scholarly journals Effect ofNelumbo nuciferaPetal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chandrasekaran Chinampudur Velusami ◽  
Amit Agarwal ◽  
Vijayalakshmi Mookambeswaran
Keyword(s):  
Medicinal Plants ◽  
Lipase Activity ◽  
Methanol Extract ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Lipid Storage ◽  
Preclinical Models ◽  
Antagonist Activity ◽  
Water Extracts ◽  
Agonist And Antagonist

N. nuciferais one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals ofN. nuciferaby studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors. Both methanol and successive water extracts ofN. nuciferapetals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis.N. nuciferapetal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC50value of 47 µg/mL.N. nuciferapetal extracts showed evident agonist and antagonist activity towards 5-HT2Cand CNR2receptors, respectively, while it showed no effect towards MCHR1and MC4R receptors. Overall, methanol extract ofN. nuciferapetals showed better activity than successive water extract.

scholarly journals EFFICIENCY OF SOME PLANT EXTRACTS TO CONTROL OF PENICILLIUM ITALICUM WEHMER CAUSING BLUE MOLD ON LEMON FRUITS IN IRAQ

2019 ◽  
Vol 31 (1) ◽  
pp. 01-05
Author(s):  
Ahed A.H. Matloob ◽  
Hamid A A. Khafaji
Keyword(s):  
Plant Extracts ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Penicillium Italicum ◽  
Blue Mold ◽  
Lemon Fruit ◽  
Water Extracts ◽  
Wild Mustard ◽  
First Time ◽  
High Inhibitory Effect

The study aimed to evaluate the efficacy of the water extract of Propolis, Wild mustard and dates vinegar in the inhibition of Penicillium italicum causal agent of Blue mold on a lemon fruits. The results showed that all tested extracts with concentrations 5, 10 and 15% had a high inhibitory effect against P. italicum. Dates vinegar is highly effective and showed 100% inhibition of P. italicum and protected lemon fruit from infection. First time this type of natural inhibitory water extracts are used in Iraq which resulted that the dates vinegar is the best suitable option for the management of lemon blue mold disease in post-harvest.

scholarly journals Antifungal ability and decay resistance of Fokienia hodginsii heartwood extract and its inhibitory effect on Gloeophyllum trabeum

BioResources ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 2784-2799
Author(s):  
Jian-Fei Wu ◽  
Xue-Feng Zhuang ◽  
Hong-mei Yuan ◽  
Quan Li ◽  
Wei Wang ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Mass Loss Rate ◽  
Water Extract ◽  
Decay Resistance ◽  
Inhibitory Effect ◽  
Hot Water ◽  
Gloeophyllum Trabeum ◽  
Test Pieces ◽  
Hot Water Extract ◽  
Acetone Extracts

The inhibitory ability of Fokienia hodginsii heartwood (FHH) extracts on Trametes versicolor (TV) and Gloeophyllum trabeum (GT) as well as the toxic effect of its heartwood extracts on GT were studied. The growth inhibition ability of the samples was analyzed using the growth rate method. The results showed that in the experiment of inhibiting TV, extracts using hot water had little effect, acetone extracts had the best inhibiting effect, and the lowest value of acetone EC50 was 0.409 g/L. The parameter EC50 is the concentration of the corresponding agent that inhibits the growth of 50% fungi. In the antifungal experiment of GT, methanol extract had the best inhibition effect, and the lowest EC50 value was 0.283 g/L. The antifungal effect of five solvent extracts of FHH was good when the concentration was 10% (w/w), and at this time, the mass loss rate of the test pieces was below 11%, all of them were Class I, indicating a strong antifungal level. After observing the samples of GT with SEM, it was found that the structure of methanol extract treatment was more complete and the antiseptic effect was better than that of the hot water extract treatment.

scholarly journals Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants

2013 ◽  
Vol 21 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Hyun Sook Kim ◽  
Tae Woo Kim ◽  
Dae Jung Kim ◽  
Jae Sung Lee ◽  
Kyoung Kon Kim ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antioxidant Activities ◽  
Inhibitory Effect ◽  
Water Extracts ◽  
Effect Of Water

scholarly journals Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 163 ◽  
Author(s):  
Kouadio Ibrahime Sinan ◽  
Annalisa Chiavaroli ◽  
Giustino Orlando ◽  
Kouadio Bene ◽  
Gokhan Zengin ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Methanol Extract ◽  
Ethyl Acetate Extract ◽  
Hct116 Cell ◽  
Antioxidant Properties ◽  
Water Extract ◽  
Stem Bark ◽  
Scientific Data ◽  
Water Extracts ◽  
Bersama Abyssinica

In this study, ethyl acetate, methanol, and water extracts of Bersama abyssinica (Melianthaceae) stem bark were screened for enzyme inhibitory and antioxidant properties. The water extract possessed the highest concentration of phenols (230.83 mg gallic acid equivalent/g extract), while the methanol extract was rich in flavonoids (75.82 mg rutin equivalent/g extract), and the ethyl acetate extract possessed the highest amount of saponins (97.37 mg quillaja equivalent/g). The aim of this study was to investigate the antiproliferative effects against the human colon cancer HCT116 cell line challenged with serotonin (5-HT) as a stimulating-proliferation factor. The level of HCT116 cell-deriving pool of kynurenic acid (KA) was also assessed. The UHPLC results confirmed the presence of 58, 68, and 63 compounds in the ethyl acetate, methanol, and water extracts, respectively. Mangiferin, vitexin and its isomer isovitexin were tentatively identified in all extracts and KA (m/z 190.05042 [M−H]+) was also tentatively identified in the methanol and water extracts. The methanol extract (1464.08 mg Trolox equivalent [TE]/g extract) showed the highest activity in the CUPRAC assay, whereas the water extract (1063.70 mg TE/g extract) showed the highest activity with the FRAP technique. The ethyl acetate extract was the most active acetylcholinesterase (4.43 mg galantamine equivalent/g extract) and α-glucosidase (mmol acarbose equivalent /g extract) inhibitor. The water extract was able to inhibit 5-HT-stimulated viability of HCT116 cells, and blunt 5-HT-induced reduction of cell-deriving KA. The scientific data generated in this study provide baseline data regarding the biological properties of B. abyssinica stem bark, highlighting its potential use for the development of new pharmaceutic and cosmetic agents.

scholarly journals The correlation of metal content in medicinal plants and their water extracts

2013 ◽  
Vol 67 (4) ◽  
pp. 585-591 ◽  
Author(s):  
Sasa Randjelovic ◽  
Danijela Kostic ◽  
Aleksandra Zarubica ◽  
Snezana Mitic ◽  
Milan Mitic
Keyword(s):  
Medicinal Plants ◽  
Plant Material ◽  
Metal Content ◽  
Water Extract ◽  
Correlation Coefficients ◽  
Absorption Spectrometry ◽  
Water Extracts ◽  
Unpolluted Area ◽  
The Impact

The quality of some medicinal plants and their water extracts from South East Serbia is determined on the basis of metal content using atomic absorption spectrometry. The two methods were used for the preparation of water extracts, to examine the impact of the preparation on the content of metals in them. Content of investigated metals in both water extracts is markedly lower then in medicinal plants, but were higher in water extract prepared by method (I), with exception of lead content. The coefficients of extraction for the observed metal can be represented in the following order: Zn > Mn > Pb > Cu > Fe. Correlation coefficients between the metal concentration in the extract and total metal content in plant material vary in the range from 0.6369 to 0.9956. This indicates need the plants to be collected and grown in the unpolluted area and to examine the metal content. The content of heavy metals in the investigated medicinal plants and their water extracts is below the maximum allowable values, so they are safe to use.

scholarly journals In VitroScreening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Guillermo Ramírez ◽  
Miguel Zavala ◽  
Julia Pérez ◽  
Alejandro Zamilpa
Keyword(s):  
Medicinal Plants ◽  
Dose Response ◽  
Lipase Activity ◽  
Digestive Enzymes ◽  
Inhibitory Effect ◽  
Active Species ◽  
Significant Inhibition ◽  
Response Curves ◽  
Inhibitory Activities ◽  
Positive Controls

This work shows the inhibitory effect on glucosidase and lipase enzymes of 23 medicinal plants described as traditional treatments for diabetes in several Mexican sources. Hydroalcoholic extracts of selected plants were evaluated at 1 mg/mL for glucosidase and 0.25 mg/mL for lipase inhibitory activities, respectively.Camellia sinensis, acarbose, and orlistat were used as positive controls. Dose-response curves were done with the most active species. Sixty percent of all tested extracts inhibited more than 25% ofα-glucosidase activity.C. sinensisdisplayed an inhibition of 85% (IC50 = 299 μg/mL), whileLudwigia octovalvisandIostephane heterophyllashowed the highest inhibition (82.7 %, IC50 = 202 μg/mL and 60.6%, CI50 = 509 μg/mL, resp.). With respect to lipase activity,L. octovalvisandTecoma stanswere the most inhibiting treatments (31.4%, IC50 = 288 μg/mL; 27.2%, IC50 = 320 μg/mL), whileC. sinensisdisplayed 45% inhibition (IC50 = 310 μg/mL). These results indicate that a high proportion of plants used in Mexico as treatment for diabetes displays significant inhibition of these digestive enzymes.

scholarly journals Uji Aktivitas Antioksidan Ekstrak Daun Karet Kebo (Ficus Elastica) dengan Metode Peredaman Radikal Bebas Dpph (1,1-Diphenyl-2-Picrylhydrazil)

2020 ◽  
Vol 6 (1) ◽  
pp. 141-150
Author(s):  
Selpida Handayani ◽  
Ida Kurniawati ◽  
Faradiba Abdul Rasyid
Keyword(s):  
Antioxidant Activity ◽  
Methanol Extract ◽  
Radical Scavenging ◽  
Water Extract ◽  
Free Radical Scavenging ◽  
Water Extracts ◽  
Activity Test ◽  
Yield Value ◽  
Ic50 Value ◽  
Tlc Plates

Ficus elastica leaf is one of the Ficus species assumed to be rich in polyphenols so that it can act as an antioxidant. The research aimed to determine the antioxidant activity and IC50 value of methanol and water extracts of rubber leaf. In this research, the extraction was conducted by maceration using methanol and obtained the yield value of 7,03%, while the infundation using water obtained the yield value of 2,82%. The antioxidant activity test was conducted by DPPH free radical scavenging (1,1-diphenyl-2-phycrilhydrazyl) using a quercetin comparator. The qualitative tests were conducted by TLC method using dicloromethane:methanol eluent with a ratio of 99:1 for methanol extracts, and a ratio of 95:5 for water extracts, where all extracts of both methanol and water positively container antioxidants characterized by the formation of yellow spots with a purple background on TLC plates. The results of the quantitative test shower that the methanol extract had medium antioxidant activity with an IC50 value of 78,39 µg/mL, and water extract had an inactive antioxidant activity with an IC50 value of 319,11 µg/mL. While quercetin was classified as a very strong antioxidant with an IC50 value of 7,62 µg/mL.  

UJI IN VITRO EKSTRAK AIR DAN ETANOL DARI BUAH ASAM GELUGUR, RIMPANG LENGKUAS, DAN KENCUR SEBAGAI INHIBITOR AKTIVITAS LIPASE PANKREAS

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Dyah Iswantini ◽  
Latifah K. Darusman ◽  
Ana Fitriyani
Keyword(s):  
Body Weight ◽  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Water Extract ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Positive Control ◽  
Reduce Body Weight ◽  
Ethanol Extracts

Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol. The aim of the research was to evaluate the potencies of these herbal as antiobesity by measurement of their water and ethanol extracts capabilities as in vitro inhibitor of pancreatic lipase activity. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, and quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanolextract contained alkaloids, flavonoids, steroids, and quinones. The highest inhibitory effect of all extracts was obtained from the ethanol extract of asam gelugur fruits with value of 86.3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm (56.2%). The highestinhibitory effect of kencur was showed by the ethanol extract with the value 37.6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical®) at 100 ppm (10.6%).

scholarly journals Cholinesterase and microbial inhibitory activities of Tetrapleura tetraptera

2012 ◽  
Vol 4 (2) ◽  
pp. 156-163
Author(s):  
N. E. Okoronkwo ◽  
J. O. Echeme
Keyword(s):  
Inhibitory Activity ◽  
Water Extract ◽  
Antimicrobial Activities ◽  
Inhibitory Effect ◽  
Klebsiella Pneumonia ◽  
Inhibitory Effects ◽  
Continuous Increase ◽  
Water Extracts ◽  
Tetrapleura Tetraptera ◽  
Inhibitory Activities

The cholinesterase and microbial inhibitory activities of different parts of Tetrapleura tetraptera plant were evaluated due to their local applications. The cholinesterase results revealed that the extracts showed some levels of inhibitory effects depending on the solvents used. Tetrapleura tetraptera leaves had better inhibitory effects with maximum inhibitory activity of 70.0% at a concentration of 1.00mg/l for the water extract. Tetrapleura tetraptera bark showed highest inhibitory effect of 71.05% and (84.34%) for the ethanol and chloroform extracts at concentrations of 0.5mg/l and 1.0 mg/l respectively. While for petroleum ether, T. tetraptera bark recorded 74.34% inhibitory effect at concentration of 2.0 mg/l and also showed continuous increase in inhibitory activity as the concentration increases for aqueous methanol. The results of the antimicrobial activities showed that among all the test organisms, theethanol and water extracts of the leaves, stem, bark and root of the plants had promising activity against Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia bacteria and Aspergillus fumigatus and Rhizopus species fungi. There was no activity shown by the ethanol and water extracts ofthe parts of the plants with Fugarium oxysporum, Penicillium chrysogenum and Mucor species fungi. The bacteria strains were more sensitive to the tested extracts than the fungi strains.

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