scholarly journals Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
David Parada ◽  
Karla B. Peña ◽  
Frances Riu
Keyword(s):  
Differential Diagnosis ◽  
Postmenopausal Woman ◽  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Vaginal Bleeding ◽  
Blue Nevus ◽  
Unusual Combination ◽  
Abnormal Vaginal Bleeding ◽  
Immunohistochemical Studies

Malignant melanoma (MM) and blue nevi of the uterine cervix are an extremely rare neoplasm, probably derived from embryologic migration of melanocytes from the neural crest. MM displays aggressive behavior with a poor prognosis. We report the case of a 76-year-old postmenopausal woman abnormal vaginal bleeding. She underwent a hysterectomy and bilateral salpingo-oophorectomy with paraaortic-iliac lymphadenectomy. Histopathological and immunohistochemical studies were consistent with the diagnosis of MM and blue nevi in the uterine cervix. Although it is extremely rare, this case suggests that MM of the uterine cervix should be considered in the differential diagnosis of undifferentiated neoplasm. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

scholarly journals Primary malignant melanoma of the uterine cervix treated with radical surgery and adjuvant chemo-radiation using temozolomide and cisplatin: a case report

2019 ◽  
Vol 8 (8) ◽  
pp. 3387
Author(s):  
Goter Doke ◽  
Shyam Tsering ◽  
Hage Nobin ◽  
Dacto Gara
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Radical Hysterectomy ◽  
Vaginal Bleeding ◽  
Radical Surgery ◽  
Pelvic Lymphadenectomy ◽  
Primary Malignant Melanoma ◽  
Rare Neoplasm

Primary malignant melanoma of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is very poor. Herein, authors report a case of 45-year-old woman who presented with vaginal bleeding for one months and examination showed an exophytic, 6 cm polypoid blackish-pigmented tumor on the cervix involving vaginal fornix. She underwent abdominal radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy and further received adjuvant concurrent chemo-radiation with cisplatin (CDDP) and temozolamide but died 7 months after surgery.

A case of alpha-fetoprotein–producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman

2006 ◽  
Vol 16 (3) ◽  
pp. 1442-1445
Author(s):  
K. Takeuchi ◽  
S. Kitazawa ◽  
S. Hamanishi ◽  
M. Inagaki ◽  
K. Murata
Keyword(s):  
Postmenopausal Woman ◽  
Vaginal Bleeding ◽  
Pap Smear ◽  
Case Reports ◽  
Unknown Origin ◽  
Serum Levels ◽  
Alpha Fetoprotein ◽  
Endometrioid Adenocarcinoma ◽  
Eosinophilic Cytoplasm ◽  
Abnormal Vaginal Bleeding

Although case reports of alpha-fetoprotein (AFP)–producing adenocarcinoma other than hepatocellular carcinoma have gradually increased in number, AFP-producing adenocarcinoma of the endometrium is very rare. The patients universally complain of abnormal vaginal bleeding. The patient presented with complaints of epigastric discomfort. No vaginal bleeding was observed. Serum AFP concentration was 453 ng/mL, and lens culinaris agglutinin–reactive AFP percentage of total AFP was increased to 67%. Radiologic imaging and endoscopy did not provide evidence of any primary carcinoma in the liver and gastrointestinal tract. To investigate the unknown origin of high AFP, Pap smear of the endometrium followed by fractional curettage was performed and revealed adenocarcinoma of the endometrium. Radical hysterectomy with pelvic lymph node dissection and partial omentectomy was performed. Histologic study showed a mixture of major AFP-negative endometrioid adenocarcinoma and minor medullary proliferation of the AFP-positive hepatoid adenocarcinoma cells with eosinophilic cytoplasm and hyaline globules. After the surgery followed by four courses of weekly carboplatin and paclitaxel administration, serum levels of AFP dropped into normal range. The possible existence of AFP-producing adenocarcinoma of the endometrium should be considered in a postmenopausal woman even if there is no vaginal bleeding, when AFP-producing tumor is clinically suspected and the imaging studies fail to confirm the diagnosis.

scholarly journals A Notorious Mimicker Nasal Melanoma: A Case Report

2021 ◽  
Vol 1 (1) ◽  
pp. 30-32
Author(s):  
Shankar Bastakoti ◽  
Dej Kumar Gautam ◽  
Suraj Raj Upreti ◽  
Nandita Jha ◽  
Ishan Dhungana
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Incisional Biopsy ◽  
Vascular Neoplasm ◽  
Sinonasal Carcinoma ◽  
Poorly Differentiated ◽  
Age And Sex ◽  
Hmb 45

Melanomas arising in the nasal cavity or paranasal sinus are rare and have a poor prognosis and is more aggressive than cutaneous counter part. The incidence rate reaches its peak when the patients are in the 5th to 8th decades of life, and the disease is slightly more common in males than females; age and sex do not affect the prognosis. We present a case with histologically deceiving features which was proven Malignant Melanoma by application of Immunohistochemistry. On sinoscopic examination, a mass noted of which incisional biopsy was obtained. Histologically, poorly differentiated Sinonasal carcinoma and Malignant Vascular Neoplasm was differential diagnosis. On immunohistochemistry, strong expression of SOX-10, Melan-A, HMB-45 was observed and p63, CK-7, CK20, Synaptophysin, CD56, CD138, CD45, S100, Desmin, Myogenin were all non-immunoreactive. Thus Malignant Melanoma was final diagnosis.Awareness of melanoma mimickers is very important for clinicians in general, and

scholarly journals A case of endocervical blue nevus

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
S. Erra
Keyword(s):  
Postmenopausal Woman ◽  
Present Article ◽  
Vaginal Bleeding ◽  
Histological Diagnosis ◽  
Blue Nevus ◽  
Cervical Mucosa

Uterine cervical mucosa is devoid of melanocytes, even if melanocitic lesions have been reported in this site on literature. In the present article, we report a case of endocervical blue nevus in a postmenopausal woman with vaginal bleeding. Histological diagnosis has been made on a curettage material obtained from the gynaecological service of our hospital.

scholarly journals Primary melanoma of the uterine cervix figo stage III B

1998 ◽  
Vol 116 (4) ◽  
pp. 1778-1780 ◽  
Author(s):  
Júlio César Teixeira ◽  
José Roberto Salina ◽  
Luiz Carlos Teixeira ◽  
Liliana Aparecida Lucci De Angelo Andrade
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Radical Surgery ◽  
Primary Melanoma ◽  
Figo Stage ◽  
Stage Iiib ◽  
Histological Evaluation ◽  
Advanced Stage ◽  
Advanced Stages

The primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. The diagnosis is made through histological evaluation and confirmed by special staining procedures. Radical surgery has been used and advocated. However in its advanced stages chemotherapy, immunotherapy or radiotherapy can be employed. A case of a patient with malignant melanoma of the uterine cervix, Stage IIIb, is presented in addition to a clinical and pathological discussion.

scholarly journals A rare presentation of deep infiltrating cervical endometriosis mimicking cervical cancer

2020 ◽  
Vol 9 (9) ◽  
pp. 3903
Author(s):  
P. Swetha ◽  
U. Nagashree ◽  
R. Kondammal
Keyword(s):  
Cervical Cancer ◽  
Differential Diagnosis ◽  
Vaginal Bleeding ◽  
Rare Case ◽  
Rare Presentation ◽  
Diagnosis And Management ◽  
Benign Disorder ◽  
Abnormal Vaginal Bleeding

Though endometriosis is a common progressive benign disorder of women, endometriosis of the cervix is rarely seen. It poses a challenge both for diagnosis and management. Most of the patients with Cervical endometriosis are asymptomatic, present with abnormal vaginal bleeding, post-coital bleeding or intermenstrual bleeding. In this paper, we report a rare case of deep infiltrating cervical endometriosis involving the ureter mimicking cervical cancer, the need for awareness to include cervical endometriosis as a differential diagnosis in case of menstural irregularities and its potential to cause serious complications.

Growth Hormone Deficiency in Twins: Three Cases with Normal Co-twins

PEDIATRICS ◽  
1982 ◽  
Vol 69 (4) ◽  
pp. 486-488
Author(s):  
Alan N. Lindsay ◽  
Margaret H. MacGillivray ◽  
Mary L. Voorhess
Keyword(s):  
Growth Hormone ◽  
Differential Diagnosis ◽  
Growth Hormone Deficiency ◽  
Vaginal Bleeding ◽  
Case Reports ◽  
Hormone Deficiency ◽  
Idiopathic Growth Hormone Deficiency ◽  
History Of ◽  
Major Discrepancy ◽  
Abnormal Vaginal Bleeding

Idiopathic growth hormone deficiency is unusual in twin sibships. We report three twins with growth hormone deficiency whose co-twins are growing normally and have no evidence of hypothalamicpituitary dysfunction. It is likely that the affected children sustained perinatal insult. The data illustrate that idiopathic growth hormone deficiency should be considered in the differential diagnosis when there is a major discrepancy in height between twins. CASE REPORTS Case 1 Male twins I were born at 36 weeks' gestation to a 27-year-old gravida 3, para 2. There was no history of abnormal vaginal bleeding, infection or, toxemia. Labor was spontaneous and lasted two hours.

Blue Nevus of the Prostate

2011 ◽  
Vol 135 (6) ◽  
pp. 799-802
Author(s):  
Virginia L. Dailey ◽  
Omar Hameed
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Benign Lesion ◽  
S100 Protein ◽  
Prostate Gland ◽  
Homogentisic Acid ◽  
Malignant Potential ◽  
Melanocytic Lesion ◽  
Blue Nevus ◽  
Hmb 45

Abstract Blue nevus is one of the melanotic lesions that can incidentally arise in the prostate gland. A literature review identified 28 previously reported cases, and although rare, the blue nevus appeared to be the commonest melanocytic lesion arising in the prostate. The differential diagnosis includes melanosis and malignant melanoma, as well as nonmelanotic lesions due to deposition of lipofuscin, hemosiderin and, rarely, homogentisic acid. The distinction among these lesions can typically be made based on morphologic grounds but may also be aided by histochemical and immunohistochemical stains such as stains for iron, S100 protein, HMB-45, and CD68 as needed. Blue nevus of the prostate is a benign lesion with no malignant potential to date, so no further treatment is warranted.

scholarly journals A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Ikuma Nozaki ◽  
Yumi Tone ◽  
Junko Yamanaka ◽  
Hideko Uryu ◽  
Yuko Shimizu-Motohashi ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Transformation ◽  
Poor Prognosis ◽  
Mediastinal Mass ◽  
Bone Biopsy ◽  
Systematic Evaluation ◽  
Anterior Mediastinal Mass ◽  
Malignant Teratoma ◽  
Experienced Pain

We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.

scholarly journals Primary Intracranial Malignant Melanoma Mimicking Meningioma—Report of Two Cases

2021 ◽  
Author(s):  
Laxmikant Bhople ◽  
Hrushikesh U. Kharosekar ◽  
Harish Naik ◽  
V. Velho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Radiological Patterns

AbstractPrimary intracranial melanoma is uncommon and accounts for only approximately 1% of all cases of melanoma. This is interesting to neuro-oncologists and neurosurgeons because the clinical and radiological patterns of these tumors can mimic the presence of meningioma. Primary central nervous system melanomas have rarely been reported with less than 25 cases reported till date. We report two cases of the primary intracranial melanoma that even though very rare should be kept as a differential diagnosis when meningioma is suspected.

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