scholarly journals A Systematic Review to Investigate Whether Angiotensin-(1-7) Is a Promising Therapeutic Target in Human Heart Failure

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Vincent C. H. Lee ◽  
Elizabeth N. Lloyd ◽  
Helena C. Dearden ◽  
Kenneth Wong
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Intervention Study ◽  
Forearm Blood Flow ◽  
Human Heart Failure ◽  
Promising Therapeutic Target ◽  
Patients With Heart Failure ◽  
Cardioprotective Effects ◽  
Normal Men

Context. Heart failure (HF) is a common condition causing much morbidity and mortality despite major advances in pharmacological and device therapies. Preclinical data suggest a cardioprotective role of Angiotensin-(1-7) in animal models of HF. Objective. Perform a systematic review on the effects of Angiotensin-(1-7) on humans, focusing on HF. Results. 39 studies were included in the review (4 in human HF and (35) in non-HF patients). There is only one intervention study on 8 patients with human HF, using Angiotensin-(1-7), with forearm blood flow (FBF) as the endpoint. Angiotensin-(1-7) caused no significant effect on FBF in this HF study but caused vasodilation in 3 out of 4 non-HF studies. In one other non-HF study, Angiotensin-(1-7) infusion led to a significant increase in blood pressure in normal men; however, effects were <0.03% that of angiotensin II. Cardioprotective effects seen in non-HF studies include for instance beneficial actions against atherosclerosis and myocardial fibrosis. Conclusions. The main finding of our systematic review is that Angiotensin-(1-7) plays an important cardioprotective role in HF in animals and in patients without heart failure. More research is required to test the hypothesis that Angiotensin-(1-7) benefits patients with heart failure.

scholarly journals The Novel Perspectives Opened by ST2 in the Pandemic: A Review of Its Role in the Diagnosis and Prognosis of Patients with Heart Failure and COVID-19

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 175
Author(s):  
Radu-Stefan Miftode ◽  
Antoniu Octavian Petriș ◽  
Viviana Onofrei Aursulesei ◽  
Corina Cianga ◽  
Irina-Iuliana Costache ◽  
...  
Keyword(s):  
Heart Failure ◽  
Myocardial Injury ◽  
Clinical Manifestations ◽  
The Novel ◽  
Inflammatory Biomarker ◽  
Diagnosis And Prognosis ◽  
Cardiovascular Comorbidities ◽  
Patients With Heart Failure ◽  
Cardioprotective Effects

The increasing incidence of coronavirus disease 19 (COVID-19) and its polymorphic clinical manifestations due to local and systemic inflammation represent a high burden for many public health systems. Multiple evidence revealed the interdependence between the presence of cardiovascular comorbidities and a severe course of COVID-19, with heart failure (HF) being incriminated as an independent predictor of mortality. Suppression of tumorigenicity-2 ST2 has emerged as one of the most promising biomarkers in assessing the evolution and prognosis of patients with HF. The uniqueness of ST2 is determined by its structural particularities. Its transmembrane isoform exerts cardioprotective effects, while the soluble isoform (sST2), which is detectable in serum, is associated with myocardial fibrosis and poor outcome in patients with HF. Some recent data also suggested the potential role of sST2 as a marker of inflammation, while other studies highlighted it as a valuable prognostic factor in patients with COVID-19. In this review, we summarized the pathways by which sST2 is related to myocardial injury and its connection to the severity of inflammation in patients with COVID-19. Also, we reviewed possible perspectives of using it as a dual cardio-inflammatory biomarker, for both early diagnosis, risk stratification and prognosis assessment of patients with concomitant HF and COVID-19.

scholarly journals Effect of Nurse-led Educational Interventions on Self-care of Adult Patients with Heart Failure: A Systematic Review

2020 ◽  
Vol 10 (2) ◽  
pp. 192
Author(s):  
Reginus Tertius Malara ◽  
Syarul Syarul
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Intervention Study ◽  
Self Care ◽  
Educational Interventions ◽  
Adult Patients ◽  
Adult Care ◽  
Education Of Patients ◽  
Pubmed Database ◽  
Patients With Heart Failure

The purpose of this systematic review is to identify the effect of individual nursing-led, patient sessions on adult care with heart failure (HF) in hospitals, outpatient clinics and at home or community. A systematic review of the intervention study. Using nurse terminology, education, heart failure, self-care in the PubMed database, ScienceDirect, Willey, ProQuest. The articles in question are related to educational interventions by individual nurses to patients with management of heart failure. The results of this review identified nursing-led education sessions to adults with heart failure proven to improve self-care abilities. These results suggest that the education of patients led by nurses to adult patients with heart failure improves self-care. Education led by nurses delivered in hospitals, outpatient and in-home clinics using diverse methods have an impact on improving self-care.

Prognostic role of myocardial work in patients with heart failure and reduced ejection fraction treated by sacubitril/valsartan

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
E Galli ◽  
Y Bouali ◽  
C Laurin ◽  
A Gallard ◽  
A Hubert ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Rank Test ◽  
Reduced Ejection Fraction ◽  
Non Invasive ◽  
Patients With Heart Failure ◽  
Increase Risk ◽  
Echocardiographic Examination ◽  
Constructive Work

Abstract Background The non-invasive assessment of myocardial work (MW) by pressure-strain loops analysis (PSL) is a relative new tool for the evaluation of myocardial performance. Sacubitril/Valsartan is a treatment for heart failure with reduced ejection fraction (HFrEF) which has a spectacular effect on the reduction of cardiovascular events (MACEs). Purposes of this study were to evaluate 1) the short and medium term effect of Sacubitril/Valsartan treatment on MW parameters; 2) the prognostic value of MW in this specific group of patients. Methods 79 patients with HFrEF (mean age: 66±12 years; LV ejection fraction: 28±9%) were prospectively included in the study and treated with Sacubitril/Valsartan. Echocardiographic examination was performed at baseline, and after 6- and 12-month of therapy with Sacubitril/Valsartan. Results Sacubitril/Valsartan significantly increased global myocardial constructive work (CW) (1023±449 vs 1424±484 mmHg%, p&lt;0.0001) and myocardial work efficiency (WE) [87 (78–90) vs 90 (86–95), p&lt;0.0001]. During FU (2.6±0.9 years), MACEs occurred in 13 (16%) patients. After correction for LV size, LVEF and WE, CW was the only predictor of MACEs (Table 1). A CW&lt;910 mmHg (AUC=0.81, p&lt;0.0001, Figure 1A) identified patients at particularly increase risk of MACEs [HR 11.09 (1.45–98.94), p=0.002, log-rank test p&lt;0.0001] (Figure 1 B). Conclusions In patients with HFrEF who receive a comprehensive background beta-blocker and mineral-corticoid receptor antagonist therapy, Sacubitril/Valsartan induces a significant improvement of myocardial CW and WE. In this population, the estimation of CW before the initiation of Sacubitril/Valsartan therapy allows the prediction of MACEs. Funding Acknowledgement Type of funding source: None

scholarly journals Prognostic role of anemia in heart failure with preserved ejection fraction: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Monil Majmundar ◽  
Rajkumar Doshi ◽  
Harshvardhan Zala ◽  
Palak Shah ◽  
Devina Adalja ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Ejection Fraction ◽  
Meta Analysis ◽  
Preserved Ejection Fraction ◽  
Prognostic Role
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