scholarly journals Nanoparticles in Cancer Imaging and Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Leon Smith ◽  
Zdenka Kuncic ◽  
Kostya (Ken) Ostrikov ◽  
Shailesh Kumar
Keyword(s):  
Titanium Dioxide ◽  
Radiation Therapy ◽  
Tumor Cells ◽  
Titanium Dioxide Nanoparticles ◽  
Current Status ◽  
Considerable Research ◽  
Image Contrast Enhancement ◽  
Reduced Toxicity ◽  
Targeted Radiation Therapy ◽  
Selective Accumulation

Nanoparticle contrast agents offer the potential to significantly improve existing methods of cancer diagnosis and treatment. Advantages include biocompatibility, selective accumulation in tumor cells, and reduced toxicity. Considerable research is underway into the use of nanoparticles as enhancement agents for radiation therapy and photodynamic therapy, where they may be used to deliver treatment agents, produce localized enhancements in radiation dose and selectively target tumor cells for localized damage. This paper reviews the current status of nanoparticles for cancer treatment and presents preliminary results of a pilot study investigating titanium dioxide nanoparticles for dual-mode enhancement of computed tomography (CT) imaging and kilovoltage radiation therapy. Although titanium dioxide produced noticeable image contrast enhancement in the CT scans, more sensitive detectors are needed to determine whether the nanoparticles can also produce localized dose enhancement for targeted radiation therapy.

Overcoming drug resistance with functional mesoporous titanium dioxide nanoparticles combining targeting, drug delivery and photodynamic therapy

2018 ◽  
Vol 6 (46) ◽  
pp. 7750-7759 ◽  
Author(s):  
Zhaoming Guo ◽  
Kun Zheng ◽  
Zhenquan Tan ◽  
Ye Liu ◽  
Ziyin Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Titanium Dioxide Nanoparticles ◽  
Nano Drug Delivery ◽  
Targeting Strategy

We have designed a nano-drug delivery system ADH-1-HA-MTN, which can overcome the drug resistance of tumor cells based on an EMT cell targeting strategy in combination with PDT.

Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy

2020 ◽  
Vol 75 ◽  
pp. 69-76 ◽  
Author(s):  
Masao Nakayama ◽  
Clare L. Smith ◽  
Bryce N. Feltis ◽  
Terrence J. Piva ◽  
Farnaz Tabatabaie ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Radiation Therapy ◽  
Titanium Dioxide Nanoparticles ◽  
Doped Titanium Dioxide ◽  
Theranostic Agents

scholarly journals Using C-doped TiO2 Nanoparticles as a Novel Sonosensitizer for Cancer Treatment

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 880 ◽  
Author(s):  
Chun-Chen Yang ◽  
Chong-Xuan Wang ◽  
Che-Yung Kuan ◽  
Chih-Ying Chi ◽  
Ching-Yun Chen ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Tumor Cells ◽  
Titanium Dioxide Nanoparticles ◽  
Sol Gel ◽  
Inorganic Materials ◽  
Sonodynamic Therapy ◽  
Carbon Doped ◽  
Significant Difference ◽  
Doped Titanium Dioxide

Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with higher penetration ultrasound and inducing the free radicals. Titanium dioxide has attracted the most attention due to its properties among many nanosensitizers. Hence, in this study, carbon doped titanium dioxide, one of inorganic materials, is applied to avoid the foregoing, and furthermore, carbon doped titanium dioxide is used to generate ROS under ultrasound irradiation to eliminate tumor cells. Spherical carbon doped titanium dioxide nanoparticles are synthesized by the sol-gel process. The forming of C-Ti-O bond may also induce defects in lattice which would be beneficial for the phenomenon of sonoluminescence to improve the effectiveness of sonodynamic therapy. By dint of DCFDA, WST-1, LDH and the Live/Dead test, carbon doped titanium dioxide nanoparticles are shown to be a biocompatible material which may induce ROS radicals to suppress the proliferation of 4T1 breast cancer cells under ultrasound treatment. From in vivo study, carbon doped titanium dioxide nanoparticles activated by ultrasound may inhibit the growth of the 4T1 tumor, and it showed a significant difference between sonodynamic therapy (SDT) and the other groups on the seventh day of the treatment.

LOCAL HYPERTHERMIA IN TREATMENT FOR MALIGNANT BRAIN TUMORS

2018 ◽  
Vol 64 (1) ◽  
pp. 54-61
Author(s):  
A. Ryabova ◽  
O. Gribova ◽  
V. Novikov ◽  
E. Choinzonov ◽  
Zh. Starceva ◽  
...  
Keyword(s):  
Experimental Data ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Combined Treatment ◽  
Complex Treatment ◽  
Local Hyperthermia ◽  
Malignant Brain Tumors ◽  
Sensitizing Effect ◽  
Methods Of Treatment

Unsatisfactory results of complex treatment for malignant brain tumors stimulate search of new effective methods of treatment. Radiation therapy is an integral part of the combined treatment but often does not influence lethally on resistant tumor cells. Thereby in recent decades there has been an active search for different modifiers, which can increase the sensitivity of tumors to chemotherapy and radiotherapy. One of the universal sensitizers is the local hyperthermia. Experimental data showed that the effect of high temperatures had both a direct damaging effect on tumor cells and a sensitizing effect. The literature review given in the article provides an overview of the existing methods of the local hyperthermia for brain tumors treatment.

Targeted Radiation Therapy for Cancer Initiative

2013 ◽  
Author(s):  
Dusten Macdonald ◽  
Stephanie Ninneman
Keyword(s):  
Radiation Therapy ◽  
Targeted Radiation Therapy
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