scholarly journals Misdiagnosis and Mistreatment of Post-Kala-Azar Dermal Leishmaniasis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Mohamed El Hassan ◽  
Eltahir Awad Gasim Khalil ◽  
Waleed Mohamed Elamin ◽  
Lamyaa Ahmed Mohamed El Hassan ◽  
Mogtaba Elsaman Ahmed ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Cutaneous Leishmaniasis ◽  
Past History ◽  
Previous History ◽  
Clinical Appearance ◽  
Kala Azar ◽  
Pcr Diagnosis ◽  
The Face ◽  
History Of ◽  
High Parasite

Post-kala-azar dermal leishmaniasis (PKDL) is a known complication of visceral leishmaniasis (VL) caused byL. donovani. It is rare in VL caused byL. infantumandL. chagasi. In Sudan, it occurs with a frequency of 58% among successfully treated VL patients. In the majority of cases, PKDL can be diagnosed on the basis of clinical appearance, distribution of the lesions, and past history of treated VL. The ideal diagnostic method is to demonstrate the parasite in smears, by culture or PCR. Diagnosis is particularly difficult in patients who develop PKDL in the absence of previous history of visceral leishmaniasis. We describe a case of cutaneous leishmaniasis misdiagnosed as PKDL and 3 cases of PKDL who were either misdiagnosed or mistreated as other dermatoses. This caused exacerbation of their disease leading to high parasite loads in the lesions and dissemination to internal organs in one of the patients, who was also diabetic. The latter patient hadL. majorinfection. A fourth patient with papulonodular lesions on the face and arms of 17-year duration and who was misdiagnosed as having PKDL is also described. He turned out to have cutaneous leishmaniasis due toL. major. Fortunately, he was not treated with steroids. He was cured with intravenous sodium stibogluconate.

scholarly journals Post-Kala-Azar Dermal Leishmaniasis Without Previous History of Visceral Leishmaniasis

2016 ◽  
Vol 95 (6) ◽  
pp. 1383-1385 ◽  
Author(s):  
Golam Hasnain ◽  
Dinesh Mondal ◽  
Shakhawat Hossain ◽  
Shinjiro Hamano ◽  
Prakash Ghosh ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Previous History ◽  
Kala Azar ◽  
History Of

scholarly journals Visceral leishmaniasis (Kala-azar) in Qom Province, Iran: Report of two cases

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1371
Author(s):  
Leyli Zanjirani Farahani ◽  
Abedin Saghafipour ◽  
Mehdi Mohebali ◽  
Behnaz Akhoundi ◽  
Hedayatollah Raufi
Keyword(s):  
Visceral Leishmaniasis ◽  
Rural Areas ◽  
Control Strategies ◽  
Sand Fly ◽  
Recurrent Fever ◽  
Kala Azar ◽  
Periodic Monitoring ◽  
History Of ◽  
The Common

Visceral leishmaniasis (VL) is a fatal parasitic zoonotic worldwide disease, which transmits to humans by the infected Phlebotomine sand fly bite. The common form of VL in Iran is the Mediterranean type with the causative agent of Leishmania infantum, whose main reservoirs are stray and domesticated dogs. The disease has several endemic foci in Iran, mostly seen among children under the age of 10, living in rural areas and nomadic tribes. The first cases of Kala-Azar in Qom province, central Iran, were reported in the year 2001, from the villages of Ghahan district. After conducting VL control strategies in the area, no new cases of the disease had been reported until recently. The cases described here are two 2-year-old girls, living in the urban parts of Qom province, one of whom did not have a history of traveling to known endemic areas of the disease. The patients were admitted to hospital in 2016-2017, complaining from recurrent fever with unrecognized reason, associated with decreased appetite and weight loss. Disease follow-up demonstrated anemia and splenomegaly, which led to diagnosis of VL, and both patients are now fully recovered. VL was presumed to be controlled in Qom province but the present cases indicate that possible VL existence remains in the region. Therefore, urgent studies and periodic monitoring are needed to identify potential reservoirs of VL in the area.

scholarly journals I. Clusters and Associations

1959 ◽  
Vol 7 ◽  
pp. 3-12
Keyword(s):  
Stellar Evolution ◽  
Past History ◽  
Star Clusters ◽  
Galactic Structure ◽  
Empirical Approach ◽  
Star Clusters And Associations ◽  
Different Ages ◽  
The Face ◽  
History Of ◽  
Evolutionary Interpretation

Renewed interest in the study of star clusters and associations has been aroused by at least three developments.(a) Interpretation of the color-magnitude (C-M) diagrams of clusters and associations with a theory of stellar evolution promises to give data on galactic structure problems. Information of kinematic relations, origins, and past history of stars over the face of the H-R diagram will be available when proper evolutionary interpretation is achieved. Only by assembling C-M diagrams of many clusters of different ages and richness can the empirical approach to evolution be fully exploited.

scholarly journals Atypical case of mucous membrane pemphigoid in a 26-year-old man

2018 ◽  
pp. bcr-2018-225872
Author(s):  
Deepak Sambhara ◽  
Ji Hyae Lee ◽  
Seth M Pantanelli
Keyword(s):  
Mucous Membrane ◽  
Previous History ◽  
Immunohistochemical Analysis ◽  
Mucous Membrane Pemphigoid ◽  
Epithelial Basement Membrane ◽  
The Face ◽  
History Of ◽  
The One ◽  
The Right ◽  
High Index Of Suspicion

A 26-year-old Caucasian man with no previous history of chemical injury presenting with an inability to open his right eye was investigated for mucous membrane pemphigoid and treated. Examination was notable for symblepharon of the right eye and impetigo-like lesions on the face and neck. A biopsy with immunohistochemical analysis was significant for linear deposits of C3 and immunoglobulin G at the level of the epithelial basement membrane, confirming the diagnosis of mucous membrane pemphigoid. Although mucous membrane pemphigoid classically presents bilaterally in women in the sixth and seventh decades of life, our patient was a young man with unilateral cicatrising conjunctivitis who may have been easily misdiagnosed without a high index of suspicion. A biopsy is required in cases of cicatrising conjunctivitis so that even atypical cases such as the one presented herein can be appropriately managed.

scholarly journals Comparison of KAtex, Bone Marrow Aspiration and DAT for the Diagnosis of Visceral Leishmaniasis

2019 ◽  
Vol 6 (1) ◽  
pp. 12-15
Author(s):  
Ishrat Sharmin ◽  
AKM Quamruzzaman ◽  
Rezina Parveen ◽  
M Abdulah Yusuf ◽  
Rashida Akter Khanam
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Leishmania Donovani ◽  
Bone Marrow Aspiration ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Kala Azar ◽  
History Of ◽  
One Year

Background: Newly developed KAtex test can be used as a non invasive tool for diagnosis of Kala-azar. Objectives: The aim of the present study was to compare KAtex, Bone marrow aspiration and DAT to diagnose VL. Methodology: This cross-sectional study was carried out in the Department of Microbiology at Dhaka Medical College, Dhaka, Bangladesh in collaboration with the Department of Parasitology, Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh for a period of one year. Clinically suspected Kala-azar (VL) cases of different age and sex attending IEDCR, Dhaka from different Kala-azar endemic areas of Bangladesh were selected for this study. Patients having fever for more than 2 weeks, with or without splenomegaly, having history of loss of body weight following onset of fever were clinically suspected as Kala-azar cases. Microscopy and culture was performed in bone marrow (BM). KAtex was performed with urine sample. Agglutination of sensitized latex indicated presence of Leishmania donovani antigen in urine and thereby visceral leishmaniasis. No agglutination indicates absence of antigen in urine. DAT was done with serums of all cases. Result: Among 130 clinically suspected VL cases, 70 (53.85%) cases were BM positive and 60(46.15%) cases were BM negative. All the 70 BM positive cases were positive by KAtex and DAT. Among 60 BM negative cases, 15 were positive by KAtex and 23 were positive by DAT. The sensitivity of KAtex was 100.0% and specificity was 75.0%. The sensitivity of DAT was 100.0% and specificity is 61.6%. Conclusion: In conclusion, KAtex test is a good diagnostic tool for the detection of VL in comparison with DAT. Bangladesh Journal of Infectious Diseases, June 2019;6(1):12-15

A study of deliberate self-poisoning in a Dublin hospital 1986 – 1990

1994 ◽  
Vol 11 (2) ◽  
pp. 70-72 ◽  
Author(s):  
Fergus Coakley ◽  
Catherine Hayes ◽  
John Fennell ◽  
Zachary Johnson
Keyword(s):  
Past History ◽  
Dublin Hospital ◽  
Psychiatric Inpatient ◽  
Previous History ◽  
Psychiatric Hospitals ◽  
High Rate ◽  
Medical Complication ◽  
Motivating Factors ◽  
History Of ◽  
Low Threshold

AbstractObjective: The study was undertaken to determine the current demographic and clinical features of cases of deliberate self-poisoning (DSP) presenting to an acute general hospital and to compare the findings with previous work in Ireland and elsewhere. Method: Four hundred and sixty seven consecutive admissions for DSP presenting to a Dublin hospital between 1986 and 1990 inclusive were identified retrospectively and the case notes reviewed. Data was collected on age, sex, marital status, past history, date of DSP, drugs used, motivating factors and outcome. Results: The peak age of DSP was 15-24 years. The female:male ratio was 1.5:1. There was an increased incidence of DSP in women in July and August. In 32% there was a previous history of DSP. Benzodiazepines, antidepressants and analgesics/anti-inflammatories were the commonest drugs taken. There was a significant medical complication in 10.5% of cases, but no fatalities. Twenty-five percent of patients were subsequently admitted to psychiatric inpatient care. Conclusions: DSP is an ongoing problem. The summer peak in females may be related to the parenting burden during the summer recess. The high rate of repetition suggests a significant reduction could be achieved with successful strategies for secondary prevention. The high rate of psychiatric in-patient referral may be related to a low threshold for admissions to Irish psychiatric hospitals.

scholarly journals Is It Possible to use Cross-sectional and Vertical Facial Measurements to establish the Shape of the Mandibular Arch?

2014 ◽  
Vol 15 (6) ◽  
pp. 735-739
Author(s):  
Adilson Luiz Ramos ◽  
Ossam Abu El Haje ◽  
Daniela Daufenback Pompeo ◽  
Gisela Crippa Furtado ◽  
Luciana Monti Lima Rivera
Keyword(s):  
Previous History ◽  
Dental Arch ◽  
Cross Sectional ◽  
Method Error ◽  
Significance Level ◽  
Mandibular Arch ◽  
The Face ◽  
History Of ◽  
Examiner Agreement ◽  
Plaster Models

ABSTRACT Background Given the benefits of radiographic cephalometric studies in determining patterns of dental-skeletal-facial normality in orthodontics, the aim of this study was to investigate the association between mandibular dental arch shape and cross-sectional and vertical facial measurements. Materials and methods It was analyzed plaster casts and teleradiographs in frontal and lateral norm belonging to 50 individuals, aged between 15 and 19 years, with no previous history of orthodontic treatment and falling into four of the six Andrews's occlusion keys. The plaster models were scanned (3D) and the images of the dental arches were classified subjectively as oval, triangular and quadrangular by three calibrated examiners, with moderate inter-examiner agreement (Kappa = 0.50). After evaluation of the method error by paired t test (p > 0.05), it was carried out the analysis of cross-sectional and vertical facial measurements to be compared to the shape of the dental arch. Data were subjected to one-way analysis of variance with a significance level of 5%. Results When the VERT index was compared with the three arch shapes, no measurement showed statistically significant differences (p > 0.05): triangular (0.54); oval (0.43); and quadrangular (0.73); as well as there were no differences (p > 0.05) in the widths of the face (141.20; 141.26; 143.27); maxilla (77.27; 77.57; 78.59) and mandible (105.13; 103.96; 104.28). Conclusion It can be concluded that there was no correlation between different shapes of the mandibular dental arch and the cross-sectional and vertical facial measurements investigated. How to cite this article El Haje OA, Pompeo DD, Furtado GC, Rivera LML, Paranhos LR. Is It Possible to use Cross-sectional and Vertical Facial Measurements to establish the Shape of the Mandibular Arch? J Contemp Dent Pract 2014;15(6):735-739.

scholarly journals Emergence of visceral leishmaniasis in Kollam district, Kerala, southern India

2019 ◽  
Vol 6 (3) ◽  
pp. 1350 ◽  
Author(s):  
R. Sandhya ◽  
P. S. Rakesh ◽  
Soumya Dev
Keyword(s):  
Visceral Leishmaniasis ◽  
Cutaneous Leishmaniasis ◽  
Southern India ◽  
Outbreak Investigation ◽  
Epidemiological Analysis ◽  
Major Threat ◽  
Kala Azar ◽  
Epidemiological Link

An outbreak investigation was initiated following an unusual occurence of kala azar reported among people residing in the tribal belt of Kulathupuzha area, eastern part of Kollam district, Kerala, Southern India. 2 cases of kala azar were investigated during 2016-2018. Epidemiological analysis indicated no epidemiological link between the cases. However the Visceral leishmaniasis and cutaneous leishmaniasis intruding into newer regions pose a major threat to ongoing leishmaniasis elimination and maintenance programs.

scholarly journals ACUTE HEART FAILURE

2018 ◽  
Vol 25 (09) ◽  
pp. 1392-1396
Author(s):  
Jasia Reham Din ◽  
Shahid Maqbool ◽  
Shakeel ur Rehman ◽  
Naeem Hameed
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
De Novo ◽  
Past History ◽  
Previous History ◽  
Young Male ◽  
Uncontrolled Hypertension ◽  
Cross Sectional ◽  
History Of ◽  
Emergency Department Patients

Objectives: To determine the frequency of the major precipitating factorsamong the patients presenting with acute heart failure. Study Design: Cross sectional study.Setting: Faisalabad Institute of Cardiology, Faisalabad. Period: July 2014 to January 2015.Materials and Methods: 190 patients of acute heart failure were included after obtaininginformed consent from emergency department. Patients from age of 25 years to 80 years andof either sex either diabetic or non-diabetic were enrolled in study. ECG and CXR were takenin emergency with baseline investigations. Precipitating cause was identified from collectedhistory, clinical examination and ECG, CXR and lab results. Results: Mean age of these patientswere 54.4 + 8.92, 100 (52.6%) were male, 90 (47.4%) were females, 88 patients (46.3%) werediabetic, 102 patients (53.68%) were non-diabetic and 124 (65.3%) had previous history of heartfailure and 66 (34.7%) had no past history of heart failure. ACS was the common precipitatingfactor of Acute Heart Failure ( 31.57% ) among all the patients of the study with non-complianceof drugs 27.9% , arrhythmias 17.9% uncontrolled hypertension 17.36% and infections 5.3%.Conclusion: Young, male, diabetics and patients with history of chronic HF suffered more fromAHF. ACS was the most common precipitating factor while in patients with de novo Acute HeartFailure; it was ACS and non-compliance with drugs.

scholarly journals Problem-Based Review: Paracetamol Overdose

2011 ◽  
Vol 10 (4) ◽  
pp. 212-215
Author(s):  
Tom Heaps ◽  
Keyword(s):  
Emergency Department ◽  
Glasgow Coma Scale ◽  
Past History ◽  
Previous History ◽  
Past Medical History ◽  
Minute Period ◽  
Normal Diameter ◽  
History Of ◽  
Self Harm ◽  
History Of Depression

A 29-year old male presents to the emergency department 1h after an overdose of cocodamol. He admits to taking approximately 60 x 8/500mg tablets, with alcohol, over a 20 minute period. He has a past history of depression, treated by his GP with citalopram 20mg OD. He has no previous history of deliberate self-harm. His past medical history is otherwise unremarkable and he is not on any additional medications. He drinks approximately 40 units of alcohol per week. Physical examination is unremarkable, his pupils are normal diameter and his Glasgow Coma Scale is 15. He weighs 82kg.

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