scholarly journals Evaluation of Therapeutic Intervention with a Natural Product in Cutaneous Wound Healing: The Use of Capybara Oil

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Polyana Cury Marinho ◽  
Rodrigo Neto-Ferreira ◽  
Jorge José de Carvalho
Keyword(s):  
Wound Healing ◽  
Mast Cells ◽  
Tissue Repair ◽  
Polymorphonuclear Leukocytes ◽  
Elastic Fibers ◽  
South American ◽  
Skin Wounds ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
American Medicine

Capybara oil is commonly used for cutaneous wound healing in traditional South American medicine, although its beneficial effect has never been experimentally proven. The aim of this study was to investigate the effects of the topical application of capybara oil on skin wounds in Swiss mice. The following characteristics of the wounds were observed and evaluated: wound contraction and reepithelialization, the number of polymorphonuclear leukocytes and mast cells, the thickness of the neoepidermis, and the distribution of collagen and elastic fibers. Our study showed that oil extracted from subcutaneous capybara fat was beneficial for wound healing, indicating that capybara oil plays an important role in promoting tissue repair.

scholarly journals MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Huiyi Tang ◽  
Xueer Wang ◽  
Min Zhang ◽  
Yuan Yan ◽  
Simin Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Luciferase Reporter ◽  
Skin Wounds ◽  
Cutaneous Wound Healing ◽  
Mirna Regulation ◽  
Cutaneous Wound ◽  
Cutaneous Wounds ◽  
Keratinocyte Migration ◽  
Epithelial Plasticity ◽  
Tgf Β1

Abstract Cutaneous wound healing is pivotal for human skin to regain barrier function against pathogens. MicroRNAs (miRNAs) have been found to play regulatory roles in wound healing. However, the mechanism of miRNA regulation remains largely unknown. In this study, we focused on microRNA-200b/c-3p (miR-200b/c-3p) whose expression was abundant in intact epidermis, but dramatically decreased in skin wounds. In silico prediction identified RAC1 as a potential miR-200b/c-3p target. Luciferase reporter assay confirmed that miR-200b/c-p repressed RAC1 by direct targeting to its mRNA 3′UTR. Consistently, miR-200b/c-3p expression was discordantly related to RAC1 protein level during wound healing. Forced miR-200b/c-3p expression repressed RAC1 and inhibited keratinocyte migration as well as re-epithelialization in a mouse back skin full-thickness wound healing model. Mechanistically, miR-200b/c-3p modulated RAC1 to inhibit cell migration by repressing lamellipodia formation and intercellular adhesion dissolution in keratinocytes. Furthermore, we found that TGF-β1, which was highly expressed in skin wounds, contributed to the downregulation of miR-200b/c-3p in wound edge keratinocytes. Taken together, miR-200b/c-3p-mediated RAC1 repression inhibited keratinocyte migration to delay re-epithelialization. TGF-β1 induction attenuated miR-200b/c-3p regulation of RAC1 signaling in cutaneous wounds and the repression of miR-200b/c-3p accelerated keratinocyte migration to promote wound healing. Our data provide new insight into how miR-200b/c-3p affects keratinocyte migration and highlight the potential of miR-200b/c-3p targeting for accelerating wound healing.

scholarly journals Mast cells and their mediators in cutaneous wound healing ? active participants or innocent bystanders?

1999 ◽  
Vol 8 (1) ◽  
pp. 1-16 ◽  
Author(s):  
M. Artuc ◽  
B. Hermes ◽  
U. M. Stckelings ◽  
A. Grützkau ◽  
B. M. Henz
Keyword(s):  
Wound Healing ◽  
Mast Cells ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Isabgol–silk fibroin 3D composite scaffolds as an effective dermal substitute for cutaneous wound healing in rats

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73617-73626 ◽  
Author(s):  
Thangavel Ponrasu ◽  
Pagidipally Vishal ◽  
Ramya Kannan ◽  
Lonchin Suguna ◽  
Vignesh Muthuvijayan
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Freeze Drying ◽  
Dermal Substitute ◽  
Cutaneous Wound Healing ◽  
Drying Method ◽  
Bioactive Substances ◽  
Cutaneous Wound ◽  
Psyllium Husk ◽  
3D Composite

Psyllium husk based silk 3D scaffolds were developed via freeze drying method without adding any bioactive substances to enhance tissue repair during cutaneous wound healing in rats.

Regulatory roles of androgens in cutaneous wound healing

2003 ◽  
Vol 90 (12) ◽  
pp. 978-985 ◽  
Author(s):  
Stephen Gilliver ◽  
Fred Wu ◽  
Gillian Ashcroft
Keyword(s):  
Wound Healing ◽  
Androgen Receptor ◽  
Tissue Repair ◽  
Systemic Treatment ◽  
Current Knowledge ◽  
Inflammatory Cells ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Repair Processes ◽  
Androgen Receptor Antagonist

SummaryAlthough the effects of androgens on wound healing are poorly characterised, the androgen receptor is expressed by inflammatory cells, keratinocytes and fibroblasts during wound healing, suggesting that androgens may regulate inflammatory and/or repair processes. In fact, it appears that endogenous testosterone inhibits wound healing and promotes inflammation since castration of male mice or systemic treatment with the androgen receptor antagonist flutamide accelerates cutaneous wound healing and reduces the inflammatory response. The aim of this review is to summarise our current knowledge about the regulation of tissue repair processes by androgens.

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time
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