scholarly journals Muscle Relaxant and Sedative-Hypnotic Activities of Extract ofViola betonicifoliain Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Naveed Muhammad ◽  
Mohammad Saeed ◽  
Haroon Khan ◽  
Achyut Adhikari ◽  
Khalid Mohammed Khan
Keyword(s):  
Muscle Relaxant ◽  
Safety Profile ◽  
Methanolic Extract ◽  
Muscle Relaxation ◽  
Antidepressant Activity ◽  
Relaxant Effect ◽  
Whole Plant ◽  
Hydroxy Coumarin ◽  
Isolated Compound ◽  
Dose Dependent

The crude methanolic extract of the whole plant ofViola betonicifolia(VBME) was investigated for anxiolytic, muscle relaxant, sleep induction, antidepressant, and sedative activities) to ascertain its scientific values. VBME showed a significant (P<0.05) dose dependent anxiolytic action in staircase test. In muscle relaxant paradigms, a dose dependent muscle relaxation was observed. For phenobarbitone sleep induction test, VBME notably (P<0.05) reduced the latency time and increased total sleeping duration. Our tested extract was found free of any antidepressant activity, while the movement was significantly (P<0.05) shortened in locomotor activity. The whole plant ofV. betonicifolialed to the isolation of 4-hydroxyl coumarin (4HC) which showed substantial safety profile in acute toxicity test. When challenged in Traction and Chimney tests, it showed significant (P<0.05) muscle relaxant effect in both muscle relaxant paradigms at 20 and 30 mg/kg during various assessment times. Nevertheless, 4HC was devoid of sedative and hypnotic potentials. In conclusion, VBME had strong muscle relaxant and sedative-hypnotic properties, while its isolated compound, 4HC, possessed a significant muscle relaxant action with substantial safety profile without sedative-hypnotic effects.

Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima

2018 ◽  
Vol 73 (11-12) ◽  
pp. 413-416 ◽  
Author(s):  
Abdur Rauf ◽  
Saud Bawazeer ◽  
Ghias Uddin ◽  
Bina S. Siddiqui ◽  
Haroon Khan ◽  
...  
Keyword(s):  
Muscle Relaxant ◽  
Current Work ◽  
Dependent Manner ◽  
Dominant Effect ◽  
Inclined Plane ◽  
Rotarod Test ◽  
Relaxant Effect ◽  
Muscle Relaxant Activity ◽  
Dose Dependent ◽  
Inclined Plane Test

Abstract The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p<0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment. In conclusion, PA possesses strong muscle relaxant activity in various animal-based models.

Cyclobenzaprine: a possible mechanism of action for its muscle relaxant effect

1981 ◽  
Vol 59 (1) ◽  
pp. 37-44 ◽  
Author(s):  
John W. Commissiong ◽  
Farouk Karoum ◽  
Rhoderick J. Reiffenstein ◽  
Norton H. Neff
Keyword(s):  
Locus Coeruleus ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Ventral Horn ◽  
Muscle Rigidity ◽  
Release Of Noradrenaline ◽  
Relaxant Effect ◽  
Decerebrate Rat ◽  
Metabolism Of Noradrenaline ◽  
Thoracic Cord

Intravenously administered cyclobenzaprine (CBZ) (Flexeril), a clinically used, centrally acting muscle relaxant, abolished muscle rigidity in the intercollicular decerebrate rat. In animals in which the locus coeruleus was lesioned bilaterally previously, CBZ failed to attenuate the electromyogram. In the ventral horn of the cord, which receives a dense noradrenergic innervation from the locus coeruleus, CBZ caused an increase in the metabolism of noradrenaline. In the zona intermedia of the thoracic cord, which is not innervated by the locus coeruleus, CBZ caused only minimal effects on noradrenaline metabolism. Cells in the locus coeruleus were activated by CBZ. The results indicate that in the intercollicular decerebrate rat, an intact, coerulospinal, noradrenergic projection is essential for the muscle relaxant effect of CBZ. Muscle relaxation apparently results from an activation of locus coeruleus neurones, leading to an increased release of noradrenaline in the ventral horn of the cord and the subsequent inhibitory action of noradrenaline on α motoneurones.

scholarly journals A Straight-Chain Alcohol Glycoside, with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2007 ◽  
Vol 2 (9) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Asmita V. Patel ◽  
Christopher G. Dacke ◽  
Gerald Blunden ◽  
Janne Rojas Vera
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Methanolic Extract ◽  
Rubus Idaeus ◽  
Straight Chain ◽  
Spectrometric Data ◽  
Muscle Relaxant Activity ◽  
Dose Dependent ◽  
Smooth Muscle Relaxant

A methanolic extract of Rubus idaeus leaves, when fractionated by column chromatography, yielded two distinct bands containing compounds that demonstrated in vitro, dose dependent, smooth muscle relaxant activity using transmurally-stimulated Guinea pig ileum preparations. From band two, following extensive chromatographic separation, several compounds with smooth muscle relaxant activity were obtained, one of which was characterized, from spectroscopic and mass spectrometric data, as 1- O-(1,2-dihydroxyethyl)-4- O-methoxy-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside.

scholarly journals Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of Saccharum spontaneum Linn.

1970 ◽  
Vol 1 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Md Mynol Islam Vhuiyan ◽  
Israt Jahan Biva ◽  
Moni Rani Saha ◽  
Muhammad Shahidul Islam
Keyword(s):  
Castor Oil ◽  
Methanolic Extract ◽  
Experimental Models ◽  
Saccharum Spontaneum ◽  
Cns Depressant ◽  
Whole Plant ◽  
The Central Nervous System ◽  
Dose Dependent Decrease ◽  
Cns Depressant Activity ◽  
Dose Dependent

Preliminary phytochemical screening of the methanolic extract of the whole plant of Saccharum spontaneum Linn. (Family- Gramineae) revealed the presence of alkaloids, flavonoids, reducing sugar, tannins and saponins. The antidiarrhoeal activity of the extract (200 and 400 mg/kg) was assessed on experimental animal and a dose dependent decrease in the total number of faecal dropping was obsereved in castor oil induced diarrhoea in mice. The plant extract was also assessed for effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract produced a dosedependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possesses antidiarrhoeal and CNS depressant activity. Key Words: Saccharum spontaneum, Castor oil, Loperamide, Pentobarbitone.     doi:10.3329/sjps.v1i1.1810 S. J. Pharm. Sci. 1(1&2): 63-68

In-vitro Antioxidant and Antibacterial Activity of Methanolic Extract of Shorea robusta Gaertn. F. Resin

2016 ◽  
Vol 6 (4) ◽  
pp. 68
Author(s):  
Sushma Vashisht ◽  
Manish Pal Singh ◽  
Viney Chawla
Keyword(s):  
Antibacterial Activity ◽  
Methanolic Extract ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Disc Diffusion ◽  
Gram Positive ◽  
Gram Negative ◽  
Shorea Robusta ◽  
Dose Dependent ◽  
Resin Extract

The methanolic extract of the resin of Shorea robusta was subjected to investigate its antioxidant and antibacterial properties its utility in free radical mediated diseases including diabetic, cardiovascular, cancer etc. The methanol extract of the resin was tested for antioxidant activity using scavenging activity of DPPH (1,1-diphenyl-2-picrylhydrazil) radical method, reducing power by FeCl3 and antibacterial activity against gram positive and gram negative bacteria using disc diffusion method. The phytochemical screening considered the presence of triterpenoids, tannins and flavoniods. Overall, the plant extract is a source of natural antioxidants which might be helpful in preventing the progress of various oxidative stress mediated diseases including aging. The half inhibition concentration (IC50) of resin extract of Shorea robusta and ascorbic acid were 35.60 µg/ml and 31.91 µg/ml respectively. The resin extract exhibit a significant dose dependent inhibition of DPPH activity. Antibacterial activity was observed against gram positive and gram negative bacteria in dose dependent manner.Key Words: Shorea robusta, antioxidant, antibacterial, Disc-diffusion, DPPH.

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

scholarly journals Antioxidant and antidiabetic properties of isolated fractions from methanolic extract derived from the whole plant of Cleome viscosa L.

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yarrappagaari Suresh ◽  
Gutha Rajasekar ◽  
Thopireddy Lavanya ◽  
Benne Lakshminarsimhulu ◽  
Kesireddy Sathyavelu Reddy ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Antidiabetic Activity ◽  
Total Phenolic ◽  
Whole Plant ◽  
Glucose Diffusion ◽  
Ft Ir ◽  
Study Support ◽  
Important Medicinal Plant ◽  
Cleome Viscosa

Abstract Background Cleome viscosa is considered as an important medicinal plant extensively used in India, China, Bangladesh, and a few countries in Africa. In the present study, in vitro anti-radical and antidiabetic potential of isolated fractions of methanolic extract of C. viscosa whole plant (MeCV) has been investigated. The identification of polyphenols and their related functional groups in the bioactive fraction was categorized by using HPLC and FT-IR. Results The total phenolic and flavonoid contents of F-D were higher than those of F-A, F-B, and F-C. The F-D exhibited superior antioxidant capacity when compared with the remaining three fractions. However, the F-D showed the highest glucose diffusion activity over the 30 min–27 h incubation period and also inhibited both α-glucosidase and α-amylase enzyme activity. HPLC analysis revealed the presence of the two known compounds (protocatechuic acid hexoside, rutin) and six unknown compounds in the F-D. FTIR spectrum confirmed the presence of phenol group. Conclusion The isolated F-D obtained from MeCV displayed superior antioxidant and antidiabetic activity which indicate the presence of polyphenols in the fraction. The data findings of the present study support the traditional uses of the whole plant of C. viscosa as a promising natural source of biological medicines for oxidative stress and diabetes.

Role of extracellular calcium and calmodulin in prolactin secretion induced by hyposmolarity, thyrotropin-releasing hormone, and high K+ in GH4C1 cells

1990 ◽  
Vol 123 (2) ◽  
pp. 218-224 ◽  
Author(s):  
Xiangbing Wang ◽  
Noriyuki Sato ◽  
Monte A. Greer ◽  
Susan E. Greer ◽  
Staci McAdams
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Prolactin Secretion ◽  
Thyrotropin Releasing Hormone ◽  
Dependent Manner ◽  
Cell Toxicity ◽  
High K ◽  
Dose Dependent ◽  
Smooth Muscle Relaxant

Abstract. The mechanism by which 30% medium hyposmolarity induces PRL secretion by GH4C1 cells was compared with that induced by 100 nmol/l TRH or 30 mmol/l K+. Removing medium Ca2+, blocking Ca2+ channels with 50 μmol/l verapamil, or inhibiting calmodulin activation with 20 μmol/l trifluoperazine, 10 μmol/l chlorpromazine or 10 μmol/l pimozide almost completely blocked hyposmolarity-induced secretion. The smooth muscle relaxant, W-7, which is believed relatively specific in inhibiting the Ca2+-calmodulin interaction, depressed hyposmolarity-induced PRL secretion in a dose-dependent manner (r = −0.991, p<0.01 ). The above drugs also blocked or decreased high K+-induced secretion, but had much less effect on TRH-induced secretion. Secretion induced by TRH, hyposmolarity, or high K+ was optimal at pH 7.3-7.65 and was significantly depressed at pH 6.0 or 8.0, indicating that release of hormone induced by all 3 stimuli is due to an active cell process requiring a physiologic extracellular pH and is not produced by nonspecific cell toxicity. The data suggest hyposmolarity and high K+ may share some similarities in their mechanism of stimulating secretion, which is different from that of TRH.

PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF ROTULA AQUATICA LOUR. ROOTS

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (11) ◽  
pp. 34-38
Author(s):  
T. Shyam ◽  
◽  
S Ganapaty
Keyword(s):  
Body Weight ◽  
Spectroscopic Data ◽  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Dependent Manner ◽  
Biological Studies ◽  
Bacteria And Fungi ◽  
Dose Levels ◽  
Dose Dependent ◽  
Chemical Evidence

Four compounds viz α-amyrin, β- amyrin, bauerenol and ellagic acid were isolated from the methanolic extract of Rotula aquatica roots. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. The extract was evaluated for hepatoprotective activity against carbon tetrachloride induced hepatotoxic model at a dose levels of 200,400 and 800 mg/ kg body weight and compared with that of the standard silymarin (25mg/kg body weight). It showed good hepatoprotective activity in a dose dependent manner. The extract was also screened for antimicrobial activity against various types of organisms like bacteria and fungi.

A specific benzodiazepine antagonist CGS 8216 reverses the muscle relaxant effect of diazepam but not that of phenobarbitone

1984 ◽  
Vol 98 (3-4) ◽  
pp. 441-444 ◽  
Author(s):  
Waldemar A. Turski ◽  
Michael Schwartz ◽  
Lechoslaw Turski ◽  
Karl-Heinz Sontag
Keyword(s):  
Muscle Relaxant ◽  
Benzodiazepine Antagonist ◽  
Relaxant Effect ◽  
Cgs 8216
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