scholarly journals Dietaryω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Nicolò Merendino ◽  
Lara Costantini ◽  
Laura Manzi ◽  
Romina Molinari ◽  
Donatella D'Eliseo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Antitumor Activity ◽  
Cell Invasion ◽  
Current Knowledge ◽  
Oxidative Status ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis ◽  
Human Diet ◽  
Potential Use

ω-3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.

scholarly journals Salmonids as Natural Functional Food Rich in Omega-3 PUFA

2021 ◽  
Vol 11 (5) ◽  
pp. 2409
Author(s):  
Wojciech Kolanowski
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Functional Food ◽  
Fat Content ◽  
Salmonid Fish ◽  
Omega 3 ◽  
Pufa Content ◽  
Human Diet ◽  
Fish Fillets ◽  
Food Market

Salmonids are valuable fish in the human diet due to their high content of bioactive omega-3 very long-chain polyunsaturated fatty acid (VLC PUFA). The aim of this study was to assess the omega-3 VLC PUFA content in selected salmonid fish present on the food market regarding whether they were farm-raised or wild. It was assumed that farm-raised fish, by eating well-balanced feed enriched with omega-3 PUFA, might contain omega-3 VLC PUFA in levels similar to that of wild fish. Fat content, fatty acid composition and omega-3 VLC PUFA content in fish fillets were measured. Farm-raised salmon from Norway, wild Baltic salmon, farm-raised rainbow trout and brown trout were bought from a food market whereas wild trout (rainbow and brown) were caught alive. The fat content in fish ranged from 3.3 to 8.0 g/100 g of fillet. It was confirmed that although wild salmonid fish contain 10–25% more omega-3 VLC PUFA in lipid fraction, the farm-raised ones, due to the 60–100% higher fat content, are an equally rich source of these desirable fatty acids in the human diet. One serving (130 g) of salmonid fish fillets might provide a significant dose of omega-3 VLC PUFA, from 1.2 to 2.5 g. Thus, due to very high content of bioactive fatty acids eicosapentaenoic (EPA), docosapentaenoic (DPA) and docosahexaenoic (DHA) in their meat, salmonid fish currently present on the food market, both sea and freshwater as well as wild and farm-raised, should be considered as natural functional food.

scholarly journals Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications

Plants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 524 ◽  
Author(s):  
Lu ◽  
Eiriksson ◽  
Thorsteinsdóttir ◽  
Simonsen
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Higher Plants ◽  
Aqueous Environment ◽  
Omega 3 ◽  
Biotic And Abiotic Stresses ◽  
Human Diet ◽  
Omega 3 Fatty Acid ◽  
Algae Oil ◽  
Fatty Acid Compositions

Bryophytes (mosses, liverworts and hornworts) often produce high amounts of very long-chain polyunsaturated fatty acids (vl-PUFAs) including arachidonic acid (AA, 20:4 △5,8,11,14) and eicosapentaenoic acid (EPA, 20:5 △5,8,11,14,17). The presence of vl-PUFAs is common for marine organisms such as algae, but rarely found in higher plants. This could indicate that bryophytes did not lose their marine origin completely when they landed into the non-aqueous environment. Vl-PUFA, especially the omega-3 fatty acid EPA, is essential in human diet for its benefits on healthy brain development and inflammation modulation. Recent studies are committed to finding new sources of vl-PUFAs instead of fish and algae oil. In this review, we summarize the fatty acid compositions and contents in the previous studies, as well as the approaches for qualification and quantification. We also conclude different approaches to enhance AA and EPA productions including biotic and abiotic stresses.

Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells

2009 ◽  
Vol 33 (10) ◽  
pp. 1087-1094 ◽  
Author(s):  
Yuzuru Yamazoe ◽  
Masanobu Tsubaki ◽  
Hiroshi Matsuoka ◽  
Takao Satou ◽  
Tatsuki Itoh ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Melanoma Cells ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis

The fatty acid composition of grass silages

1998 ◽  
Vol 1998 ◽  
pp. 35-35 ◽  
Author(s):  
R.J. Dewhurst ◽  
P.J. King
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Saturated Fatty Acids ◽  
Fish Oils ◽  
Omega 3 ◽  
Human Diet ◽  
Omega 3 Fatty Acid ◽  
Grass Silage

Ruminant products have been criticised for the possible adverse effects of their saturated fatty acids on human health. Conversely, the omega-3 polyunsaturated fatty acids, notably those in fish oils, have been identified as beneficial components of the human diet. Earlier studies have shown that a small, but useful, amount of forage α-linolenic acid (C18:3), an omega-3 fatty acid, appears in ruminant products (Wood and Enser, 1996). The objective of the current work was to evaluate the range of α-linolenic acid concentrations in laboratory grass silages in order to assess the opportunities to modify ensiling techniques to increase the natural delivery of omega-3 fatty acid from grass silage to milk or meat.

scholarly journals Effect of Dietary n‐3 Source on Rabbit Male Reproduction

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Cesare Castellini ◽  
Simona Mattioli ◽  
Cinzia Signorini ◽  
Elisa Cotozzolo ◽  
Daria Noto ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Sperm Count ◽  
Reproductive Traits ◽  
Human Sperm ◽  
Oxidative Status ◽  
Male Reproduction ◽  
Analytical Determination ◽  
Control Group ◽  
Chain Pufa

In the last two decades, the human sperm count linearly decreased in Western countries. Health problems, lifestyle, pollutants, and dietary behaviours are considered as the main risk factors, and the unbalance of dietary n‐6/n‐3 fatty acids is one of the most relevant. The aim of the present research is to study the effect of different dietary sources of n‐3 polyunsaturated fatty acids (PUFA) on reproductive traits using rabbit buck as the animal model. Fifteen rabbit bucks were assigned to three experimental groups: the control group, the FLAX group fed 10% extruded flaxseed, and the FISH group fed 3.5% fish oil for 110 days (50-day adaptation and 60-day experimental periods). Semen samples were collected weekly, whereas blood was collected every two weeks for the analytical determination of semen traits, oxidative status, fatty acid profiles, isoprostanes, neuroprostanes, and the immunocytochemistry of docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) acid. At the end of the trial, the rabbits were killed and the testes were removed and stored for the analysis of fatty acid profile and immunocytochemistry. Results showed that dietary administration of n‐3 PUFA improved the track speed of the sperm and increased the n‐3 long-chain PUFA mainly confined in the sperm tail. Seminal plasma increased the thiobarbituric reactive substances (TBARs) by three times in the groups fed supplemental n‐3, whereas the F2-isoprotanes (F2-IsoPs) and F4-neuroprostanes (F4-NeuroPs) were lower and higher, respectively, in both supplemented groups than in the control. The testes and sperm showed a higher DHA and EPA distribution in rabbits from the n‐3 supplemented groups compared with the control. In conclusion, supplemental dietary n‐3 PUFA improved sperm motion traits and resulted in an enrichment of membrane fatty acid in the sperm and testes of the rabbits. However, such an increased amount of PUFA negatively affected the sperm oxidative status, which was mainly correlated with the generation of F4-NeuroPs with respect to F2-IsoPs. Accordingly, the latter cannot be considered a good marker of oxidation when diets rich in n‐3 PUFA are provided.

scholarly journals Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0137369
Author(s):  
Ling Wang ◽  
Stephanie M. Cossette ◽  
Kevin R. Rarick ◽  
Jill Gershan ◽  
Michael B. Dwinell ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis

scholarly journals Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis

2016 ◽  
Vol 76 (21) ◽  
pp. 6205-6217 ◽  
Author(s):  
Lorena Alba-Castellón ◽  
Rubén Olivera-Salguero ◽  
Aida Mestre-Farrera ◽  
Raúl Peña ◽  
Mercedes Herrera ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis ◽  
Epithelial Tumor ◽  
Cancer Associated Fibroblast ◽  
Epithelial Tumor Cell
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