scholarly journals INF-αand Ototoxicity

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Reza Sharifian ◽  
Shima Kamandi ◽  
Hamid Reza Sima ◽  
Mohammad Ali Zaringhalam ◽  
Mehdi Bakhshaee
Keyword(s):  
Hepatitis B ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Frequency Range ◽  
Common Drug ◽  
High Frequency Audiometry ◽  
Significant Difference ◽  
Transiently Evoked Otoacoustic Emissions ◽  
Normal Controls ◽  
Control Study

Introduction. INF-αis a common drug for the treatment of hepatitis B and C. Although a variety of related complications are discussed, possible ototoxic effects of this mediation are not well described.Methods and Materials. In a before-after control study, 24 patients who received INF-αfor the treatment of hepatitis B and C and 30 normal controls were included. Subjective and objective ototoxicity evaluations via questionnaire, high frequency audiometry, and measuring transiently evoked otoacoustic emissions (TEOAEs) were performed one week before and one month after the prescription of the drug.Results. Subjective hearing complaint, tinnitus, and vertigo were seen in just 3 cases, which was not statistically significant (). In the frequency range of 4000 to 8000 Hz before (9.38 ± 1.0 and 10.7 ± 1.2, resp.) and after (17.9 ± 2.6 and 17.6 ± 2.6, resp.) one month of treatment, a significant difference () was detected. Progressive decreases in amplitude of the OAE during TEOAE measurement in 1, 2, and 4 frequencies among 41.66%, 18.75 %, and 43.75% were observed, respectively. The hearing loss was seen more among older and male cases significantly. Conclusion. The results showed ototoxicity of INF-αthat may encourage planning hearing monitoring in patients receiving this drug.

scholarly journals Changes in the hearing threshold using high frequency audiometry in medical personnel exposed to ionizing radiation

2018 ◽  
Vol 4 (6) ◽  
pp. 1411
Author(s):  
Pradeep Pooja ◽  
Karuthedeth Sridevi ◽  
Anie Melootil Thomas ◽  
Ariyamparampil Rajagopalan Vinayakumar ◽  
Pulakkil Arun
Keyword(s):  
Ionizing Radiation ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Low Dose ◽  
Medical Personnel ◽  
Impedance Audiometry ◽  
Pure Tone Audiogram ◽  
High Frequency Audiometry ◽  
Significant Difference

<p class="abstract"><strong>Background:</strong> Effect on sensorineural hearing loss by low dose ionizing radiation exposure in radiation workers has been rarely evaluated. A case control study was done among the radiation associated workers and normal subjects.</p><p class="abstract"><strong>Methods:</strong> The study was designed in low dose of radiation exposing healthy medical personnel. Age and sex matched healthy control group of subjects were selected. Groups were evaluated by normal otoscopic evaluation; normal tuning fork test and normal standard pure tone audiogram at frequencies from 250 to 8000 Hz. They underwent impedance audiometry, transient evoked otoacoustic emissions, and high frequency audiometry (from frequencies 10000 to 20000 Hz) was done.  </p><p class="abstract"><strong>Results:</strong> No statistically significant difference was found in the results of impedance audiometry, transient evoked otoacoustic emissions and standard pure tone audiogram from 250 to 8000 Hz between cases and controls. In the high frequency range, statistically significant difference was observed (p=0.0001). Mean thresholds were higher at all frequencies in cases compared to controls, except at 4000 Hz. A statistically significant correlation was found between duration of exposure and thresholds at 500 Hz (p=0.014) and 10000 Hz (p=0.048). Tinnitus, vertigo, ear block, hard of hearing and loss of appetite were seen more in cases, but was not significant.</p><p class="abstract"><strong>Conclusions:</strong> Taking account of the very low incidence of nerve and parathyroid injury in this series, the authors suggest that meticulous capsular dissection is superior to dissection of the entire nerve in avoiding transcient nerve damage as well as temporary hypocalcemia. However it is stated that a deliberate search for the nerve is definitely indicated in cases where there is likely to be distorted anatomy, as in infiltrating malignancies and recurrent thyroidectomies.</p>

Early Changes in Auditory Function As a Result of Platinum Chemotherapy: Use of Extended High-Frequency Audiometry and Evoked Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 25 (10) ◽  
pp. 1190-1195 ◽  
Author(s):  
Kristin R. Knight ◽  
Dale F. Kraemer ◽  
Christiane Winter ◽  
Edward A. Neuwelt
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Function ◽  
Cochlear Function ◽  
Serial Measurement ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Platinum Based Chemotherapy ◽  
Platinum Chemotherapy

Purpose The objective is to describe progressive changes in hearing and cochlear function in children and adolescents treated with platinum-based chemotherapy and to begin preliminary evaluation of the feasibility of extended high-frequency audiometry and distortion product otoacoustic emissions for ototoxicity monitoring in children. Patients and Methods Baseline and serial measurement of conventional pure-tone audiometry (0.5 to 8 kHz) and evoked distortion product otoacoustic emissions (DPOAEs) were conducted for 32 patients age 8 months to 20 years who were treated with cisplatin and/or carboplatin chemotherapy. Seventeen children also had baseline and serial measurement of extended high-frequency (EHF) audiometry (9 to 16 kHz). Audiologic data were analyzed to determine the incidence of ototoxicity using the American Speech-Language-Hearing Association criteria, and the relationships between the different measures of ototoxicity. Results Of the 32 children, 20 (62.5%) acquired bilateral ototoxicity in the conventional frequency range during chemotherapy treatment, and 26 (81.3%) had bilateral decreases in DPOAE amplitudes and dynamic range. Of the 17 children with EHF audiometry results, 16 (94.1%) had bilateral ototoxicity in the EHF range. Pilot data suggest that EHF thresholds and DPOAEs show ototoxic changes before hearing loss is detected by conventional audiometry. Conclusion EHF audiometry and DPOAEs have the potential to reveal earlier changes in auditory function than conventional frequency audiometry during platinum chemotherapy in children.

scholarly journals Hearing Thresholds Changes after MRI 1.5T of Head and Neck

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Maryam Bahaloo ◽  
Mohammad Hossein Davari ◽  
Mohammad Sobhan ◽  
Seyyed Jalil Mirmohammadi ◽  
Mohammad Taghi Jalalian ◽  
...  
Keyword(s):  
Head And Neck ◽  
High Frequency ◽  
Repeated Measures ◽  
Hearing Threshold ◽  
Significant Shift ◽  
Auditory Thresholds ◽  
Hearing Thresholds ◽  
High Frequency Audiometry ◽  
Significant Difference ◽  
Before And After

Introduction. Exposure to high intensity noise produced by MRI is a cause for concern. This study was conducted to determine the temporary and permanent effects of exposure to noise created by performing MRI on the hearing threshold of the subjects using conventional and extended high frequency audiometry. Methods. This semiexperimental study was performed on 35 patients referred to Shahid Rahnemoun Hospital for head and neck MRI due to different clinical conditions. The hearing threshold of patients was measured before, immediately after, and 24 hours after performing 1.5 Tesla MRI using conventional and extended high frequency audiometry. SPSS version 18 was used to compare the mean hearing thresholds before and after MRI using paired T test and repeated measures analysis. Results. Comparison of auditory thresholds in conventional and extended high frequencies before and immediately after MRI showed a significant shift at 4 KHz (P = 0.008 and P = 0.08 for right and left ears), 6 KHz (P = 0.03 and P = 0.01 for right and left ears), and 14 KHz (P =0.03 and P = 0.31 for right and left ears). However, there was no significant difference between audiometric thresholds before and 24 hours after MRI. Conclusion. Noise due to 1.5 Tesla MRI can only cause transient threshold shift.

scholarly journals Does Vincristine affect Cochlear function in children with acute lymphoblastic leukaemia?

2016 ◽  
Vol 27 (1) ◽  
pp. 3-7
Author(s):  
Suchetha Rao ◽  
Ranjith Kumar ◽  
Jayashree Bhat ◽  
Nutan Kamath
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Lymphoblastic Leukemia ◽  
Statistical Significance ◽  
Pure Tone Audiometry ◽  
Cochlear Function ◽  
Hearing Sensitivity ◽  
Distortion Product ◽  
High Frequency Audiometry

Context: Vincristine chemotherapy has dose dependent ototoxicity. Early detection of ototoxicity is better with otoacoustic emissions and high frequency audiometry than conventional pure tone audiometry. The study was done to see if vincristine treatment interferes with hearing sensitivity in children.Methods and Material: A prospective study was conducted on twenty-three children with acute lymphoblastic leukemia (ALL) on Multi Center Protocol (MCP 841).These were subjected to conventional audiometry, high frequency audiometry and distortion product otoacoustic emissions (DPOAEs) before starting chemotherapy. The follow up audiological evaluation after early intensive phase chemotherapy (approximately 6 months) was conducted in thirteen children, who received 12 doses of vincristine (1.4 mg/m2), cranial irradiation of 1800cGy (>3 years) as per protocol and antibiotics as per clinical demands.Results: Baseline audiological evaluation was normal. Follow-up evaluation DPOAEs showed a declining tendency, however changes did not reach statistical significance. Differences in median hearing thresholds prior and post treatment in higher frequency audiometry were also minimal which was not statistically significant. Conventional audiometric thresholds were not altered.Conclusions: The reduction in the signal noise ratio of DPOAE, and reduced hearing sensitivity in high frequencies in post chemotherapy in comparison with baseline measures cannot be ignored though it has failed to reach the level of statistical significance. children on vincristine should have a pre chemotherapy and follow up audiological evaluation with DPOAE The results of the present study needs to be strengthened by including larger sample and long term follow up.Bangladesh J Medicine Jan 2016; 27(1) : 3-7

scholarly journals Extended High Frequency Audiometry in Polycystic Ovary Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Cuneyt Kucur ◽  
Suna Kabil Kucur ◽  
Ilay Gozukara ◽  
Ali Seven ◽  
Kadriye Beril Yuksel ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
High Frequency ◽  
Polycystic Ovary ◽  
Endothelial Damage ◽  
Reproductive Age ◽  
Control Group ◽  
Fasting Insulin ◽  
High Frequencies ◽  
High Frequency Audiometry ◽  
Significant Difference

Objective. Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 5–10% of women in reproductive age. Insulin resistance, dyslipidemia, glucose intolerance, hypertension, and obesity are metabolic disorders accompanying the syndrome. PCOS is a chronic proinflammatory state and the disease is associated with endothelial dysfunction. In diseases with endothelial damage, hearing in high frequencies are mostly effected in early stages. We evaluated extended high frequency hearing loss in PCOS patients.Material Methods. Forty women diagnosed as PCOS and 25 healthy controls were included in this study. Age and BMI of PCOS and control groups were comparable. Each subject was tested with low (250–2000 Hz), high (4000–8000 Hz), and extended high frequency audiometry (8000–20000). Hormonal and biochemical values including LH, LH/FSH, testosterone, fasting glucose, fasting insulin, HOMA-I, and CRP were calculated.Results. PCOS patients showed high levels of LH, LH/FSH, testosterone, fasting insulin, glucose, HOMA-I, and CRP levels. The hearing thresholds of the groups were similar at frequencies of 250, 500, 1000, 2000, and 4000 Hz; statistically significant difference was observed in 8000–14000 Hz in PCOS group compared to control group.Conclusion. PCOS patients have hearing impairment especially in extended high frequencies. Further studies are needed to help elucidate the mechanism behind hearing impairment in association with PCOS.

scholarly journals On the Noise Hazard Assessment within the Intermediate Range of the High Audible and the Low Ultrasonic Frequencies

2016 ◽  
Vol 41 (2) ◽  
pp. 331-338 ◽  
Author(s):  
Antoni Śliwiński
Keyword(s):  
Hazard Assessment ◽  
High Frequency ◽  
Low Frequency ◽  
Frequency Range ◽  
Research Activity ◽  
High Frequency Audiometry ◽  
Noise Assessment ◽  
The Subject ◽  
The One ◽  
Assessment Procedures

AbstractIn parallel to the ultrasonic noise assessment procedures and research activity in the field there have appeared several papers in the domain of so called high-frequency audiometry which covers the range of frequencies 8-20 kHz. They are important for recognizing the harmfulness and hazard of the audible high frequency sound components in the same range as the one of the low frequency ultrasonic noise. On the other hand there exists a certain inconsequent situation in the general approach to the problem of ultrasonic noise hazard assessment in work places environment which concerns the convention to include the frequency range of 10-20 kHz to the domain of ultrasonics. The range consists of one third octave bands of central frequencies: 10, 12.5, 16, 20 kHz and conventionally is called low frequency ultrasonic noise though at least the components of the two lowest bands are naturally audible by a majority of population (mainly young people).The paper presents a discussion related to some achievements of the two domains and some conclusions which could be useful for a more consequent description of the subject and could be taken into account in the future regulations for the ultrasonic noise assessment in work places environment.

The effect of coronavirus disease 2019 on the hearing system

2021 ◽  
pp. 1-5
Author(s):  
Ö Gedik ◽  
H Hüsam ◽  
M Başöz ◽  
N Tas ◽  
F Aksoy
Keyword(s):  
Auditory Brainstem Response ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Brainstem Response ◽  
Hearing System

Abstract Objective This study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019. Methods Twenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted. Results The pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III–V were significantly different between groups. Conclusion Coronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.

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