scholarly journals Flaxseed Prevents Leukocyte and Platelet Adhesion to Endothelial Cells in Experimental Atherosclerosis by Reducing sVCAM-1 and vWF

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Raluca Ecaterina Haliga ◽  
Roxana Irina Iancu ◽  
Doina Butcovan ◽  
Veronica Mocanu
Keyword(s):  
Endothelial Cells ◽  
High Fat Diet ◽  
Platelet Adhesion ◽  
Estrogen Deficiency ◽  
Ovariectomized Rats ◽  
Histological Evaluation ◽  
High Dose ◽  
High Fat ◽  
Atherosclerotic Lesions ◽  
Ground Flaxseed

We studied the possible effect of flaxseed to prevent leukocytes and platelets adhesion to endothelial cells and to reduce soluble adhesion molecules (sVCAM-1) and endothelial integrity markers (vWF) in ovariectomized rats fed a high-fat diet. Forty-two female Wistar rats were either sham-operated or ovariectomized and randomly assigned for 36 weeks to three different diets: (1) low-fat diet (8% energy as fat); (2) high-fat diet (40% energy as fat, lard based, lard group); (3) high-fat diet enriched with ground flaxseed 15 g/100 g of food (40% energy as fat, lard + flaxseed group). The ovariectomized rats fed with lard + flaxseeds had significantly lower serum concentrations of sVCAM and vWF, reduced platelet adhesiveness, and lower extent of platelet and leukocyte adherence to endothelium in the histological evaluation of the aorta as compared to Ovx + lard group. In our study, high dose of ground flaxseed incorporated to lard-based diet prevented the progression of atherosclerotic lesions in estrogen deficiency rats by decreasing platelet and endothelium reactivity. Assessment of platelet adhesion, serum soluble adhesion molecule sVCAM, and endothelium integrity molecule vWF could be useful to detect the risk for atherosclerotic lesions in estrogen deficiency states and to estimate the effect of flaxseed supplementation.

scholarly journals Agrimonia pilosa Ledeb. Ameliorates Hyperglycemia and Hepatic Steatosis in Ovariectomized Rats Fed a High-Fat Diet

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1631
Author(s):  
Hwan-Hee Jang ◽  
Ji Hyun Bae ◽  
Mi-Ju Kim ◽  
Mi Young Park ◽  
Haeng Ran Kim ◽  
...  
Keyword(s):  
Dietary Intake ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Coenzyme A ◽  
Density Lipoprotein ◽  
Estrogen Deficiency ◽  
Ovariectomized Rats ◽  
Sprague Dawley ◽  
High Fat ◽  
Hepatic Expression

Estrogen deficiency is associated with obesity, dyslipidemia, and increased insulin resistance in postmenopausal women. An efficient therapeutic agent prevents or improves postmenopausal conditions induced by estrogen deficiency. Here, we investigated the effects of aqueous Agrimonia pilosa Ledeb. extract on glucose and lipid metabolism in ovariectomized rats fed a high-fat diet (HFD). Female Sprague-Dawley rats were sham-operated or ovariectomized, and 3 weeks later were assigned to the following groups: sham-operated + HFD (S); ovariectomized + HFD (OVX); and ovariectomized + HFD with 0.5% A. pilosa aqueous extract (OVX + 0.5A) groups. Ovariectomy significantly increased body weight and dietary intake relative to the S group. However, A. pilosa treatment did not significantly affect weight gain or dietary intake. Blood triacylglycerol, total cholesterol, and low-density lipoprotein cholesterol levels tended to decrease in the A. pilosa-supplemented group. Blood glucose levels were significantly lower in the OVX + 0.5A group than those in the OVX group. Blood adiponectin and insulin concentrations increased significantly after A. pilosa treatment in the ovariectomized group. A. pilosa supplementation tended to decrease liver weights and prevented lipid accumulation. These effects correlated with reduced hepatic expression of lipogenesis-related genes (fatty acid synthase, acetyl-coenzyme A carboxylase alpha, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase). Therefore, A. pilosa may improve metabolic disorders in ovariectomized rats.

Cardioprotective action of chia (Salvia hispanica L.) in ovariectomized rats fed a high fat diet

2021 ◽  
Vol 12 (7) ◽  
pp. 3069-3082
Author(s):  
Marcella Duarte Villas Mishima ◽  
Luiz Carlos Maia Ladeira ◽  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Thomás Valente de Oliveira ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Mineral Content ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Positive Effects ◽  
Biometric Parameters ◽  
Pump Activity ◽  
Salvia Hispanica L ◽  
Cardioprotective Action

The combination of ovariectomy with high fat diet consumption, in this study, affected biometric parameters, oxidative stress, mineral content and ATPase pump activity, while chia consumption had positive effects on these factors.

scholarly journals PPAR? in endothelial cells influences high fat diet-induced hypertension

2005 ◽  
Vol 18 (4) ◽  
pp. 549-556 ◽  
Author(s):  
C NICOL ◽  
M ADACHI ◽  
T AKIYAMA ◽  
F GONZALEZ
Keyword(s):  
Endothelial Cells ◽  
High Fat Diet ◽  
High Fat ◽  
Induced Hypertension

scholarly journals Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

2021 ◽  
Vol 53 (9) ◽  
pp. 1379-1389
Author(s):  
Hao Kan ◽  
Ka Zhang ◽  
Aiqin Mao ◽  
Li Geng ◽  
Mengru Gao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Single Cell ◽  
High Fat Diet ◽  
Cell Types ◽  
Ascending Aorta ◽  
Normal Diet ◽  
Cellular Heterogeneity ◽  
Cellular Composition ◽  
High Fat ◽  
Aortic Diseases

AbstractThe aorta contains numerous cell types that contribute to vascular inflammation and thus the progression of aortic diseases. However, the heterogeneity and cellular composition of the ascending aorta in the setting of a high-fat diet (HFD) have not been fully assessed. We performed single-cell RNA sequencing on ascending aortas from mice fed a normal diet and mice fed a HFD. Unsupervised cluster analysis of the transcriptional profiles from 24,001 aortic cells identified 27 clusters representing 10 cell types: endothelial cells (ECs), fibroblasts, vascular smooth muscle cells (SMCs), immune cells (B cells, T cells, macrophages, and dendritic cells), mesothelial cells, pericytes, and neural cells. After HFD intake, subpopulations of endothelial cells with lipid transport and angiogenesis capacity and extensive expression of contractile genes were defined. In the HFD group, three major SMC subpopulations showed increased expression of extracellular matrix-degradation genes, and a synthetic SMC subcluster was proportionally increased. This increase was accompanied by upregulation of proinflammatory genes. Under HFD conditions, aortic-resident macrophage numbers were increased, and blood-derived macrophages showed the strongest expression of proinflammatory cytokines. Our study elucidates the nature and range of the cellular composition of the ascending aorta and increases understanding of the development and progression of aortic inflammatory disease.

scholarly journals Hypocholesterolaemic effect of whole-grain highland hull-less barley in rats fed a high-fat diet

2018 ◽  
Vol 119 (10) ◽  
pp. 1102-1110 ◽  
Author(s):  
Xuejuan Xia ◽  
Guannan Li ◽  
Jiaxin Song ◽  
Jiong Zheng ◽  
Jianquan Kan
Keyword(s):  
Bile Acid ◽  
High Fat Diet ◽  
Control Diet ◽  
Ldl Receptor ◽  
Acid Synthesis ◽  
Farnesoid X Receptor ◽  
High Dose ◽  
Whole Grain ◽  
Sprague Dawley ◽  
High Fat

AbstractWhole-grain highland hull-less barley (WHLB) contains high amounts of bioactive compounds that potentially exhibit cholesterol-lowering effects. This study investigated the hypocholesterolaemic effect of WHLB. A total of seventy-two male Sprague–Dawley rats were divided into four groups and were fed with the normal control diet, high-fat diet (HFD) and HFD containing low or high dose (10 or 48·95 %) of WHLB. High dose of WHLB significantly decreased the organ indexes of liver and abdominal fat and lipid levels of plasma and liver in HFD rats. The lipid regulation effect of WHLB, which was reconfirmed through hepatocyte morphologic observation, was accompanied by a large excretion of bile acids in the small intestinal contents and the faeces. Real-time PCR analyses, which were further reconfirmed through Western blot analyses, revealed that a high dose of WHLB significantly enhanced the hepatic expressions of AMP-activated protein kinase α, cholesterol 7α-hydroxylase, LDL receptor, liver X receptor, and PPARα and decreased the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. It also enhanced the ileal expression of farnesoid X receptor and resulted in the decrease of expression of apical sodium-dependent bile acid transporter. WHLB exhibited hypocholesterolaemic effects mainly by inhibiting cholesterol synthesis, cholesterol accumulation in peripheral tissue, and bile acid reabsorption and by stimulating bile acid synthesis.

Bioavailability of Calcium from Chia (Salvia hispanica L.) in Ovariectomized Rats Fed a High Fat Diet

2020 ◽  
pp. 1-11
Author(s):  
Marcella Duarte Villas Mishima ◽  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Neuza Maria Brunoro Costa ◽  
Hércia Stampini Duarte Martino
Keyword(s):  
High Fat Diet ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Salvia Hispanica L
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