scholarly journals Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
James H. Tabibian ◽  
Jayant A. Talwalkar ◽  
Keith D. Lindor
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Clinical Evidence ◽  
Cholestatic Liver Disease ◽  
Concise Review ◽  
Inflammatory Bowel ◽  
Considerable Morbidity

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.

Primary sclerosing cholangitis

2010 ◽  
pp. 2468-2473
Author(s):  
R.W. Chapman ◽  
K.D. Williamson
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Close Association ◽  
Biliary Tree ◽  
Cholestatic Liver Disease ◽  
Immune Mediated ◽  
Inflammatory Bowel

Case History—A 60 yr old woman, known to have long standing colitis, now presenting with abdominal pain and weight loss. Primary sclerosing cholangitis is a chronic cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The cause is unknown, but presumed to be immune mediated, and there is a very close association with inflammatory bowel disease, particularly ulcerative colitis....

scholarly journals Characterization of the Gut Microbiota in Patients with Primary Sclerosing Cholangitis Compared to Inflammatory Bowel Disease and Healthy Controls

2021 ◽  
Author(s):  
Samaneh Ostadmohammadi ◽  
Masoumeh Azimirad ◽  
Hamidreza Houri ◽  
Kaveh Naseri ◽  
Ehsan Javanmard ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Primary Sclerosing Cholangitis ◽  
Relative Abundance ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Bacterial Species ◽  
Cholestatic Liver Disease ◽  
Healthy Controls ◽  
Inflammatory Bowel

Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. Its aetiology remains largely unknown, although frequent concomitant inflammatory bowel disease (IBD) hints towards common factors underlying intestinal and bile duct inflammation. Herein, we aimed to explore the relative abundance of fecal microbiota in PSC-IBD patients compared to IBD-only subjects and healthy controls.We included 14 PSC-IBD patients, 12 IBD patients, and 8 healthy controls (HCs). A quantitative real-time PCR (qPCR) assay was to determine a selection of bacterial phyla, families, and genera.Relative abundance of taxa showed that Bacteroidetes was the most abundant phylum among the patients with PSC-IBD (29.46%) and also HCs (39.34%), whereas the bacterial species belonging to the phylum Firmicutes was the most frequent group in IBD-only subjects (37.61%). The relative abundance of Enterobacteriaceae family was higher among PSC-IBD (3%) than HCs (0.5%), and thus, could be used as a PSC-associated microbial signature.Our findings showed that intestinal microbiota composition in PSC-IBD patients was completely different from that of IBD-only patients. Further studies using large-scale cohorts should be performed to better describe the contribution of the gut microbiota to PSC pathogenesis with underlying IBD.

Su1984 CLINICAL PRESENTATION AND OUTCOMES OF PRIMARY SCLEROSING CHOLANGITIS AND AUTOIMMUNE HEPATITIS IN INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 158 (6) ◽  
pp. S-732-S-733
Author(s):  
Camilla A. Martins ◽  
Ana Elisa R. Caon ◽  
Marilia G. Cruz ◽  
Luísa L. Barros ◽  
Alexandre Carlos ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Autoimmune Hepatitis ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Clinical Presentation ◽  
Inflammatory Bowel

scholarly journals Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease

2018 ◽  
Vol 2 (8) ◽  
pp. 960-971 ◽  
Author(s):  
Brian K. Chung ◽  
Eva Kristine Klemsdal Henriksen ◽  
Kristin Kaasen Jørgensen ◽  
Tom H. Karlsen ◽  
Gideon M. Hirschfield ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
B Cells ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Clonal Origin ◽  
Inflammatory Bowel

S1160 Does Primary Sclerosing Cholangitis Impact Quality of Life in Patients with Inflammatory Bowel Disease?

2009 ◽  
Vol 136 (5) ◽  
pp. A-203
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Dawn B. Beaulieu ◽  
Amar S. Naik ◽  
Yelena Zadvornova ◽  
Susan Skaros ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Inflammatory Bowel
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