scholarly journals Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Jian-hua Liu ◽  
Zhi-feng Wu ◽  
Jian Sun ◽  
Li Jiang ◽  
Shuo Jiang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Antidepressant Treatment ◽  
Signal Transduction Pathway ◽  
Cyclic Adenosine Monophosphate ◽  
Chronic Mild Stress ◽  
Adenosine Monophosphate ◽  
Mild Stress ◽  
Transduction Pathway ◽  
Antidepressant Action

Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression. The present study was conducted to explore the role of the cAMP cascade in antidepressant action of electroacupuncture (EA) treatment for chronic mild stress (CMS)-induced depression model rats. The results showed that EA improved significantly behavior symptoms in depression and dysfunction of AC-cAMP-PKA signal transduction pathway induced by CMS, which was as effective as fluoxetine. Moreover, the antidepressant effects of EA rather than Fluoxetine were completely abolished by H89, a specific PKA inhibitor. Consequently, EA has a significant antidepressant treatment in CMS-induced depression model rats, and AC-cAMP-PKA signal transduction pathway is crucial for it.

Signal transduction pathway and physiological role of endothelin in the kidney

1994 ◽  
Vol 1 ◽  
pp. 80
Author(s):  
K. Tomita ◽  
A. Owada ◽  
H. Nonoguchi ◽  
Y. Terada ◽  
F. Marumo
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Physiological Role ◽  
Transduction Pathway

III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system

1998 ◽  
Vol 275 (2) ◽  
pp. G183-G186 ◽  
Author(s):  
V. Pachnis ◽  
P. Durbec ◽  
S. Taraviras ◽  
M. Grigoriou ◽  
D. Natarajan
Keyword(s):  
Signal Transduction ◽  
Nervous System ◽  
Enteric Nervous System ◽  
Signal Transduction Pathway ◽  
Multiple Roles ◽  
Tyrosine Kinase Receptor ◽  
Transduction Pathway ◽  
Complex Part ◽  
Induced Mutagenesis

The enteric nervous system (ENS) in vertebrates is derived from the neural crest and constitutes the most complex part of the peripheral nervous system. Natural and induced mutagenesis in mammals has shown that the tyrosine kinase receptor RET and its functional ligand glial cell line-derived neurotrophic factor (GDNF) play key roles in the development of the ENS in humans and mice. We have developed and briefly describe here a number of assays that analyze the specific function of the RET receptor and its ligand. Our data suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.

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