scholarly journals Merkel Cell Carcinoma of the Retroperitoneum with No Identifiable Primary Site

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Daniele Rossini ◽  
Salvatore Caponnetto ◽  
Vittoria Lapadula ◽  
Lucilla De Filippis ◽  
Gabriella Del Bene ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Immunohistochemical Analysis ◽  
Primary Site ◽  
Neuroendocrine Neoplasm ◽  
Atypical Presentation ◽  
Merkel Cell ◽  
Retroperitoneal Mass ◽  
Tumor Mass

Merkel cell carcinoma (MCC) is an extremely rare primary neuroendocrine neoplasm of the skin that shows aggressive behavior and a poor prognosis. We report a case of a 67-year-old male with a Merkel cell carcinoma which initially presented itself as a large retroperitoneal mass. Pathological and immunohistochemical analysis revealed tissue consistent with neuroendocrine carcinoma. Despite complete medical workup, no other primary MCC could be detected. While being an atypical presentation, the tumor mass showed an excellent response to the combination of chemotherapy followed by radiotherapy.

scholarly journals Merkel Cell Carcinoma : A Rare Neuroendocrine Neoplasm

2016 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Hanane Atarguine ◽  
Said Amal
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Neuroendocrine Neoplasm ◽  
Merkel Cell

Merkel cell carcinoma remains a rare cutaneous neuroendocrine malignancy that exhibits clinically aggressive features and is associated with a poor prognosis.

Merkel Cell Carcinoma of the Eyelid: A Case Report

2000 ◽  
Vol 10 (2) ◽  
pp. 173-176 ◽  
Author(s):  
L. Collaço ◽  
J.P. Silva ◽  
M. Gonçalves ◽  
P. Abrantes
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
The Elderly ◽  
Primary Site ◽  
Wide Resection ◽  
Merkel Cell ◽  
Unique Case ◽  
Upper Eyelid

A 22-year-old woman who presented with a tumour of the upper eyelid with clinical, histological, immunohistochemical and ultrastructural features of a Merkel cell carcinoma is reported. This is a unique case of Merkel cell carcinoma in such a young patient. This neuroendocrine tumour is typically found in the elderly. It can grow rapidly, has the potential for local recurrence and early metastatic spread. The authors recommend wide resection of the primary site, which proved effective in this case.

scholarly journals 131 Loss of PD-L1 expression in metastatic Merkel cell carcinoma strongly correlates with a poor prognosis

2019 ◽  
Vol 139 (5) ◽  
pp. S23
Author(s):  
M. Nakamura ◽  
Y. Teramoto ◽  
M. Yasuda ◽  
H. Wada ◽  
T. Ozawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Merkel Cell

scholarly journals Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Cancer ◽  
2001 ◽  
Vol 92 (6) ◽  
pp. 1650-1655 ◽  
Author(s):  
Peter J. Allen ◽  
Klaus Busam ◽  
Arnold D. K. Hill ◽  
Alexander Stojadinovic ◽  
Daniel G. Coit
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immunohistochemical Analysis ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

Merkel cell carcinoma of unknown primary site

2007 ◽  
Vol 121 (4) ◽  
Author(s):  
Y Nazarian ◽  
B Shalmon ◽  
Z Horowitz ◽  
L Bedrin ◽  
M R Pfeffer ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Distant Metastases ◽  
Primary Site ◽  
Unknown Primary ◽  
Merkel Cell ◽  
Unknown Primary Site ◽  
Carcinoma Of Unknown Primary ◽  
Skin Malignancy

Merkel cell carcinoma is an uncommon and aggressive primary neuroendocrine skin malignancy which mostly affects the extremities and the head and neck region of elderly patients. Merkel cell carcinoma occurs with increased frequency in sun-exposed areas, in individuals exposed to arsenic and in immunosuppressed patients. Many patients with Merkel cell carcinoma present with other malignancies, mainly skin cancers. Characteristic features are frequent recurrences and regional and distant metastases. Mortality rates range from 20 to 65 per cent. The mainstay of treatment is surgery, with wide local excision, and adjuvant radiotherapy is usually administered. Merkel cell carcinoma of unknown primary site is rare, and the majority of the few cases described have not been from head and neck areas. We present a case of Merkel cell carcinoma of unknown primary site, with upper neck and distant metastases.

Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers

2005 ◽  
Vol 46 (6) ◽  
pp. 622-634 ◽  
Author(s):  
B Llombart ◽  
C Monteagudo ◽  
J A Lopez-Guerrero ◽  
C Carda ◽  
E Jorda ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Prognostic Markers ◽  
Immunohistochemical Analysis ◽  
Merkel Cell

Merkel Cell Carcinoma of the Genitourinary Tract

2011 ◽  
Vol 135 (8) ◽  
pp. 1067-1071 ◽  
Author(s):  
Manju Aron ◽  
Ming Zhou
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Causative Agent ◽  
Targeted Therapies ◽  
Poor Prognosis ◽  
Accurate Diagnosis ◽  
Genitourinary Tract ◽  
Merkel Cell ◽  
Urothelial Carcinomas ◽  
Aggressive Tumor

Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary tract, including urothelial carcinomas and prostatic carcinomas. However, primary Merkel cell carcinoma of the genitourinary tract is a very aggressive tumor with poor prognosis. Accurate diagnosis is crucial for appropriate clinical treatment. The discovery of the Merkel cell polyomavirus as a possible causative agent adds a new dimension in the understanding of the pathogenesis and diagnosis, and possible targeted therapies for this tumor.

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