scholarly journals Vibrio parahaemolyticusInduced Necrotizing Fasciitis: An Atypical Organism Causing an Unusual Presentation

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Asim Ahmad ◽  
Lisa Brumble ◽  
Michael Maniaci
Keyword(s):  
Bacterial Infection ◽  
Necrotizing Fasciitis ◽  
Vibrio Parahaemolyticus ◽  
Subcutaneous Tissue ◽  
Treatment Strategies ◽  
Disease Process ◽  
Initial Presentation ◽  
Unusual Presentation ◽  
Life Threatening

Background necrotizing fasciitis (NF) represents a life-threatening bacterial infection characterized by a rapid necrosis of deep subcutaneous tissue and facia underlying the skin. Despite its lethal nature, NF occurs infrequently, leaving many physicians unfamiliar with the disease process, common pathogens, and treatment strategies. Here we present a case of NF caused by an unlikely organism,Vibrio parahaemolyticus. We highlight the innocuous nature of initial presentation and the potentially devastating sequela.

scholarly journals Necrotizing Fasciitis of the Nose Complicated with Cavernous Sinus Thrombosis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
D. Swaminath ◽  
R. Narayanan ◽  
M. A. Orellana-Barrios ◽  
B. Temple
Keyword(s):  
Bacterial Infection ◽  
Necrotizing Fasciitis ◽  
Cavernous Sinus ◽  
Sinus Thrombosis ◽  
Subcutaneous Tissue ◽  
Cavernous Sinus Thrombosis ◽  
Early Use ◽  
The Face ◽  
Life Threatening ◽  
Empirical Antibiotics

Necrotizing fasciitis is a rapidly progressive life threatening bacterial infection of the skin, the subcutaneous tissue, and the fascia. We present a case of necrotizing fasciitis involving the nose complicated by cavernous sinus thrombosis. Few cases of septic cavernous sinus thrombosis have been reported to be caused by cellulitis of the face but necrotizing fasciitis of the nose is rare. It is very important to recognize the early signs of cavernous thrombosis. Treatment for septic cavernous sinus thrombosis is controversial but early use of empirical antibiotics is imperative.

scholarly journals Pyelonephritis can be a source of a life threatening necrotizing myofasciitis

2014 ◽  
Vol 8 (5-6) ◽  
pp. 462
Author(s):  
Haytham Kamel ◽  
Mohamed Soliman Edris Awed ◽  
Ahmed Fouad Kotb
Keyword(s):  
Necrotizing Fasciitis ◽  
Adult Male ◽  
Soft Tissues ◽  
Subcutaneous Tissue ◽  
Relevant Literature ◽  
Deep Fascia ◽  
Necrotizing Myositis ◽  
Life Threatening

Necrotizing fasciitis is a progressive, rapidly spreading, inflammatory infection located in deep fascia. It may cause necrosis of skin and subcutaneous tissue and can even result in involvement of adjacent soft tissues such as muscles resulting in necrotizing myositis. We report the case of an adult male presenting with necrotizing myofasciitis secondary to left pyelonephritis. We also review the relevant literature.

scholarly journals Necrotizing Fasciitis of Face in Odontogenic Infection: A Rare Clinical Entity

2012 ◽  
Vol 3 (3) ◽  
pp. 261-264 ◽  
Author(s):  
GK Vivek ◽  
Ranjith Singh ◽  
GC Veena ◽  
Prappanna Arya
Keyword(s):  
Necrotizing Fasciitis ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Odontogenic Infection ◽  
Clinical Entity ◽  
Rare Clinical Entity ◽  
Head And Neck Region ◽  
The Face ◽  
Life Threatening ◽  
Group A

ABSTRACT Necrotizing fasciitis is a progressive, life-threatening, bacterial infection of the skin, the subcutaneous tissue and the underlying fascia, in most cases caused by β-hemolytic group A Streptococcus. Only early diagnosis and aggressive therapy including broad spectrum antibiotics and surgical intervention can avoid systemic toxicity with a high mortality rate. This disease is commonly known to occur in the lower extremities and trunk, and only rarely in the head and neck region, the face being rarest finding. When located in the face necrotizing fasciitis is associated with severe cosmetic and functional complication due to the invasive nature, infection and often due to the necessary surgical treatment. In the following article, we present the successful diagnosis and management of an isolated facial necrotizing fasciitis as a consequence of odontogenic infection. How to cite this article Vivek GK, Singh R, Veena GC, Arya P. Necrotizing Fasciitis of Face in Odontogenic Infection: A Rare Clinical Entity. World J Dent 2012;3(3):261-264.

scholarly journals Necrotizing Fasciitis of The Abdominal Wall Following Colonoscopy with Fatal Outcome - A Case Report

2019 ◽  
pp. 1-3
Author(s):  
Daniel Matz ◽  
Oleg Heizmann
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Soft Tissue Infection ◽  
Group A Streptococcus ◽  
Subcutaneous Tissue ◽  
Fatal Outcome ◽  
Anaerobic Bacteria ◽  
Tissue Infection ◽  
Life Threatening ◽  
Staphylococcus Spp

Necrotizing fasciitis (NF) is a serious and potentially life threatening soft tissue infection, usually caused by different types of bacteria such as group A streptococcus, staphylococcus spp. (type 1 infection) or mixed infection by aerobic and anaerobic bacteria (type 2 infection). Usually, the infection arises from skin injury, in injections or surgical procedures and effects the fascia as well as the subcutaneous tissue. Overwhelming progression and difficulties in diagnosing are very common. Mortality rate is up to 100% depending on the type of soft tissue infection and did not markedly decrease in the past decades [1]. Here we present a case of NF with fatal outcome following colonoscopy, which was primarily suspected to be a post polypectomy syndrome.

scholarly journals Streptococcus pyogenes Transcriptome Changes in the Inflammatory Environment of Necrotizing Fasciitis

2019 ◽  
Vol 85 (21) ◽  
Author(s):  
Yujiro Hirose ◽  
Masaya Yamaguchi ◽  
Daisuke Okuzaki ◽  
Daisuke Motooka ◽  
Hiroshi Hamamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Necrotizing Fasciitis ◽  
Treatment Strategies ◽  
Oxidative Stress Response ◽  
Rna Seq ◽  
Content Type ◽  
Novel Treatment ◽  
Life Threatening ◽  
Novel Treatment Strategies ◽  
Bacterial Genes

ABSTRACT Streptococcus pyogenes is a major cause of necrotizing fasciitis, a life-threatening subcutaneous soft-tissue infection. At the host infection site, the local environment and interactions between the host and bacteria have effects on bacterial gene expression profiles, while the gene expression pattern of S. pyogenes related to this disease remains unknown. In this study, we used a mouse model of necrotizing fasciitis and performed RNA-sequencing (RNA-seq) analysis of S. pyogenes M1T1 strain 5448 by isolating total RNA from infected hind limbs obtained at 24, 48, and 96 h postinfection. RNA-seq analysis results identified 483 bacterial genes whose expression was consistently altered in the infected hindlimbs compared to their expression under in vitro conditions. Genes showing consistent enrichment during infection included 306 encoding molecules involved in virulence, carbohydrate utilization, amino acid metabolism, trace-metal transport, and the vacuolar ATPase transport system. Surprisingly, drastic upregulation of 3 genes, encoding streptolysin S precursor (sagA), cysteine protease (speB), and secreted DNase (spd), was noted in the present mouse model (log2 fold change, >6.0, >9.4, and >7.1, respectively). Conversely, the number of consistently downregulated genes was 177, including those associated with the oxidative stress response and cell division. These results suggest that in necrotizing fasciitis, S. pyogenes shows an altered metabolism, decreased cell proliferation, and upregulation of expression of major toxins. Our findings are considered to provide critical information for developing novel treatment strategies and vaccines for necrotizing fasciitis. IMPORTANCE Necrotizing fasciitis, a life-threatening subcutaneous soft-tissue infection, is principally caused by S. pyogenes. The inflammatory environment at the site of infection causes global gene expression changes for survival of the bacterium and pathogenesis. However, no known study regarding transcriptomic profiling of S. pyogenes in cases of necrotizing fasciitis has been presented. We identified 483 bacterial genes whose expression was consistently altered during infection. Our results showed that S. pyogenes infection induces drastic upregulation of the expression of virulence-associated genes and shifts metabolic pathway usage. In particular, high-level expression of toxins, such as cytolysins, proteases, and nucleases, was observed at infection sites. In addition, genes identified as consistently enriched included those related to metabolism of arginine and histidine as well as carbohydrate uptake and utilization. Conversely, genes associated with the oxidative stress response and cell division were consistently downregulated during infection. The present findings provide useful information for establishing novel treatment strategies.

scholarly journals Transcriptomic profiling of Streptococcus pyogenes M1T1 strain in a mouse model of necrotizing fasciitis

2019 ◽  
Author(s):  
Yujiro Hirose ◽  
Masaya Yamaguchi ◽  
Daisuke Okuzaki ◽  
Daisuke Motooka ◽  
Hiroshi Hamamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Necrotizing Fasciitis ◽  
Streptococcus Pyogenes ◽  
Treatment Strategies ◽  
Rna Seq ◽  
Novel Treatment ◽  
Genes Encoding ◽  
Life Threatening ◽  
Novel Treatment Strategies

AbstractStreptococcus pyogenes is a major cause of necrotizing fasciitis, a life-threatening subcutaneous soft-tissue infection. At the host infection site, the local environment and interaction between host and bacteria affect bacterial gene-expression profiles, but the S. pyogenes gene-expression pattern in necrotizing fasciitis remains unknown. In this study, we used a mouse model of necrotizing fasciitis and performed RNA-sequencing (RNA-seq) analysis of S. pyogenes M1T1 strain 5448 by using infected hindlimbs obtained at 24, 48, and 96 h post-infection. The RNA-seq analysis identified 483 bacterial genes whose expression was consistently altered in the infected hindlimbs as compared to their expression under in vitro conditions. The consistently enriched genes during infection included 306 genes encoding molecules involved in virulence, carbohydrate utilization, amino acid metabolism, trace-metal transport and vacuolar ATPase transport system. Surprisingly, drastic upregulation of 3 genes, encoding streptolysin S precursor (sagA), cysteine protease (speB), and secreted DNase (spd), was noted in the mouse model of necrotizing fasciitis (log2 fold-change values: >6.0, >9.4, and >7.1, respectively). Conversely, the consistently downregulated genes included 177 genes, containing genes associated with oxidative-stress response and cell division. These results suggest that S. pyogenes in necrotizing fasciitis changes its metabolism, decreases cell proliferation, and upregulates the expression of major toxins. Our findings could provide critical information for developing novel treatment strategies and vaccines for necrotizing fasciitis.Author summaryNecrotizing fasciitis, a life-threatening subcutaneous soft-tissue infection, principally caused by a Streptococcus pyogenes. At infection sites in hosts, bacterial pathogens are exposed to drastically changing environmental conditions and alter global gene expression patterns for survival and pathogenesis. However, there is no previous report about transcriptomic profiling of S. pyogenes in the necrotizing fasciitis. Here, we conducted comprehensive gene-expression analyses of S. pyogenes in the mouse model of necrotizing fasciitis at three distinct time points during infection. Our results indicated that S. pyogenes drastically upregulates the expression of virulence-associated genes and shifts metabolic-pathway usage during infection. The high-level expressions in particular of toxins, such as cytolysins, proteases, and nucleases, were observed at infection sites. In addition, the consistently enriched genes identified here included genes for metabolism of arginine and histidine, and carbohydrate uptake and utilization. Conversely, the genes associated with oxidative-stress response and cell division were consistently downregulated in the mouse model of necrotizing fasciitis. These data will provide useful information necessary for establishing novel treatment strategies (166 words).

scholarly journals Necrotizing Fasciitis: a Clinical Case and a Review of the Literature

2020 ◽  
Vol 12 (4) ◽  
pp. 141-146
Author(s):  
Ivanka Danchova Temelkova ◽  
Yordan Stoyanov Milev ◽  
Zhasmina Krasimirova Garkova ◽  
Tsveta Ivanova Kalinova ◽  
Zhenya Krasimirova Dimitrova ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Early Diagnosis ◽  
Necrotizing Fasciitis ◽  
Severe Pain ◽  
Clinical Case ◽  
Subcutaneous Tissue ◽  
Good Prognosis ◽  
Review Of The Literature ◽  
Fatal Course ◽  
Life Threatening

Abstract Necrotizing fasciitis is a soft tissue, life-threatening infection with a fulminant and often fatal course. Early diagnosis is usually delayed as the onset of the disease is often masked in the form of erysipelas or cellulite. The condition is characterized by necrosis of the skin, subcutaneous tissue and underlying fascia. We describe a case of a 42-year-old man with a complaint of erythema, fever and severe pain in his right leg 4 days before hospitalization. The patient was admitted and treated with a diagnosis of erysipelas. A few hours after admission, in connection with a drastic deterioration in the general condition and dermatological status, he was transferred to a purulentseptic ward with a fulminant picture of necrotizing fasciitis. Debridement and fasciotomy were performed successfully and timely. Good prognosis and survival in patients with NF correlate directly with the complex of measures. Appropriate antibiotics and intensive general support avoid massive systemic diffusion. Early and adequate surgical debridement and fasciotomy are associated with improved survival.

scholarly journals An Unusual Presentation of Ludwig’s Angina Complicated by Cervical Necrotizing Fasciitis: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kristelle Chueng ◽  
David J. Clinkard ◽  
Danny Enepekides ◽  
Yousef Peerbaye ◽  
Vincent Y. W. Lin
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Literature Review ◽  
Necrotizing Fasciitis ◽  
Disease Process ◽  
Unusual Presentation ◽  
Airway Compromise ◽  
Review Of The Literature ◽  
Ludwig’S Angina ◽  
Ludwig's Angina

Ludwig’s angina can seldom be complicated by necrotizing fasciitis. Due to the rapidly progressing nature of this infection and the potential for airway compromise and death, it is important to be aware of different ways in which this disease process can present in order to recognize and treat it emergently. We report here an unusual presentation of a case of Ludwig’s angina complicated by necrotizing fasciitis in an elderly patient. The clinical features, diagnosis, and treatment are discussed in detail as well as a brief literature review on craniocervical necrotizing fasciitis.

Fatal Necrotizing Fasciitis as a Consequence of Blunt Trauma: A Case Report

2021 ◽  
Vol 11 (3) ◽  
pp. 170-173
Author(s):  
Chandrakanth HV ◽  
Hemanth Kumar RG ◽  
Smitha Rani
Keyword(s):  
Case Report ◽  
Antibiotic Therapy ◽  
Bacterial Infection ◽  
Necrotizing Fasciitis ◽  
Subcutaneous Tissue ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Clinical Signs And Symptoms ◽  
Medicolegal Issues ◽  
Early Debridement

Necrotizing fasciitis is an uncommon lethal bacterial infection that involves the subcutaneous tissue and fascia. It can be mono or polymicrobial infection. The diagnosis is mainly dependent on clinical signs and symptoms. Trauma is the commonest cause for it. The early signs and symptoms may mimic cellulitis. We present a case of necrotizing fasciitis following an assault. The patient was received in a state of shock. Despite all measures, the patient could not be saved. Early debridement and antibiotic therapy have a key role in the prognosis of the disease. Medicolegal issues can arise when the disease develops post-assault because of the vague and unpredictable nature of the disease and its challenging prognosis.

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