scholarly journals Distribution of Vapor Pressure in the Vacuum Freeze-Drying Equipment

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Shiwei Zhang ◽  
Jun Liu

In the big vacuum freeze-drying equipment, the drying rate of materials is uneven at different positions. This phenomenon can be explained by the uneven distribution of vapor pressure in chamber during the freeze-drying process. In this paper, a mathematical model is developed to describe the vapor flow in the passageways either between material plates and in the channel between plate groups. The distribution of vapor pressure along flow passageway is given. Two characteristic factors of passageways are defined to express the effects of structural and process parameters on vapor pressure distribution. The affecting factors and their actions are quantitatively discussed in detail. Two examples are calculated and analyzed. The analysis method and the conclusions are useful to estimate the difference of material drying rate at different parts in equipment and to direct the choice of structural and process parameters.

LWT ◽  
2009 ◽  
Vol 42 (8) ◽  
pp. 1325-1334 ◽  
Author(s):  
Jelena Babić ◽  
María J. Cantalejo ◽  
Cristina Arroqui

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Tim Wenzel ◽  
Henning Gieseler

AbstractCurrent trends in the pharmaceutical industry led to a demand for more flexible manufacturing processes with smaller batch sizes. Prepackaged nested vials that can be processed as a unit were introduced into the market to fulfill this need. However, vial nests provide a different thermal environment for the vials compared to a hexagonal packaging array and could therefore influence product temperature profiles, primary drying times, and product quality attributes. Polymer caps with the possibility of vial closure inside the freeze-drying chamber were developed to remove the risks and need of a crimping process. A general concern with the use of such caps is the possibility of an increase in resistance to water vapor flow out of the vial. This case study investigated the effect of the LyoSeal® and PLASCAP® polymer caps and EZ-fill® nests on the freeze-drying process. Amorphous and partially crystalline model formulations were freeze-dried. Process data and product quality attributes were compared for regularly stoppered vials and vials with polymer caps as well as vials in a hexagonal packaging array and nested vials. The results indicated no increased resistance or impeded water vapor flow by the polymer caps. Differences in the macro- and microscopic appearances of products and a trend towards lower product temperatures were observed for the investigated nest type compared to a regular hexagonal packaging array. Consequently, the polymer caps could be used as an alternative to regular stoppers without affecting freeze-drying process data or product quality attributes, while the different thermal environment of nested vials should be considered.


1968 ◽  
Vol 22 (2) ◽  
pp. 291-295 ◽  
Author(s):  
J. Davidson ◽  
R. B. Williams

1. In a balance study with young chicks estimates of nitrogen retention were made by a balance method and by a body analysis method.2. N retention appeared to be about 15% greater by the balance method when no allowance was made for N in alimentary tract contents. Allowance for tract contents reduced the difference to about 13%.3. Only about one-third of the discrepancy could be accounted for interms of the possible sources of N loss investigated.4. About a quarter of the difference was due to loss of N on drying the droppings before analysis and another tenth to loss of N on freeze-drying minced chick tissues.5. No appreciable loss of ammonia could be detected from chickens and excreta under conditions prevailing in the balance trial. The efficiency of digestion of feathers, uric acid and droppings from birds appeared to be complete by the Kjeldahl method employed.6. A difference of about 8% could therefore not be explained.


2020 ◽  
pp. 004051752095523
Author(s):  
Shuangqing Wang ◽  
Huile Zhang ◽  
Huimin Chen ◽  
Yi Zhong ◽  
Xiaoli Yue

As an indispensable part of textile processing, the fabric drying process has a great impact on product quality and overall energy consumption. To reveal the characteristics of the continuous drying process of various fabrics and optimize process parameters for improving productivity and saving energy, a finite element model is built to simulate the continuous fabric drying process, and an optimization method is applied to optimize process parameters based on the model. Specifically, a finite element model is first built; the model can predict distribution of water content and surface temperature of three kinds of fabric in the continuous drying process under different process parameters. The model is then verified by experiments, and the experimental results agree well with the numerical results: The mean absolute errors of distribution of water content and surface temperature of fabrics are 4.22% and 2.15℃, respectively. The numerical results indicate that wind velocity, wind temperature, and fabric velocity have a significant influence on the drying rate and surface temperature of fabrics in the continuous drying process, which, however, are not affected obviously by initial water content. It is also found that under the same initial and technological conditions, the drying rate and surface temperature of fabrics in the continuous drying process are lower than those in the intermittent drying process. Second, the Taguchi method is applied to design continuous fabric drying schemes, considering the interaction effect of technological parameters on the drying process. The numerical model is then applied to simulate these schemes, and the TOPSIS method is applied to analyze and compare these numerical results. The optimal technological parameters are determined; the optimal parameters can help to save energy by about 27.8 % and enhance energy efficiency by about 16 % in the continuous drying process. It is worth noting that the interaction effect of fabric velocity and wind temperature on the continuous drying process is more significant than their independent effects.


Author(s):  
Alan S. Rudolph ◽  
Ronald R. Price

We have employed cryoelectron microscopy to visualize events that occur during the freeze-drying of artificial membranes by employing real time video capture techniques. Artificial membranes or liposomes which are spherical structures within internal aqueous space are stabilized by water which provides the driving force for spontaneous self-assembly of these structures. Previous assays of damage to these structures which are induced by freeze drying reveal that the two principal deleterious events that occur are 1) fusion of liposomes and 2) leakage of contents trapped within the liposome [1]. In the past the only way to access these events was to examine the liposomes following the dehydration event. This technique allows the event to be monitored in real time as the liposomes destabilize and as water is sublimed at cryo temperatures in the vacuum of the microscope. The method by which liposomes are compromised by freeze-drying are largely unknown. This technique has shown that cryo-protectants such as glycerol and carbohydrates are able to maintain liposomal structure throughout the drying process.


2020 ◽  
Vol 6 (2) ◽  
pp. 187-197
Author(s):  
Nurlaila Suci Rahayu Rais ◽  
Dedeh Apriyani ◽  
Gito Gardjito

Monitoring of warehouse inventory data processing is an important thing for companies. PT Talaga mulya indah is still manual using paper media, causing problems that have an effect on existing information, namely: problems with data processing of incoming and outgoing goods. And the difference between data on the amount of stock of goods available with physical data, often occurs inputting data more than once for the same item, searching for available data, and making reports so that it impedes companies in monitoring inventory of existing stock of goods. Which aims to create a system that can provide updated information to facilitate the warehouse admin in making inventory reports, and reduce errors in input by means of integrated control. In this study, the authors used the data collection method used in this analysis using the method of observation, interviews, and literature review (literature study). For analysis using the PIECES analysis method. Furthermore, the system design used is UML (Unified Modeling Language). The results of this study are expected to produce the right data in the process of monitoring inventory data processing, also can provide the right information and make it easier to control the overall availability of goods.


Manuskripta ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Novarina Novarina

Abstract: This research is a comparative literary study that uses Malay and Javanese versions of Mahabarata text sources. The research objects used were the text edition of Pandhawa Gubah (PG) by Sudibjo Z. Hadisutjipto and the text of Cheritera Pandawa Lima (CPL) by Khalid Hussain. The research method used is descriptive-analysis method. In the comparative study used a comparative literary theory proposed by Endraswara (2011). The results of the text comparison reveal the similarities and differences in the image of Bima figures in the Javanese and Malay versions. The equation as a whole is that both texts contain the same heroic storyline and heroic character, Bima. In addition, Indian influence is still evident in the two texts seen from the nuances of Hinduism that exist in both texts. While the difference is seen in the events that accompany Bima's struggle in achieving his victory. Based on these similarities and differences, it can be seen that the authors attempt to represent the concept of metaphysical interactions vertically and horizontally expressed through PG text. --- Abstrak: Penelitian ini adalah satu kajian sastra bandingan yang menggunakan sumber teks Mahabarata versi Melayu dan Jawa. Objek penelitian yang digunakan adalah edisi teks Pandhawa Gubah (PG) karya Sudibjo Z. Hadisutjipto dan teks Cheritera Pandawa Lima (CPL) karya Khalid Hussain. Metode penelitian yang digunakan adalah metode deskriptif-analisis. Dalam telaah perbandingan digunakan teori sastra bandingan yang dikemukakan Endraswara (2011). Hasil perbandingan teks mengungkapkan adanya persamaan dan perbedaan citra tokoh Bima dalam versi Jawa maupun versi Melayu. Persamaan secara keseluruhan adalah kedua teks tersebut mengandung alur cerita kepahlawanan dan tokoh pahlawan yang sama yaitu Bima. Selain itu, pengaruh India masih tampak dalam kedua teks tersebut dilihat dari nuansa Hinduisme yang ada dalam kedua teks. Sementara perbedaannya tampak pada peristiwa-peristiwa yang menyertai perjuangan Bima dalam mencapai kemenangannya. Berdasarkan persamaan dan perbedaan tersebut tampak adanya upaya penulis untuk merepresentasikan konsep interaksi metafisik secara vertikal dan horizontal yang diungkapkan melalui teks PG.


Metahumaniora ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 368
Author(s):  
Gilang Januarsyah

ABSTRAKUntuk menghasilkan sebuah karangan berbahasa Perancis yang dapat dipahamioleh khalayak umum, mahasiswa harus menguasai kemampuan berbahasa Perancis ragamtulis yang baik dan benar sesuai dengan kaidah yang berlaku. Penelitian ini bertujuanuntuk menjelaskan kesalahan sintaksis yang dilakukan oleh mahasiswa Program StudiSastra Perancis Universitas Padjadjaran. Data yang digunakan dalam penelitian ini diambildari sepuluh karangan mahasiwa yang duduk di semester lima dan tujuh dan dianalisisdengan menggunakan metode simak dan metode analisis padan referensial translasionaldengan pendekatan kualitatif. Hasil dari penelitian ini menunjukkan bahwa kesalahantertinggi yang dilakukan mahasiswa adalah kesalahan dalam penggunaan passé composédan imparfait sebesar 50%, kemudian diikuti oleh kesalahan dalam penggunaan pronomrelatif simple et composé ‘pronomina penghubung bebas dan turunan’ sebesar 30%, danterakhir kesalahan dalam penggunaan pronom COD et COI ‘pronomina COD dan COI’ sebesar20%. Faktor yang menyebabkan terjadinya kesalahan tersebut adalah faktor linguistikyang disebabkan oleh perbedaan kaidah tatabahasa bahasa Indonesia dan Perancis.Selain itu terdapat pula faktor sosiolinguistik yang disebabkan oleh jarangnya mahasiswamembiasakan diri mereka untuk mengaplikasikan bahasa Perancis di luar kelas.Kata kunci: kesalahan, sintaksis, bahasa Perancis, tulis, pengajaranABST RACTTo produce a French-language essay that can be understood by the general public,the students should master the ability of French language in good and true writing skill inaccordance with the applicable rules. The aim of this research is to explain the syntactic errorsmade by students of French literature’s program at University Padjadjaran. The sources ofdata are taken from the ten student essays who sit in the fifth and seventh semesters, and themethods used in this research are Observation Method ‘Metode Simak’ and the analyticalreference translational analysis method with a qualitative approach. The results of thisresearch indicate that the highest errors that students make are the use of passé composéand imparfait as much as fifty percent, followed by errors in the use of pronom relatifsimple et composé ‘the free and derivative pronouns’ thirty percent, and the last error is inthe use of pronom CO D et CO I ‘‘The COD and COI pronouns’ twenty percent. The factors thatcause those errors are a linguistic caused by the difference rules of Indonesian and Frenchgrammar. In addition there are also sociolinguistic factors caused by the rarity of studentsfamiliarize themselves to apply the French language outside the classroom.Keywords: Error, syntax, French language, writing, teaching


2016 ◽  
Vol 52 ◽  
pp. 128-133
Author(s):  
I. V. Khatko ◽  
A. O. Onyshchenko ◽  
V. O. Vovk ◽  
T. M. Konks

The modern state of social-economic processes development demands increasing the level of food safety of the state, especially providing population by the high quality foods of domestic production, specifically by pork. One of criteria for estimating pigs' meatness is determining the fat thickness in different points of a trunk. The informative content of measuring in different parts of a trunk is different and it needs detailed study. The fat thickness is the most common as trait for pigs' meatness in the practice of pig breeding because it has high correlation with meat yield in carcasses. The aim of our research was the comparative study of fat deposition regularities in different parts of a trunk of Large White and Mirgorod pigs in different age periods. For conducting researches 24 pigs of both breeds with average live weight about 40 kg and at age not more 4 months were selected. The fat thickness was measured at live animals using ultrasonic device Draminski in such points: on withers, the level of the 6-7th thoracic vertebra, the level of the 1st-2nd loins vertebra and sacrum. Measuring the fat thickness was carried out at the age of 4, 5, 6, 7 and 8 months. During researches it was carried out the statistical processing of obtained material. Reliability of obtained indexes of productivity was determined. Regularities of formatting fat thickness and fat deposition rate depending on the age were studied. For the results of researches it has been studied and compared economically valuable traits of the most spread domestic pigs of Large White and Mirgorod breeds. By comparative study of growth and development of young pigs of experimental and control groups it has been found that animals of Large White breed differed by lesser fat deposits in all points of measuring. Thus, at 6-months’ age they had lesser thickness of fat in all parts of a trunk. More expressed tendency was at withers and the level of the 6-7th thoracic vertebra, at that in the first case the difference between groups was reliable (p < 0.01). The fat deposition rate in young pigs of both breeds was not the same in different points of measuring along a trunk. Above mentioned tendencies were intensified with the age. Purebred animals of intrabreed type LW-1 at 7-months’ age had reliable less thickness of fat in comparison with the control group: on withers (p < 0.01), at the level of the 6-7th thoracic vertebra, the level of the 1st-2nd loins vertebra (p < 0.05) and on sacrum (p < 0.01). In future, according to economic and scientific expediency, the animals of Mirgorod breed were excluded from the experiment. Concerning Large White breed, the researches were finished when animals were at 8 months’ age. The process of fat deposition in Large White pigs was less intensive in comparison to Mirgorod breed. The highest relative rate of fat thickness increase in both breeds was observed at the level of the 1st-2nd loins vertebra. By statistical processing of the obtained materials it has been found that the difference of average arithmetical indexes (as absolute and relative) between the experimental and control groups during growth and development had distinct tendency to increasing in all points of measuring. The reliability of the difference between the averages in groups with the age of animals increased. A higher reliability of data was obtained at measuring of the front parts of a trunk of pigs at the level of the 6th-7th thoracic vertebra and on withers. The carried out researches at all points of measuring give the reason to confirm that the fat deposits of Large White pigs are less comparing to Mirgorod breed. Conclusions. 1. Carcasses of animals of intrabreed type ULW-1 are comparatively more technologically suitable and economically beneficial for agricultural proceeding industry. 2. Animals of intrabreed type ULW-1 at 7-months’ age had reliable less thickness of fat in comparison with the control group: on withers, at the level of the 6-7th thoracic vertebra, the level of the 1st-2nd loins vertebra and on sacrum. 3. The process of fat deposition in Large White pigs was less intensive in comparison to Mirgorod breed.


2012 ◽  
Vol 2 (1) ◽  
pp. 14-20
Author(s):  
Yuwana Yuwana

Experiment on catfish drying employing ‘Teko Bersayap’ solar dryer was conducted. The result of the experiment indicated that the dryer was able to increase ambient temperature up to 44% and decrease ambient relative humidity up to 103%. Fish drying process followed equations : KAu = 74,94 e-0,03t for unsplitted fish and KAb = 79,25 e-0,09t for splitted fish, where KAu = moisture content of unsplitted fish (%), KAb = moisture content of splitted fish (%), t = drying time. Drying of unsplitted fish finished in 43.995 hours while drying of split fish completed in 15.29 hours. Splitting the fish increased 2,877 times drying rate.


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