scholarly journals Chitosan-Hyaluronate Hybrid Gel Intraarticular Injection Delays Osteoarthritis Progression and Reduces Pain in a Rat Meniscectomy Model as Compared to Saline and Hyaluronate Treatment

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Shachar Patchornik ◽  
Edward Ram ◽  
Noah Ben Shalom ◽  
Zvi Nevo ◽  
Dror Robinson
Keyword(s):  
Femoral Condyle ◽  
Weight Bearing ◽  
Cyst Formation ◽  
Hybrid Gel ◽  
Ameliorative Effect ◽  
Control Knee ◽  
Osteoarthritis Progression ◽  
Surgically Induced ◽  
Therapeutic Substance ◽  
Delay Progression

Chitosan-Hyaluronate hybrid gel (CHHG) is a self-forming thermo-responsive hydrogel. The current study was undertaken in order to assess the effect of CHHG on rat's surgically induced osteoarthritis.Methods. Thirteen rats were included in the study. In all rats weight-bearing was assessed using a Linton Incapacitance tester. All rats underwent bilateral medial partial meniscectomy. Four rats received a saline injection in the control knee and a 200-microliter injection of CHHG in the experimental knee. Five rats received a high-molecular weight hyaluronate injection to the control knee and a 200-microliter injection of CHHG in the experimental knee. Four rats underwent the same surgical procedure, allowed to recuperate for seven days and then CHHG and hyaluronate were injected. The animals were followed for 6 weeks. Two weeks after injection of a therapeutic substance the amount of weight-bearing on each knee was evaluated using a Linton Incapacitance meter.Results. Two weeks after induction of osteoarthritis there is less pain in the CHHG-treated knee than in the control-treated knee, as determined using a Lintron Incapacitance meter. After six-weeks the histological appearance of the CHHG-treated knee was superior to that of the controls. This is indicated by thicker cartilage remaining on the medial femoral condyle as well as less cyst formation in the CHHG-treated knee.Discussion. CHHG appears to delay progression of osteoarthritis and lessen pain in a rat surgically-induced knee osteoarthritis model. These results support other published results, indicating that there is an ameliorative effect of chitosan on human and rabbit osteoarthritis.

scholarly journals Case Report of a Medial Femoral Condyle Fracture in a Unicompartmental Oxford Knee Replacement Surgery

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Femoral Condyle ◽  
Intraoperative Complications ◽  
Weight Bearing ◽  
Full Range ◽  
Postoperative Rehabilitation ◽  
Medial Condyle ◽  
Case Presentation ◽  
Replacement Surgery ◽  
Stable Osteosynthesis ◽  
Condyle Fracture

Introduction: The unicompartmental Oxford prosthesis has been used as a goodalternative for medial unicompartmental osteoarthritis because it is associated with earlyrehabilitation and a low rate of intraoperative complications. This case describes a rarecomplication during the procedure. Case Presentation: We present an intraoperative fracture of the medial condyle in a 70-year-old woman that was treated with 6.5 mm cannulated screws with a compressiontechnique. The patient remained in a non-weight bearing protocol for 6 weeks andreached a full range of mobility at 3 months. Complete radiological consolidation and agood functional outcome were observed. Conclusion: Intraoperative fractures benefit from a stable osteosynthesis that allows freerange of mobility and does not delay postoperative rehabilitation.

Distal femoral osteotomy for genu valgum deformity caused by malunited Hoffa fracture

2021 ◽  
Vol 14 (2) ◽  
pp. e238615
Author(s):  
Taiga Oda ◽  
Akira Maeyama ◽  
Tetsuro Ishimatsu ◽  
Takuaki Yamamoto
Keyword(s):  
Internal Fixation ◽  
Femoral Condyle ◽  
Weight Bearing ◽  
Young Patients ◽  
Femoral Osteotomy ◽  
Posterior Aspect ◽  
Distal Femoral Osteotomy ◽  
Non Union ◽  
Hoffa Fracture ◽  
Articular Fractures

Hoffa fractures are unstable intra-articular fractures of the femoral condyle that occur in the coronal plane.Insufficient anatomical reduction and internal fixation may lead to non-union or malunion. A 39-year-old man was involved in a traffic accident while riding a motorcycle and was diagnosed with left Hoffa fracture and avulsion fracture of the femoral attachment of the medial collateral ligament. Open reduction and internal fixation were performed 5 days after injury. The patient experienced intermittent knee pain, joint contracture and deformity, and attended our hospital for further treatment 18 months after surgery. CT revealed depression and malunion of the posterior aspect of the lateral femoral condyle, and weight-bearing X-ray showed valgus deformity due to malunion. Distal femoral osteotomy (DFO) was performed and good functional and radiographic results were obtained. This report suggests that DFO is a reasonable treatment for young patients suffering from malalignment due to malunited Hoffa fracture.

scholarly journals A Preliminary Study of Combined Detection of COMP, TIMP-1, and MMP-3 in Synovial Fluid: Potential Indicators of Osteoarthritis Progression

Cartilage ◽  
2020 ◽  
pp. 194760352094638
Author(s):  
Jana Plsikova Matejova ◽  
Timea Spakova ◽  
Denisa Harvanova ◽  
Marek Lacko ◽  
Vladimir Filip ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Matrix Protein ◽  
Weight Bearing ◽  
Knee Oa ◽  
Significant Linear Correlation ◽  
Starting Point ◽  
Osteoarthritis Progression ◽  
Grading Scale ◽  
Severity Of The Disease ◽  
End Stage

Objective Osteoarthritis (OA) commonly affects weight-bearing joints and is characterized by articular cartilage breakdown combined with osteophyte formation at the joint margins and chronic nonspecific inflammation of synovium. Understanding the profile of inflammation in a patient population is an essential starting point to predict or prevent OA progression. The aim of this study was to identify the profile of selected biomolecules in synovial fluid (SF) and investigate the correlation according to gender, age, and severity of the disease within patients from among the general knee OA population. Design In our study SF samples were aspirated from the knees of 65 OA patients (46 patients with early knee OA and 19 patients with end-stage knee OA according to the Kellgren-Lawrence grading scale). The concentration of interleukins (IL-6, IL-8), matrix metalloproteinases (MMP-1, MMP-3, MMP-13), MMPs inhibitors (TIMP-1, TIMP-2), cartilage oligomeric matrix protein (COMP), and adiponectin was analyzed using a multiplex ELISA-based approach. Conclusions Our results indicate significant linear correlation of MMP-13 and COMP concentration with age ( P < 0.05), but not with OA severity. In fact, 3 of the examined biomolecules, MMP-3 ( P < 0.01), TIMP-1 ( P < 0.01), and COMP ( P < 0.05) significantly correlate with the grade of knee OA and might be associated with OA severity.

Prayer's fracture: rare cases of knee insufficiency fracture in non-weight-bearing femoral condyle

2019 ◽  
Vol 58 ◽  
pp. 80-83
Author(s):  
Sana Salehi ◽  
Aidin Abedi ◽  
Jordan S. Gross ◽  
Ali Gholamrezanezhad
Keyword(s):  
Femoral Condyle ◽  
Weight Bearing ◽  
Insufficiency Fracture

Medial femoral condyle fracture during an Oxford unicompartmental knee replacement surgery: case report

2020 ◽  
pp. jisakos-2019-000311
Author(s):  
Rafael Calvo ◽  
David Figueroa ◽  
Zoy Anastasiadis ◽  
Gonzalo Espinoza ◽  
Daniel Sarango
Keyword(s):  
Range Of Motion ◽  
Rare Complication ◽  
Femoral Condyle ◽  
Intraoperative Complications ◽  
Weight Bearing ◽  
Full Range ◽  
Unicompartmental Knee Replacement ◽  
Medial Condyle ◽  
Unicompartmental Knee ◽  
Condyle Fracture

Oxford unicompartmental knee arthroplasty has been used as a good alternative for medial unicompartmental osteoarthritis due to its association with early rehabilitation and a low rate of intraoperative complications. This case describes a rare complication during the procedure of an intraoperative fracture of the medial condyle that was treated with osteosynthesis with 6.5 mm cannulated screws and a compression technique. The patient followed a non-weight-bearing protocol for 6 weeks and reached full range of motion at 3 months. Complete radiological fusion and good functional outcome were observed. Intraoperative fractures can benefit from stable osteosynthesis that allows free range of motion and does not jeopardise the final surgical result.

scholarly journals Current Practice of Analysis and Treatment of underlying Varus Deformity in Patients with Cartilage Defects of the medial Femoral Condyle: Data of the German Cartilage Registry (KnorpelRegister DGOU)

2019 ◽  
Vol 7 (6_suppl4) ◽  
pp. 2325967119S0023
Author(s):  
Svea Faber ◽  
Johannes Zellner ◽  
Alfred Hochrein ◽  
Gunter Spahn ◽  
Philipp Niemeyer
Keyword(s):  
Cartilage Repair ◽  
Femoral Condyle ◽  
Weight Bearing ◽  
Combined Treatment ◽  
Varus Deformity ◽  
Outcome Evaluation ◽  
Medial Femoral Condyle ◽  
Tibial Osteotomy ◽  
Leg Axis ◽  
Preoperative Analysis

Aims and Objectives: In the context of cartilage repair, identification of the underlying pathologies depends on detailed preoperative evaluation. High tibial osteotomy (HTO) for varus deformities is one of the most common concomitant treatments, though scientific evidence about efficiency of concomitant HTO is still limited. The present study was initiated to describe preoperative analysis of alignment and to analysis outcome comparing patients with combined cartilage repair and HTO with those who received cartilage repair procedures alone. Materials and Methods: The multicenter data (3855 data sets on April 15, 2018) was provided by the attending physician and a self-reported outcome analysis (KOOS). Inclusion criteria: Existence of a leg full length portrait, a single defect at the medial femoral condyle, either no accompanying surgery or a HTO and information on leg axis misalignment. For outcome evaluation patients were divided into three different groups with regard to the extent of varus deformity: MILD (0-4° varus), MODERATE (5-9° varus) and SEVERE (> 10°). Statistical Analysis was performed using SPSS (IBM) Version 23. For detection of significances between different groups one-way ANOVA test was applied. P-values < 0.05 were considered statistical significant. Results: In 55.1% (n=2125) of the patients a full leg weight-bearing radiographs has been performed preoperatively. Out of these 834 (39%) cases with isolated defects of the medial femoral condyle have been identified of which 179 received HTO in combination with the cartilage repair procedure (21.5%), while 411 cases have been treated with isolated cartilage repair (49.3%). From the remaining 385 patients, 256 patients were considered MILD (67,3%), 113 MODERATE (29.5%) and 4.2% (n=16) SEVERE. Incidence of HTO significantly depended on the degree of varus deformity for mild (19% HTO) and moderate (83% HTO) deformity, but there was no significance between the moderate and severe (81% HTO) group. Significant differences of the KOOS score could be shown preoperatively between the mild (mean: 57.3), as well as moderate (mean: 55.95), and the severe group (mean 39.53) and six months postoperatively between the mild (mean: 71.48) and the severe (mean: 52.6) group. Conclusion: The present analysis of a large patients cohort extracted from the German Cartilage Registry (KnorpelRegister DGOU) demonstrates that, against common guidelines, full-leg weigth-bearing radiographs are not conducted on a regular basis in patients assigned for cartilage repair procedures. In those cases with detailed preoperative analysis of alignment, the degree of deformity seems to influence the decision, whether a realignment procedure (HTO) is performed. For the moderate subgroup a trend towards better clinical outcome was found for combined treatment in terms of realignment and cartilage repair in comparison to cartilage repair alone. Since there was no difference in the MILD subgroup, more evidence is needed to proof, whether those patients benefit from a HTO or not.

scholarly journals Mosaic arthroplasty of the medial femoral condyle in horses — An experimental study

2014 ◽  
Vol 62 (2) ◽  
pp. 155-168 ◽  
Author(s):  
Gábor Bodó ◽  
Gábor Vásárhelyi ◽  
László Hangody ◽  
László Módis
Keyword(s):  
Hyaline Cartilage ◽  
Femoral Condyle ◽  
Weight Bearing ◽  
Medial Femoral Condyle ◽  
The Other ◽  
Bearing Surface ◽  
Femoral Trochlea ◽  
Osteochondral Grafts ◽  
Mosaic Arthroplasty

One Arabian and 5 Hungarian half-bred horses were used to study the macroscopic and microscopic survival of autologous osteochondral grafts in the weight-bearing surface of the medial femoral condyle (MFC). Grafts were harvested from the cranial surface of the medial femoral trochlea (MFT) under arthroscopic control. Three of them were transplanted into the weight-bearing surface of the contralateral MFC using an arthrotomy approach. Three months later this transplantation procedure was repeated on the opposite stifle joints in the same animals, but at that time transplantation was performed arthroscopically. Follow-up arthroscopy was carried out 12 months after the first operations, and biopsies were taken from both the recipient and the donor sites for histological examination. During follow-up arthroscopy, the transplanted areas looked congruent and smooth. Microscopically, the characteristics of hyaline cartilage were present in 5 out of the 10 biopsies examined; however, in the other half of biopsies glycosaminoglycan (GAG) loss and change in the architecture of the transplanted cartilage was observed. In a 16-year-old horse, all grafts broke during harvesting, and thus transplantation was not performed. No radiological signs of osteoarthritic changes were detected 9 to 12 months after the operations in the donor and recipient joints. Clinically, no lameness or effusion was present three months after the transplantations.

scholarly journals Sagittal-Plane Knee Moment During Gait and Knee Cartilage Thickness

2017 ◽  
Vol 52 (6) ◽  
pp. 560-566 ◽  
Author(s):  
Randy J. Schmitz ◽  
David Harrison ◽  
Hsin-Min Wang ◽  
Sandra J. Shultz
Keyword(s):  
Body Weight ◽  
Sagittal Plane ◽  
Femoral Condyle ◽  
Weight Bearing ◽  
Knee Extensor ◽  
Initial Step ◽  
Cartilage Thickness ◽  
Healthy Population ◽  
Tibiofemoral Angle ◽  
Control Factors

Context:  Understanding the factors associated with thicker cartilage in a healthy population is important when developing strategies aimed at minimizing the cartilage thinning associated with knee osteoarthritis progression. Thicker articular cartilage is commonly thought to be healthier cartilage, but whether the sagittal-plane biomechanics important to gait are related to cartilage thickness is unknown. Objective:  To determine the relationship of a weight-bearing region of the medial femoral condyle's cartilage thickness to sagittal gait biomechanics in healthy individuals. Design:  Descriptive laboratory study. Setting:  Laboratory. Patients or Other Participants:  Twenty-eight healthy participants (15 women: age = 21.1 ± 2.1 years, height = 1.63 ± 0.07 m, weight = 64.6 ± 9.9 kg; 13 men: age = 22.1 ± 2.9 years, height = 1.79 ± 0.05 m, weight = 75.2 ± 9.6 kg). Main Outcome Measure(s):  Tibiofemoral angle (°) was obtained via goniometric assessment, thickness of the medial femoral condyle cartilage (mm) was obtained via ultrasound imaging, and peak internal knee-extensor moment (% body weight · height) was measured during 10 trials of over-ground walking at a self-selected pace. We used linear regression to examine the extent to which peak internal knee-extensor moment predicted cartilage thickness after accounting for tibiofemoral angle and sex. Results:  Sex and tibiofemoral angle (12.3° ± 3.2°) were entered in the initial step as control factors (R2 = 0.01, P = .872). In the final step, internal knee-extensor moment (1.5% ± 1.3% body weight · height) was entered, which resulted in greater knee-extensor moment being related to greater cartilage thickness (2.0 ± 0.3 mm; R2Δ = 0.31, PΔ = .003). Conclusion:  Individuals who walked with a greater peak internal knee-extensor moment during gait had a cartilage structure that is generally considered beneficial in a healthy population. Our study offers promising findings that a potentially modifiable biomechanical factor is associated with cartilage status in a healthy population. Establishing these baseline relationships in uninjured populations may help us to better understand potential factors related to maladaptive gait patterns that predispose a person to adverse changes in the cartilage environment.

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