scholarly journals Sphingosine Kinase-1-Dependent and -Independent Inhibitory Effects ofZanthoxyliFructus to Attenuate the Activation of Mucosal Mast Cells and Ameliorate Food Allergies in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-12
Author(s):  
Xiaoyu Wang ◽  
Natsuko Kageyama-Yahara ◽  
Shusaku Hayashi ◽  
Takeshi Yamamoto ◽  
Makoto Kadowaki
Keyword(s):  
Mast Cells ◽  
Sphingosine Kinase ◽  
Food Allergies ◽  
Sphingosine Kinase 1 ◽  
Inhibitory Effects ◽  
Mucosal Mast Cells

scholarly journals Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1586
Author(s):  
Tomoe Yashiro ◽  
Hanako Ogata ◽  
Syed Faisal Zaidi ◽  
Jaemin Lee ◽  
Shusaku Hayashi ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Imaging System ◽  
Receptor Gene ◽  
Nerve Fibers ◽  
Enteric Neurons ◽  
Food Allergies ◽  
Adenosine A3 Receptor ◽  
Myenteric Neurons ◽  
Mucosal Mast Cells

Recently, the involvement of the nervous system in the pathology of allergic diseases has attracted increasing interest. However, the precise pathophysiological role of enteric neurons in food allergies has not been elucidated. We report the presence of functional high-affinity IgE receptors (FcεRIs) in enteric neurons. FcεRI immunoreactivities were observed in approximately 70% of cholinergic myenteric neurons from choline acetyltransferase-eGFP mice. Furthermore, stimulation by IgE-antigen elevated intracellular Ca2+ concentration in isolated myenteric neurons from normal mice, suggesting that FcεRIs are capable of activating myenteric neurons. Additionally, the morphological investigation revealed that the majority of mucosal mast cells were in close proximity to enteric nerve fibers in the colonic mucosa of food allergy mice. Next, using a newly developed coculture system of isolated myenteric neurons and mucosal-type bone-marrow-derived mast cells (mBMMCs) with a calcium imaging system, we demonstrated that the stimulation of isolated myenteric neurons by veratridine caused the activation of mBMMCs, which was suppressed by the adenosine A3 receptor antagonist MRE 3008F20. Moreover, the expression of the adenosine A3 receptor gene was detected in mBMMCs. Therefore, in conclusion, it is suggested that, through interaction with mucosal mast cells, IgE-antigen-activated myenteric neurons play a pathological role in further exacerbating the pathology of food allergy.

scholarly journals Globule Leukocytes and Other Mast Cells in the Mouse Intestine

2017 ◽  
Vol 55 (1) ◽  
pp. 76-97 ◽  
Author(s):  
Peter Vogel ◽  
Laura Janke ◽  
David M. Gravano ◽  
Meifen Lu ◽  
Deepali V. Sawant ◽  
...  
Keyword(s):  
Mast Cells ◽  
Immune Responses ◽  
Intestinal Mucosa ◽  
Critical Role ◽  
Food Allergies ◽  
Intestinal Helminth ◽  
Mucosal Mast Cells ◽  
Helminth Infections ◽  
Tuft Cell

Only 2 major mast cell (MC) subtypes are commonly recognized in the mouse: the large connective tissue mast cells (CTMCs) and the mucosal mast cells (MMCs). Interepithelial mucosal inflammatory cells, most commonly identified as globule leukocytes (GLs), represent a third MC subtype in mice, which we term interepithelial mucosal mast cells (ieMMCs). This term clearly distinguishes ieMMCs from lamina proprial MMCs (lpMMCs) while clearly communicating their common MC lineage. Both lpMMCs and ieMMCs are rare in normal mouse intestinal mucosa, but increased numbers of ieMMCs are seen as part of type 2 immune responses to intestinal helminth infections and in food allergies. Interestingly, we found that increased ieMMCs were consistently associated with decreased mucosal inflammation and damage, suggesting that they might have a role in controlling helminth-induced immunopathology. We also found that ieMMC hyperplasia can develop in the absence of helminth infections, for example, in Treg-deficient mice, Arf null mice, some nude mice, and certain graft-vs-host responses. Since tuft cell hyperplasia plays a critical role in type 2 immune responses to intestinal helminths, we looked for (but did not find) any direct relationship between ieMMC and tuft cell numbers in the intestinal mucosa. Much remains to be learned about the differing functions of ieMMCs and lpMMCs in the intestinal mucosa, but an essential step in deciphering their roles in mucosal immune responses will be to apply immunohistochemistry methods to consistently and accurately identify them in tissue sections.

Author response for "The role of galanin in the differentiation of mucosal mast cells in mice"

2019 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Yumi Ikeda ◽  
Katsuhisa Tashiro ◽  
Yasuyuki Ohkawa ◽  
Kenji Kawabata
Keyword(s):  
Mast Cells ◽  
Author Response ◽  
Mucosal Mast Cells

Sphingosine kinase 1 is a relevant molecular target in gastric cancer

2011 ◽  
Vol 22 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Thorsten Fuereder ◽  
Doris Hoeflmayer ◽  
Agnes Jaeger-Lansky ◽  
Doris Rasin-Streden ◽  
Sabine Strommer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Sphingosine Kinase ◽  
Molecular Target ◽  
Sphingosine Kinase 1

scholarly journals The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. VOLUME 282 (2007) PAGES 23147-23162

2008 ◽  
Vol 283 (9) ◽  
pp. 5972
Author(s):  
David J. Kusner ◽  
Christopher R. Thompson ◽  
Natalie A. Melrose ◽  
Stuart M. Pitson ◽  
Lina M. Obeid ◽  
...  
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Cytoskeletal Dynamics ◽  
Actin Cytoskeletal Dynamics
Sign in / Sign up

Export Citation Format

Share Document