scholarly journals Progression of Voice and Speech Impairment in the Course of Parkinson's Disease: A Longitudinal Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
S. Skodda ◽  
W. Grönheit ◽  
N. Mancinelli ◽  
U. Schlegel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Motor Impairment ◽  
Time Interval ◽  
Speech Impairment ◽  
Speech Performance ◽  
The Individual ◽  
Voice And Speech

Impairment of voice and speech occurs in the majority of patients in the course of Parkinson's disease (PD). The aim of the current study was to survey the changes of voice and speech performance in the individual patients over time. 80 patients with PD and 60 healthy speakers were tested and retested after at least 12 months (average time interval: 32.5 months). Participants had to read a given text which was digitally recorded as a source for the perceptual and acoustic analysis. Stage of the disease and global motor impairment were rated according to the accepted scales. As a result, abnormalities of voice and speech were already present in mildly affected patients and there were significant deteriorations of quality of voice and articulatory velocity and precision between baseline and followup examination which showed no correlation with the time interval between the visits. Summarized, voice, and speech performance were found to further deteriorate in the individual patient in the course of time although global motor impairment was widely stable which might be a hint for nondopaminergic mechanisms of progression of dysarthrophonia. Further investigations are warranted to get a better insight into the dynamics of the progression of voice and speech impairment in PD as a precondition for the development of therapeutic approaches.

scholarly journals Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson’s disease

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Gregory M. Pontone ◽  
Nadeeka Dissanayaka ◽  
Liana Apostolova ◽  
Richard G. Brown ◽  
Roseanne Dobkin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expert Panel ◽  
Motor Impairment ◽  
Future Research ◽  
Severe Problem ◽  
High Prevalence ◽  
Expert Meeting ◽  
Clinician Scientist

AbstractAnxiety is a severe problem for at least one-third of people living with Parkinson’s disease (PD). Anxiety appears to have a greater adverse impact on quality of life than motor impairment. Despite its high prevalence and impact on daily life, anxiety is often undiagnosed and untreated. To better address anxiety in PD, future research must improve knowledge about the mechanism of anxiety in PD and address the lack of empirical evidence from clinical trials. In response to these challenges, the Parkinson’s Foundation sponsored an expert meeting on anxiety on June 13th and 14th 2018. This paper summarizes the findings from that meeting informed by a review of the existing literature and discussions among patients, caregivers, and an international, clinician-scientist, expert panel working group. The goal is to provide recommendations to improve our understanding and treatment of anxiety in PD.

scholarly journals Which measures of physical function and motor impairment best predict quality of life in Parkinson’s disease?

2011 ◽  
Vol 17 (9) ◽  
pp. 693-697 ◽  
Author(s):  
T. Ellis ◽  
J.T. Cavanaugh ◽  
G.M. Earhart ◽  
M.P. Ford ◽  
K.B. Foreman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Function ◽  
Motor Impairment

scholarly journals A Multimodal Approach to the Quantification of Kinetic Tremor in Parkinson’s Disease

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 184
Author(s):  
Mateusz Szumilas ◽  
Krzysztof Lewenstein ◽  
Elżbieta Ślubowska ◽  
Stanisław Szlufik ◽  
Dariusz Koziorowski
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expert Knowledge ◽  
Motor Impairment ◽  
Kinetic Tremor ◽  
Model Predictions ◽  
Model Ensembles ◽  
Selection Operator ◽  
Lasso Method

Parkinson’s disease results in motor impairment that deteriorates patients’ quality of life. One of the symptoms negatively interfering with daily activities is kinetic tremor which should be measured to monitor the outcome of therapy. A new instrumented method of quantification of the kinetic tremor is proposed, based on the analysis of circles drawn on a digitizing tablet by a patient. The aim of this approach is to obtain a tremor scoring equivalent to that performed by trained clinicians. Models are trained with the least absolute shrinkage and selection operator (LASSO) method to predict the tremor scores on the basis of the parameters computed from the patients’ drawings. Signal parametrization is derived from both expert knowledge and the response of an artificial neural network to the raw data, thus the approach was named multimodal. The fitted models are eventually combined into model ensembles that provide aggregated scores of the kinetic tremor captured in the drawings. The method was verified with a set of clinical data acquired from 64 Parkinson’s disease patients. Automated and objective quantification of the kinetic tremor with the presented approach yielded promising results, as the Pearson’s correlations between the visual ratings of tremor and the model predictions ranged from 0.839 to 0.890 in the best-performing models.

scholarly journals Predictors of clinically significant quality of life impairment in Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Santos García D. ◽  
Teresa de Deus Fonticoba ◽  
Carlos Cores ◽  
Guillermo Muñoz ◽  
Jose M. Paz González ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Independent Living ◽  
Motor Impairment ◽  
Control Group ◽  
Health Related Qol ◽  
Clinically Significant

AbstractQuality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

scholarly journals Understanding Parkinson’s Disease (PD) in Ayurvedic Prospective

2021 ◽  
pp. 86-92
Author(s):  
Nimmi M Menon ◽  
Manjunath Adiga ◽  
Amritha E Pady
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
World Population ◽  
Sex Distribution ◽  
Aging Society ◽  
Ayurvedic Drugs ◽  
The World ◽  
The Individual ◽  
Treatment Aspect

Parkinson’s disease (PD) known as Kampavata in Ayurveda, is a degenerative neurological disorder of central nervous system, mainly affecting the motor system. It is the major cause of disability in the aging society, which usually affects after the age of 50 years. This disease is increasing in its frequency with the world population showing an incidence of 1-2 per 1000 population and has equal sex distribution. Symptoms like Kampa (Tremor), Stambha (Rigidity), Chestasanga (Bradykinesia and Akinesia), Vakvikriti (disturbance in speech) etc were described in different contexts of Charaka Samhita, Susruta Samhita and Basavarajeeyam. There is no cure for Parkinson’s disease, but medications, surgery and multidisciplinary management can provide relief and improve the quality of life of the individual. In the treatment aspect, the drug L-Dopa has shown better results similarly Ayurvedic drugs having the similar compounds are useful in this disorder. Based on the symptoms manifested, the disease can be correlated to Kampavata mentioned in Ayurveda classics. Despite of so many advances in the field of medicine, treatment of PD remains highly symptomatic. This instills the need for Ayurvedic management of Kampavata. The present article is intended to focus on the Nidana, Lakshanas, Samprapthi and the management principles of Parkinson’s disease (Kampavata).

scholarly journals Speech impairment in Parkinson’s disease: acoustic analysis of unvoiced consonants in Italian native speakers

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Federica Amato ◽  
Luigi Borzi ◽  
Gabriella Olmo ◽  
Carlo Alberto Artusi ◽  
Gabriele Imbalzano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Native Speakers ◽  
Speech Impairment

Laser arytenoidectomy for bilateral vocal fold palsy in Parkinson's disease

2005 ◽  
Vol 119 (10) ◽  
pp. 831-833 ◽  
Author(s):  
A Qayyum ◽  
K Mierzwa ◽  
M See ◽  
A Sharma ◽  
P Q Montgommery
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Option ◽  
Vocal Fold ◽  
English Literature ◽  
Vocal Fold Palsy ◽  
The Individual ◽  
Abductor Palsy

We report a case of laser arytenoidectomy for bilateral abductor palsy of the vocal fold in a patient with Parkinson's disease. Parkinson's disease is known to be a rare cause for bilateral vocal fold palsy and this is the second case reported in the English literature. Majority of the reports to date are in the non-English literature. Tracheostomy has been the classic treatment option offered to these patients. To date no report has been found in the literature about a laser arytenoidectomy being performed in a patient suffering from bilateral vocal fold palsy in Parkinson's disease. We have suggested this option as it improves the quality of life of the individual and avoids the difficulty faced by a Parkinson's patient in managing tracheostomy care due to bradykinesia, rigidity and tremor.

Effects of Ai Chi on balance, quality of life, functional mobility, and motor impairment in patients with Parkinson’s disease

2017 ◽  
Vol 40 (7) ◽  
pp. 791-797 ◽  
Author(s):  
Emine Eda Kurt ◽  
Buket Büyükturan ◽  
Öznur Büyükturan ◽  
Hatice Rana Erdem ◽  
Figen Tuncay
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment ◽  
Functional Mobility

Distribution of motor impairment influences quality of life in Parkinson's disease

2008 ◽  
Vol 23 (10) ◽  
pp. 1466-1468 ◽  
Author(s):  
Kim C. Stewart ◽  
Hubert H. Fernandez ◽  
Michael S. Okun ◽  
Charles E. Jacobson ◽  
Chris J. Hass
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment
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