scholarly journals Personalized Lifestyle Medicine: Relevance for Nutrition and Lifestyle Recommendations

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Deanna M. Minich ◽  
Jeffrey S. Bland
Keyword(s):  
Chronic Disease ◽  
Clinical Medicine ◽  
Lifestyle Modification ◽  
Point Of Care ◽  
Exercise Stress ◽  
Patient Specific ◽  
Lifestyle Medicine ◽  
Genes And Environment ◽  
Personalized Approach ◽  
The Individual

Public health recommendations for lifestyle modification, including diet and physical activity, have been widely disseminated for the prevention and treatment of disease. These guidelines are intended for the overall population without significant consideration for the individual with respect to one’s genes and environment. Personalized lifestyle medicine is a newly developed term that refers to an approach to medicine in which an individual’s health metrics from point-of-care diagnostics are used to develop lifestyle medicine-oriented therapeutic strategies for improving individual health outcomes in managing chronic disease. Examples of the application of personalized lifestyle medicine to patient care include the identification of genetic variants through laboratory tests and/or functional biomarkers for the purpose of designing patient-specific prescriptions for diet, exercise, stress, and environment. Personalized lifestyle medicine can provide solutions to chronic health problems by harnessing innovative and evolving technologies based on recent discoveries in genomics, epigenetics, systems biology, life and behavioral sciences, and diagnostics and clinical medicine. A comprehensive, personalized approach to medicine is required to promote the safety of therapeutics and reduce the cost of chronic disease. Personalized lifestyle medicine may provide a novel means of addressing a patient’s health by empowering them with information they need to regain control of their health.

Validation of Material Parameters of Collagen Compositions for the Application as a Bioink

2018 ◽  
Vol 941 ◽  
pp. 2437-2441
Author(s):  
Volker Schlegel ◽  
Andreas Engels ◽  
Stefano Bifaretti ◽  
Andreas H. Foitzik
Keyword(s):  
Point Of Care ◽  
Individualized Medicine ◽  
Extrusion Process ◽  
Patient Specific ◽  
The Novel ◽  
Material Parameters ◽  
Novel Approach ◽  
Physiological Properties ◽  
Printing System ◽  
Personalized Approach

The novel approach of an individualized medicine affects nowadays various areas of therapeutic treatment. Primarily, these include the application of pharmaceuticals, private point-of-care solutions, surgical procedures as well as steps of rehabilitation. However, beside these existing strategies the development of patient specific models for the training of clinical personal is currently insufficient. Such models are essential to prepare a personalized approach of medical care. One possible solution to address this problem could be the adaption of the established 3d printing technology for the processing of suitable biopolymers. The presented work is focused on the development of a printing system utilizing collagen. Therefore, it is intended to design multiple extrusion heads in accordance with the material parameters. In order to achieve the aspired physiological properties of the final model, a first set of experiments will be performed with several compositions of collagen to validate the fundamental mechanical characteristics. Hereby, the elasticity, thermal stability, force resistance as well as the haptic behaviour are of most interest. Afterwards, these obtained experimental results should be used to simulate the extrusion process and to validate the extruder concepts. In case of a positive evaluation these concepts are realized by using rapid prototyping technologies. Finally, this novel 3d printer will be used to print first organic test structures with collagen.

Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know

Heart ◽  
2019 ◽  
Vol 105 (Suppl 2) ◽  
pp. s21-s27 ◽  
Author(s):  
Peter de Jaegere ◽  
Giorgia Rocatello ◽  
Bernard D Prendergast ◽  
Ole de Backer ◽  
Nicolas M Van Mieghem ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Heart Disease ◽  
Treatment Planning ◽  
Clinical Medicine ◽  
Biomechanical Properties ◽  
Patient Specific ◽  
Acquired Heart Disease ◽  
The Individual

Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. In this paper, we describe the technical background and a number of illustrations to illustrate how patient-specific computer simulation may be used for catheter-based treatment planning of acquired heart disease.

scholarly journals Metabolomics of pulmonary exacerbations reveals the personalized nature of cystic fibrosis disease

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2174 ◽  
Author(s):  
Robert A. Quinn ◽  
Yan Wei Lim ◽  
Tytus D. Mak ◽  
Katrine Whiteson ◽  
Mike Furlan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Platelet Activating Factor ◽  
Clinical State ◽  
Patient Specific ◽  
Rrna Gene ◽  
Chronic Infections ◽  
Metabolomics Data ◽  
Pulmonary Exacerbations ◽  
Personalized Approach ◽  
The Individual

Background.Cystic fibrosis (CF) is a genetic disease that results in chronic infections of the lungs. CF patients experience intermittent pulmonary exacerbations (CFPE) that are associated with poor clinical outcomes. CFPE involves an increase in disease symptoms requiring more aggressive therapy.Methods.Longitudinal sputum samples were collected from 11 patients (n= 44 samples) to assess the effect of exacerbations on the sputum metabolome using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The data was analyzed with MS/MS molecular networking and multivariate statistics.Results.The individual patient source had a larger influence on the metabolome of sputum than the clinical state (exacerbation, treatment, post-treatment, or stable). Of the 4,369 metabolites detected, 12% were unique to CFPE samples; however, the only known metabolites significantly elevated at exacerbation across the dataset were platelet activating factor (PAF) and a related monacylglycerophosphocholine lipid. Due to the personalized nature of the sputum metabolome, a single patient was followed for 4.2 years (capturing four separate exacerbation events) as a case study for the detection of personalized biomarkers with metabolomics. PAF and related lipids were significantly elevated during CFPEs of this patient and ceramide was elevated during CFPE treatment. Correlating the abundance of bacterial 16S rRNA gene amplicons to metabolomics data from the same samples during a CFPE demonstrated that antibiotics were positively correlated toStenotrophomonasandPseudomonas, while ceramides and other lipids were correlated withStreptococcus,Rothia, and anaerobes.Conclusions.This study identified PAF and other inflammatory lipids as potential biomarkers of CFPE, but overall, the metabolome of CF sputum was patient specific, supporting a personalized approach to molecular detection of CFPE onset.

scholarly journals Italy on gaining official parliamentary recognition that obesity is a chronic disease

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F Serra ◽  
A Lenzi ◽  
R Pella ◽  
C Spinato ◽  
G Fatati ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Obesity Prevention ◽  
Diagnostic Procedures ◽  
Healthcare Systems ◽  
Surgical Approaches ◽  
Life Years ◽  
Significant Burden ◽  
The Government ◽  
The Individual ◽  
Multi Stakeholder

Abstract Obesity places a significant burden on people affected, increasing their risk of unintended health consequences and reducing their life expectancy. Rising obesity levels have also had an adverse effect on society and economic prosperity, causing a decrease in economic activity through loss of productive life years, and by placing increasing demands on healthcare systems. Despite the scientific community recognising obesity as a multifactorial chronic disease which requires long-term management, it is often considered to be the responsibility of the individual by governments, healthcare systems and even people with obesity. Obesity is not recognition as disease in Italy, but it has a relevant impact on heath policy, clinical, social and economic. On November 13th 2019, the Chamber of Deputies of the Italian Parliament voted unanimously to approve a motion that recognises obesity as a chronic disease and asks the Government to implement specific actions to promote and improve obesity prevention and management. Among the various commitments there is also a national plan that harmonises the activities in the field of prevention and the fight against obesity; full access to the diagnostic procedures for comorbidities, to dietary-food treatments in the most serious cases, access to second-level centres to evaluate psychological, pharmacological and surgical approaches; guidelines concerning the “first 1,000 days of life” of the child and programs for the prevention of childhood obesity. Obesity now recognised as a chronic disease in Italy. The collaborative, multi-stakeholder effort was long in the making and includes a Charter of Human Rights for People Living with Obesity. The document enumerates actions necessary for the protection of health for obesity prevention and treatment of people living with obesity. The process implemented as a typical policy domino game. Key messages Obesity now recognised as a chronic disease. Policy domino game.

scholarly journals Fully Data-Driven Pseudohealthy Synthesis for Planning Valve-Sparing Aortic Root Reconstruction using Conditional Variational Autoencoders

2020 ◽  
Vol 6 (3) ◽  
pp. 284-287
Author(s):  
Jannis Hagenah ◽  
Mohamad Mehdi ◽  
Floris Ernst
Keyword(s):  
Aortic Root ◽  
Similarity Index ◽  
Ground Truth ◽  
Representation Learning ◽  
Patient Specific ◽  
Ultrasound Images ◽  
Specific Geometry ◽  
The Individual ◽  
Native Root ◽  
Original Information

AbstractAortic root aneurysm is treated by replacing the dilated root by a grafted prosthesis which mimics the native root morphology of the individual patient. The challenge in predicting the optimal prosthesis size rises from the highly patient-specific geometry as well as the absence of the original information on the healthy root. Therefore, the estimation is only possible based on the available pathological data. In this paper, we show that representation learning with Conditional Variational Autoencoders is capable of turning the distorted geometry of the aortic root into smoother shapes while the information on the individual anatomy is preserved. We evaluated this method using ultrasound images of the porcine aortic root alongside their labels. The observed results show highly realistic resemblance in shape and size to the ground truth images. Furthermore, the similarity index has noticeably improved compared to the pathological images. This provides a promising technique in planning individual aortic root replacement.

scholarly journals Identifying enablers and barriers to referral, uptake and completion of lifestyle modification programmes: a rapid literature review

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e045094
Author(s):  
Yvonne Zurynski ◽  
Carolynn Smith ◽  
Joyce Siette ◽  
Bróna Nic Giolla Easpaig ◽  
Mary Simons ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Lifestyle Modification ◽  
Data Extraction ◽  
Empirical Studies ◽  
Grey Literature ◽  
International Health ◽  
Rapid Review ◽  
Eligibility Criteria ◽  
Relevant Evidence ◽  
Literature Reviews

ObjectiveTo identify current, policy-relevant evidence about barriers and enablers associated with referral, uptake and completion of lifestyle modification programmes (LMPs) for secondary prevention of chronic disease in adults.DesignA rapid review, co-designed with policymakers, of peer-reviewed and grey literature using a modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework.Data sourcesMedline, Embase, Scopus, PsycINFO and CINAHL were searched for relevant studies and literature reviews. Grey literature was identified through Advanced Google searching and targeted searching of international health departments’ and non-government organisations’ websites.Eligibility criteria for selecting studiesDocuments published 2010–2020, from high-income countries, reporting on programmes that included referral of adults with chronic disease to an LMP by a health professional (HP).Data extraction and synthesisData from grey and peer-reviewed literature were extracted by two different reviewers. Extracted data were inductively coded around emergent themes. Regular meetings of the review group ensured consistency of study selection and synthesis.ResultsTwenty-nine documents were included: 14 grey literature, 11 empirical studies and four literature reviews. Key barriers to HPs referring patients included inadequate HP knowledge about LMPs, perceptions of poor effectiveness of LMPs and perceptions that referral to LMPs was not part of their role. Patient barriers to uptake and completion included poor accessibility and lack of support to engage with the LMPs. Enablers to HP referral included training/education, effective interdisciplinary communication and influential programme advocates. Support to engage with LMPs after HP referral, educational resources for family members and easy accessibility were key enablers to patient engagement with LMPs.ConclusionsFactors related to HPs’ ability and willingness to make referrals are important for the implementation of LMPs, and need to be coupled with support for patients to engage with programmes after referral. These factors should be addressed when implementing LMPs to maximise their impact.

Adverse Childhood Experiences as “Upstream” Determinants of Lifestyle-Related Chronic Disease: A Scoping Perspective

2021 ◽  
pp. 155982762110012
Author(s):  
Garry Egger ◽  
Andrew Binns ◽  
Bob Morgan ◽  
John Stevens
Keyword(s):  
Chronic Disease ◽  
Adverse Childhood Experiences ◽  
Health Problems ◽  
Lifestyle Medicine ◽  
Childhood Experiences ◽  
Disease Outcomes ◽  
Adverse Childhood ◽  
Chronic Disorders ◽  
Distal Disease ◽  
Upstream Determinants

We have previously proposed a list of determinants (causes) of modern lifestyle-related chronic disorders, which provides a structure for the emerging discipline of lifestyle medicine. This consists of lifestyle factors with a common immune biomarker ( metaflammation) that interact in a systems fashion linked with chronic disease outcomes. We considered this to be a work in progress and later added 3 psychosocial determinants into the causal mix: meaninglessness, alienation, and loss of culture and identity (MAL). Here, we propose adverse childhood experiences (ACEs) as deeper, or even more distal, disease drivers that may act directly or indirectly through MAL to influence later chronic disease. The links with metaflammation and the need for recognition of these embedded scars in the management of lifestyle-related health problems is discussed.

scholarly journals Testing for SARS-CoV-2 seroprevalence: experiences of a tertiary eye centre

2021 ◽  
Vol 6 (1) ◽  
pp. e000688
Author(s):  
Focke Ziemssen ◽  
You-Shan Feng ◽  
Sven Schnichels ◽  
Tarek Bayyoud ◽  
Marius Ueffing ◽  
...  
Keyword(s):  
Point Of Care ◽  
Kappa Statistics ◽  
Antibody Testing ◽  
Self Assessment ◽  
Individual Assessment ◽  
Hygiene Measures ◽  
Antibody Titres ◽  
Antiviral Antibody ◽  
Sequential Combination ◽  
The Individual

IntroductionThe actual prevalence of a SARS-CoV-2 infection and the individual assessment of being or having been infected may differ. Facing the great uncertainty—especially at the beginning of the pandemic—and the possibility of asymptomatic or mildly symptomatic, subclinical infections, we evaluate the experience of SARS-CoV-2 antibody screening at a tertiary clinical setting.Methods and analysisAll employees of a tertiary eye centre and a research institute of ophthalmology were offered antibody testing in May 2020, using a sequential combination of different validated assays/antigens and point-of-care (POC) testing for a subset (NCT04446338). Before taking blood, a systematic inquiry into past symptoms, known contacts and a subjective self-assessment was documented. The correlations between serostatus, patient contacts and demographic characteristics were analysed. Different tests were compared by Kappa statistics.ResultsAmong 318 participants, SARS-CoV-2 antibodies were detected in 9 employees. Chemiluminescence assays (chemiluminescence immunoassay and electrochemiluminescence) showed superior specificity and high reproducibility, compared with ELISA and POC results.In contrast to the low seropositivity (2.8%) of healthcare workers, higher than that of the other departments of the hospital, a large proportion mistakenly assumed that they might have already been infected. Antiviral antibody titres increased and remained on a plateau for at least 3 months.ConclusionsThe great demand and acceptance confirmed the benefit of highly sensitive testing methods in the early phase of the pandemic. The coincidence of low seroprevalence and anxious employees may have contributed to internalising the need of hygiene measures.

scholarly journals Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michele Mussap ◽  
Vassilios Fanos
Keyword(s):  
Molecular Mechanisms ◽  
Vascular Dysfunction ◽  
Asymptomatic Infection ◽  
Multiple Organ ◽  
Therapeutic Interventions ◽  
Patient Specific ◽  
Wide Range ◽  
Life Threatening ◽  
The Individual ◽  
Host Metabolism

Abstract Human Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection activates a complex interaction host/virus, leading to the reprogramming of the host metabolism aimed at the energy supply for viral replication. Alterations of the host metabolic homeostasis strongly influence the immune response to SARS-CoV-2, forming the basis of a wide range of outcomes, from the asymptomatic infection to the onset of COVID-19 and up to life-threatening acute respiratory distress syndrome, vascular dysfunction, multiple organ failure, and death. Deciphering the molecular mechanisms associated with the individual susceptibility to SARS-CoV-2 infection calls for a system biology approach; this strategy can address multiple goals, including which patients will respond effectively to the therapeutic treatment. The power of metabolomics lies in the ability to recognize endogenous and exogenous metabolites within a biological sample, measuring their concentration, and identifying perturbations of biochemical pathways associated with qualitative and quantitative metabolic changes. Over the last year, a limited number of metabolomics- and lipidomics-based clinical studies in COVID-19 patients have been published and are discussed in this review. Remarkable alterations in the lipid and amino acid metabolism depict the molecular phenotype of subjects infected by SARS-CoV-2; notably, structural and functional data on the lipids-virus interaction may open new perspectives on targeted therapeutic interventions. Several limitations affect most metabolomics-based studies, slowing the routine application of metabolomics. However, moving metabolomics from bench to bedside cannot imply the mere determination of a given metabolite panel; rather, slotting metabolomics into clinical practice requires the conversion of metabolic patient-specific data into actionable clinical applications.

Volunteers: An Effective Medium for Delivering Therapeutic Lifestyle Interventions

2021 ◽  
pp. 089011712110625
Author(s):  
Lillian M. Kent ◽  
Paul M. Rankin ◽  
Darren P. Morton ◽  
Rebekah M. Rankin ◽  
Roger L. Greenlaw ◽  
...  
Keyword(s):  
United States ◽  
Chronic Disease ◽  
Lifestyle Modification ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
The United States ◽  
Analysis Of Covariance ◽  
Health Improvement ◽  
Improvement Program ◽  
Blood Lipid Profile

Purpose Lifestyle modification programs have been shown to effectively treat chronic disease. The Coronary Health Improvement Program has been delivered by both paid professional and unpaid volunteer facilitators. This study compared participant outcomes of each mode in the United States. Design Pre-/post-analysis of CHIP interventions delivered between 1999 and 2012. Setting Professional-delivered programs in Rockford Illinois 1999-2004 and volunteer-delivered programs across North America 2005-2012. Subjects Adults ≥21 years (professional programs N = 3158 34.3% men, mean age = 54.0 ± 11.4 years; volunteer programs N = 7115 33.4% men, mean age = 57.4 ± 13.0 years). Measures Body mass index, blood pressure (systolic and diastolic), blood lipid profile (total cholesterol, high-density lipoprotein, triglycerides, low-density lipoprotein), and fasting plasma glucose. Analysis Analysis of Covariance, with adjustment for age, gender, BMI change and baseline biometric and effect sizes. Results The professional-delivered programs achieved significantly greater reductions in BMI (.4%, P < .001) and HDL (1.9%, P < .001) and the volunteer-delivered programs achieved greater reductions in SBP (1.4%, P < .001), DBP (1.1%, P < .001), TC (1.4%, P = .004), LDL (2.3%, P < .001), TG (4.0%, P = .006), and FPG (2.7%, P < .001). However, the effect size differences between the groups were minimal (Cohen’s d .1-.2). Conclusions Lifestyle modification programs have been shown to effectively treat chronic disease. The Complete Health Improvement Program (CHIP) lifestyle intervention has been delivered by both paid professional and unpaid volunteer facilitators. This study compared selected chronic disease biometric outcomes of participants in each mode in the United States. It found volunteer-delivered programs do not appear to be any less effective than programs delivered by paid professionals, which is noteworthy as volunteers may provide important social capital in the combat of chronic disease.

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