scholarly journals Modeling Complex Systems with Particles Refuge by Thermostatted Kinetic Theory Methods

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Carlo Bianca
Keyword(s):  
Mathematical Modeling ◽  
Kinetic Theory ◽  
Complex Systems ◽  
Future Research ◽  
Research Perspectives

This paper is concerned with the mathematical modeling of complex systems characterized by particles refuge. Specifically the paper focuses on the derivation and moments analysis of thermostatted kinetic frameworks with conservative and nonconservative interactions for closed and open complex systems at nonequilibrium. Applications and future research perspectives are discussed in the last section of the paper.

scholarly journals Special Issue “Kinetic Theory and Swarming Tools to Modeling Complex Systems—Symmetry problems in the Science of Living Systems”—Editorial and Research Perspectives

Symmetry ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 456
Author(s):  
Nicola Bellomo ◽  
Damián A. Knopoff ◽  
Pietro Terna
Keyword(s):  
Kinetic Theory ◽  
Complex Systems ◽  
Collective Learning ◽  
Living Systems ◽  
Theory Approach ◽  
Vehicular Traffic ◽  
Modeling And Simulations ◽  
Special Issue ◽  
Research Perspectives

This editorial paper presents a special issue devoted to the development of mathematical tools from kinetic and swarms theory to the modeling and simulations of the dynamics of living systems constituted by very many interacting living entities. Applications refer to several fields: collective learning, behavioral economy, multicellular systems, vehicular traffic, and human crowds. A forward look to research perspectives is focused on the conceptual links between swarms methods and the kinetic theory approach.

LOOKING FOR NEW PARADIGMS TOWARDS A BIOLOGICAL-MATHEMATICAL THEORY OF COMPLEX MULTICELLULAR SYSTEMS

2006 ◽  
Vol 16 (07) ◽  
pp. 1001-1029 ◽  
Author(s):  
NICOLA BELLOMO ◽  
GUIDO FORNI
Keyword(s):  
Kinetic Theory ◽  
Complex Systems ◽  
Critical Analysis ◽  
Mathematical Theory ◽  
Classical Mechanics ◽  
Biological Functions ◽  
Living Matter ◽  
Research Perspectives ◽  
Active Particles ◽  
Large Systems

This paper deals with the development of new paradigms based on the methods of the mathematical kinetic theory for active particles to model the dynamics of large systems of interacting cells. Interactions are ruled, not only by laws of classical mechanics, but also by a few biological functions which are able to modify the above laws. The paper technically shows, also by reasoning on specific examples, how the theory can be applied to model large complex systems in biology. The last part of the paper deals with a critical analysis and with the indication of research perspectives concerning the challenging target of developing a biological-mathematical theory for the living matter.

Decision support tools for oil spill response (OSR-DSTs): Approaches, challenges, and future research perspectives

2021 ◽  
Vol 167 ◽  
pp. 112313
Author(s):  
Zhaoyang Yang ◽  
Zhi Chen ◽  
Kenneth Lee ◽  
Edward Owens ◽  
Michel C. Boufadel ◽  
...  
Keyword(s):  
Decision Support ◽  
Oil Spill ◽  
Future Research ◽  
Decision Support Tools ◽  
Research Perspectives ◽  
Support Tools ◽  
Oil Spill Response

scholarly journals The use of Qualitative Comparative Analysis (QCA) to address causality in complex systems: a systematic review of research on public health interventions

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Benjamin Hanckel ◽  
Mark Petticrew ◽  
James Thomas ◽  
Judith Green
Keyword(s):  
Public Health ◽  
Comparative Analysis ◽  
Complex Systems ◽  
Qualitative Comparative Analysis ◽  
Complex Interventions ◽  
Health Interventions ◽  
Data Availability ◽  
Future Research ◽  
Public Health Interventions ◽  
Minimum Criteria

Abstract Background Qualitative Comparative Analysis (QCA) is a method for identifying the configurations of conditions that lead to specific outcomes. Given its potential for providing evidence of causality in complex systems, QCA is increasingly used in evaluative research to examine the uptake or impacts of public health interventions. We map this emerging field, assessing the strengths and weaknesses of QCA approaches identified in published studies, and identify implications for future research and reporting. Methods PubMed, Scopus and Web of Science were systematically searched for peer-reviewed studies published in English up to December 2019 that had used QCA methods to identify the conditions associated with the uptake and/or effectiveness of interventions for public health. Data relating to the interventions studied (settings/level of intervention/populations), methods (type of QCA, case level, source of data, other methods used) and reported strengths and weaknesses of QCA were extracted and synthesised narratively. Results The search identified 1384 papers, of which 27 (describing 26 studies) met the inclusion criteria. Interventions evaluated ranged across: nutrition/obesity (n = 8); physical activity (n = 4); health inequalities (n = 3); mental health (n = 2); community engagement (n = 3); chronic condition management (n = 3); vaccine adoption or implementation (n = 2); programme implementation (n = 3); breastfeeding (n = 2), and general population health (n = 1). The majority of studies (n = 24) were of interventions solely or predominantly in high income countries. Key strengths reported were that QCA provides a method for addressing causal complexity; and that it provides a systematic approach for understanding the mechanisms at work in implementation across contexts. Weaknesses reported related to data availability limitations, especially on ineffective interventions. The majority of papers demonstrated good knowledge of cases, and justification of case selection, but other criteria of methodological quality were less comprehensively met. Conclusion QCA is a promising approach for addressing the role of context in complex interventions, and for identifying causal configurations of conditions that predict implementation and/or outcomes when there is sufficiently detailed understanding of a series of comparable cases. As the use of QCA in evaluative health research increases, there may be a need to develop advice for public health researchers and journals on minimum criteria for quality and reporting.

scholarly journals Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression

2021 ◽  
Vol 22 (7) ◽  
pp. 3571
Author(s):  
Bonglee Kim ◽  
Ji-Eon Park ◽  
Eunji Im ◽  
Yongmin Cho ◽  
Jinjoo Lee ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Future Research ◽  
Clinical Implications ◽  
Research Perspectives ◽  
Current Review ◽  
Gold Silver ◽  
Significant Efficacy ◽  
Rapid Clearance

Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles), dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and gold/silver have contributed to imaging diagnosis and targeted cancer therapy. However, only some NP drugs, including Doxil® (liposome-encapsulated doxorubicin), Abraxane® (albumin-bound paclitaxel), and Oncaspar® (PEG-Asparaginase), have emerged on the pharmaceutical market to date. By contrast, several phytochemicals that were found to be effective in cultured cancer cells and animal studies have not shown significant efficacy in humans due to poor bioavailability and absorption, rapid clearance, resistance, and toxicity. Research to overcome these drawbacks by using phytochemical NPs remains in the early stages of clinical translation. Thus, in the current review, we discuss the progress in nanotechnology, research milestones, the molecular mechanisms of phytochemicals encapsulated in NPs, and clinical implications. Several challenges that must be overcome and future research perspectives are also described.

scholarly journals Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 49 ◽  
Author(s):  
André G. Buret ◽  
Simone M. Cacciò ◽  
Loïc Favennec ◽  
Staffan Svärd
Keyword(s):  
Cell Biology ◽  
Health Management ◽  
Giardia Duodenalis ◽  
Basic Research ◽  
Basic Knowledge ◽  
Future Research ◽  
World Knowledge ◽  
Main Research ◽  
Research Perspectives ◽  
New Findings

Although Giardia duodenalis is recognized as one of the leading causes of parasitic human diarrhea in the world, knowledge of the mechanisms of infection is limited, as the pathophysiological consequences of infection remain incompletely elucidated. Similarly, the reason for and consequences of the very specific genome-organization in this parasite with 2 active nuclei is only partially known. Consistent with its tradition, the 7th International Giardia and Cryptosporidium Conference (IGCC 2019) was held from June 23 to 26, 2019, at the Faculty of Medicine and Pharmacy of the University of Rouen-Normandie, France, to discuss current research perspectives in the field. This renowned event brought together an international delegation of researchers to present and debate recent advances and identify the main research themes and knowledge gaps. The program for this interdisciplinary conference included all aspects of host-parasite relationships, from basic research to applications in human and veterinary medicine, as well as the environmental issues raised by water-borne parasites and their epidemiological consequences. With regard to Giardia and giardiasis, the main areas of research for which new findings and the most impressive communications were presented and discussed included: parasite ecology and epidemiology of giardiasis, Giardia-host interactions, and cell biology of Giardia, genomes and genomic evolution. The high-quality presentations discussed at the Conference noted breakthroughs and identified new opportunities that will inspire researchers and funding agencies to stimulate future research in a “one health” approach to improve basic knowledge and clinical and public health management of zoonotic giardiasis.

The approach to patients with cognitive impairment and hip fracture: the role of orthogeriatric care

2014 ◽  
Vol 24 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Francisco J Tarazona-Santabalbina ◽  
Juan R Doménech-Pascual ◽  
Ángel Belenguer-Varea A ◽  
Eduardo Rovira Daudi
Keyword(s):  
Cognitive Impairment ◽  
Hip Fracture ◽  
Functional Recovery ◽  
Functional Outcomes ◽  
Older Patients ◽  
Future Research ◽  
Research Perspectives ◽  
Increased Risk ◽  
Risk Of Falls

SummaryHip fracture is very common among older patients, who are characterized by increased co-morbidities, including cognitive impairment. These patients have an increased risk of falls and fractures, poorer functional recovery and lower survival both in hospital and 12 months after discharge. We review the survival and functional outcomes of older patients with cognitive impairment and hip fracture managed in orthogeriatric units, and highlight the gaps in our knowledge of the efficacy and efficiency of specific orthogeriatric programmes for such patients and the future research perspectives in this field.

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