scholarly journals Utility of Activated Nitriles in the Synthesis of Novel Heterocyclic Compounds with Antitumor Activity

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Asmaa S. Salman
Keyword(s):  
Heterocyclic Compounds ◽  
Acid Hydrazide ◽  
Cancer Cell Line ◽  
Human Breast ◽  
Cyanoacetic Acid ◽  
Elemental Analyses ◽  
Cyanoacetic Acid Hydrazide ◽  
Antitumor Evaluation ◽  
Mcf 7

Reaction of cyanoacetic acid hydrazide (1) with 4-methoxyacetophenone and 4-chlorobenzaldehyde (2a,b) afforded the corresponding 2-cyanoacetohydrazide derivatives (3a,b) respectively. The latter compounds were utilized as a key intermediate for the synthesis of new heterocyclic compounds. Newly synthesized compounds were characterized by elemental analyses and spectral data. The antitumor evaluation of some newly synthesized compounds was screened in vitro against human breast cancer cell line (MCF-7).

scholarly journals Homoeopathic Viscum album (10-3) is More Cytotoxic to in vitro Culture of Human Breast Cancer Cell Line than to Human Mesenchymal Stem Cells

2021 ◽  
Vol 19 (4) ◽  
pp. 25-34
Author(s):  
Ana Catarina Viana Valle ◽  
Lana Ribeiro Aguiar ◽  
Hilana dos Santos Sena Brunel ◽  
Patricia Furtado Malard ◽  
Carla Lujan Pereira Villarroel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Line ◽  
Culture Medium ◽  
Cancer Cell Line ◽  
Viscum Album ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

BACKGROUND Adenocarcinomas can be of several types, and MCF-7 is an adenocarcinoma of human breast cell line useful as preclinical model to screen therapeutic agents such as ultra-diluted Viscum album, an European plant whose extract is commonly used in cancer therapy. AIMS MCF-7 and mesenchymal stem cells were used to evaluate the in vitro cytotoxicity of homoeopathic Viscum album 1x10-3 (VAD3). METHODS cells were cultured for 24 hours in controlled environment (37.5oC and 5% CO2) in 96-well plates. After this time, VAD3 was added to the culture medium in concentrations varying from 10 to 100 ?L/mL for MTT assay (evaluation of viability of cells). A control group was maintained with culture medium only. After 48 hours, the procedures of analysis of cells viability were performed. RESULTS MTT assay showed that the concentrations of 42 ?L/mL and 62 ?L/mL were able to reduce cell viability to 50% in MCF-7 and mesenchymal stem cells, respectively, which means that half of the cells cultured were dead after 48 hours in contact with VAD3. CONCLUSION Viscum album presented higher cytotoxic action on human breast cancer cell line culture than on mesenchymal stem cells. This medicine is extensively used against cancer, and the use of the homoeopathic form of it brings new possibilities as no or fewer adverse effects would be present.

Diethylenetriamine Pentaacetic Acid Derivative of Toremifene and In Vitro Evaluation in Human Breast Cancer Cell Line MCF-7

2011 ◽  
Vol 26 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Ayfer Yurt Kilcar ◽  
F. Zumrut Biber Muftuler ◽  
Perihan Unak ◽  
Cigir Biray Avci ◽  
Cumhur Gunduz
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Acid Derivative ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

In vitro andin vivo modulation of growth regulation in the human breast cancer cell line MCF-7 by estradiol metabolites

Breast Cancer ◽  
1999 ◽  
Vol 6 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Akihiko Suto ◽  
Nitin T. Telang ◽  
Hirokazu Tanino ◽  
Toshio Takeshita ◽  
Harumi Ohmiya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Growth Regulation ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Estradiol Metabolites ◽  
Mcf 7

SYNTHESIS AND EVALUATION OF NOVEL CHEMICAL ENTITIES AS ANTI-BREAST CANCER AGENTS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (12) ◽  
pp. 28-31
Author(s):  
D Nikam ◽  
◽  
S. Tanvar ◽  
A Kute ◽  
S Lokhande ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Aromatic Aldehydes ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Compound I ◽  
Green Method ◽  
Mcf 7

A series of dihydropyrimidone derivatives was synthesized by an efficient, simple and solvent less green method by using Beginelli reaction. Various aromatic aldehydes, urea and ethyl acetoacetate were refluxed for a few hours and the reaction monitored by periodic TLC (hexane: ethyl acetate 6:4 v/v) and products are purified by recrystallization, with characterization by FTIR, 1H NMR. All the purified compounds were subjected to evaluatation by in vitro human breast cancer cell line MDA-MB-231 and MCF-7. Compound I-k was found to be moderately active against MCF-7 with GI 50 value of -4.38.

scholarly journals Design, Molecular Modeling and Synthesis of Some New Purine-diones and Pyridopyrimidine-diones with Anticancer Activity

2017 ◽  
Vol 13 (2) ◽  
pp. 5959-5976
Author(s):  
Alaa M. Hayallah
Keyword(s):  
Anticancer Activity ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Inhibition Activity ◽  
Human Breast ◽  
Reference Drug ◽  
Elemental Analyses ◽  
New Compounds ◽  
Mcf 7

An olomoucine analogues of 2-[(1-substituted)-2,6-dioxo-2,3,6,7–tetrahydro-1H-purin-8-ylsulfanyl]-N-substituted acetamide 6a-g and 7a-g, 1-substituted-8-[2-(4-substituted phenyl)-2-oxoethylsulphanyl]-3,7-dihydro-1H-purine-2,6-diones 9a-g and 10a-g, 3-(2-substituted benzyl)-6-(4-substituted phenyl)-1H-thiazolo[2,3-f]purine-2,4-dione 11a-g and 12a-g and their isosteres 3-substituted benzyl-5-methyl-7-substituted-1H-pyrido[2,3-d]pyrimidine-2,4-dione 13a-c and 14a-c were designed and synthesized. The target compounds 11a-g and 12a-g were prepared by cyclodehydration of 9a-g and 10a-g in PPA, while 13a-c and 14a-c were synthesized by condensation of 6-amino-3-(2-substituted benzyl)-1H-pyrimidine-2,4-dione 1a or 1b and the appropriate acylacetone in glacial acetic acid. Structures of the new compounds were verified on the basis of their IR, 1H NMR, MS, HRMS and elemental analyses. The newly synthesized compounds were tested for their anticancer activity and most of the tested compounds showed good to excellent inhibition activity against the tested human breast cancer cell line MCF-7 in comparison to doxorubicin as a reference drug. KEYWORDS: olomoucine; cyclin-depenent kinase; synthesis; anticancer  

Synthesis and characterization of novel bis(pyridine-2(1H)-thiones) and their bis(2-methylsulfanylpyridines) incorporating 2,6-dibromophenoxy moiety

2019 ◽  
Vol 97 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Sherif M.H. Sanad ◽  
Azza M. Abdel-Fattah ◽  
Fawzy A. Attaby ◽  
Mohamed A.A. Elneairy
Keyword(s):  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Cyanoacetic Acid ◽  
Elemental Analyses ◽  
Hydrazide Derivative ◽  
Target Molecules ◽  
Cyanoacetic Acid Hydrazide ◽  
Active Methylene

The novel 1,4-bis(2,6-dibromo-4-formylphenoxy)butane (3), prepared from 3,5-dibromobenzaldehyde (1), reacted with different hydrazines 4a–4d and active methylene containing compounds 9a–9d to give the corresponding bis(hydrazones) 5a–5d and bis(cinnamonitriles) 11a–11d, respectively. Both bis(2-cyanoacetic acid hydrazide) derivative 5d and bis(thioacrylamide) derivative 11a were taken as synthetic precursors for the synthesis of the target molecules bis(pyridine-2(1H)-thione) derivative 10 and 13a–13c and their bis(2-methylsulfanylpyridine) derivative 14 and 17a–17c. Another synthetic route was designed to prepare the target molecules 14 and 17a–17c in a better yield using pyridine-2(1H)-thione) derivative 15 and 19a–19c. Characterization of the newly prepared compounds via elemental analyses and spectral data are established.

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