scholarly journals Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Chuanfeng Lv ◽  
Tie Hong ◽  
Zhen Yang ◽  
Yu Zhang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
Glutathione Peroxidase ◽  
Mouse Model ◽  
Protective Effect ◽  
Mechanisms Of Action ◽  
Quercetin Treatment

In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated. Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days. The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na+, K+-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.

scholarly journals Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson’s Disease

2017 ◽  
Vol 45 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Shaosong Kuang ◽  
Lin Yang ◽  
Ziliang Rao ◽  
Zhiyong Zhong ◽  
Jinfeng Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Superoxide Dismutase ◽  
Locomotor Activity ◽  
Tyrosine Hydroxylase ◽  
Glutathione Peroxidase ◽  
Transgenic Mice ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Dopamine Transporters

AbstractBackground: Parkinson’s disease (PD) is a degenerative disorder of the central nervous system mainly affecting the motor system. Presently, there is no effective and safe drug to treat patients with PD. Ginkgo biloba extract (GBE), obtained from leaves of the Ginkgo biloba tree, is a complex mixture of ingredients primarily containing two active components: flavonoids and terpenoids. In this study, we investigated the effects of GBE on A53T α-synuclein transgenic mice, a PD model that has better simulated the progression of PD patients than other models such as the 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine–induced PD model. Methods: Fifty α-synuclein A53T transgenic mice were fed and treated with GBE, and locomotor activity was detected by pole test, forced swim test, and wire-hang test. The expression of tyrosine hydroxylase and dopamine transporters was detected using immunohistochemistry. Superoxide dismutase activity, glutathione peroxidase activity, and malondialdehyde expression were detected using an assay kit. Results: Our results show that GBE treatment improved locomotor activity and that superoxide dismutase and glutathione peroxidase inhibited the expression of methane dicarboxylic aldehyde and recovered the expression of tyrosine hydroxylase and dopamine transporters. Conclusions: The GBE treatment improved locomotor activity and inhibited the development of PD in the A53T α-synuclein transgenic mice, which may be partly responsible for decreased oxidative damage and maintain the normal dopamine homeostasis.

scholarly journals Protective Effect of Chinonin in MPTP-Induced C57BL/6 Mouse Model of Parkinson’s Disease

2014 ◽  
Vol 37 (8) ◽  
pp. 1301-1307 ◽  
Author(s):  
Guoshuai Feng ◽  
Zhijian Zhang ◽  
Qingqing Bao ◽  
Zaijun Zhang ◽  
Libing Zhou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Protective Effect

Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson’s disease

2016 ◽  
Vol 38 (3) ◽  
pp. 425-431 ◽  
Author(s):  
Burcu Gökçe Çokal ◽  
Mustafa Yurtdaş ◽  
Selda Keskin Güler ◽  
Hafize Nalan Güneş ◽  
Ceyla Ataç Uçar ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase

scholarly journals TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease

2019 ◽  
Vol 40 (12) ◽  
pp. 1503-1512 ◽  
Author(s):  
Qian-hang Shao ◽  
Ying Chen ◽  
Fang-fang Li ◽  
Shuo Wang ◽  
Xiao-ling Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Protective Effect

Dopaminergic therapy does not affect body weight in Parkinson's disease patients

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
C.G. Bachmann ◽  
C. Werner ◽  
E. Brunner ◽  
C. Trenkwalder
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Body Weight ◽  
Dopaminergic Therapy ◽  
Affect Body Weight
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