scholarly journals Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Ali Aydin ◽  
Hatice Pinarbasi ◽  
Mustafa Gurelik
Keyword(s):  
Brain Tumor ◽  
Genetic Susceptibility ◽  
Gene Polymorphisms ◽  
Epoxide Hydrolase ◽  
Population Analysis ◽  
Primary Brain Tumor ◽  
Tumor Patients ◽  
Tumor Susceptibility ◽  
Pcr Rflp ◽  
History Of

mEH is a critical biotransformation enzyme that catalyzes the conversion of xenobiotic epoxide substrates into more polar diol metabolites: it is also capable of inactivating a large number of structurally different molecules. Two polymorphisms affecting enzyme activity have been described in the exon 3 and 4 of the mEH gene. The hypothesis of this study is that inherent genetic susceptibility to a primary brain tumor is associated with mEH gene polymorphisms. The polymorphisms of the mEH gene were determined with PCR-RFLP techniques and 255 Turkish individuals. Our results indicate that the frequency of the mEH exon 4 polymorphism (in controls) is significantly higher than that of primary brain tumor patients (OR = 1.8, 95% CI = 1.0–3.4). This report, however, failed to demonstrate a significant association between mEH exon 3 polymorphism and primary brain tumor susceptibility in this population. Analysis of patients by both histological types of primary brain tumor and gene variants showed no association, although analysis of family history of cancer between cases and controls showed a statistically significant association (χ2=7.0, P=0.01). Our results marginally support the hypothesis that genetic susceptibility to brain tumors may be associated with mEPHX gene polymorphisms.

Swallowing assessment in primary brain tumor patients with dysphagia

Neurology ◽  
1994 ◽  
Vol 44 (10) ◽  
pp. 1927-1927 ◽  
Author(s):  
H. B. Newton ◽  
C. Newton ◽  
D. Pearl ◽  
T. Davidson
Keyword(s):  
Brain Tumor ◽  
Primary Brain Tumor ◽  
Tumor Patients ◽  
Swallowing Assessment

scholarly journals Primary brain tumor patients admitted to a US intensive care unit: a descriptive analysis

CNS Oncology ◽  
2021 ◽  
pp. CNS77
Author(s):  
Jennifer H Kang ◽  
Christa B Swisher ◽  
Evan D Buckley ◽  
James E Herndon ◽  
Eric S Lipp ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Brain Tumor ◽  
Hematological Malignancies ◽  
Descriptive Analysis ◽  
Primary Brain Tumor ◽  
Icu Mortality ◽  
Tumor Patients ◽  
Common Indication ◽  
Better Than

Purpose: To describe our population of primary brain tumor (PBT) patients, a subgroup of cancer patients whose intensive care unit (ICU) outcomes are understudied. Methods: Retrospective analysis of PBT patients admitted to an ICU between 2013 to 2018 for an unplanned need. Using descriptive analyses, we characterized our population and their outcomes. Results: Fifty-nine PBT patients were analyzed. ICU mortality was 19% (11/59). The most common indication for admission was seizures (n = 16, 27%). Conclusion: Our ICU mortality of PBT patients was comparable to other solid tumor patients and the general ICU population and better than patients with hematological malignancies. Further study of a larger population would inform guidelines for triaging PBT patients who would most benefit from ICU-level care.

Gender difference in relation to depression and quality of life among patients with a primary brain tumor

2006 ◽  
Vol 21 (3) ◽  
pp. 194-199 ◽  
Author(s):  
Arja Mainio ◽  
Helinä Hakko ◽  
Asko Niemelä ◽  
John Koivukangas ◽  
Pirkko Räsänen
Keyword(s):  
Quality Of Life ◽  
Brain Tumor ◽  
Functional Status ◽  
Primary Brain Tumor ◽  
Karnofsky Performance Scale ◽  
Tumor Patients ◽  
The Relationship ◽  
Depressive Patients ◽  
Performance Scale

AbstractObjective. –We studied the relationship between depressive symptoms and quality of life (QOL) as well as functional status in primary brain tumor patients at recurrent measurements. Differences in QOL between depressive and non-depressive samples by gender were controlled for tumor characteristics and patients' psychosocial factors.Materials and methods. –The data consisted of 77 patients with a primary brain tumor, 30 males and 47 females. Depression of the patients was assessed by Beck Depression Inventory (BDI) and Crown-Crisp Experiential Index (CCEI), functional status by Karnofsky Performance scale (KPS) and QOL by Sintonen's 15D before tumor operation as well as at 3 months and at 1 year from surgical operation of the tumor.Results.The level of QOL in females was lower compared to that of males. Depression was the main predictor for worse QOL in the patients at all measurements. Depressive patients with a benign brain tumor had significantly worse QOL versus non-depressive ones.Discussion and conclusion. –Decreased QOL was strongly related to depression, especially among patients with a benign brain tumor. Further studies are needed to find whether sufficient depression therapy improves the QOL of patients.

Somatization Symptoms Are Related to Right-Hemispheric Primary Brain Tumor: A Population-Based Prospective Study of Tumor Patients in Northern Finland

2009 ◽  
Vol 50 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Arja Mainio ◽  
Helinä Hakko ◽  
Asko Niemelä ◽  
John Koivukangas ◽  
Pirkko Räsänen
Keyword(s):  
Brain Tumor ◽  
Prospective Study ◽  
Population Based ◽  
Primary Brain Tumor ◽  
Tumor Patients

scholarly journals Input of molecular analysis in medical management of primary brain tumor patients

2015 ◽  
Vol 171 (6-7) ◽  
pp. 457-465
Author(s):  
A. Idbaih ◽  
A. Duran-Peña ◽  
C. Bonnet ◽  
F. Ducray
Keyword(s):  
Brain Tumor ◽  
Molecular Analysis ◽  
Medical Management ◽  
Primary Brain Tumor ◽  
Tumor Patients

Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study

2016 ◽  
Vol 131 (2) ◽  
pp. 385-391 ◽  
Author(s):  
Adomas Bunevicius ◽  
Edward R. Laws ◽  
Vytenis Deltuva ◽  
Arimantas Tamasauskas
Keyword(s):  
Quality Of Life ◽  
Brain Tumor ◽  
Pilot Study ◽  
Thyroid Hormone ◽  
Primary Brain Tumor ◽  
Tumor Patients
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