scholarly journals Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Inês Campos Costa ◽  
Hugo Nogueira Carvalho ◽  
Luís Pacheco-Figueiredo ◽  
Inês Tomada ◽  
Nuno Tomada
Keyword(s):  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Waist Circumference ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Aging Male ◽  
Age Related ◽  
Hormonal Modulation ◽  
Circulating Levels ◽  
Complex Subject

Erectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, and hypogonadism. Patients were stratified into groups in accordance with the presence (or not) of MetS and/or hypogonadism. Noticeable differences in total testosterone (TT) and free testosterone (FT) levels were found between patients with and without MetS. Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed. Regarding the hypothalamic-pituitary-gonadal axis, patients with hypogonadism did not exhibit raised LH levels. Interestingly, among those with higher LH levels, estradiol values were also increased. Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms. Estradiol is possibly a molecule with further interactions beyond the currently described. Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities.

scholarly journals In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study

2007 ◽  
Vol 156 (5) ◽  
pp. 585-594 ◽  
Author(s):  
Bu B Yeap ◽  
Osvaldo P Almeida ◽  
Zoë Hyde ◽  
Paul E Norman ◽  
S A Paul Chubb ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Older Men ◽  
Early Morning ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Limited Data ◽  
Cross Sectional ◽  
Testosterone Concentration ◽  
Age Related ◽  
Clinical Consequences

Objective: An age-related decline in serum total and free testosterone concentration may contribute to ill health in men, but limited data are available for men > 70 years of age. We sought to determine the distribution and associations of reduced testosterone concentrations in older men. Design: The Health in Men Study is a community-representative prospective cohort investigation of 4263 men aged ≥ 70 years. Cross-sectional hormone data from 3645 men were analysed. Methods: Early morning sera were assayed for total testosterone, sex hormone binding globulin (SHBG) and LH. Free testosterone was calculated using the Vermeulen method. Results: Mean (± s.d.) serum total testosterone was 15.4 ± 5.6 nmol/l (444 ± 162 ng/dl), SHBG 42.4 ± 16.7 nmol/l and free testosterone 278 ± 96 pmol/l (8.01 ± 2.78 ng/dl). Total testosterone correlated with SHBG (Spearman’s r = 0.6, P < 0.0001). LH and SHBG increased with age (r = 0.2, P < 0.0001 for both). Instead of declining, total testosterone increased marginally (r = 0.04, P = 0.007) whilst free testosterone declined with age (r = −0.1, P < 0.0001). Free testosterone was inversely correlated with LH (r = −0.1, P < 0.0001). In multivariate analyses, increasing age, body mass index (BMI) and LH were associated with lower free testosterone. Conclusions: In men aged 70–89 years, modulation of androgen action may occur via an age-related increase in SHBG and reduction in free testosterone without a decline in total testosterone concentration. Increasing age, BMI and LH are independently associated with lower free testosterone. Further investigation would be required to assess the clinical consequences of low serum free testosterone, particularly in older men in whom total testosterone may be preserved.

scholarly journals The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia

2019 ◽  
Vol 16 (6) ◽  
pp. 1006
Author(s):  
Katarzyna Grzesiak ◽  
Aleksandra Rył ◽  
Ewa Stachowska ◽  
Marcin Słojewski ◽  
Iwona Rotter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Benign Prostatic Hyperplasia ◽  
Free Testosterone ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Lipid Mediators ◽  
Total Testosterone ◽  
Blood Samples ◽  
Mediators Of Inflammation ◽  
The Relationship

Background: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods: The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results: We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions: Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.

scholarly journals Prevalence of Age-Associated Testosterone Deficiency Syndrome in Indian Population

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Ghanendra Kumar Yadav ◽  
Mrinal Pahwa ◽  
Mahendra Singh ◽  
Vipin Tyagi ◽  
Sudhir Chadha
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Deficiency Syndrome ◽  
Related Phenomenon ◽  
Aging Male ◽  
Testosterone Deficiency ◽  
Male Population ◽  
Age Related ◽  
Study Population ◽  
Testosterone Deficiency Syndrome

Testosterone deficiency syndrome (TDS) is a gradual age-related phenomenon that occurs in a large proportion of the aging male population. This current prospective study was done with the objective to estimate the prevalence of age-associated TDS in India and its clinical profile. A total of 800 male patients aged ≥40 year were approached to participate in the study. A brief history and focused examination was done. Based on our exclusion criteria, 55 patients were excluded. Androgen deficiency in aging male (ADAM) questionnaire was administered to all remaining 745 patients. Out of these 745 patients, ADAM-positive (symptomatic TDS) patients were found to be 359 and enrolled in the study. In all ADAM-positive patients, serum testosterone levels were measured. Prevalence of symptomatic TDS in study population was found to be 48.18%. Mean total and free testosterone level of symptomatic TDS population were 3.287 ± 1.494 ng/ml (1.12–9.61) and 7.476 ± 2.902 pg/ml (2.18–21.76), respectively. Prevalence of biochemically confirmed TDS among symptomatic TDS population was 60.17%. Prevalence of TDS increases progressively with each decade of life (p=0.034). Prevalence was higher in patients with diabetes, hypertension, coronary artery disease, obesity, and metabolic syndrome. TDS is a real phenomenon with a prevalence of 28.99% in our study population.

scholarly journals Waist Circumference Coupled with Either HDL-C or TG Can Be Used as a Diagnostic Marker for Metabolic Syndrome in Chinese Women with Polycystic Ovary Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Yan Sun ◽  
Wenxiang Wang ◽  
Qi Shen ◽  
Shengrong Du ◽  
Yiwei Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Polycystic Ovary Syndrome ◽  
Fasting Glucose ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Total Testosterone ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Diagnostic Biomarkers

Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To identify early and reliable diagnostic biomarkers for MS in Chinese women with PCOS, a total of 401 patients (200 PCOS patients and 201 controls) were enrolled in our present study. All of the subjects were examined for anthropometric (weight, waist circumference, blood pressure, etc.) and biochemical (fasting glucose, serum lipid indices, total testosterone, etc.) parameters. Our results showed that the prevalence of MS in the PCOS patients (20.50%) was 6.8-fold higher (P<0.05) than that in the controls (2.99%). Nearly 71.0% of the PCOS patients had at least one component of MS, of which dyslipidemia was the most prevalent. Furthermore, within the PCOS group, the prevalence of MS increased with increasing age and body mass index (BMI). Logistic analysis indicated that BMI, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), hypertension, and fasting glucose were significantly associated with the presence of MS in PCOS patients. Analysis of the ability of the potential diagnostic biomarkers to indicate MS in PCOS patients showed that the PPV, NPV, specificity, sensitivity, and Youden’s index for waist circumference (WC) coupled with HDL-C were 59.68%, 97.10%, 84.28%, 90.24%, and 74.52, respectively, and those for WC coupled with TG were 93.33%, 92.35%, 98.74%, 68.29%, and 67.03%, respectively. ROC curve analysis showed that the areas under the ROC curves (AUCs) for WC coupled with HDL-C and for WC coupled with TG were 0.882 and 0.901, respectively. Our present study demonstrates that WC coupled with either HDL-C or TG can be used as a relatively early and reliable diagnostic biomarker for MS in Chinese PCOS patients.

scholarly journals Prevalence of Symptomatic Androgen Deficiency in Men

2007 ◽  
Vol 92 (11) ◽  
pp. 4241-4247 ◽  
Author(s):  
Andre B. Araujo ◽  
Gretchen R. Esche ◽  
Varant Kupelian ◽  
Amy B. O’Donnell ◽  
Thomas G. Travison ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Free Testosterone ◽  
Population Based ◽  
Total Testosterone ◽  
Androgen Deficiency ◽  
Male Population ◽  
Clinical Criteria ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
Osteoporosis Fracture

Abstract Context: Despite recognition that androgen deficiency in men should be defined according to biochemical and clinical criteria, most prevalence estimates are based on low testosterone levels alone. Objective: The objective of this study was to examine the association between symptoms of androgen deficiency and low total and calculated free testosterone levels and estimate the prevalence of symptomatic androgen deficiency in men. Design: This study was a population-based, observational survey. Participants: A total of 1475 Black, Hispanic, and white men, between the ages of 30–79 yr, with complete data on testosterone, SHBG, and symptoms of androgen deficiency, and who are not taking medications that impact sex steroid levels were randomly selected from the Boston Area Community Health Survey. Outcome: Outcomes were measured as symptomatic androgen deficiency, defined as low total (&lt;300 ng/dl) and free (&lt;5 ng/dl) testosterone plus presence of low libido, erectile dysfunction, osteoporosis or fracture, or two or more of following symptoms: sleep disturbance, depressed mood, lethargy, or diminished physical performance. Results: Mean age of the sample was 47.3 ± 12.5 yr. Approximately 24% of subjects had total testosterone less than 300 ng/dl, and 11% of subjects had free testosterone less than 5 ng/dl. Prevalence of symptoms were as follows: low libido (12%), erectile dysfunction (16%), osteoporosis/fracture (1%), and two or more of the nonspecific symptoms (20%). Low testosterone levels were associated with symptoms, but many men with low testosterone levels were asymptomatic (e.g. in men 50+ yr, 47.6%). Crude prevalence of symptomatic androgen deficiency was 5.6% (95% confidence interval: 3.6%, 8.6%), and was not significantly related to race and ethnic group. Prevalence was low in men less than 70 yr (3.1–7.0%) and increased markedly with age to 18.4% among 70 yr olds. Projection of these estimates to the year 2025 suggests that there will be as many as 6.5 million American men ages 30–79 yr with symptomatic androgen deficiency, an increase of 38% from 2000 population estimates. Conclusions: Prevalence of symptomatic androgen deficiency in men 30 and 79 yr of age is 5.6% and increases substantially with age. The aging of the U.S. male population will cause a large increase in the burden of symptomatic androgen deficiency. Future work should address the clinical significance of low testosterone levels in asymptomatic men.

The impact of metabolic syndrome on serum total testosterone level in patients with erectile dysfunction

2014 ◽  
Vol 17 (2) ◽  
pp. 76-80 ◽  
Author(s):  
Yilmaz Aslan ◽  
Ozer Guzel ◽  
Melih Balci ◽  
Altug Tuncel ◽  
Muslum Yildiz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Total Testosterone ◽  
The Impact

scholarly journals Age-related hypogonadism in men with metabolic syndrome

2010 ◽  
Vol 13 (1) ◽  
pp. 21-25
Author(s):  
Yulia Alexandrovna Tishova ◽  
Georgy Zhiulievich Mskhalaya ◽  
Svetlana Yur'evna Kalinchenko
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Immunoreactive Insulin ◽  
Age Related ◽  
The Relationship

Aim. To elucidate the relationship between testosterone and SSBG levels in men with age-related hypogonadism and metabolic syndrome. Materials and methods. The study included 125 men aged 30-80 years with a diagnosis of age-related hypogonadism. In all the cases, testosterone(T) and SSBG levels were determined, free T fraction calculated, and waist circumference measured. Almost half of the patients (n=56) presentedwith metabolic syndrome (MS) and underwent measurement of basal immunoreactive insulin (IRI). Results. Mean age of the patients (n=125) was 54 [46; 65] years, waist circumference 108 [102; 115] cm, total T 8.3 [5.9; 11] nmol/l (norm 12 -33.5), free T 140 [99.6; 184] pmol/l (norm

scholarly journals Correlation of Hyperandrogenemia and Metabolic Syndrome in Thai Women With Polycystic Ovary Syndrome (PCOS).

2021 ◽  
Author(s):  
Suchada Indhavivadhana ◽  
Matinuch Kuichanuan ◽  
Thanyarat Wongwananuruk ◽  
Kitirat Techatraisak ◽  
Panicha Chantrapanichkul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
National Cholesterol Education Program ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Total Testosterone ◽  
Adult Treatment Panel ◽  
Ovary Syndrome ◽  
Thai Women ◽  
Blood Data

Abstract Objective: To investigate the prevalence of metabolic syndrome compared between hyperandrogenemia and non-hyperandrogenemia in Thai women with PCOS, and to identify factors significantly associated with metabolic syndrome in this PCOS population.Methods: Thai PCOS women were conducted during 2010-2018. Patients were categorized into the non-hyperandrogenemia group or the hyperandrogenemia group defined by total testosterone >0.8 ng/mL or free testosterone >0.006 ng/mL or dehydroepiandrosterone sulfate (DHEA-S) >350 mcg/dL. Metabolic syndrome was diagnosed according to National Cholesterol Education Program-Adult Treatment Panel III criteria. Demographic, anthropometric, clinical, and biochemical blood data were collected and analyzed.Results: 520 PCOS women were included. 22.6% had metabolic syndrome and 75.0% had hyperandrogenemia. Free testosterone cut-off to define hyperandrogenemia for determining metabolic syndrome in PCOS yielded the highest sensitivity (88.9%) and the highest negative predictive value (90.8%). The prevalence of metabolic syndrome was 27.1% in hyperandrogenemia and 9.2% in non-hyperandrogenemia. Factors significantly associating with metabolic syndrome in Thai PCOS women were age, BMI, free testosterone, and DHEA-S.Conclusion: The prevalence of metabolic syndrome was to be significantly higher in hyperandrogenemia women than in their non-hyperandrogenemia counterparts. Older age, higher BMI, higher free testosterone, and lower DHEA-S were all identified as factors significantly associated with metabolic syndrome.

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