scholarly journals In SilicoModelling of Treatment-Induced Tumour Cell Kill: Developments and Advances

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Loredana G. Marcu ◽  
Wendy M. Harriss-Phillips
Keyword(s):  
Tumour Cell ◽  
Health Professionals ◽  
Treatment Modality ◽  
Tumour Growth ◽  
Comprehensive Overview ◽  
Fractionated Radiotherapy ◽  
The Past ◽  
Cell Kill ◽  
Relevant Field ◽  
Tumour System

Mathematical and stochastic computer (in silico) models of tumour growth and treatment response of the past and current eras are presented, outlining the aims of the models, model methodology, the key parameters used to describe the tumour system, and treatment modality applied, as well as reported outcomes from simulations. Fractionated radiotherapy, chemotherapy, and combined therapies are reviewed, providing a comprehensive overview of the modelling literature for current modellers and radiobiologists to ignite the interest of other computational scientists and health professionals of the ever evolving and clinically relevant field of tumour modelling.

Recruitment Policies of Non-EU/EEA Nurses and Ethical Issues

2018 ◽  
Author(s):  
Angèle Flora Mendy
Keyword(s):  
Public Opinion ◽  
Health Professionals ◽  
Ethical Issues ◽  
Health Workers ◽  
Ethical Considerations ◽  
Host Countries ◽  
Ethical Argument ◽  
The Past ◽  
The United Kingdom ◽  
Institutional Legacies

By examining policies of recruiting non-EU/EEA health workers and how ethical considerations are taken into account when employing non-EU/EEA nurses in the United Kingdom, France, and Switzerland, this chapter intends to show that the use of the so-called ‘ethical’ argument to convince national public opinion of the relevance of restrictive recruitment policies is recent (since the 1990s). The analysis highlights the fact that in addition to the institutional legacies, qualification and skills—through the process of their recognition—play an important role in the opening or restriction of the labour market to health professionals from the Global South. The legacy of the past also largely determines the place offered to non-EU/EEA health professionals in the different health systems of host countries.

scholarly journals Flying Free: A Research Overview of Deep Learning in Drone Navigation Autonomy

Drones ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 52
Author(s):  
Thomas Lee ◽  
Susan Mckeever ◽  
Jane Courtney
Keyword(s):  
Deep Learning ◽  
Research Work ◽  
Learning Approaches ◽  
Clear Definition ◽  
Top Down ◽  
Research Activity ◽  
Comprehensive Overview ◽  
The Past ◽  
Computer Vision Applications ◽  
Definition Of

With the rise of Deep Learning approaches in computer vision applications, significant strides have been made towards vehicular autonomy. Research activity in autonomous drone navigation has increased rapidly in the past five years, and drones are moving fast towards the ultimate goal of near-complete autonomy. However, while much work in the area focuses on specific tasks in drone navigation, the contribution to the overall goal of autonomy is often not assessed, and a comprehensive overview is needed. In this work, a taxonomy of drone navigation autonomy is established by mapping the definitions of vehicular autonomy levels, as defined by the Society of Automotive Engineers, to specific drone tasks in order to create a clear definition of autonomy when applied to drones. A top–down examination of research work in the area is conducted, focusing on drone navigation tasks, in order to understand the extent of research activity in each area. Autonomy levels are cross-checked against the drone navigation tasks addressed in each work to provide a framework for understanding the trajectory of current research. This work serves as a guide to research in drone autonomy with a particular focus on Deep Learning-based solutions, indicating key works and areas of opportunity for development of this area in the future.

Hierarchical Reinforcement Learning

2021 ◽  
Vol 54 (5) ◽  
pp. 1-35
Author(s):  
Shubham Pateria ◽  
Budhitama Subagdja ◽  
Ah-hwee Tan ◽  
Chai Quek
Keyword(s):  
Reinforcement Learning ◽  
Future Research ◽  
Comprehensive Overview ◽  
Open Problems ◽  
Practical Applications ◽  
Hierarchical Reinforcement Learning ◽  
The Past ◽  
Agent Learning ◽  
Multi Agent ◽  
Supplementary Material

Hierarchical Reinforcement Learning (HRL) enables autonomous decomposition of challenging long-horizon decision-making tasks into simpler subtasks. During the past years, the landscape of HRL research has grown profoundly, resulting in copious approaches. A comprehensive overview of this vast landscape is necessary to study HRL in an organized manner. We provide a survey of the diverse HRL approaches concerning the challenges of learning hierarchical policies, subtask discovery, transfer learning, and multi-agent learning using HRL. The survey is presented according to a novel taxonomy of the approaches. Based on the survey, a set of important open problems is proposed to motivate the future research in HRL. Furthermore, we outline a few suitable task domains for evaluating the HRL approaches and a few interesting examples of the practical applications of HRL in the Supplementary Material.

scholarly journals A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat

1988 ◽  
Vol 59 (3) ◽  
pp. 437-442 ◽  
Author(s):  
Noel S. Skeef ◽  
John R. Duncan
Keyword(s):  
Cell Proliferation ◽  
Cell Division ◽  
Cell Line ◽  
Tumour Cell ◽  
Tumour Growth ◽  
Zn Deficiency ◽  
Regenerating Liver ◽  
Small Reduction ◽  
Dietary Zinc ◽  
Camp Concentration

1. The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats.2. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant).3. The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.

scholarly journals Glioblastoma Multiforme—A Look at the Past and a Glance at the Future

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1053
Author(s):  
Jasmine L. King ◽  
Soumya Rahima Benhabbour
Keyword(s):  
Glioblastoma Multiforme ◽  
Immune Surveillance ◽  
Standard Of Care ◽  
Current Standard ◽  
Comprehensive Overview ◽  
Therapeutic Delivery ◽  
The Past ◽  
Adults And Children ◽  
The Central Nervous System ◽  
Delivery Strategies

Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomitant and/or adjuvant chemotherapy. One of the major challenges that impedes success of chemotherapy is the presence of the blood–brain barrier (BBB). Because of the tightly regulated BBB, immune surveillance in the central nervous system (CNS) is poor, contributing to unregulated glioma cell growth. This review gives a comprehensive overview of the latest advances in treatment of GBM with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM.

Cuba and the Covid-19 pandemic

2021 ◽  
Vol 122 (1) ◽  
pp. 118-131
Author(s):  
Bob Oram
Keyword(s):  
Public Health ◽  
United States ◽  
Health System ◽  
Health Professionals ◽  
The United States ◽  
The Past ◽  
The Uk ◽  
Universal Health

For the UK struggling to deal with the Covid-19 pandemic, the experience of Cuba’s Ministry of Public Health over the past six decades provides the clearest case for a single, universal health system constituting an underlying national grid dedicated to prevention and care; an abundance of health professionals, accessible everywhere; a world-renowned science and biotech capability; and an educated public schooled in public health. All this was achieved despite being under a vicious blockade by the United States for all of that time.

International Themes in Psychotherapy Integration

2019 ◽  
pp. 448-473
Author(s):  
Beatriz Gómez ◽  
Shigeru Iwakabe ◽  
Alexandre Vaz
Keyword(s):  
Mental Health ◽  
Mental Health Professionals ◽  
Health Professionals ◽  
Psychotherapy Integration ◽  
Historical Background ◽  
The Past ◽  
Current Climate ◽  
The World ◽  
Training And Research ◽  
Sociopolitical Issues

Interest in psychotherapy integration has steadily expanded over the past decades, reaching most continents of the world and more mental health professionals than ever. Nevertheless, a country’s cultural and historical background significantly influences the nurturance or hindrance of integrative endeavors. This chapter seeks to explicate the current climate of psychotherapy integration in different continents and specific countries. With the aid of local integrative scholars, brief descriptions are presented on integrative practice, training, and research, as well as on cultural and sociopolitical issues that have shaped this movement’s impact around the world.

Some Pain, Some Gain: Reflections on the Past Two Decades of Neonatal Pain Research and Treatment

2002 ◽  
Vol 21 (5) ◽  
pp. 37-41 ◽  
Author(s):  
Linda Franck
Keyword(s):  
Health Professionals ◽  
Future Research ◽  
Pain Research ◽  
Attitudes And Practices ◽  
Neonatal Pain ◽  
The Past ◽  
New Directions ◽  
Infant Pain ◽  
Made In

This review reflects back on the progress that has been made in infant pain research over the past 20 years and how the research has influenced (or has failed to influence) the attitudes and practices of health professionals about infant pain. Progress in understanding of infant pain neurobiology, treatment, and measurement are discussed, and new directions for future research are proposed.

Sign in / Sign up

Export Citation Format

Share Document