenteric Artery ◽  
Foreign Body Reaction ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Pacing Lead

We described a case of an 82-year-old male who presented with a granuloma entrapping the polyurethane-coated pacing lead at the site of contact on the atrium. He had been paced for 8 years without symptoms or signs suggestive of an allergic reaction to the pacemaker system and died from thrombosis of the superior mesenteric artery and heart failure. A histological examination of the nodule showed an incidental granuloma with multinucleated giant cells. No granuloma was found in the heart or the lung.

The Influence of Bioactive Glass Particles on Osteolysis

2007 ◽  
Vol 330-332 ◽  
pp. 193-196
Author(s):  
Duck Hyun Kim ◽  
Kang Sik Lee ◽  
Jung Hwa Kim ◽  
Jae Suk Chang ◽  
Yung Tae Kim
Keyword(s):  
Foreign Body ◽  
Bioactive Glass ◽  
Foreign Body Reaction ◽  
Statistical Significance ◽  
Giant Cells ◽  
In Vivo Test ◽  
Micro Particles ◽  
Rat Calvaria ◽  
Replacement Arthroplasty

We observed the cytotoxicity of human bone marrow stromal cells(hBMSCs) by microparticles of bioactive glass with four particle groups(same chemical composition-45S5 but produced by two different manufacturer and two different size groups). In vivo test using rat calvaria were also carried out. The apoptosis rates of all small particle groups(10-20 ㎛) were increased than large(500-700 ㎛ or 200-900 ㎛) particle groups in any culture time and any amount of particles with statistical significance. In vivo study we observed pathologic signs such as macrophages and foreign-body giant cells in rat calvaria by micro-particles of bioglass. Small(10- 20 ㎛) sized particles induced foreign body reaction and bone resorption. There was proliferation of macrophages and cells in large number. But in large particle groups, only fibroblasts were surrounding the particles. The micro-particles of bioglass induced apoptosis of hBMSC and foreign body reaction in calvaria of rat, therefore micro-particles of bioglass may cause osteolysis if used in replacement arthroplasty.

Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP.

2020 ◽  
Author(s):  
Javier Blanco-Rivero ◽  
Gisele Kruger Couto ◽  
Suliana Mesquita Paula ◽  
Milene Tavares Fontes ◽  
Luciana Venturini Rossoni
Keyword(s):  
Heart Failure ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Peripheral Resistance ◽  
Atp Release ◽  
Electrical Field Stimulation ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
No Donor ◽  
Vascular Tonus

Heart failure (HF) is associated with neurohumoral activation, which in turn leads to an increased peripheral resistance. In mesenteric vasculature, perivascular innervation plays relevant role maintaining vascular tonus and resistance. Therefore, we aimed to determine the possible alterations in superior mesenteric artery (SMA) perivascular innervation function in HF rats. HF was induced by coronary artery occlusion in male Wistar rats, and sham-operated (SO) rats were used as controls. After 12 weeks, a greater vasoconstrictor response to electrical field stimulation (EFS) was observed in endothelium-intact and -denuded SMA of HF rats. Alpha-adrenoceptor antagonist phentolamine diminished this response in a higher magnitude in HF than in SO animals. However, the noradrenaline (NA) reuptake inhibitor desipramine increased EFS-induced vasoconstriction more in segments from HF rats. Besides, EFS-induced NA release was greater in HF animals, due to a higher tyrosine hydroxylase expression and activity. P2 purinoceptor antagonist suramin reduced EFS-induced vasoconstriction only in segments from SO rats, and ATP release was lower in HF than in SO. Moreover, nitric oxide (NO) synthase inhibitor L-NAME enhanced EFS-induced vasoconstriction in a similar extent in both groups. HF was not associated with changes in EFS-induced NO release or the vasodilator response to NO donor sodium nitroprusside. In conclusion, HF post myocardial infarction enhanced noradrenergic function and diminished purinergic co-transmission in SMA and did not change nitrergic innervation. The net effect was an increased sympathetic participation on the EFS-induced vasoconstriction, that could help to understand the neurotransduction involved on the control of vascular tonus in HF.

scholarly journals Massive Silicone-Induced Orbital Granuloma

2019 ◽  
Vol 6 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Ann Shue ◽  
Jeffrey M. Joseph ◽  
Jeremiah P. Tao ◽  
Ann E. Barker-Griffith ◽  
Jerrold L. Abraham ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Foreign Body ◽  
Retinal Detachment ◽  
Silicone Oil ◽  
Intraoperative Complications ◽  
Giant Cells ◽  
Histopathologic Examination ◽  
Multinucleated Giant Cells ◽  
Retinal Surgery

We report a large subconjunctival-orbital granuloma in a 51-year-old male presenting with a blind painful right eye and marked chemosis 15 months after undergoing vitrectomy and silicone oil retinal tamponade for retinal detachment with no reported intraoperative complications. Gross and histopathologic examination of the enucleated eye and episcleral tumor revealed a bosselated mass measuring 17 × 10 × 5 mm containing prominent vacuoles with surrounding epithelioid histiocytes and foreign body multinucleated giant cells. Such a large silicone-induced orbital granuloma following uncomplicated retinal surgery in a grossly intact eye has not been previously reported to the authors’ knowledge. High intraocular pressure and emulsification of oil may facilitate silicone extravasation through scleral wounds after retinal surgery.

scholarly journals Pulse Granulomas of the Gastrointestinal Tract and Gallbladder: Report of Five Cases

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Tom C. DeRoche ◽  
Gregory A. Gates ◽  
Aaron R. Huber
Keyword(s):  
Gastrointestinal Tract ◽  
Foreign Body ◽  
Incidental Finding ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Ultrastructural Studies ◽  
Foreign Body Giant Cells ◽  
Edible Seeds ◽  
Mass Lesions ◽  
Vegetable Material

Hyaline rings with admixed multinucleated giant cells characterize pulse granulomas; the term pulse refers to edible seeds of legume vegetables. The etiology has been controversial, with theories including vascular degenerative changes or a reaction to vegetable material; ultrastructural studies and experimentally induced lesions in animals favor the latter. This lesion is typically seen in the oral cavity, with only rare reports in the gastrointestinal tract and gallbladder. We herein describe five cases of pulse granulomas identified in these sites. All cases contained foreign-body giant cells and vegetable debris within or near hyaline rings. Pulse granulomas may form mass lesions but are usually an incidental finding on microscopic examination. In incidentally detected cases, recognition of pulse granulomas can suggest a mural abscess, fistula, or perforation of the gut, findings which may not be grossly apparent. The presence of vegetable material in all five cases further supports an exogenous pathogenesis.

Rectal Pulse Granuloma

2001 ◽  
Vol 125 (6) ◽  
pp. 822-823 ◽  
Author(s):  
Telma C. Pereira ◽  
Jeffrey W. Prichard ◽  
Mushtaq Khalid ◽  
David S. Medich ◽  
Jan F. Silverman
Keyword(s):  
Foreign Body ◽  
Oral Cavity ◽  
Microscopic Examination ◽  
Foreign Body Reaction ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Mass Lesion ◽  
Delay In Diagnosis ◽  
Foreign Body Giant Cells ◽  
Histopathologic Features

Abstract Pulse granuloma is a rare benign entity, most likely representing a foreign body reaction to vegetable particles. We report a case of a pulse granuloma involving the rectum. The patient presented with a submucosal and intramuscular mass lesion found at routine rectal examination and subsequent colonoscopy. The mass was excised and the microscopic examination revealed acute and chronic inflammatory cells, foreign-body giant cells, vegetable matter, and convoluted hyaline rings and scattered circular structures containing basophilic granules, consistent with pulse granuloma. There are a few reports in the literature of pulse granulomas, with most occurring in the oral cavity or lungs. To the best of our knowledge, this is the first reported example of pulse granuloma in the rectum. Although rare, familiarity with this entity's distinctive histopathologic features may avoid a delay in diagnosis and prevent the expense of distinguishing it from its histologic lookalikes.

scholarly journals Local Foreign-Body Reaction to Commercial Biodegradable Implants: An in Vivo Animal Study

2014 ◽  
Vol 7 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Amy S. Xue ◽  
John C. Koshy ◽  
William M. Weathers ◽  
Erik M. Wolfswinkel ◽  
Yoav Kaufman ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Close Association ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Inflammatory Reactions ◽  
Debris Accumulation ◽  
Foreign Body Reactions ◽  
The 1960S

Biodegradable plates have been used extensively in fracture fixation since the 1960s. They rarely cause stress-protection atrophy or problems requiring secondary plate removal, common complications seen with metallic plates. However, aseptic foreign-body reactions have been reported, sometimes years after the original implantation. Both inadequate polymer degradation and debris accumulation have been implicated as causes. The current generation of commercial biodegradable plates is formulated to minimize this complication by altering the ratio of polylactic and polyglycolic acids. This in vivo study compares the degree of local foreign-body reaction of two commercially available resorbable plates in rabbits. Two types of biodegradable plates were examined: poly(D/L)lactide acid (PDLLA) and polylactide-co-glycolide acid (PLGA). Each plate was placed into a periosteal pericalvarial pocket created beneath the anterior or posterior scalp of a rabbit. Humane killing occurred at 3, 6, and 12 months postoperatively. Foreign-body reaction was evaluated histologically. The PDLLA plates demonstrated marked local foreign-body reactions within the implant capsule as early as 3 months after implantation, with presence of inflammatory cells and granulomatous giant cells in close association with the implant material. All local foreign-body reactions were subclinical with no corresponding tissue swelling requiring drainage. PLGA plates did not demonstrate any signs of inflammatory reactions. In addition, the PLGA plates did not appear to resorb or integrate at 12 months. Neither PDLLA nor PLGA plates demonstrated inflammation of the soft tissue or adjacent bone outside the implant capsule. In our study, the PDLLA plates demonstrated histological evidence of foreign-body reaction that is confined within the implant capsule, which was not seen with the PLGA plates. This finding may be attributable to the lack of significant resorption seen in the PLGA plates. Both PDLLA and PLGA plates were biocompatible with the rabbit tissue environment and should be considered for continued use in craniofacial, maxillofacial, and orthopedic reconstruction.

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