scholarly journals Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
C. Pellicoro ◽  
R. Marsella ◽  
K. Ahrens
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Barrier Function ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Naturally Occurring

scholarly journals Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ju-Yong Park ◽  
Seon-Myeong Kim ◽  
Jung-Hyun Kim
Keyword(s):  
Atopic Dermatitis ◽  
Relative Abundance ◽  
Barrier Function ◽  
Therapeutic Option ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Canine Atopic Dermatitis ◽  
Allergic Skin

The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.

16437 Effects of cleansing on skin barrier function in atopic dermatitis and healthy skin: A pilot study

2020 ◽  
Vol 83 (6) ◽  
pp. AB63
Author(s):  
Aleksi J. Hendricks ◽  
Bryan W. Kromenacker ◽  
Alyssa Thompson ◽  
Elizabeth I. Mata ◽  
Catherine M. Ludwig ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Healthy Skin

scholarly journals Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis

2012 ◽  
Vol 13 (2) ◽  
pp. 187 ◽  
Author(s):  
Eui-Hwa Nam ◽  
Seol-Hee Park ◽  
Ji-Young Jung ◽  
Seung-Hee Han ◽  
Hwa-Young Youn ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function

Pilot study using five methods to evaluate skin barrier function in healthy dogs and in dogs with atopic dermatitis

2019 ◽  
Vol 30 (2) ◽  
pp. 121-e34 ◽  
Author(s):  
Danielle Cobiella ◽  
Linda Archer ◽  
Mary Bohannon ◽  
Domenico Santoro
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Healthy Dogs

scholarly journals The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers

2015 ◽  
Vol 4 ◽  
Author(s):  
Frank Looringh van Beeck ◽  
Adrian Watson ◽  
Margriet Bos ◽  
Vincent Biourge ◽  
Ton Willemse
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
First Year ◽  
Environmental Allergen ◽  
Major Route ◽  
Labrador Retrievers

AbstractWe investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their subsequent litters (up to 1 year of age) were fed either supplemented or unsupplemented diets. Nutrients supplemented were nicotinamide, pantothenate, histidine, inositol and choline. Circulating IgE levels to dust mute allergens Der f and Der p were measured when the puppies were 6 and 12 months old. Two owner questionnaires were used to assess the occurrence of typical signs associated with atopic dermatitis when dogs were between the ages of 22 and 36, and 34 and 48 months. Using linear mixed models we observed higher levels of circulating anti-Der f (P = 0·021) and -Der p IgE (P = 0·01) during the first year in the dogs fed the unsupplemented than in those fed the supplemented diet. The owner-assessed incidence of atopic dermatitis signs amongst the dogs was significantly greater in the unsupplemented group at the time of the second follow-up questionnaire (10/33 dogs v. 2/24 dogs). These outcomes suggest that a nutritionally derived improvement to barrier function early in life may reduce the frequency of signs associated with atopic dermatitis. The effect is possibly the result of making the epidermis, now thought to be a major route of environmental allergen exposure, more resistant to penetration.

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