scholarly journals Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hua Qu ◽  
Huacong Deng ◽  
Zhenping Hu
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Diabetes And Obesity

scholarly journals MicroRNAs in Insulin Resistance and Obesity

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Michael D. Williams ◽  
Geraldine M. Mitchell
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Messenger Rna ◽  
Physiological Role ◽  
Mrna Translation ◽  
Aberrant Expression ◽  
Peripheral Tissues ◽  
Pancreatic Islets Of Langerhans ◽  
Diabetes And Obesity

MicroRNAs (miRNAs) are a class of short, single-stranded non-protein coding gene products which can regulate the gene expression through post-transcriptional inhibition of messenger RNA (mRNA) translation. They are known to be involved in many essential biological processes including development, insulin secretion, and adipocyte differentiation. miRNAs are involved in complex metabolic processes, such as energy and lipid metabolism, which have been studied in the context of diabetes and obesity. Obesity, hyperlipidemia (elevated levels of blood lipids), and insulin resistance are strongly associated with the onset of type 2 diabetes. These conditions are also associated with aberrant expression of multiple essential miRNAs in pancreatic islets of Langerhans and peripheral tissues, including adipose tissue. A thorough understanding of the physiological role these miRNAs play in these tissues, and changes to their expression under pathological conditions, will allow researchers to develop new therapeutics with the potential to correct the aberrant expression of miRNAs in type 2 diabetes and obesity.

scholarly journals Vitamin D 3, osteoprotegerin and other hormonal and metabolic parameters in female patients with type 2 diabetes

2012 ◽  
Vol 9 (4) ◽  
pp. 23-27 ◽  
Author(s):  
A F Verbovoi ◽  
L A Sharonova ◽  
A V Kapishnikov ◽  
D V Demidova
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Metabolic Parameters ◽  
Female Patients ◽  
Vitamin D 3 ◽  
Diabetes And Obesity

The article presents the results of evaluation of vitamin D3, osteoprotegerin, carbohydrate and fat metabolic parameters in women with type 2 diabetes and obesity. The study subjects showed an increase of osteoprotegerin, decrease of vitamin D3, insulin resistance and compensatory hyperinsulinemia.

scholarly journals Role of GALNT2 on Insulin Sensitivity, Lipid Metabolism and Fat Homeostasis

2022 ◽  
Vol 23 (2) ◽  
pp. 929
Author(s):  
Alessandra Antonucci ◽  
Antonella Marucci ◽  
Vincenzo Trischitta ◽  
Rosa Di Paola
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Common Ground ◽  
Metabolic Diseases ◽  
Atherogenic Dyslipidemia ◽  
Physiological Processes ◽  
Protein Functions ◽  
Heavy Burden ◽  
Diabetes And Obesity

O-linked glycosylation, the greatest form of post-translational modifications, plays a key role in regulating the majority of physiological processes. It is, therefore, not surprising that abnormal O-linked glycosylation has been related to several human diseases. Recently, GALNT2, which encodes the GalNAc-transferase 2 involved in the first step of O-linked glycosylation, has attracted great attention as a possible player in many highly prevalent human metabolic diseases, including atherogenic dyslipidemia, type 2 diabetes and obesity, all clustered on the common ground of insulin resistance. Data available both in human and animal models point to GALNT2 as a molecule that shapes the risk of the aforementioned abnormalities affecting diverse protein functions, which eventually cause clinically distinct phenotypes (a typical example of pleiotropism). Pathways linking GALNT2 to dyslipidemia and insulin resistance have been partly identified, while those for type 2 diabetes and obesity are yet to be understood. Here, we will provide a brief overview on the present knowledge on GALNT2 function and dysfunction and propose novel insights on the complex pathogenesis of the aforementioned metabolic diseases, which all impose a heavy burden for patients, their families and the entire society.

scholarly journals 3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism

Diabetes ◽  
2020 ◽  
Vol 69 (9) ◽  
pp. 1903-1916 ◽  
Author(s):  
Mona S. Nilsen ◽  
Regine Å. Jersin ◽  
Arve Ulvik ◽  
André Madsen ◽  
Adrian McCann ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Brown Adipocyte ◽  
Diabetes And Obesity
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