scholarly journals Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Brigitte Gonthier ◽  
Nathalie Allibe ◽  
Cécile Cottet-Rousselle ◽  
Frédéric Lamarche ◽  
Laurence Nuiry ◽  
...  
Keyword(s):  
Free Radical ◽  
Cell Injury ◽  
Fluorescent Dyes ◽  
Protective Action ◽  
Primary Cultures ◽  
Radical Scavenging ◽  
Brain Cell ◽  
Ethanol Exposure ◽  
Low Concentrations ◽  
Radical Scavenging Properties

Aims. 3,5,4′-Trihydroxy-trans-stilbene, a natural polyphenolic compound present in wine and grapes and better known as resveratrol, has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism. Today, the mechanism by which ethanol exerts its toxicity is still not well understood, but it is generally considered that free radical generation plays an important role in the appearance of structural and functional alterations in cells. The aim of this study was to evaluate the protective action of resveratrol against ethanol-induced brain cell injury.Methods. Primary cultures of rat astrocytes were exposed to ethanol, with or without a pretreatment with resveratrol. We examined the dose-dependent effects of this resveratrol pretreatment on cytotoxicity and genotoxicity induced by ethanol. Cytotoxicity was assessed using the MTT reduction test. Genotoxicity was evidenced using single cell gel electrophoresis. In addition, DNA staining with fluorescent dyes allowed visualization of nuclear damage using confocal microscopy.Results. Cell pretreatment with low concentrations oftrans-resveratrol (0.1–10 μM) slowed down cell death and DNA damage induced by ethanol exposure, while higher concentrations (50–100 μM) enhanced these same effects. No protection bycis-resveratrol was observed.Conclusion. Protection offered bytrans-resveratrol against ethanol-induced neurotoxicity was only effective for low concentrations of this polyphenol.

scholarly journals Chemical Analysis, Toxicity Study, and Free-Radical Scavenging and Iron-Binding Assays Involving Coffee (Coffea arabica) Extracts

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4169
Author(s):  
Nuntouchaporn Hutachok ◽  
Pimpisid Koonyosying ◽  
Tanachai Pankasemsuk ◽  
Pongsak Angkasith ◽  
Chaiwat Chumpun ◽  
...  
Keyword(s):  
Free Radical ◽  
Mononuclear Cells ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Chemical Compositions ◽  
Coffee Bean ◽  
Dependent Manner ◽  
Roasted Coffee ◽  
Instant Coffee ◽  
Radical Scavenging Properties

We aimed to analyze the chemical compositions in Arabica coffee bean extracts, assess the relevant antioxidant and iron-chelating activities in coffee extracts and instant coffee, and evaluate the toxicity in roasted coffee. Coffee beans were extracted using boiling, drip-filtered and espresso brewing methods. Certain phenolics were investigated including trigonelline, caffeic acid and their derivatives, gallic acid, epicatechin, chlorogenic acid (CGA) and their derivatives, p-coumaroylquinic acid, p-coumaroyl glucoside, the rutin and syringic acid that exist in green and roasted coffee extracts, along with dimethoxycinnamic acid, caffeoylarbutin and cymaroside that may be present in green coffee bean extracts. Different phytochemicals were also detected in all of the coffee extracts. Roasted coffee extracts and instant coffees exhibited free-radical scavenging properties in a dose-dependent manner, for which drip coffee was observed to be the most effective (p < 0.05). All coffee extracts, instant coffee varieties and CGA could effectively bind ferric ion in a concentration-dependent manner resulting in an iron-bound complex. Roasted coffee extracts were neither toxic to normal mononuclear cells nor breast cancer cells. The findings indicate that phenolics, particularly CGA, could effectively contribute to the iron-chelating and free-radical scavenging properties observed in coffee brews. Thus, coffee may possess high pharmacological value and could be utilized as a health beverage.

Free radical scavenging properties and phenolic characterization of some edible plants

2009 ◽  
Vol 114 (1) ◽  
pp. 276-281 ◽  
Author(s):  
Ilkay Orhan ◽  
Murat Kartal ◽  
Mahmoud Abu-Asaker ◽  
F. Sezer Şenol ◽  
Gülderen Yilmaz ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Edible Plants ◽  
Radical Scavenging Properties

Antihypertensive and free radical scavenging properties of enzymatic rapeseed protein hydrolysates

2013 ◽  
Vol 141 (1) ◽  
pp. 153-159 ◽  
Author(s):  
Rong He ◽  
Adeola Alashi ◽  
Sunday A. Malomo ◽  
Abraham T. Girgih ◽  
Dongfang Chao ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Protein Hydrolysates ◽  
Rapeseed Protein ◽  
Rapeseed Protein Hydrolysates ◽  
Radical Scavenging Properties

Antioxidant and Antifungal Properties of Benzimidazole Derivatives

2010 ◽  
Vol 65 (9-10) ◽  
pp. 537-542 ◽  
Author(s):  
Canan Kuş ◽  
Fatma Sözüdönmez ◽  
Benay Can-Eke ◽  
Tülay Çoban
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging ◽  
Liver Microsomes ◽  
Thiobarbituric Acid ◽  
Benzimidazole Derivatives ◽  
Rat Liver Microsomes ◽  
Inhibitory Effects ◽  
Stable Free Radical ◽  
Radical Scavenging Properties

Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/ piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10-3 M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.

scholarly journals EVALUATION OF ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF DIFFERENT SOLVENT EXTRACTS OF LEAVES OF PIPER UMBELLATUM

2017 ◽  
Vol 10 (2) ◽  
pp. 274
Author(s):  
Sethupandian Geetha ◽  
Kokkaiah Irulandi ◽  
Palanichamy Mehalingam
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Methanol Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Free Radical Scavenging ◽  
Frap Assay ◽  
Radical Scavenging Properties

Objective: This study was designed to determine the Total phenol, flavonoid content, antioxidant and free radical scavenging properties of different solvent extracts of Piper umbellatum.  Methods: Different solvent extracts evaluated with DPPH radical scavenging activity and Reducing power activity.Results: The presence of phenol and flavonoid showed highly in the methanol extracts than ethyl acetate and acetone extracts. All the extracts have various level of antioxidant activity. Methanol solvent extract have good extraction and show significant antioxidant activity. The effect of reducing power of methanol extract revealed good antioxidant activity compare with other tested extracts.Conclusion: On the basis of the above results we concluded that methanol extract of Piper umbellatum whole plant extracts shows significant antioxidant activity than ethyl acetate and acetone extracts.Keywords: Piper umbellatum, Antioxidant, DPPH, FRAP assay, Polar, Non polar solvents

Synthesis, Characterization and Free Radical Scavenging Properties of Rosmarinic Acid Fatty Esters

2010 ◽  
Vol 87 (6) ◽  
pp. 615-620 ◽  
Author(s):  
Jérôme Lecomte ◽  
Luis Javier López Giraldo ◽  
Mickaël Laguerre ◽  
Bruno Baréa ◽  
Pierre Villeneuve
Keyword(s):  
Free Radical ◽  
Rosmarinic Acid ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Fatty Esters ◽  
Radical Scavenging Properties

Possible Involvement of Free Radical Scavenging Properties in the Action of Tumor Necrosis Factor-α

1997 ◽  
Vol 22 (4) ◽  
pp. 679-687 ◽  
Author(s):  
Nagahide Matsubara ◽  
Midori Hiramatsu ◽  
Rei Edamatsu ◽  
Kiminao Mizukawa ◽  
Akitane Mori ◽  
...  
Keyword(s):  
Free Radical ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Radical Scavenging Properties ◽  
Factor Α ◽  
Necrosis Factor
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