scholarly journals Designing Gold Nanoparticle-Ensembles as Surface Enhanced Raman Scattering Tags inside Human Retinal Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Sanda Boca ◽  
Dumitrita Rugina ◽  
Adela Pintea ◽  
Nicolae Leopold ◽  
Simion Astilean
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Plasmonic Nanostructures ◽  
Retinal Cells ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Active Nanoparticles ◽  
Enhanced Raman Scattering ◽  
Poly Ethylene ◽  
Sers Tags

Apart from the traditional development of surface-enhanced raman scattering (SERS) substrates for ultrasensitive spectroscopic analysis, an increasing interest is given nowadays to the design of the so-called SERS nanotags which integrate multiple SERS applications into single plasmonic nanoparticles. The fabrication of SERS tags is still a challenging task due to the complicated fabrication process. Typically, SERS tags are hybrid nanoconstructs consisting in a unique plasmonic nanoobject encoded with specific reporter molecules and enveloped in a protective shell that provides both biocompatibility and targeting function. Herein, we produce effective SERS tags consisting in small aggregates of gold nanoparticles (mainly dimers and trimers) which are captured from solution and then transferred into cells to perform as individual plasmonic nanostructures. Actually the small aggregates formed under controlled conditions are stabilized in solution by interlocking into a polymeric envelope made of thiol-modified poly(ethylene) glycol (PEG-SH). No further encoding operation is necessary in our case since part of ascorbic acid used as reducing agent remains attached in the interparticle junctions, providing persistent and strong SERS signal when the fabricated tags are internalized by human retinal cells. Our studies demonstrate a promising potential of new SERS-active nanoparticles to serve as effective reporters for biomedical tracing and imaging.

scholarly journals Plasmonic Nanostructures: 3D Nanostar Dimers with a Sub-10-nm Gap for Single-/Few-Molecule Surface-Enhanced Raman Scattering (Adv. Mater. 15/2014)

2014 ◽  
Vol 26 (15) ◽  
pp. 2352-2352 ◽  
Author(s):  
Manohar Chirumamilla ◽  
Andrea Toma ◽  
Anisha Gopalakrishnan ◽  
Gobind Das ◽  
Remo Proietti Zaccaria ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Plasmonic Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Molecule Surface

scholarly journals Development of Effectual Substrates for SERS by Nanostructures-on flexible surfaces

2021 ◽  
Vol 2114 (1) ◽  
pp. 012084
Author(s):  
Hammad R. Humud ◽  
Fatimah Jumaah Moaen
Keyword(s):  
Raman Scattering ◽  
Ag Nanoparticles ◽  
Surface Enhanced Raman Scattering ◽  
Wave Number ◽  
Plasmonic Nanostructures ◽  
Sers Substrate ◽  
Two Dimensional ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Abstract The current study examines recent advancements in surface-enhanced Raman scattering (SERS), a technique that employs flexible surfaces as an active substrate, this surfaces consist from two-dimensional thermo-plasmonic grating. With 53 nm Au layer (was deposited on the 2D grating structure of the PDMS by the PVD method). The explosive wire technique was used to preparing Ag nanoparticles that were used for the purpose of SERS. The effect of the plasmonic nanostructures on the absorption spectra and Surface - Enhanced Raman Scattering (SERS) activities was examined. Rhodamine 6G dye was used as a probe molecule. X-Ray diffraction (XRD) was used to examine the structural characteristics of the nanoparticles. The morphology was assessed using Field Emission Scanning Electron Microscopy(FESEM). A twin beam UV-Vis Spectrophotometer was used to measure the absorption of the combined Rh6G dye (concentration 1×10“–6M) with the nanostructures. a Sunshine Raman microscope system and a 50mm objective lens, used for investigating the Raman spectra of the Rh6G combined with nanostructures. The results showed that the enhancement factor (EF) for SERS of R6G (1×M) reached to (2.2×10 3) When using Ag nanoparticles and (0.08 × 103) when R6G deposited directly on the flexible substrates without nanostructures at the wave number (1650 cm−1), we produced a recyclable, homogeneous, and highly sensitive SERS substrate with dependable reproducibility. For the SERS substrate, a surface made up of two-dimensional (2D) flexible grating substrates was chosen to provide multiple modalities in electrical and medicinal applications.

Centimeter-scale-homogeneous SERS substrates with seven-order global enhancement through thermally controlled plasmonic nanostructures

Nanoscale ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 5099-5105 ◽  
Author(s):  
Hongmei Liu ◽  
Xinping Zhang ◽  
Tianrui Zhai ◽  
Thomas Sander ◽  
Limei Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Plasmonic Nanostructures ◽  
Solution Processed ◽  
Homogeneous Surface ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Highly homogeneous surface-enhanced Raman scattering substrates were produced on the centimeter scale by annealing solution-processed gold nanoparticles into plasmonic nanoislands.

scholarly journals Probing the plasmonic near-field by one- and two-photon excited surface enhanced Raman scattering

2013 ◽  
Vol 4 ◽  
pp. 834-842 ◽  
Author(s):  
Katrin Kneipp ◽  
Harald Kneipp
Keyword(s):  
Raman Scattering ◽  
Photon Energy ◽  
Near Field ◽  
Single Molecules ◽  
Surface Enhanced Raman Scattering ◽  
Plasmonic Nanostructures ◽  
Two Photon ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Strongly enhanced and spatially confined near-fields in the vicinity of plasmonic nanostructures open up exciting new capabilities for photon-driven processes and particularly also for optical spectroscopy. Surface enhanced Raman signatures of single molecules can provide us with important information about the optical near-field. We discuss one- and two-photon excited surface enhanced Raman scattering at the level of single molecules as a tool for probing the plasmonic near-field of silver nanoaggregates. The experiments reveal enhancement factors of local fields in the hottest hot spots of the near-field and their dependence on the photon energy. Also, the number of the hottest spots and their approximate geometrical size are found. Near-field amplitudes in the hottest spots can be enhanced by three orders of magnitudes. Nanoaggregates of 100 nm dimensions provide one hot spot on this highest enhancement level where the enhancement is confined within less than 1nm dimension. The near-field enhancement in the hottest spots increases with decreasing photon energy.

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