scholarly journals A Systematic Review of Bilateral Upper Limb Training Devices for Poststroke Rehabilitation

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
A. (Lex) E. Q. van Delden ◽  
C. (Lieke) E. Peper ◽  
Gert Kwakkel ◽  
Peter J. Beek
Keyword(s):  
Upper Limb ◽  
Statistical Power ◽  
Relevant Literature ◽  
Qualitative Evaluation ◽  
Clinical Results ◽  
Mesh Term ◽  
Active Involvement ◽  
Bilateral Training ◽  
Sufficient Statistical Power ◽  
Rule Out

Introduction. In stroke rehabilitation, bilateral upper limb training is gaining ground. As a result, a growing number of mechanical and robotic bilateral upper limb training devices have been proposed.Objective. To provide an overview and qualitative evaluation of the clinical applicability of bilateral upper limb training devices.Methods. Potentially relevant literature was searched in the PubMed, Web of Science, and Google Scholar databases from 1990 onwards. Devices were categorized as mechanical or robotic (according to the PubMed MeSH term of robotics).Results. In total, 6 mechanical and 14 robotic bilateral upper limb training devices were evaluated in terms of mechanical and electromechanical characteristics, supported movement patterns, targeted part and active involvement of the upper limb, training protocols, outcomes of clinical trials, and commercial availability.Conclusion. Initial clinical results are not yet of such caliber that the devices in question and the concepts on which they are based are firmly established. However, the clinical outcomes do not rule out the possibility that the concept of bilateral training and the accompanied devices may provide a useful extension of currently available forms of therapy. To actually demonstrate their (surplus) value, more research with adequate experimental, dose-matched designs, and sufficient statistical power are required.

scholarly journals Use of Feldspathic Porcelain Veneers to Improve Smile Harmony: A 3-Year Follow-up Report

2016 ◽  
Vol 27 (6) ◽  
pp. 767-774 ◽  
Author(s):  
Leonardo Federizzi ◽  
Érica Alves Gomes ◽  
Samantha Schaffer Pugilato Báratro ◽  
Flares Baratto-Filho ◽  
Ataís Bacchi ◽  
...  
Keyword(s):  
Clinical Success ◽  
Relevant Literature ◽  
Clinical Results ◽  
Anterior Teeth ◽  
Correct Execution ◽  
Bond Interface ◽  
Laboratory Procedures ◽  
Feldspathic Porcelain ◽  
Strength And Durability

Abstract This case report describes an esthetic treatment to improve the shape and alignment of the anterior teeth, reestablishing smile harmony, using feldspathic porcelain veneers. Results of clinical follow up after 36 months are also presented. The advantages, disadvantages and limitations of the technique are detailed with reference to the relevant literature. This suggests that the success of treatment depends on adequate conditions of bonding between the veneers and the tooth complex, which involves parameters such as the strength and durability of the bond interface. Therefore, the clinical success of feldspathic porcelain veneers depends on the accurate selection of cases and correct execution of clinical and laboratory procedures. The rehabilitation involved from first right premolar to the left with feldspathic porcelain veneers made on refractory dies. After the 3-year follow up, excellent clinical results and patient satisfaction were achieved.

Clinical results of an investigation of paediatric upper limb myoelectric prosthesis fitting at the Quebec rehabilitation institute

2001 ◽  
Vol 25 (2) ◽  
pp. 119-131 ◽  
Author(s):  
F. Routhier ◽  
C. Vincent ◽  
M-J. Morissette ◽  
L. Desaulniers
Keyword(s):  
Upper Limb ◽  
Dropout Rate ◽  
Clinical Results ◽  
User Evaluation ◽  
Rehabilitation Centre ◽  
Myoelectric Prosthesis ◽  
Myoelectric Prostheses ◽  
Prosthesis Fitting ◽  
Children And Parents

This study was designed to investigate the satisfaction level of young users of myoelectric prostheses who received an upper limb myoelectric prosthesis, to assess their dropout rate and to identify which factors influence the use or non-use of the upper limb myoelectric prosthesis in the eastern part of Quebec (Canada). The users were fitted between 1990 and 1999 at the Quebec Rehabilitation Institute, a major rehabilitation centre located in the province of Quebec. This rehabilitation centre provides cutting-edge expertise not only for the eastern part of Quebec, but also across the entire province, because it is one of only two highly specialised centres serving all of Quebec.A literature review was completed to compile the results obtained in other rehabilitation centres and to identify factors influencing the use or non-use of paediatric upper limb myoelectric prostheses. The Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) was used in order to assess the degree to which the children were satisfied with their prostheses.Eighteen (18) children were fitted and trained to use an upper limb myoelectric prosthesis. A total of 10 children and parents agreed to participate. Some 80% of participants said that they were satisfied with their prostheses. A dropout rate of 53% for the overall group (participants and non-participants) seems high compared with that of other studies. Recommendations linked to factors identified in the literature are made. The authors conclude that a multidisciplinary team and structured training and follow-up can improve the clinical results pertaining to all the factors proposed in the literature.

scholarly journals Common genomic regions underlie natural variation in diverse toxin responses

2018 ◽  
Author(s):  
Kathryn S. Evans ◽  
Shannon C. Brady ◽  
Joshua S. Bloom ◽  
Robyn E. Tanny ◽  
Daniel E. Cook ◽  
...  
Keyword(s):  
Phenotypic Variation ◽  
Statistical Power ◽  
Natural Variation ◽  
Growth Parameters ◽  
Heritable Variation ◽  
Phenotypic Complexity ◽  
Response Variation ◽  
Genomic Regions ◽  
Chromosome Substitution Strains ◽  
Sufficient Statistical Power

AbstractPhenotypic complexity is caused by the contributions of environmental factors and multiple genetic loci, interacting or acting independently. Studies of yeast and Arabidopsis found that the majority of natural variation across phenotypes is attributable to independent additive quantitative trait loci (QTL). Detected loci in these organisms explain most of the estimated heritable variation. By contrast, many heritable components underlying phenotypic variation in metazoan models remain undetected. Before the relative impacts of additive and interactive variance components on metazoan phenotypic variation can be dissected, high replication and precise phenotypic measurements are required to obtain sufficient statistical power to detect loci contributing to this missing heritability. Here, we used a panel of 296 recombinant inbred advanced intercross lines of Caenorhabditis elegans and a high-throughput fitness assay to detect loci underlying responses to 16 different toxins, including heavy metals, chemotherapeutic drugs, pesticides, and neuropharmaceuticals. Using linkage mapping, we identified 82 QTL that underlie variation in responses to these toxins and predicted the relative contributions of additive loci and genetic interactions across various growth parameters. Additionally, we identified three genomic regions that impact responses to multiple classes of toxins. These QTL hotspots could represent common factors impacting toxin responses. We went further to generate near-isogenic lines and chromosome-substitution strains and then experimentally validated these QTL hotspots, implicating additive and interactive loci that underlie toxin-response variation.

scholarly journals Is there sufficient scientific evidence to rule out the use of hydroxychloroquine for postexposure prophylaxis of COVID-19?

2020 ◽  
Author(s):  
Llorenç Quintó ◽  
Jose Miguel Morales-Asencio ◽  
Raquel González ◽  
Clara Menéndez
Keyword(s):  
Public Health ◽  
Effect Size ◽  
Statistical Power ◽  
Scientific Evidence ◽  
Post Exposure Prophylaxis ◽  
Postexposure Prophylaxis ◽  
Post Hoc Analysis ◽  
Exposure Prophylaxis ◽  
Post Hoc ◽  
Rule Out

Since the beginning of the COVID-19 pandemic, the use of hydroxychloroquine (HCQ) has been surrounded by a lot of controversy, both scientific and non-scientific. This has continued with the publication of two trials of HCQ for post-exposure prophylaxis of the infection, which concluded that HCQ is not efficacious to prevent SARS-CoV-2 infection, and their results are influencing public health decisions.We have carried out a comprehensive post-hoc analysis of the statistical power of the two trials, which shows that their power to detect an effect of HCQ in preventing COVID-19 is low, not only for their observed effect size, but also for other clinically important levels of efficacy, and therefore both studies are inconclusive.

scholarly journals Crossover design

2019 ◽  
Vol 7 (30) ◽  
pp. 63-66
Author(s):  
Shengpin Yang ◽  
Gilbert Berdine
Keyword(s):  
Clinical Trial ◽  
Study Design ◽  
Statistical Power ◽  
Crossover Design ◽  
Type Ii ◽  
Meaningful Difference ◽  
Total Budget ◽  
Sufficient Statistical Power

I am planning a clinical trial to compare two diets on reducing the risk of type II diabetes.Because there is a restriction on the total budget, I would prefer to enroll a small number ofparticipants. Meanwhile, it is important that there is sufficient statistical power to detect aclinically meaningful difference. Is there any study design that can be utilized?

scholarly journals Towards a simplified justification of the chosen sample size

2021 ◽  
Author(s):  
Nick J. Broers ◽  
Henry Otgaar
Keyword(s):  
Sample Size ◽  
Effect Size ◽  
Power Analysis ◽  
Statistical Power ◽  
Minimal Effect ◽  
Expected Effect ◽  
Sufficient Statistical Power

Since the early work of Cohen (1962) psychological researchers have become aware of the importance of doing a power analysis to ensure that the predicted effect will be detectable with sufficient statistical power. APA guidelines require researchers to provide a justification of the chosen sample size with reference to the expected effect size; an expectation that should be based on previous research. However, we argue that a credible estimate of an expected effect size is only reasonable under two conditions: either the new study forms a direct replication of earlier work or the outcome scale makes use of meaningful and familiar units that allow for the quantification of a minimal effect of psychological interest. In practice neither of these conditions is usually met. We propose a different rationale for a power analysis that will ensure that researchers will be able to justify their sample size as meaningful and adequate.

scholarly journals An atlas of genetic associations in UK Biobank

2017 ◽  
Author(s):  
Oriol Canela-Xandri ◽  
Konrad Rawlik ◽  
Albert Tenesa
Keyword(s):  
Complex Traits ◽  
Statistical Power ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Uk Biobank ◽  
Genetic Associations ◽  
Genome Wide ◽  
Related Individuals ◽  
Sufficient Statistical Power

ABSTRACTGenome-wide association studies have revealed many loci contributing to the variation of complex traits, yet the majority of loci that contribute to the heritability of complex traits remain elusive. Large study populations with sufficient statistical power are required to detect the small effect sizes of the yet unidentified genetic variants. However, the analysis of huge cohorts, like UK Biobank, is complicated by incidental structure present when collecting such large cohorts. For instance, UK Biobank comprises 107,162 third degree or closer related participants. Traditionally, GWAS have removed related individuals because they comprised an insignificant proportion of the overall sample size, however, removing related individuals in UK Biobank would entail a substantial loss of power. Furthermore, modelling such structure using linear mixed models is computationally expensive, which requires a computational infrastructure that may not be accessible to all researchers. Here we present an atlas of genetic associations for 118 non-binary and 599 binary traits of 408,455 related and unrelated UK Biobank participants of White-British descent. Results are compiled in a publicly accessible database that allows querying genome-wide association summary results for 623,944 genotyped and HapMap2 imputed SNPs, as well downloading whole GWAS summary statistics for over 30 million imputed SNPs from the Haplotype Reference Consortium panel. Our atlas of associations (GeneATLAS,http://geneatlas.roslin.ed.ac.uk) will help researchers to query UK Biobank results in an easy way without the need to incur in high computational costs.

The “Mnemonic Time-Travel Effect”

2019 ◽  
Vol 66 (6) ◽  
pp. 437-442 ◽  
Author(s):  
Laura Mieth ◽  
Raoul Bell ◽  
Axel Buchner
Keyword(s):  
Statistical Power ◽  
Time Travel ◽  
Original Study ◽  
Memory Test ◽  
Forward Motion ◽  
Space And Time ◽  
The Moment ◽  
The One ◽  
Sufficient Statistical Power

Abstract. This registered report aims at replicating the so-called “mnemonic time-travel” effect. Aksentijevic, Brandt, Tsakanikos, and Thorpe (2019) reported that memory was improved when their participants experienced backward motion before a memory test in comparison to when they experienced forward motion or no motion. This finding was interpreted as suggesting that backward motion brought individuals back to the moment of encoding. In the original study, the mnemonic time-travel effect was robustly found with various types of backward motion (real, simulated, and imagined). Such a spectacular finding calls for a preregistered replication. To determine the robustness of the effect, we performed a close replication of Experiment 4 of Aksentijevic et al. in which the mnemonic time-travel effect was most pronounced. Despite sufficient statistical power to detect an even considerably smaller effect than the one reported by Aksentijevic et al., we found no significant differences among the different motion conditions. The present results thus disconfirm the idea that experiencing backward motion improves memory which suggests that the empirical robustness of the mnemonic time travel effect should be further scrutinized before any conclusions about mnemonic space and time can be drawn.

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